Gene: IDO1

3620
IDO|IDO-1|INDO
indoleamine 2,3-dioxygenase 1
protein-coding
8p11.21
Ensembl:ENSG00000131203 MIM:147435 Vega:OTTHUMG00000164057 UniprotKB:P14902
NG_028155.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.747e-2 (AD)  3.048e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KRTAP20-10.995
RUFY40.975
CCL70.973
ZBP10.969
CYP19A10.961
CCL80.943
IL270.939
LGALS140.904
SIGLEC120.894
LAG30.888

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ATP6V1E2-0.279
SNX22-0.269
NME5-0.237
GNG7-0.233
HCN2-0.23
OLIG1-0.228
FOXRED2-0.223
CDH4-0.219
BTBD2-0.208
KCNN1-0.206

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00435Nitric OxideSmall Molecule10102-43-9ApprovedTarget
DB00150L-TryptophanSmall Molecule73-22-3Approved|Nutraceutical|WithdrawnEnzyme
DB01065MelatoninSmall Molecule73-31-4Approved|NutraceuticalEnzyme
DB09061CannabidiolSmall Molecule13956-29-1Approved|InvestigationalEnzyme
ID Drug Name Action PubMed
C0917683'-methoxy-4'-nitroflavone3'-methoxy-4'-nitroflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IDO1 mRNA]18694728
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IDO1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IDO1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IDO1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IDO1 mRNA"27188386
C1118556-formylindolo(3,2-b)carbazole"6-formylindolo(3,2-b)carbazole results in increased expression of IDO1 mRNA"18694728|2778311
D000082AcetaminophenAcetaminophen affects the expression of IDO1 mRNA17562736
D000212AcyclovirAcyclovir results in decreased activity of IDO1 protein17174341
C109925AM 281AM 281 inhibits the reaction [Dronabinol inhibits the reaction [Plant Preparations results in increased activity of IDO1 protein]]19167098
C109925AM 281AM 281 inhibits the reaction [Plant Preparations results in increased activity of IDO1 protein]19167098
C109925AM 281AM 281 promotes the reaction [Cannabidiol inhibits the reaction [Plant Preparations results in increased activity of IDO1 protein]]19167098
D019798NeopterinCannabidiol inhibits the reaction [[Plant Preparations results in increased activity of IDO1 protein] which results in increased abundance of Neopterin]19167098
D019798NeopterinDronabinol inhibits the reaction [[Plant Preparations results in increased activity of IDO1 protein] which results in increased abundance of Neopterin]19167098
D019798Neopterin[Plant Preparations results in increased activity of IDO1 protein] which results in increased abundance of Neopterin19167098
D000643Ammonium ChlorideAmmonium Chloride affects the expression of IDO1 mRNA16483693
D001241AspirinIDO1 affects the susceptibility to Aspirin19489917
C447119bazedoxifenebazedoxifene inhibits the reaction [Estradiol results in increased expression of IDO1 mRNA]18367319
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IDO1 mRNA"27188386
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of IDO1 mRNA20064835
D004958Estradiolbazedoxifene inhibits the reaction [Estradiol results in increased expression of IDO1 mRNA]18367319
D004958EstradiolEstradiol results in increased expression of IDO1 mRNA18367319
D004958EstradiolLasofoxifene inhibits the reaction [Estradiol results in increased expression of IDO1 mRNA]18367319
D004958EstradiolRaloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of IDO1 mRNA]18367319
C006780bisphenol Abisphenol A results in decreased expression of IDO1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of IDO1 gene28505145
C018475butyraldehydebutyraldehyde results in increased expression of IDO1 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of IDO1 promoter22457795
C055494caffeic acid phenethyl ester[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of IDO1 mRNA20360939
D002185CannabidiolAM 281 promotes the reaction [Cannabidiol inhibits the reaction [Plant Preparations results in increased activity of IDO1 protein]]19167098
D002185CannabidiolCannabidiol inhibits the reaction [Plant Preparations results in increased activity of IDO1 protein]19167098
D002185CannabidiolCannabidiol inhibits the reaction [[Plant Preparations results in increased activity of IDO1 protein] which results in increased abundance of Neopterin]19167098
D002185CannabidiolCannabidiol inhibits the reaction [Plant Preparations results in increased expression of IDO1 mRNA]19167098
D002185Cannabidioliodopravadoline promotes the reaction [Cannabidiol inhibits the reaction [Plant Preparations results in increased activity of IDO1 protein]]19167098
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of IDO1 mRNA28472532
C551788CL 075CL 075 results in increased expression of IDO1 mRNA27783115
C034456CMF regimenIDO1 mRNA affects the susceptibility to CMF regimen18925433
C029892cupric chloridecupric chloride results in decreased expression of IDO1 mRNA24650576
D003474CurcuminCurcumin results in decreased expression of IDO1 mRNA18348204
C014347decitabinedecitabine affects the expression of IDO1 mRNA23300844
D013759DronabinolAM 281 inhibits the reaction [Dronabinol inhibits the reaction [Plant Preparations results in increased activity of IDO1 protein]]19167098
D013759DronabinolDronabinol inhibits the reaction [Plant Preparations results in increased activity of IDO1 protein]19167098
D013759DronabinolDronabinol inhibits the reaction [[Plant Preparations results in increased activity of IDO1 protein] which results in increased abundance of Neopterin]19167098
D013759DronabinolDronabinol inhibits the reaction [Plant Preparations results in increased expression of IDO1 mRNA]19167098
D013759Dronabinoliodopravadoline inhibits the reaction [Dronabinol inhibits the reaction [Plant Preparations results in increased activity of IDO1 protein]]19167098
D016264Dextran SulfateDextran Sulfate results in increased expression of IDO1 mRNA23894361
D002945CisplatinCisplatin affects the expression of IDO1 mRNA23300844
D002945CisplatinCisplatin results in increased expression of IDO1 mRNA27392435
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of IDO1 mRNA20360939
C118739entinostatentinostat results in increased expression of IDO1 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IDO1 mRNA"27188386
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of IDO1 mRNA23550701
C064925gadodiamidegadodiamide results in increased expression of IDO1 mRNA20959327
D006820Hyaluronic AcidHyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of IDO1 protein]23178681
D006820Hyaluronic AcidHyaluronic Acid analog results in decreased expression of IDO1 protein23178681
D006861Hydrogen PeroxideHyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of IDO1 protein]23178681
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of IDO1 protein23178681
C474021indirubin-3'-monoximeindirubin-3'-monoxime results in increased expression of IDO1 protein21948866
C474021indirubin-3'-monoximeLipopolysaccharides affects the susceptibility to [indirubin-3'-monoxime results in increased expression of IDO1 protein]21948866
C016517indole-3-carbinolindole-3-carbinol results in increased expression of IDO1 mRNA21948866
C016517indole-3-carbinolLipopolysaccharides affects the susceptibility to [indole-3-carbinol results in increased expression of IDO1 mRNA]21948866
C094023iodopravadolineiodopravadoline inhibits the reaction [Dronabinol inhibits the reaction [Plant Preparations results in increased activity of IDO1 protein]]19167098
C094023iodopravadolineiodopravadoline inhibits the reaction [Plant Preparations results in increased activity of IDO1 protein]19167098
C094023iodopravadolineiodopravadoline promotes the reaction [Cannabidiol inhibits the reaction [Plant Preparations results in increased activity of IDO1 protein]]19167098
D007736Kynurenic AcidIDO1 protein results in increased chemical synthesis of Kynurenic Acid analog27020609
C111332LasofoxifeneLasofoxifene inhibits the reaction [Estradiol results in increased expression of IDO1 mRNA]18367319
C111332LasofoxifeneLasofoxifene results in increased expression of IDO1 mRNA18367319
C008261lead acetatelead acetate results in increased expression of IDO1 mRNA20542052
C482199lipopolysaccharide, E coli O55-B5"IDO1 gene mutant form affects the susceptibility to lipopolysaccharide, E coli O55-B5"24930766
C482199lipopolysaccharide, E coli O55-B5"IDO1 gene mutant form promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL10 protein]"24930766
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of IDO1 protein"24930766
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of IDO1 mRNA20884048|2778311
D008070LipopolysaccharidesSulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of IDO1 mRNA]20884048
D008070LipopolysaccharidesLipopolysaccharides affects the susceptibility to [indirubin-3'-monoxime results in increased expression of IDO1 protein]21948866
D008070LipopolysaccharidesLipopolysaccharides affects the susceptibility to [indole-3-carbinol results in increased expression of IDO1 mRNA]21948866
D008070Lipopolysaccharides[[Lipopolysaccharides binds to and results in increased activity of TLR4 protein] which co-treated with Tetrachlorodibenzodioxin] results in increased expression of IDO1 mRNA21097750
D009532NickelNickel results in increased expression of IDO1 mRNA24768652|2558310
C029938nickel sulfatenickel sulfate results in increased expression of IDO1 mRNA16780908
D009569Nitric OxideNitric Oxide binds to and affects the folding of and results in increased degradation of and results in decreased activity of IDO1 protein16834326
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of IDO1 mRNA27935865
C010262norharmannorharman results in decreased activity of IDO1 protein27020609
C522391perfluorododecanoic acidperfluorododecanoic acid results in increased expression of IDO1 protein19854247
C006253pirinixic acidNCF1 protein promotes the reaction [pirinixic acid results in decreased expression of IDO1 mRNA]17950772
C006253pirinixic acidpirinixic acid results in decreased expression of IDO1 mRNA17426115|1795077
D028321Plant PreparationsAM 281 inhibits the reaction [Dronabinol inhibits the reaction [Plant Preparations results in increased activity of IDO1 protein]]19167098
D028321Plant PreparationsAM 281 inhibits the reaction [Plant Preparations results in increased activity of IDO1 protein]19167098
D028321Plant PreparationsAM 281 promotes the reaction [Cannabidiol inhibits the reaction [Plant Preparations results in increased activity of IDO1 protein]]19167098
D028321Plant PreparationsCannabidiol inhibits the reaction [Plant Preparations results in increased activity of IDO1 protein]19167098
D028321Plant PreparationsCannabidiol inhibits the reaction [[Plant Preparations results in increased activity of IDO1 protein] which results in increased abundance of Neopterin]19167098
D028321Plant PreparationsCannabidiol inhibits the reaction [Plant Preparations results in increased expression of IDO1 mRNA]19167098
D028321Plant PreparationsDronabinol inhibits the reaction [Plant Preparations results in increased activity of IDO1 protein]19167098
D028321Plant PreparationsDronabinol inhibits the reaction [[Plant Preparations results in increased activity of IDO1 protein] which results in increased abundance of Neopterin]19167098
D028321Plant PreparationsDronabinol inhibits the reaction [Plant Preparations results in increased expression of IDO1 mRNA]19167098
D028321Plant Preparationsiodopravadoline inhibits the reaction [Dronabinol inhibits the reaction [Plant Preparations results in increased activity of IDO1 protein]]19167098
D028321Plant Preparationsiodopravadoline inhibits the reaction [Plant Preparations results in increased activity of IDO1 protein]19167098
D028321Plant Preparationsiodopravadoline promotes the reaction [Cannabidiol inhibits the reaction [Plant Preparations results in increased activity of IDO1 protein]]19167098
D028321Plant PreparationsPlant Preparations results in increased activity of IDO1 protein19167098
D028321Plant Preparations[Plant Preparations results in increased activity of IDO1 protein] which results in increased abundance of Neopterin19167098
D028321Plant PreparationsPlant Preparations results in increased expression of IDO1 mRNA19167098
D011070Poly I-CPoly I-C results in increased expression of IDO1 mRNA27783115
D011794QuercetinQuercetin results in increased expression of IDO1 protein15221776
C502851quinocetonequinocetone results in increased expression of IDO1 mRNA27046791
D017378Quinolinic AcidIDO1 protein results in increased chemical synthesis of Quinolinic Acid16365156|1717434
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of IDO1 mRNA]18367319
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in increased expression of IDO1 mRNA18367319
C059514resveratrolresveratrol affects the activity of IDO1 protein16154495
D019821SimvastatinSimvastatin results in increased expression of IDO120491794
D012460SulfasalazineSulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of IDO1 mRNA]20884048
D013739TestosteroneTestosterone results in increased expression of IDO1 mRNA19693291
C004648testosterone enanthatetestosterone enanthate affects the expression of IDO1 mRNA17440010
D013749Tetrachlorodibenzodioxin3'-methoxy-4'-nitroflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IDO1 mRNA]18694728
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of IDO1 mRNA18694728|2778311
D013749Tetrachlorodibenzodioxin[[Lipopolysaccharides binds to and results in increased activity of TLR4 protein] which co-treated with Tetrachlorodibenzodioxin] results in increased expression of IDO1 mRNA21097750
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of IDO1 mRNA18694728|2035056
C012589trichostatin Atrichostatin A results in decreased expression of IDO1 mRNA24935251
C015559trimellitic anhydridetrimellitic anhydride affects the expression of IDO1 mRNA19042947
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of IDO1 mRNA17982090
D014635Valproic AcidValproic Acid affects the expression of IDO1 mRNA25979313
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of IDO1 gene25560391
D014800VitalliumVitallium analog results in decreased expression of IDO1 mRNA23825117
C581157XL147[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of IDO1 mRNA27935865
C088658zoledronic acidzoledronic acid results in increased expression of IDO1 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004833tryptophan 2,3-dioxygenase activity-EXP16477023  
GO:0009055electron transfer activity-TAS2109605  
GO:0020037heme binding-IEA-  
GO:0033754indoleamine 2,3-dioxygenase activity-IMP25310899  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002376immune system process-IEA-  
GO:0002534cytokine production involved in inflammatory response-IEA-  
GO:0002666positive regulation of T cell tolerance induction-IEA-  
GO:0002678positive regulation of chronic inflammatory response-IEA-  
GO:0002830positive regulation of type 2 immune response-IEA-  
GO:0006569tryptophan catabolic process-TAS-  
GO:0007565female pregnancy-TAS9712583  
GO:0019441tryptophan catabolic process to kynurenine-IEA-  
GO:0022900electron transport chain-IEA-  
GO:0032496response to lipopolysaccharide-IEA-  
GO:0032693negative regulation of interleukin-10 production-IEA-  
GO:0032735positive regulation of interleukin-12 production-IEA-  
GO:0033555multicellular organismal response to stress-IEA-  
GO:0034276kynurenic acid biosynthetic process-IEA-  
GO:0036269swimming behavior-IEA-  
GO:0042130negative regulation of T cell proliferation-IEA-  
GO:0046006regulation of activated T cell proliferationNOTIMP25310899  
GO:0070233negative regulation of T cell apoptotic process-IEA-  
GO:0070234positive regulation of T cell apoptotic process-IMP25310899  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
GO:0030485smooth muscle contractile fiber-IEA-  
GO:0032421stereocilium bundle-IEA-  
KEGG ID KEGG Term
hsa00380Tryptophan metabolism
hsa01100Metabolic pathways
hsa05143African trypanosomiasis
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-6788656Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolismTAS
R-HSA-71240Tryptophan catabolismTAS
R-HSA-71291Metabolism of amino acids and derivativesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29796641Tryptophan Metabolism through the Kynurenine Pathway is Associated with Endoscopic Inflammation in Ulcerative Colitis. (2018 May 22)Sofia MAInflamm Bowel Dis
23036591Dendritic cells provide a potential link between smoking and inflammation in rheumatoid arthritis. (2012 Oct 4)Kazantseva MGArthritis Res Ther