Gene: INHA

3623
-
inhibin subunit alpha
protein-coding
2q35
Ensembl:ENSG00000123999 MIM:147380 Vega:OTTHUMG00000059237 UniprotKB:P05111
NC_000002.12
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.027e-1 (AD)  3.121e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NOXA10.799
SPPL2B0.78
TTC21A0.774
LMF10.759
MYL50.758
TARBP10.758
CHTF180.752
SGSH0.739
NPEPL10.739
COQ40.736

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DLEU1-0.484
CYP39A1-0.479
CCDC102A-0.451
SRPX-0.395
RAB39A-0.386
PABPC4L-0.372
MIA-0.371
LCN10-0.365
MTRNR2L9-0.359
CARD16-0.354

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5405961,2,5,6-tetrabromocyclooctane"1,2,5,6-tetrabromocyclooctane results in decreased expression of INHA mRNA"25646719
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of INHA mRNA"23829299
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [FSHB protein affects the expression of INHA mRNA]"19414516
C00799725-hydroxycholesterol25-hydroxycholesterol results in increased expression of INHA mRNA19464342
C00799725-hydroxycholesterol25-hydroxycholesterol results in increased expression of INHA protein19464342
D000082AcetaminophenAcetaminophen results in decreased expression of INHA mRNA22230336
D000643Ammonium ChlorideAmmonium Chloride affects the expression of INHA mRNA16483693
D003913DextroamphetamineDextroamphetamine results in increased expression of INHA mRNA16715494
D001280AtrazineAtrazine results in increased expression of INHA mRNA18461179
D001280AtrazineNR5A1 protein promotes the reaction [Atrazine results in increased expression of INHA mRNA]18461179
D001280Atrazine[Atrazine co-treated with Bucladesine] results in increased expression of INHA mRNA23200735
D001280AtrazineAtrazine inhibits the reaction [Bucladesine results in decreased expression of INHA mRNA]21693180
D001280AtrazineAtrazine results in increased expression of INHA mRNA23200735
D001280AtrazineQuercetin inhibits the reaction [[Atrazine co-treated with Bucladesine] results in increased expression of INHA mRNA]23200735
D001280AtrazineQuercetin inhibits the reaction [Atrazine results in increased expression of INHA mRNA]23200735
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of INHA gene25435355
D004958EstradiolEstradiol results in decreased expression of INHA mRNA23373633
D004958EstradiolEstradiol results in decreased expression of INHA mRNA17255206
D004958EstradiolINHA protein results in decreased abundance of Estradiol18992787
C006780bisphenol Abisphenol A affects the expression of INHA mRNA25181051
C027561butylbenzyl phthalatebutylbenzyl phthalate results in decreased expression of INHA mRNA26472102
D004390ChlorpyrifosChlorpyrifos results in increased expression of INHA mRNA20350560
D003024ClozapineClozapine results in decreased expression of INHA mRNA16715494
D003042CocaineCocaine results in decreased expression of INHA mRNA18000554
D003078ColchicineColchicine results in decreased expression of INHA mRNA20624997
D003907DexamethasoneDexamethasone results in decreased expression of INHA mRNA14618091
D003907DexamethasoneDexamethasone results in increased expression of INHA mRNA14618091
C053316di-(2-ethylhexyl) terephthalatedi-(2-ethylhexyl) terephthalate results in decreased expression of INHA mRNA26472102
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of INHA mRNA18214805
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of INHA mRNA17379624|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of INHA protein17379624|2174549
D003994Bucladesine[Atrazine co-treated with Bucladesine] results in increased expression of INHA mRNA23200735
D003994BucladesineAtrazine inhibits the reaction [Bucladesine results in decreased expression of INHA mRNA]21693180
D003994BucladesineBucladesine results in decreased expression of INHA mRNA21693180
D003994BucladesineQuercetin inhibits the reaction [[Atrazine co-treated with Bucladesine] results in increased expression of INHA mRNA]23200735
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of INHA mRNA28962523
D004041Dietary FatsDietary Fats results in increased expression of INHA mRNA25016146
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of INHA mRNA26472102
C007379diethyl phthalatediethyl phthalate results in increased expression of INHA mRNA26472102
D004054DiethylstilbestrolDiethylstilbestrol promotes the reaction [FSHB protein results in increased expression of INHA mRNA]15878960
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of INHA protein9361775
C089799diheptyl phthalatediheptyl phthalate results in decreased expression of INHA mRNA22112501
C027387di-n-hexyl phthalatedi-n-hexyl phthalate results in decreased expression of INHA mRNA22112501
C034171di-n-pentyl phthalatedi-n-pentyl phthalate results in decreased expression of INHA mRNA25055962|2647210
C034171di-n-pentyl phthalate[Simvastatin co-treated with di-n-pentyl phthalate] results in decreased expression of INHA mRNA25055962
C015854estradiol valerateestradiol valerate results in increased expression of INHA protein17532555
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of INHA mRNA12655037|1583489
C002994ethylene dimethanesulfonateethylene dimethanesulfonate results in increased expression of INHA protein2544411
C002994ethylene dimethanesulfonateethylene dimethanesulfonate results in increased secretion of INHA protein2612737
D005411Flame RetardantsFlame Retardants results in decreased expression of INHA mRNA27219277
D005419FlavonoidsFlavonoids results in decreased expression of INHA mRNA18035473
D004397FonofosFonofos results in increased methylation of INHA promoter22847954
D005620Freund's Adjuvant[Urethane co-treated with Freund's Adjuvant] results in increased expression of INHA mRNA12400877
C039281furanfuran results in increased expression of INHA mRNA20562052|2207923
D055768Halogenated Diphenyl EthersHalogenated Diphenyl Ethers results in decreased expression of INHA mRNA27219277
D006220HaloperidolHaloperidol results in decreased expression of INHA mRNA16715494
C098607JP8 aviation fuelJP8 aviation fuel results in increased expression of INHA mRNA15618438
D007854LeadLead affects the expression of INHA mRNA28903495
C008261lead acetatelead acetate results in decreased expression of and results in decreased secretion of [INHBB protein binds to INHA protein]29273543
D008694MethamphetamineMethamphetamine results in decreased expression of INHA mRNA19149911
D008694MethamphetamineValproic Acid inhibits the reaction [Methamphetamine results in decreased expression of INHA mRNA]19149911
C013598methoxyacetic acidmethoxyacetic acid results in increased secretion of INHA protein1898883
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of INHA mRNA22087261
C025256nonylphenolnonylphenol results in increased expression of INHA mRNA27832966
D016912Levonorgestrel[testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of INHA mRNA19074003
D010278ParathionParathion results in increased methylation of INHA promoter22847954
D010578PetroleumPetroleum results in increased expression of INHA mRNA25208076
D010656PhenylephrinePhenylephrine results in increased expression of INHA mRNA18158353
D010795Phthalic AcidsPhthalic Acids results in decreased expression of INHA mRNA15728792
C006253pirinixic acidpirinixic acid results in increased expression of INHA mRNA20813756
D010936Plant ExtractsPlant Extracts results in decreased expression of INHA mRNA23557933
D011374ProgesteroneINHA mutant form inhibits the reaction [FSHB protein results in increased secretion of Progesterone]20660033
D011374ProgesteroneINHA mutant form inhibits the reaction [GDF9 protein inhibits the reaction [INHBA protein inhibits the reaction [FSHB protein results in increased secretion of Progesterone]]]20660033
D011374ProgesteroneProgesterone results in increased expression of INHA mRNA22285243
D011374ProgesteroneINHA protein results in decreased abundance of Progesterone18992787
C043680ptaquiloside[ptaquiloside co-treated with Sodium Selenite] results in decreased expression of INHA mRNA23274088
D011794QuercetinQuercetin inhibits the reaction [[Atrazine co-treated with Bucladesine] results in increased expression of INHA mRNA]23200735
D011794QuercetinQuercetin inhibits the reaction [Atrazine results in increased expression of INHA mRNA]23200735
D018967RisperidoneRisperidone results in increased expression of [INHA protein binds to INHBB protein]18838228
D019821Simvastatin[Simvastatin co-treated with di-n-pentyl phthalate] results in decreased expression of INHA mRNA25055962
D012969Sodium FluorideSodium Fluoride results in increased expression of INHA protein28918527
D018038Sodium Selenite[ptaquiloside co-treated with Sodium Selenite] results in decreased expression of INHA mRNA23274088
C012568terbufosterbufos results in increased methylation of INHA promoter22847954
D013739Testosterone[FSHB protein co-treated with Testosterone] results in increased expression of INHA mRNA18535249
D013739Testosterone[PRKACA protein mutant form co-treated with Testosterone] results in increased expression of INHA mRNA18535249
C010792testosterone undecanoate[testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of INHA mRNA19074003
C010792testosterone undecanoatetestosterone undecanoate results in decreased expression of INHA mRNA19074003
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of INHA mRNA15644576
C009495titanium dioxidetitanium dioxide results in decreased expression of INHA mRNA23565150
C009495titanium dioxidetitanium dioxide results in decreased expression of INHA protein23565150
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of INHA mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of INHA mRNA19140230
D014520UrethaneUrethane results in decreased expression of INHA mRNA28818685
D014520Urethane[Urethane co-treated with Freund's Adjuvant] results in increased expression of INHA mRNA12400877
D014520UrethaneUrethane results in increased expression of INHA mRNA12400877
D014635Valproic AcidValproic Acid results in increased methylation of INHA gene29154799
D014635Valproic AcidValproic Acid inhibits the reaction [Methamphetamine results in decreased expression of INHA mRNA]19149911
D014747VinblastineVinblastine results in decreased expression of INHA mRNA20624997
D014750VincristineVincristine results in decreased expression of INHA mRNA20624997
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in increased expression of INHA mRNA"25208076

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005102signaling receptor binding-IPI9032295  
GO:0005125cytokine activity-IBA21873635  
GO:0005125cytokine activity-TAS12456957  
GO:0005160transforming growth factor beta receptor binding-IBA21873635  
GO:0005179hormone activity-TAS12456957  
GO:0005515protein binding-IPI2575216  12697670  25416956  25910212  
GO:0005515protein bindingcontributes_toIPI10746731  
GO:0008083growth factor activity-TAS12324653  
GO:0034711inhibin binding-IEA-  
GO:0046982protein heterodimerization activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001501skeletal system development-TAS10865214  
GO:0001541ovarian follicle development-NAS9166111  
GO:0007050cell cycle arrest-TAS12456957  
GO:0007165signal transduction-TAS3267209  
GO:0007166cell surface receptor signaling pathway-TAS12456957  
GO:0007267cell-cell signaling-TAS12456957  
GO:0008584male gonad development-IEA-  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0010862positive regulation of pathway-restricted SMAD protein phosphorylation-IBA21873635  
GO:0030154cell differentiation-TAS12456957  
GO:0030218erythrocyte differentiation-NAS1310063  
GO:0042127regulation of cell proliferation-IDA9032295  
GO:0042326negative regulation of phosphorylation-TAS12456957  
GO:0042541hemoglobin biosynthetic process-IDA1310063  
GO:0042981regulation of apoptotic process-IBA21873635  
GO:0043408regulation of MAPK cascade-IBA21873635  
GO:0045077negative regulation of interferon-gamma biosynthetic process-TAS12456957  
GO:0045578negative regulation of B cell differentiation-TAS12456957  
GO:0045650negative regulation of macrophage differentiation-TAS12456957  
GO:0045786negative regulation of cell cycle-TAS12456957  
GO:0046881positive regulation of follicle-stimulating hormone secretion-TAS12456957  
GO:0046882negative regulation of follicle-stimulating hormone secretion-NAS3267209  
GO:0048468cell development-IBA21873635  
GO:0051726regulation of cell cycle-IDA9032295  
GO:0060395SMAD protein signal transduction-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0001750photoreceptor outer segment-IEA-  
GO:0001917photoreceptor inner segment-IEA-  
GO:0005576extracellular region-TAS12456957  
GO:0005615extracellular space-IBA21873635  
GO:0005737cytoplasm-IEA-  
GO:0034673inhibin-betaglycan-ActRII complex-IDA10746731  
GO:0043025neuronal cell body-IEA-  
GO:0043512inhibin A complex-IDA7890768  
GO:0043513inhibin B complex-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-209822Glycoprotein hormonesTAS
R-HSA-209952Peptide hormone biosynthesisTAS
R-HSA-2980736Peptide hormone metabolismTAS
R-HSA-392499Metabolism of proteinsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
10901828Guideline for the management of chronic asthma in children--2000 update. Allergy Society of South Africa Working Group. (2000 May)Motala CS Afr Med J
21480302Impact of smoking on maternal serum markers and prenatal screening in the first and second trimesters. (2011 Jun)Zhang JPrenat Diagn
24847019In utero exposure to cigarette smoke dysregulates human fetal ovarian developmental signalling. (2014 Jul)Fowler PAHum Reprod