Gene: AQP4

361
MIWC|WCH4
aquaporin 4
protein-coding
18q11.2
Ensembl:ENSG00000171885 MIM:600308 Vega:OTTHUMG00000131955 UniprotKB:P55087
NG_029560.1
PubMed
0   ANCO-SNPs
CD|OD|ND|AD
8   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.477e-2 (AD)  7.155e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC1A30.916
LRIG10.911
GJA10.906
ELOVL20.899
BMPR1B0.898
SDC20.888
AHCYL10.887
NTRK20.884
NPAS30.884
RFX40.879

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.425
OR4F29-0.398
COL22A1-0.389
CETP-0.368
DUSP27-0.36
ABCC12-0.356
SULT2B1-0.338
TRABD2A-0.337
LGI2-0.336
ADRA1D-0.335

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0067181,12-benzoperylene"1,12-benzoperylene results in increased expression of AQP4 mRNA"26377693
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of AQP4 mRNA"25614096
C0228302-methoxyestradiol2-methoxyestradiol affects the expression of AQP4 protein21092735
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl affects the expression of AQP4 mRNA"20638727
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of AQP4 mRNA]"19467301
C0179063-dinitrobenzene3-dinitrobenzene results in decreased expression of AQP4 mRNA16142770
D000082AcetaminophenAcetaminophen affects the expression of AQP4 mRNA17562736
D000082AcetaminophenAcetaminophen results in decreased expression of AQP4 mRNA17585979
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of AQP4 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of AQP4 mRNA]17585979
D019342Acetic AcidAcetic Acid results in increased expression of AQP4 protein18406487
D020106AcrylamideAcrylamide results in decreased expression of AQP4 mRNA28959563
C006418adrenocorticotropin zincadrenocorticotropin zinc results in increased expression of AQP4 mRNA19920212
C038491allyl sulfideallyl sulfide inhibits the reaction [AQP4 protein affects the susceptibility to 1-Methyl-4-phenylpyridinium]20615459
C038491allyl sulfideallyl sulfide inhibits the reaction [AQP4 protein affects the susceptibility to Ethanol]20615459
C038491allyl sulfideallyl sulfide inhibits the reaction [AQP4 protein affects the susceptibility to Lipopolysaccharides]20615459
D000641AmmoniaAmmonia results in decreased expression of AQP4 mRNA20217200
D000641AmmoniaIL1B protein inhibits the reaction [Ammonia results in decreased expression of AQP4 mRNA]20217200
D000643Ammonium ChlorideAmmonium Chloride affects the expression of AQP4 mRNA16483693
D000643Ammonium ChlorideAmmonium Chloride results in increased expression of AQP4 protein14663195
D000975AntioxidantsAntioxidants inhibits the reaction [Manganese results in increased expression of AQP4 protein]20648640
C006632arsenic trioxidearsenic trioxide results in increased expression of AQP4 mRNA22214486
C044946benazeprilbenazepril inhibits the reaction [Glucose results in increased expression of AQP4 mRNA]11510275
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of AQP4 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of AQP4 mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of AQP4 mRNA22228805
D001623BetamethasoneBetamethasone results in increased expression of AQP4 mRNA9409467
C006780bisphenol Abisphenol A results in decreased expression of AQP4 mRNA28159858
C006780bisphenol Abisphenol A results in increased expression of AQP4 mRNA26364221
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in decreased expression of AQP4 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of AQP4 mRNA25181051
C086539BQ 788BQ 788 inhibits the reaction [EDN1 protein results in decreased expression of AQP4 mRNA]21259319
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of and affects the localization of AQP4 protein20648640
D019256Cadmium ChlorideCadmium Chloride results in increased expression of AQP4 mRNA23178640
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of AQP4 mRNA17805973
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of AQP4 mRNA20938992
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of AQP4 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of AQP4 mRNA]17585979
D003471CuprizoneCuprizone results in increased expression of AQP4 mRNA27523638
D003513Cycloheximide[Lactic Acid co-treated with Cycloheximide] results in increased expression of AQP4 protein18406487
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of AQP4 mRNA23640034
D003676DeferoxamineDeferoxamine inhibits the reaction [manganese(III) acetate dihydrate results in increased expression of AQP4 protein]20648640
D013759DronabinolDronabinol results in decreased expression of AQP4 mRNA21955143
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of AQP4 mRNA]"19467301
D004041Dietary FatsDietary Fats results in increased expression of AQP4 mRNA19467301
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of AQP4 mRNA24535843
D004317DoxorubicinDoxorubicin results in decreased expression of AQP4 protein9573539
D000431Ethanolallyl sulfide inhibits the reaction [AQP4 protein affects the susceptibility to Ethanol]20615459
D000431EthanolAQP4 protein affects the susceptibility to Ethanol20615459
D000431Ethanol[AQP4 protein affects the susceptibility to Ethanol] which affects the abundance of Reactive Oxygen Species20615459
D000431Ethanol[AQP4 protein affects the susceptibility to Ethanol] which affects the expression of CYP2E1 mRNA20615459
D000431EthanolEthanol results in increased expression of AQP4 mRNA21955143
C024565ethylene dichlorideethylene dichloride results in increased expression of AQP4 mRNA24964198
C024565ethylene dichlorideethylene dichloride results in increased expression of AQP4 protein24964198
C000591741Firemaster 550Firemaster 550 results in decreased expression of AQP4 mRNA27957850
D005485FlutamideFlutamide results in decreased expression of AQP4 mRNA21126777
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of AQP4 mRNA20938992
C039281furanfuran results in increased expression of AQP4 mRNA27387713
D005839Gentamicins[Gentamicins results in increased expression of DMD protein mutant form] which results in increased expression of AQP4 protein18694830
D005839GentamicinsGentamicins results in decreased expression of AQP4 mRNA22061828
D005947Glucosebenazepril inhibits the reaction [Glucose results in increased expression of AQP4 mRNA]11510275
D005947GlucoseGlucose results in increased expression of AQP4 mRNA11510275
D005947GlucoseValsartan inhibits the reaction [Glucose results in increased expression of AQP4 mRNA]11510275
D006046Gold[Polyethyleneimine binds to Gold] which results in decreased expression of AQP4 mRNA28433809
D0193071-(5-Isoquinolinesulfonyl)-2-Methylpiperazine1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [TNF protein results in increased expression of AQP4 mRNA]22298391
D006851Hydrochloric AcidHydrochloric Acid results in increased expression of AQP4 protein18406487
D002112CalcifediolCalcifediol deficiency results in decreased expression of AQP4 mRNA17293106
D007501IronIron deficiency results in increased expression of AQP4 mRNA16629162
D019266Iron, Dietary"Iron, Dietary affects the expression of AQP4 mRNA"15637178
C098607JP8 aviation fuelJP8 aviation fuel results in decreased expression of AQP4 mRNA15618438
D019344Lactic AcidLactic Acid affects the localization of AQP4 protein18406487
D019344Lactic Acid[Lactic Acid co-treated with Cycloheximide] results in increased expression of AQP4 protein18406487
D019344Lactic AcidLactic Acid results in increased expression of AQP4 protein18406487
D064747LansoprazoleLansoprazole results in increased expression of AQP4 mRNA20437101
D064747LansoprazoleLansoprazole results in increased expression of AQP4 protein20437101
D007854LeadLead affects the expression of AQP4 mRNA28903495
D008070Lipopolysaccharidesallyl sulfide inhibits the reaction [AQP4 protein affects the susceptibility to Lipopolysaccharides]20615459
D008070LipopolysaccharidesAQP4 protein affects the susceptibility to Lipopolysaccharides20615459
D008070Lipopolysaccharides[AQP4 protein affects the susceptibility to Lipopolysaccharides] which affects the abundance of Reactive Oxygen Species20615459
D008070Lipopolysaccharides[AQP4 protein affects the susceptibility to Lipopolysaccharides] which affects the expression of CYP2E1 mRNA20615459
D008345ManganeseAntioxidants inhibits the reaction [Manganese results in increased expression of AQP4 protein]20648640
C521134manganese(III) acetate dihydrateAQP4 protein affects the susceptibility to manganese(III) acetate dihydrate20648640
C521134manganese(III) acetate dihydrateDeferoxamine inhibits the reaction [manganese(III) acetate dihydrate results in increased expression of AQP4 protein]20648640
C521134manganese(III) acetate dihydratemanganese(III) acetate dihydrate results in increased expression of and affects the localization of AQP4 protein20648640
C521134manganese(III) acetate dihydrateSB 239063 inhibits the reaction [manganese(III) acetate dihydrate results in increased expression of AQP4 protein]20648640
C521134manganese(III) acetate dihydrateU 0126 inhibits the reaction [manganese(III) acetate dihydrate results in increased expression of AQP4 protein]20648640
C521134manganese(III) acetate dihydrateVitamin E inhibits the reaction [manganese(III) acetate dihydrate results in increased expression of AQP4 protein]20648640
D008627Mercuric ChlorideMercuric Chloride results in decreased expression of AQP4 mRNA25854323
D008627Mercuric ChlorideMercuric Chloride results in decreased expression of AQP4 protein25854323
D008628MercuryMercury affects the activity of AQP4 protein11311979
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of AQP4 mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of AQP4 mRNA22863855
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of AQP4 protein22863855|2701272
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of AQP4 mRNA23179753|2800136
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of AQP4 mRNA25854323
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of AQP4 protein25854323
D0156551-Methyl-4-phenylpyridiniumallyl sulfide inhibits the reaction [AQP4 protein affects the susceptibility to 1-Methyl-4-phenylpyridinium]20615459
D0156551-Methyl-4-phenylpyridiniumAQP4 protein affects the susceptibility to 1-Methyl-4-phenylpyridinium20615459
D0156551-Methyl-4-phenylpyridinium[AQP4 protein affects the susceptibility to 1-Methyl-4-phenylpyridinium] which affects the expression of CYP2E1 mRNA20615459
D0156551-Methyl-4-phenylpyridiniumAQP4 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased abundance of Reactive Oxygen Species]20615459
D009020MorphineMorphine results in decreased expression of AQP4 mRNA21955143
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of AQP4 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of AQP4 mRNA"25620056
D009538NicotineNicotine results in increased expression of AQP4 mRNA21955143
C007350nitrofennitrofen results in decreased expression of AQP4 mRNA20638522
C076029olanzapineAQP4 gene polymorphism affects the susceptibility to olanzapine22544010
C076029olanzapineAQP4 protein results in increased susceptibility to olanzapine22544010
D010047Ovalbumin[Particulate Matter co-treated with Ovalbumin] results in increased expression of AQP4 mRNA19176365
D010126OzoneOzone results in increased expression of AQP4 mRNA27206323
D052638Particulate Matter[Particulate Matter co-treated with Ovalbumin] results in increased expression of AQP4 mRNA19176365
C004282periodate-oxidized adenosine 5'-triphosphateperiodate-oxidized adenosine 5'-triphosphate inhibits the reaction [TNF protein results in increased expression of AQP4 mRNA]22298391
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of AQP4 mRNA24535843
D010634PhenobarbitalPhenobarbital affects the expression of AQP4 mRNA23091169
D010862PilocarpinePilocarpine results in decreased expression of AQP4 protein20886625
D011094Polyethyleneimine[Polyethyleneimine binds to Gold] which results in decreased expression of AQP4 mRNA28433809
D059808PolyphenolsPolyphenols results in decreased expression of AQP4 mRNA16293270
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of AQP4 mRNA28903501
D011374ProgesteroneProgesterone results in increased expression of AQP4 mRNA19690047
D017382Reactive Oxygen Species[AQP4 protein affects the susceptibility to Ethanol] which affects the abundance of Reactive Oxygen Species20615459
D017382Reactive Oxygen Species[AQP4 protein affects the susceptibility to Lipopolysaccharides] which affects the abundance of Reactive Oxygen Species20615459
D017382Reactive Oxygen SpeciesAQP4 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased abundance of Reactive Oxygen Species]20615459
D012293RifampinRifampin results in decreased expression of AQP4 mRNA24552687
C406525SB 239063SB 239063 inhibits the reaction [manganese(III) acetate dihydrate results in increased expression of AQP4 protein]20648640
C017947sodium arsenitesodium arsenite results in decreased expression of AQP4 mRNA20308225
D012965Sodium ChlorideSodium Chloride results in decreased expression of AQP4 mRNA22291652
D012999SomanSoman results in increased expression of AQP4 mRNA19281266
D053260SootSoot results in decreased expression of AQP4 mRNA26551751
C030141taurine-ursodeoxycholate conjugatetaurine-ursodeoxycholate conjugate inhibits the reaction [LEP gene mutant form results in increased expression of AQP4 mRNA]21079772
D013726TerbutalineTerbutaline results in increased expression of AQP4 mRNA9409467
D013739Testosterone[bisphenol A co-treated with Testosterone] results in decreased expression of AQP4 mRNA26496021
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of AQP4 mRNA26377647
D013792ThalidomideThalidomide results in increased expression of AQP4 mRNA26217789
D013890ThioureaThiourea results in decreased expression of AQP4 mRNA15248066
C009495titanium dioxidetitanium dioxide affects the expression of AQP4 mRNA23557971
D014028Tobacco Smoke PollutionNFE2L2 protein inhibits the reaction [Tobacco Smoke Pollution affects the expression of AQP4 mRNA]20133372
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of AQP4 mRNA20133372
D014050TolueneToluene results in increased expression of AQP4 mRNA22967744
D014212TretinoinTretinoin results in increased expression of AQP4 mRNA11311979
D014212TretinoinTretinoin results in increased expression of AQP4 protein11311979
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in decreased expression of AQP4 mRNA]27469509
C012589trichostatin Atrichostatin A results in increased expression of AQP4 mRNA24935251
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of AQP4 mRNA23537331
C113580U 0126U 0126 inhibits the reaction [manganese(III) acetate dihydrate results in increased expression of AQP4 protein]20648640
D014635Valproic AcidValproic Acid results in increased expression of AQP4 mRNA28001369
D014635Valproic AcidValproic Acid results in increased methylation of AQP4 gene29154799
D000068756ValsartanValsartan inhibits the reaction [Glucose results in increased expression of AQP4 mRNA]11510275
C025643vinclozolinvinclozolin results in decreased expression of AQP4 mRNA21126777
C025643vinclozolinvinclozolin affects the expression of AQP4 mRNA19015723
C029297vinylidene chloridevinylidene chloride results in decreased expression of AQP4 mRNA26682919
D014810Vitamin EVitamin E inhibits the reaction [manganese(III) acetate dihydrate results in increased expression of AQP4 protein]20648640
D014867WaterAQP4 protein results in increased susceptibility to Water20815926
D014867WaterAQP4 protein affects the transport of Water7528931
D014867WaterAQP4 protein results in increased transport of Water21251984
D014867WaterWater deficiency results in increased expression of AQP4 mRNA15462210
D015032ZincZinc deficiency results in decreased expression of AQP4 mRNA19111725

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005372water transmembrane transporter activity-TAS7559426  
GO:0005515protein binding-IPI25910212  
GO:0015250water channel activity-EXP1373524  1510932  7530250  9369468  9405233  9806845  
9829975  10318966  10510269  10564231  11001937  11034202  
11076974  11573934  12084581  14701836  15948717  16596446  
17178220  18202181  18501347  18511455  18762715  21251984  
GO ID GO Term Qualifier Evidence PubMed
GO:0003091renal water homeostasis-TAS-  
GO:0006833water transport-TAS-  
GO:0050891multicellular organismal water homeostasis-IEP16814974  17645239  
GO:0071346cellular response to interferon-gamma-IDA17645239  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA18392839  
GO:0005886plasma membrane-IDA16814974  
GO:0005886plasma membrane-TAS-  
GO:0009897external side of plasma membrane-IDA17645239  
GO:0016323basolateral plasma membrane-IBA21873635  
KEGG ID KEGG Term
hsa04962Vasopressin-regulated water reabsorption
hsa04976Bile secretion
Reactome ID Reactome Term Evidence
R-HSA-382551Transport of small moleculesTAS
R-HSA-432040Vasopressin regulates renal water homeostasis via AquaporinsTAS
R-HSA-432047Passive transport by AquaporinsTAS
R-HSA-445717Aquaporin-mediated transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19203409Aquaporin 4 knockout resists negative regulation of neural cell proliferation by cocaine in mouse hippocampus. (2009 Jul)Xie LLInt J Neuropsychopharmacol
24282821Effect of alcohol on diffuse axonal injury in rat brainstem: diffusion tensor imaging and aquaporin-4 expression study. (2013)Kong LBiomed Res Int
18540352[Update on the etiology and pathogenesis of multiple sclerosis and neuromyelitis optica]. (2008 Jun)Fujihara KNihon Rinsho
23032072Striatal adenosine signaling regulates EAAT2 and astrocytic AQP4 expression and alcohol drinking in mice. (2013 Feb)Lee MRNeuropsychopharmacology
23184649Docosahexaenoic acid (DHA) prevents binge ethanol-dependent aquaporin-4 elevations while inhibiting neurodegeneration: experiments in rat adult-age entorhino-hippocampal slice cultures. (2013 Jan)Collins MANeurotox Res
23051665Aquaporin-4 deficiency attenuates opioid dependence through suppressing glutamate transporter-1 down-regulation and maintaining glutamate homeostasis. (2013 Jan)Yan HTCNS Neurosci Ther
24705861Alcohol, phospholipase A2-associated neuroinflammation, and omega3 docosahexaenoic acid protection. (2014 Aug)Collins MAMol Neurobiol
22907296Effects of aquaporin 4 deficiency on the expression of spinal PKCalpha, PKCgamma and c-Fos in naloxone-precipitated morphine withdrawal mice. (2012 Aug 25)Chen MLSheng Li Xue Bao