Gene: AQP5

362
AQP-5|PPKB
aquaporin 5
protein-coding
12q13.12
Ensembl:ENSG00000161798 MIM:600442 Vega:OTTHUMG00000169710 UniprotKB:P55064
NG_033883.1
PubMed
0   ANCO-SNPs
ND
3   
6.945e-2 (AD)  5.492e-1 (ND)   (Frontal_Cortex)
9.045e-2 (AD)  8.900e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LYPD10.674
S100A160.663
PDLIM30.66
BCL7C0.657
RARRES20.648
PINLYP0.639
PPP1R14B0.636
DDAH20.633
MAPKAPK30.631
RBP10.624

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FMN1-0.556
IPCEF1-0.536
PTPN3-0.532
ZNF385B-0.531
POU6F2-0.531
SAMD12-0.53
CLSTN2-0.527
MUM1L1-0.523
RYR2-0.522
LSM11-0.521

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5575311,7-diphenyl-5-heptene-3-one"1,7-diphenyl-5-heptene-3-one results in increased expression of AQP5 mRNA"19654927
C4656642-(1-(3-dimethylaminopropyl)-5-methoxyindol-3-yl)-3-(1H-indol-3-yl)maleimide2-(1-(3-dimethylaminopropyl)-5-methoxyindol-3-yl)-3-(1H-indol-3-yl)maleimide inhibits the reaction [WNT5A protein results in increased expression of AQP5 protein]26833564
C4656642-(1-(3-dimethylaminopropyl)-5-methoxyindol-3-yl)-3-(1H-indol-3-yl)maleimide2-(1-(3-dimethylaminopropyl)-5-methoxyindol-3-yl)-3-(1H-indol-3-yl)maleimide results in decreased expression of AQP5 protein26833564
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Capsaicin results in increased expression of AQP5 mRNA]20360133
D000242Cyclic AMPChloroquine inhibits the reaction [Cyclic AMP results in decreased expression of AQP5 protein]15536076
D000242Cyclic AMPCyclic AMP affects the expression of and results in increased phosphorylation of and results in increased localization of AQP5 protein15536076
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of AQP5 mRNA23630614
D000643Ammonium ChlorideAmmonium Chloride affects the expression of AQP5 mRNA16483693
D001285AtropineAtropine inhibits the reaction [Pilocarpine affects the localization of AQP5 protein]26208470
D001374AzacitidineAzacitidine promotes the reaction [SP1 protein binds to AQP5 promoter]17198683
D001374AzacitidineAzacitidine results in decreased methylation of AQP5 promoter17198683
D001374Azacitidine[Azacitidine results in decreased methylation of AQP5 promoter] which results in increased expression of AQP5 mRNA17198683|1719868
D001374AzacitidineAzacitidine results in increased expression of AQP5 protein17198683
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of AQP5 mRNA22228805
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Oxygen inhibits the reaction [AQP5 protein results in increased stability of EPAS1 protein]]23545307
D004958EstradiolEstradiol results in increased expression of AQP5 mRNA19484750|1965492
D004958EstradiolTetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of AQP5 mRNA]24052564
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of AQP5 mRNA28341573
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of AQP5 protein28341573
D004958EstradiolEstradiol results in decreased expression of AQP5 mRNA20381596|2834157
D004958EstradiolEstradiol results in increased expression of AQP5 mRNA26372666
D004958EstradiolEstradiol results in increased expression of AQP5 protein28341573
D004958EstradiolProgesterone inhibits the reaction [Estradiol results in decreased expression of AQP5 mRNA]28341573
D004958EstradiolProgesterone promotes the reaction [Estradiol results in decreased expression of AQP5 protein]28341573
D004958EstradiolQuercetin affects the reaction [[Estradiol co-treated with Progesterone] results in increased expression of AQP5 mRNA]28341573
D004958EstradiolQuercetin affects the reaction [Estradiol results in decreased expression of AQP5 mRNA]28341573
D004958EstradiolQuercetin affects the reaction [Estradiol results in increased expression of AQP5 protein]28341573
C006780bisphenol Abisphenol A results in decreased expression of AQP5 protein27522653
C006780bisphenol Abisphenol A results in decreased expression of AQP5 mRNA26283537
C006780bisphenol Abisphenol A results in decreased expression of AQP5 protein26283537
C006780bisphenol ADexamethasone inhibits the reaction [bisphenol A results in decreased expression of AQP5 protein]26283537
C006780bisphenol Abisphenol A results in decreased expression of AQP5 mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of AQP5 mRNA26079696
D002211Capsaicin2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Capsaicin results in increased expression of AQP5 mRNA]20360133
D002211CapsaicinCapsaicin results in increased expression of and results in increased localization of AQP5 protein20360133
D002211CapsaicinCapsaicin results in increased expression of AQP5 mRNA20360133
D002217CarbacholCarbachol affects the localization of AQP5 protein19443731
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of AQP5 mRNA17805973
D002738ChloroquineChloroquine inhibits the reaction [Cyclic AMP results in decreased expression of AQP5 protein]15536076
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of AQP5 mRNA20938992
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of AQP5 mRNA28472532
C018021cobaltous chloride[AQP5 protein results in increased stability of EPAS1 protein] promotes the reaction [cobaltous chloride results in increased expression of EPAS1 protein]23545307
C018021cobaltous chloridecobaltous chloride results in decreased expression of AQP5 mRNA24386269
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of AQP5 mRNA23640034
D003907DexamethasoneDexamethasone inhibits the reaction [bisphenol A results in decreased expression of AQP5 protein]26283537
D003907DexamethasoneDexamethasone results in decreased expression of AQP5 mRNA22733784
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of AQP5 mRNA21266533
D004041Dietary FatsDietary Fats results in increased expression of AQP5 mRNA25016146
D002117CalcitriolCalcitriol results in decreased expression of AQP5 mRNA26485663
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of AQP5 mRNA"19480007
D004967Estrogens[Progesterone co-treated with Estrogens] affects the localization of AQP5 protein16452730
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of AQP5 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of AQP5 mRNA15834898|1617478
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in increased expression of AQP5 mRNA17187413
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of AQP5 mRNA20938992
C039281furanfuran results in increased expression of AQP5 mRNA26194646
D006575Heterocyclic Compounds, 3-Ring"Heterocyclic Compounds, 3-Ring inhibits the reaction [EP300 protein results in increased expression of AQP5 mRNA]"26833564
D006575Heterocyclic Compounds, 3-Ring"Heterocyclic Compounds, 3-Ring results in decreased expression of AQP5 mRNA"26833564
D006575Heterocyclic Compounds, 3-Ring"Heterocyclic Compounds, 3-Ring results in decreased expression of AQP5 protein"26833564
D006632HistamineHistamine affects the localization of AQP5 protein19443731
D017313FenretinideFenretinide results in decreased expression of AQP5 mRNA28973697
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of AQP5 mRNA20938992
D008748MethylcholanthreneMethylcholanthrene results in increased expression of AQP5 mRNA20713471
D008748MethylcholanthreneMethylcholanthrene results in increased expression of AQP5 mRNA26372666
C517284monomethyl phthalatemonomethyl phthalate affects the expression of AQP5 mRNA26924002
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of AQP5 mRNA20551477
D009532NickelNickel results in decreased expression of AQP5 mRNA24768652|2558310
C007350nitrofennitrofen results in decreased expression of AQP5 mRNA17245593|1727056
C007350nitrofennitrofen results in decreased expression of AQP5 protein17245593
D010100Oxygen[AQP5 protein results in increased stability of EPAS1 protein] promotes the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]23545307
D010100Oxygenbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Oxygen inhibits the reaction [AQP5 protein results in increased stability of EPAS1 protein]]23545307
D010100OxygenOxygen inhibits the reaction [AQP5 protein results in increased stability of EPAS1 protein]23545307
D010656PhenylephrinePhenylephrine affects the localization of AQP5 protein17122163
D010656PhenylephrinePhenylephrine results in increased expression of AQP5 protein17462161
D010862PilocarpineAtropine inhibits the reaction [Pilocarpine affects the localization of AQP5 protein]26208470
D010862PilocarpinePilocarpine affects the localization of AQP5 protein26208470
D011192Potassium DichromatePotassium Dichromate results in increased expression of AQP5 mRNA23608068
D011374ProgesteroneProgesterone results in decreased expression of AQP5 mRNA22238285
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of AQP5 mRNA28341573
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of AQP5 protein28341573
D011374ProgesteroneProgesterone affects the localization of AQP5 protein16452730
D011374Progesterone[Progesterone co-treated with Estrogens] affects the localization of AQP5 protein16452730
D011374ProgesteroneProgesterone inhibits the reaction [Estradiol results in decreased expression of AQP5 mRNA]28341573
D011374ProgesteroneProgesterone promotes the reaction [Estradiol results in decreased expression of AQP5 protein]28341573
D011374ProgesteroneQuercetin affects the reaction [[Estradiol co-treated with Progesterone] results in increased expression of AQP5 mRNA]28341573
D047428Protein Kinase Inhibitors[Protein Kinase Inhibitors results in decreased activity of PRKCZ protein] which results in decreased expression of AQP5 protein26833564
D011794QuercetinQuercetin affects the reaction [[Estradiol co-treated with Progesterone] results in increased expression of AQP5 mRNA]28341573
D011794QuercetinQuercetin affects the reaction [Estradiol results in decreased expression of AQP5 mRNA]28341573
D011794QuercetinQuercetin affects the reaction [Estradiol results in increased expression of AQP5 protein]28341573
D011794QuercetinQuercetin results in decreased expression of AQP5 mRNA28431985
D011794QuercetinQuercetin results in decreased expression of AQP5 protein28431985
D012834SilverSilver results in increased expression of AQP5 mRNA27131904
D013629TamoxifenTamoxifen affects the expression of AQP5 mRNA17555576
D013726TerbutalineTerbutaline affects the expression of AQP5 protein15536076
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of AQP5 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of AQP5 mRNA]24052564
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of AQP5 mRNA18990726
D013792ThalidomideThalidomide results in increased expression of AQP5 mRNA26217789
D013890ThioureaThiourea results in decreased expression of AQP5 mRNA15248066
C009495titanium dioxidetitanium dioxide results in increased expression of AQP5 mRNA27760801
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of AQP5 mRNA27865774
D014212TretinoinTretinoin results in increased expression of AQP5 mRNA17097063
D014212TretinoinTretinoin results in increased expression of AQP5 protein17097063
D014303TrinitrotolueneTrinitrotoluene affects the expression of AQP5 mRNA21346803
D014635Valproic AcidValproic Acid results in increased methylation of AQP5 gene29154799
C025643vinclozolinvinclozolin affects the expression of AQP5 mRNA19015723

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16189514  19060904  25416956  
GO:0015250water channel activity-EXP1373524  1510932  7530250  9369468  9405233  9806845  
9829975  10318966  10510269  10564231  11001937  11034202  
11076974  11573934  12084581  14701836  15948717  16596446  
17178220  18202181  18501347  18511455  18762715  21251984  
GO:0015250water channel activity-IDA12801959  
GO:0042802identical protein binding-IPI18768791  
GO ID GO Term Qualifier Evidence PubMed
GO:0006833water transport-TAS-  
GO:0007588excretion-TAS8621489  
GO:0015670carbon dioxide transport-IDA19273840  
GO:0030157pancreatic juice secretion-IEP12801959  
GO:0042476odontogenesis-IEP12522663  
GO:0046541saliva secretion-IEA-  
GO:0048593camera-type eye morphogenesis-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005783endoplasmic reticulum-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS8621489  
GO:0005902microvillus-IEA-  
GO:0009925basal plasma membrane-IEA-  
GO:0016324apical plasma membrane-IBA21873635  
GO:0016324apical plasma membrane-IDA12801959  
GO:0070062extracellular exosome-HDA19199708  
KEGG ID KEGG Term
hsa04970Salivary secretion
Reactome ID Reactome Term Evidence
R-HSA-382551Transport of small moleculesTAS
R-HSA-432047Passive transport by AquaporinsTAS
R-HSA-445717Aquaporin-mediated transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17640479Decreased expression of human aquaporin-5 correlated with mucus overproduction in airways of chronic obstructive pulmonary disease. (2007 Aug)Wang KActa Pharmacol Sin
21151978Aquaporin 5 polymorphisms and rate of lung function decline in chronic obstructive pulmonary disease. (2010 Dec 3)Hansel NNPLoS One
28266114Interaction of lifestyle, behaviour or systemic diseases with dental caries and periodontal diseases: consensus report of group 2 of the joint EFP/ORCA workshop on the boundaries between caries and periodontal diseases. (2017 Mar)Chapple ILJ Clin Periodontol