Gene: ILK

3611
HEL-S-28|ILK-1|ILK-2|P59|p59ILK
integrin linked kinase
protein-coding
11p15.4
Ensembl:ENSG00000166333 MIM:602366 Vega:OTTHUMG00000133407 UniprotKB:Q13418
NG_029702.1
PubMed
0   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.246e-3 (AD)  5.846e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NELFCD0.906
PHF10.884
CSNK2B0.881
HNRNPA2B10.875
HDGF0.873
GABARAP0.872
ENO10.872
TECR0.871
ACAA10.87
SF3B20.868

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.854
OR4F29-0.833
OR6C74-0.146
HMHB1-0.146
SDR42E1-0.139
DPPA4-0.137
UPK1B-0.134
BMP15-0.134
CEACAM20-0.133
OR51F1-0.132

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of ILK mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of ILK mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of ILK mRNA"21346803
C0299552-nitrotoluene2-nitrotoluene results in decreased expression of ILK mRNA16460773
C5830744,4'-hexafluorisopropylidene diphenol"[4,4'-hexafluorisopropylidene diphenol binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to ILK protein modified form]"28751236
D000082AcetaminophenAcetaminophen results in decreased expression of ILK mRNA21420995
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ILK mRNA16483693
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of ILK mRNA"10783328
D001241AspirinAspirin results in decreased activity of ILK protein11593435
D001241AspirinAspirin results in decreased expression of ILK mRNA15928584
D004958EstradiolEstradiol affects the expression of ILK mRNA23557687
C006780bisphenol Abisphenol A affects the expression of ILK mRNA23557687
C006780bisphenol A[bisphenol A binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to ILK protein modified form]28751236
C006780bisphenol Abisphenol A results in decreased expression of ILK mRNA29275510
C006780bisphenol Abisphenol A affects the expression of ILK mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of ILK mRNA28628672
C099813bromochloroacetic acidbromochloroacetic acid results in decreased expression of ILK mRNA16460773
D002084Butylated Hydroxytoluene[Butylated Hydroxytoluene co-treated with Oxygen] results in increased expression of ILK protein16272459
D002104CadmiumCadmium results in increased expression of ILK mRNA17327699
D019256Cadmium ChlorideCadmium Chloride results in increased expression of ILK mRNA17327699
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased activity of ILK protein16941698
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ILK protein16941698
D004390ChlorpyrifosChlorpyrifos results in increased expression of ILK mRNA21356183
D004390Chlorpyrifos[Copper co-treated with Chlorpyrifos] results in increased expression of ILK mRNA21356183
D060729Coal AshCoal Ash results in increased expression of ILK mRNA19000753
C018021cobaltous chloridecobaltous chloride results in decreased expression of ILK mRNA19320972
D003042CocaineCocaine affects the reaction [ILK protein affects the phosphorylation of AKT1 protein]18702665
D003042CocaineCocaine results in increased expression of ILK protein18702665
D003042CocaineILK mutant form inhibits the reaction [Cocaine results in increased expression of DLG4 protein]19629758
D003042CocaineILK mutant form inhibits the reaction [Cocaine results in increased expression of SYN1 protein]19629758
D003042CocaineILK mutant form inhibits the reaction [Cocaine results in increased phosphorylation of GRIA1 protein]19629758
D003300Copper[Copper co-treated with Chlorpyrifos] results in increased expression of ILK mRNA21356183
D019327Copper SulfateCopper Sulfate results in decreased expression of ILK mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of ILK mRNA25562108
C017160cypermethrincypermethrin results in decreased expression of ILK mRNA22528246
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of ILK mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ILK mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ILK mRNA21266533
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of ILK mRNA20920545
D004317DoxorubicinDoxorubicin results in increased oxidation of ILK protein28818578
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of ILK mRNA17555576
C032773ethyl caffeateethyl caffeate affects the expression of ILK protein24892518
D005419FlavonoidsFlavonoids results in increased expression of ILK mRNA18035473
C056507gemcitabineILK protein affects the susceptibility to gemcitabine15867245
D019833GenisteinGenistein results in decreased expression of ILK mRNA22228119
D005839GentamicinsGentamicins results in increased expression of ILK mRNA22061828
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of ILK protein18951874
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of ILK mRNA28628672
D007213IndomethacinIndomethacin results in decreased expression of ILK mRNA28201806
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of ILK mRNA28628672
C410337K 7174K 7174 results in increased expression of ILK mRNA24086573
C002385linsidominelinsidomine results in increased oxidation of ILK protein28086193
C010052mizoribinemizoribine inhibits the reaction [Puromycin Aminonucleoside results in increased activity of ILK protein]20502051
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of ILK protein"21135415
C562238N-methyl-3-(1-(4-(piperazin-1-yl)phenyl)-5-(4'-(trifluoromethyl)-(1,1'-biphenyl)-4-yl)-1H-pyrazol-3-yl)propanamide"ILK protein inhibits the reaction [N-methyl-3-(1-(4-(piperazin-1-yl)phenyl)-5-(4'-(trifluoromethyl)-(1,1'-biphenyl)-4-yl)-1H-pyrazol-3-yl)propanamide results in decreased expression of EGFR mRNA]"21823616
C562238N-methyl-3-(1-(4-(piperazin-1-yl)phenyl)-5-(4'-(trifluoromethyl)-(1,1'-biphenyl)-4-yl)-1H-pyrazol-3-yl)propanamide"ILK protein inhibits the reaction [N-methyl-3-(1-(4-(piperazin-1-yl)phenyl)-5-(4'-(trifluoromethyl)-(1,1'-biphenyl)-4-yl)-1H-pyrazol-3-yl)propanamide results in decreased expression of EGFR protein]"21823616
C562238N-methyl-3-(1-(4-(piperazin-1-yl)phenyl)-5-(4'-(trifluoromethyl)-(1,1'-biphenyl)-4-yl)-1H-pyrazol-3-yl)propanamide"ILK protein inhibits the reaction [N-methyl-3-(1-(4-(piperazin-1-yl)phenyl)-5-(4'-(trifluoromethyl)-(1,1'-biphenyl)-4-yl)-1H-pyrazol-3-yl)propanamide results in decreased expression of ERBB2 mRNA]"21823616
C562238N-methyl-3-(1-(4-(piperazin-1-yl)phenyl)-5-(4'-(trifluoromethyl)-(1,1'-biphenyl)-4-yl)-1H-pyrazol-3-yl)propanamide"ILK protein inhibits the reaction [N-methyl-3-(1-(4-(piperazin-1-yl)phenyl)-5-(4'-(trifluoromethyl)-(1,1'-biphenyl)-4-yl)-1H-pyrazol-3-yl)propanamide results in decreased expression of ERBB2 protein]"21823616
C562238N-methyl-3-(1-(4-(piperazin-1-yl)phenyl)-5-(4'-(trifluoromethyl)-(1,1'-biphenyl)-4-yl)-1H-pyrazol-3-yl)propanamide"ILK protein inhibits the reaction [N-methyl-3-(1-(4-(piperazin-1-yl)phenyl)-5-(4'-(trifluoromethyl)-(1,1'-biphenyl)-4-yl)-1H-pyrazol-3-yl)propanamide results in decreased expression of YBX1 mRNA]"21823616
C562238N-methyl-3-(1-(4-(piperazin-1-yl)phenyl)-5-(4'-(trifluoromethyl)-(1,1'-biphenyl)-4-yl)-1H-pyrazol-3-yl)propanamide"ILK protein inhibits the reaction [N-methyl-3-(1-(4-(piperazin-1-yl)phenyl)-5-(4'-(trifluoromethyl)-(1,1'-biphenyl)-4-yl)-1H-pyrazol-3-yl)propanamide results in decreased expression of YBX1 protein]"21823616
C562238N-methyl-3-(1-(4-(piperazin-1-yl)phenyl)-5-(4'-(trifluoromethyl)-(1,1'-biphenyl)-4-yl)-1H-pyrazol-3-yl)propanamide"ILK protein inhibits the reaction [N-methyl-3-(1-(4-(piperazin-1-yl)phenyl)-5-(4'-(trifluoromethyl)-(1,1'-biphenyl)-4-yl)-1H-pyrazol-3-yl)propanamide results in decreased phosphorylation of AKT1 protein]"21823616
C562238N-methyl-3-(1-(4-(piperazin-1-yl)phenyl)-5-(4'-(trifluoromethyl)-(1,1'-biphenyl)-4-yl)-1H-pyrazol-3-yl)propanamide"ILK protein inhibits the reaction [N-methyl-3-(1-(4-(piperazin-1-yl)phenyl)-5-(4'-(trifluoromethyl)-(1,1'-biphenyl)-4-yl)-1H-pyrazol-3-yl)propanamide results in decreased phosphorylation of GSK3B protein]"21823616
C072936notoginsenoside R1notoginsenoside R1 inhibits the reaction [Streptozocin results in increased activity of ILK protein]25503068
C042670N-vinyl-2-pyrrolidinone[N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which results in increased expression of ILK mRNA22037397
D010100Oxygen[Butylated Hydroxytoluene co-treated with Oxygen] results in increased expression of ILK protein16272459
D010634PhenobarbitalILK affects the susceptibility to Phenobarbital19920070
D010656PhenylephrinePhenylephrine affects the reaction [ANGPT1 protein results in increased expression of ILK protein]18502941
D010656PhenylephrineILK protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]16170337
D010656PhenylephrinePhenylephrine affects the localization of ILK protein16170337
D010862PilocarpinePilocarpine results in decreased activity of ILK protein19631748
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ILK mRNA19710929
D010936Plant ExtractsKLF5 protein affects the reaction [Plant Extracts results in increased expression of ILK protein]21297082
D010936Plant ExtractsPlant Extracts results in increased expression of ILK protein21297082
C015586propiverinepropiverine binds to ILK protein29273565
D011692Puromycin Aminonucleosidemizoribine inhibits the reaction [Puromycin Aminonucleoside results in increased activity of ILK protein]20502051
D011692Puromycin AminonucleosidePuromycin Aminonucleoside results in increased activity of ILK protein20502051
D012643SeleniumSelenium results in increased expression of ILK mRNA19244175
C009277sodium arsenatesodium arsenate results in increased expression of ILK mRNA14713550
C009277sodium arsenatesodium arsenate results in increased expression of ILK protein14713550
C017947sodium arsenitesodium arsenite results in decreased expression of ILK mRNA10910055
D013311Streptozocinnotoginsenoside R1 inhibits the reaction [Streptozocin results in increased activity of ILK protein]25503068
D013311StreptozocinStreptozocin results in increased activity of ILK protein25503068
D010042OuabainOuabain results in decreased expression of ILK mRNA28795476
D013467SulindacSulindac results in decreased activity of ILK protein11593435
C061133tamibarotenetamibarotene results in increased expression of ILK mRNA15498508
D013629TamoxifenTamoxifen inhibits the reaction [ESR1 protein binds to ILK protein]23665804
D013629TamoxifenTamoxifen affects the expression of ILK mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ILK mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ILK mRNA19465110
D013806Theophylline[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of ILK protein18951874
D014212TretinoinTretinoin results in increased expression of ILK mRNA15498508
D014810Vitamin EVitamin E results in increased expression of ILK mRNA19244175
D015032ZincZinc results in decreased expression of ILK mRNA19071009

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004674protein serine/threonine kinase activity-IBA21873635  
GO:0004674protein serine/threonine kinase activity-IDA9366252  10871859  
GO:0005178integrin binding-IEA-  
GO:0005515protein binding-IPI11331582  12432066  16189514  16936772  17003112  17353931  
17553790  18339839  19074270  20926685  21516116  21643011  
23414517  23455922  23877428  25416956  25852190  26496610  
26972000  
GO:0005524ATP binding-IEA-  
GO:0017124SH3 domain binding-IEA-  
GO:0019901protein kinase binding-IPI19118217  
GO ID GO Term Qualifier Evidence PubMed
GO:0000165MAPK cascade-IBA21873635  
GO:0001658branching involved in ureteric bud morphogenesis-IEA-  
GO:0001934positive regulation of protein phosphorylation-IMP10637513  
GO:0001954positive regulation of cell-matrix adhesion-IEA-  
GO:0003151outflow tract morphogenesis-IEA-  
GO:0006468protein phosphorylation-IDA10871859  
GO:0006469negative regulation of protein kinase activity-IEA-  
GO:0007050cell cycle arrest-IEA-  
GO:0007160cell-matrix adhesion-IBA21873635  
GO:0007160cell-matrix adhesion-TAS8538749  
GO:0007229integrin-mediated signaling pathway-IBA21873635  
GO:0007229integrin-mediated signaling pathway-IDA9366252  
GO:0007275multicellular organism development-IBA21873635  
GO:0007569cell aging-IEA-  
GO:0008283cell proliferation-NAS10871859  
GO:0008284positive regulation of cell proliferation-IEA-  
GO:0009967positive regulation of signal transduction-IMP10637513  
GO:0010667negative regulation of cardiac muscle cell apoptotic process-IEA-  
GO:0010761fibroblast migration-IEA-  
GO:0014912negative regulation of smooth muscle cell migration-IEA-  
GO:0018105peptidyl-serine phosphorylation-IEA-  
GO:0021675nerve development-IEA-  
GO:0022011myelination in peripheral nervous system-IEA-  
GO:0030335positive regulation of cell migration-IEA-  
GO:0030513positive regulation of BMP signaling pathway-IEA-  
GO:0032288myelin assembly-IEA-  
GO:0032956regulation of actin cytoskeleton organization-IEA-  
GO:0033209tumor necrosis factor-mediated signaling pathway-IMP21343177  
GO:0034329cell junction assembly-TAS-  
GO:0034446substrate adhesion-dependent cell spreading-IBA21873635  
GO:0034446substrate adhesion-dependent cell spreading-IMP19118217  
GO:0042327positive regulation of phosphorylation-IMP20018240  
GO:0043406positive regulation of MAP kinase activity-IEA-  
GO:0043491protein kinase B signaling-IEA-  
GO:0043524negative regulation of neuron apoptotic process-IEA-  
GO:0045197establishment or maintenance of epithelial cell apical/basal polarity-IEA-  
GO:0045663positive regulation of myoblast differentiation-IEA-  
GO:0045669positive regulation of osteoblast differentiation-IEA-  
GO:0045773positive regulation of axon extension-IEA-  
GO:0045893positive regulation of transcription, DNA-templated-IMP20018240  
GO:0048662negative regulation of smooth muscle cell proliferation-IEA-  
GO:0048812neuron projection morphogenesis-IEA-  
GO:0050775positive regulation of dendrite morphogenesis-IEA-  
GO:0051291protein heterooligomerization-IEA-  
GO:0051897positive regulation of protein kinase B signaling-IEA-  
GO:0070527platelet aggregation-HMP23382103  
GO:0090263positive regulation of canonical Wnt signaling pathway-IMP20018240  
GO:0097435supramolecular fiber organization-IEA-  
GO:1901224positive regulation of NIK/NF-kappaB signaling-IMP21343177  
GO:2000178negative regulation of neural precursor cell proliferation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001725stress fiberCOLOCALIZES_WITHIBA21873635  
GO:0005654nucleoplasm-IDA-  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IEA-  
GO:0005911cell-cell junction-IEA-  
GO:0005925focal adhesion-HDA21423176  
GO:0005925focal adhesion-IBA21873635  
GO:0005925focal adhesion-IDA-  
GO:0016020membrane-HDA19946888  
GO:0030017sarcomere-IEA-  
GO:0030027lamellipodium-IEA-  
GO:0030054cell junction-IDA-  
GO:0032991protein-containing complex-IEA-  
GO:0043025neuronal cell body-IEA-  
GO:0043034costamere-IEA-  
GO:0043195terminal bouton-IEA-  
GO:0043198dendritic shaft-IEA-  
KEGG ID KEGG Term
hsa03320PPAR signaling pathway
hsa04510Focal adhesion
hsa05100Bacterial invasion of epithelial cells
hsa05213Endometrial cancer
Reactome ID Reactome Term Evidence
R-HSA-1500931Cell-Cell communicationTAS
R-HSA-446343Localization of the PINCH-ILK-PARVIN complex to focal adhesionsTAS
R-HSA-446353Cell-extracellular matrix interactionsTAS
R-HSA-446728Cell junction organizationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18445113Upregulation of beta-catenin levels in superior frontal cortex of chronic alcoholics. (2008 Jun)Al-Housseini AMAlcohol Clin Exp Res
27143927Integrin and gene network analysis reveals that ITGA5 and ITGB1 are prognostic in non-small-cell lung cancer. (2016)Zheng WOnco Targets Ther