Gene info: ID 3635

Gene: INPP5D

GENE ID: 3635

Description: inositol polyphosphate-5-phosphatase D

Gene type: protein-coding

Location: 2q37.1

dbXrefs: Ensembl:ENSG00000168918 MIM:601582 Vega:OTTHUMG00000133688 UniprotKB:Q92835

RefSeq: NG_033988.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 5.844e-1 (AD) 3.436e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg05208178	chr2:233928423	INPP5D		1.420e-8	Maternal smoking in pregnancy	27040690
cg16448702	chr2:234072980	INPP5D		5.800e-11	Smoking	27651444
cg05208178	chr2:233928423	INPP5D		1.000e-8	Smoking	27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CD37	0.885
MYO1F	0.873
WAS	0.871
TNFRSF1B	0.863
DOCK2	0.858
NCKAP1L	0.856
RHBDF2	0.854
SYK	0.853
CLEC7A	0.852
IL10RA	0.851

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ATOH7	-0.392
MARCH4	-0.376
C1orf53	-0.369
CPLX3	-0.363
NEUROD6	-0.356
WNT7A	-0.353
ST6GAL2	-0.347
PPEF1	-0.345
DLK2	-0.34
CRH	-0.339

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of INPP5D mRNA"	19114083
C036990	2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline	"2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of INPP5D mRNA"	20816883
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of INPP5D mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of INPP5D mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of INPP5D mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of INPP5D mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of INPP5D mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of INPP5D mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of INPP5D mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of INPP5D mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of INPP5D mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of INPP5D mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of INPP5D mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of INPP5D mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of INPP5D mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of INPP5D mRNA"	27188386
C000595015	6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine	"6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine results in increased expression of INPP5D mRNA"	28073004
D000082	Acetaminophen	Acetaminophen results in increased expression of INPP5D mRNA	22230336
D000082	Acetaminophen	Acetaminophen affects the expression of INPP5D mRNA	17562736
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of INPP5D mRNA	16483693
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of INPP5D mRNA	24449571
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of INPP5D mRNA	22316170
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of INPP5D mRNA	21569818
C006780	bisphenol A	bisphenol A results in decreased expression of INPP5D mRNA	25181051
C018475	butyraldehyde	butyraldehyde results in decreased expression of INPP5D mRNA	26079696
D019256	Cadmium Chloride	Cadmium Chloride results in increased methylation of INPP5D promoter	22457795
D000074262	Canola Oil	Canola Oil metabolite results in decreased expression of INPP5D mRNA	27363782
D002220	Carbamazepine	Carbamazepine affects the expression of INPP5D mRNA	25979313
D020245	p-Chloromercuribenzoic Acid	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of INPP5D mRNA"	27188386
D020245	p-Chloromercuribenzoic Acid	p-Chloromercuribenzoic Acid results in increased expression of INPP5D mRNA	26272509
D004390	Chlorpyrifos	Chlorpyrifos results in increased expression of INPP5D mRNA	18668222
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of INPP5D mRNA	20938992
C007095	cobaltiprotoporphyrin	cobaltiprotoporphyrin results in increased expression of INPP5D protein	25780291
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of INPP5D mRNA	19549813
C014347	decitabine	decitabine affects the expression of INPP5D mRNA	23300844
C007262	deoxynivalenol	deoxynivalenol affects the phosphorylation of INPP5D protein	23352502
D003976	Diazinon	Diazinon results in increased expression of INPP5D mRNA	29108742
D002945	Cisplatin	Cisplatin affects the expression of INPP5D mRNA	23300844
D002945	Cisplatin	Cisplatin results in increased expression of INPP5D mRNA	27392435
C000944	dicrotophos	dicrotophos results in increased expression of INPP5D mRNA	28302478
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate affects the expression of INPP5D mRNA	26924002
D004026	Dieldrin	Dieldrin affects the expression of INPP5D mRNA	22546817
D004041	Dietary Fats	Dietary Fats results in decreased expression of INPP5D mRNA	19030233
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of INPP5D mRNA	25380136
C024629	dimethyl phthalate	dimethyl phthalate affects the expression of INPP5D mRNA	26924002
D004610	Ellagic Acid	Ellagic Acid results in increased expression of INPP5D mRNA	12002526
C118739	entinostat	entinostat results in increased expression of INPP5D mRNA	26272509
C118739	entinostat	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of INPP5D mRNA"	27188386
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of INPP5D mRNA	12655037
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of INPP5D mRNA	20938992
D005557	Formaldehyde	Formaldehyde results in decreased expression of INPP5D mRNA	28937961
D005839	Gentamicins	Gentamicins results in increased expression of INPP5D mRNA	22061828
D017313	Fenretinide	Fenretinide results in decreased expression of INPP5D mRNA	28973697
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of INPP5D mRNA	26846883
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of INPP5D mRNA	25613284
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of INPP5D mRNA	23086925
D007649	Ketamine	Ketamine results in increased expression of INPP5D mRNA	20080153
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 affects the expression of INPP5D mRNA"	24972896
D058185	Magnetite Nanoparticles	[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of INPP5D mRNA	21641980
C042720	mercuric bromide	mercuric bromide results in increased expression of INPP5D mRNA	26272509
C042720	mercuric bromide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of INPP5D mRNA"	27188386
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of INPP5D mRNA	20938992
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of INPP5D mRNA	23179753\|2627250
C004925	methylmercuric chloride	"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of INPP5D mRNA"	27188386
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of INPP5D mRNA"	26251327
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of INPP5D mRNA	26924002
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of INPP5D mRNA	25380136
D009532	Nickel	Nickel results in increased expression of INPP5D mRNA	24768652\|2558310
C022838	nickel chloride	nickel chloride affects the expression of INPP5D mRNA	22546817
C028007	nickel monoxide	nickel monoxide results in increased expression of INPP5D mRNA	19167457
C014707	nitrosobenzylmethylamine	nitrosobenzylmethylamine results in increased expression of INPP5D mRNA	17616710
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in decreased expression of INPP5D mRNA	25729387
C496932	panobinostat	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of INPP5D mRNA"	27188386
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of INPP5D mRNA	19162173
D010634	Phenobarbital	Phenobarbital affects the expression of INPP5D mRNA	19159669
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of INPP5D mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of INPP5D mRNA	26272509
C014175	pyrazolo(3,4-d)pyrimidine	"pyrazolo(3,4-d)pyrimidine analog affects the expression of INPP5D mRNA"	21152443
C012526	quercitrin	quercitrin affects the expression of INPP5D mRNA	25193878
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of INPP5D mRNA	25895662
D012999	Soman	Soman results in increased expression of INPP5D mRNA	19281266
D004113	Succimer	[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of INPP5D mRNA	21641980
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of INPP5D mRNA	26377647\|2892240
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of INPP5D mRNA	22298810
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of INPP5D mRNA	25613284
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of INPP5D mRNA	28065790
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in decreased expression of INPP5D mRNA	25729387
D019772	Topotecan	Topotecan results in decreased expression of INPP5D mRNA	25729387
D014212	Tretinoin	Tretinoin results in decreased expression of INPP5D mRNA	23830798
C012589	trichostatin A	trichostatin A results in increased expression of INPP5D mRNA	24935251
D014520	Urethane	Urethane results in decreased expression of INPP5D mRNA	28818685
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of INPP5D mRNA"	27188386
D014635	Valproic Acid	Valproic Acid results in decreased expression of INPP5D mRNA	28001369
D014635	Valproic Acid	Valproic Acid results in increased expression of INPP5D mRNA	23179753\|2438349
D014635	Valproic Acid	Valproic Acid results in increased methylation of INPP5D gene	29154799
C017803	zinc protoporphyrin	zinc protoporphyrin results in decreased expression of INPP5D protein	25780291

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004445	inositol-polyphosphate 5-phosphatase activity	-	IEA	-
GO:0005515	protein binding	-	IPI	9148918 10382761 15090612 16339535 19843936 20933011 21712384 24642916 25416956 26221972 26755705
GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	-	TAS	-
GO:0017124	SH3 domain binding	-	IEA	-
GO:0034485	phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity	-	TAS	-
GO:0051425	PTB domain binding	-	IEA	-
GO:0052659	inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006661	phosphatidylinositol biosynthetic process	-	TAS	-
GO:0006796	phosphate-containing compound metabolic process	-	TAS	8769125
GO:0006915	apoptotic process	-	IEA	-
GO:0007165	signal transduction	-	TAS	8769125
GO:0008340	determination of adult lifespan	-	IEA	-
GO:0009968	negative regulation of signal transduction	-	IEA	-
GO:0016064	immunoglobulin mediated immune response	-	IEA	-
GO:0019221	cytokine-mediated signaling pathway	-	TAS	-
GO:0030889	negative regulation of B cell proliferation	-	IEA	-
GO:0035556	intracellular signal transduction	-	IEA	-
GO:0043065	positive regulation of apoptotic process	-	IEA	-
GO:0043647	inositol phosphate metabolic process	-	TAS	-
GO:0045409	negative regulation of interleukin-6 biosynthetic process	-	IEA	-
GO:0045579	positive regulation of B cell differentiation	-	IEA	-
GO:0045648	positive regulation of erythrocyte differentiation	-	IEA	-
GO:0045656	negative regulation of monocyte differentiation	-	IEA	-
GO:0045659	negative regulation of neutrophil differentiation	-	IEA	-
GO:0045671	negative regulation of osteoclast differentiation	-	IEA	-
GO:0045779	negative regulation of bone resorption	-	IEA	-
GO:0046856	phosphatidylinositol dephosphorylation	-	IEA	-
GO:0050777	negative regulation of immune response	-	IEA	-
GO:0050852	T cell receptor signaling pathway	-	TAS	-
GO:0050900	leukocyte migration	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005829	cytosol	-	IDA	-
GO:0005829	cytosol	-	TAS	-
GO:0005856	cytoskeleton	-	IEA	-
GO:0005886	plasma membrane	-	IEA	-
GO:0045121	membrane raft	-	IEA	-

KEGG ID	KEGG Term
hsa04070	Phosphatidylinositol signaling system
hsa04662	B cell receptor signaling pathway
hsa04664	Fc epsilon RI signaling pathway
hsa04666	Fc gamma R-mediated phagocytosis
hsa04910	Insulin signaling pathway

Reactome ID	Reactome Term	Evidence
R-HSA-109582	Hemostasis	TAS
R-HSA-1280215	Cytokine Signaling in Immune system	TAS
R-HSA-1280218	Adaptive Immune System	TAS
R-HSA-1430728	Metabolism	TAS
R-HSA-1483249	Inositol phosphate metabolism	TAS
R-HSA-1483255	PI Metabolism	TAS
R-HSA-1483257	Phospholipid metabolism	TAS
R-HSA-1660499	Synthesis of PIPs at the plasma membrane	TAS
R-HSA-168256	Immune System	TAS
R-HSA-1855204	Synthesis of IP3 and IP4 in the cytosol	TAS
R-HSA-202403	TCR signaling	TAS
R-HSA-202424	Downstream TCR signaling	TAS
R-HSA-202733	Cell surface interactions at the vascular wall	TAS
R-HSA-210990	PECAM1 interactions	TAS
R-HSA-449147	Signaling by Interleukins	TAS
R-HSA-451927	Interleukin-2 family signaling	TAS
R-HSA-512988	Interleukin-3, 5 and GM-CSF signaling	TAS
R-HSA-556833	Metabolism of lipids	TAS
R-HSA-912526	Interleukin receptor SHC signaling	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
28199971	Association and interaction effects of Alzheimer's disease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population. (2017 Apr 11)	Lin E	Oncotarget