Gene: INPPL1

3636
OPSMD|SHIP2
inositol polyphosphate phosphatase like 1
protein-coding
11q13.4
Ensembl:ENSG00000165458 MIM:600829 Vega:OTTHUMG00000167879 UniprotKB:O15357
NG_023253.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.665e-1 (AD)  4.525e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CAPN20.866
ARHGEF400.864
TCF30.859
ITGA70.858
PLXNB20.85
FKBP100.843
PLCB30.841
TLN10.839
SORBS30.838
SLC12A40.838

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.592
OR4F29-0.563
PPEF1-0.348
SMIM18-0.326
AARD-0.325
C8orf34-0.311
NMU-0.305
TYRP1-0.305
CRH-0.305
MYOZ3-0.303

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of INPPL1 mRNA"21346803
C5464123-((4-chlorobenzyl)oxy)-N-((1S)-1-phenylethyl)-2-thiophenecarboxamide3-((4-chlorobenzyl)oxy)-N-((1S)-1-phenylethyl)-2-thiophenecarboxamide results in decreased activity of INPPL1 protein19694723
C5464123-((4-chlorobenzyl)oxy)-N-((1S)-1-phenylethyl)-2-thiophenecarboxamide3-((4-chlorobenzyl)oxy)-N-((1S)-1-phenylethyl)-2-thiophenecarboxamide results in decreased activity of INPPL1 protein23434638
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased expression of INPPL1 mRNA19191707
D000643Ammonium ChlorideAmmonium Chloride affects the expression of INPPL1 mRNA16483693
D001151ArsenicArsenic results in decreased methylation of INPPL1 promoter23315758
C006632arsenic trioxidearsenic trioxide results in increased expression of INPPL1 mRNA20458559
D001280AtrazineAtrazine results in increased expression of INPPL1 mRNA22378314
C547126AZM551248AZM551248 results in increased expression of INPPL1 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of INPPL1 mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of INPPL1 mRNA21715664
C038328BEP protocolBEP protocol results in increased expression of INPPL1 mRNA18987330
C044887beta-methylcholinebeta-methylcholine affects the expression of INPPL1 mRNA21179406
C006780bisphenol Abisphenol A results in increased expression of INPPL1 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of INPPL1 mRNA28628672
C584509C646 compoundC646 compound results in increased expression of INPPL1 mRNA26191083
D002330CarmustineCarmustine results in decreased expression of INPPL1 mRNA15980968
D004390ChlorpyrifosChlorpyrifos results in decreased expression of INPPL1 mRNA21356183
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of INPPL1 gene20938992
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of INPPL1 mRNA28628672
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of INPPL1 gene20938992
C069837fullerene C60fullerene C60 results in increased expression of INPPL1 mRNA19167457
C492448ICG 001ICG 001 results in increased expression of INPPL1 mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of INPPL1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of INPPL1 mRNA28628672
D008694MethamphetamineMethamphetamine results in increased expression of INPPL1 mRNA26307267
D008694MethamphetamineMethamphetamine results in increased methylation of INPPL1 promoter26307267
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of INPPL1 gene20938992
D008731MethoxychlorMethoxychlor results in increased methylation of INPPL1 gene23303685
C583787N-(4-(4-chlorobenzyloxy)pyridin-2-yl)-2-(2,6-difluorophenyl)acetamide"N-(4-(4-chlorobenzyloxy)pyridin-2-yl)-2-(2,6-difluorophenyl)acetamide results in decreased activity of INPPL1 protein"23434638
C555857NGD-61338NGD-61338 binds to and results in decreased activity of INPPL1 protein19531013
C028007nickel monoxidenickel monoxide results in increased expression of INPPL1 mRNA19167457
D009538NicotineNicotine results in decreased expression of INPPL1 mRNA17456735
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of INPPL1 mRNA19710929
D010938Plant OilsPlant Oils results in decreased expression of INPPL1 mRNA23370395
C513428pyrachlostrobinpyrachlostrobin results in increased expression of INPPL1 mRNA27029645
C021751tanshinonetanshinone results in increased expression of INPPL1 mRNA15849732
C004648testosterone enanthatetestosterone enanthate affects the expression of INPPL1 mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of INPPL1 mRNA16443690
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of INPPL1 mRNA21570461|2468072
C009495titanium dioxidetitanium dioxide results in decreased expression of INPPL1 mRNA23557971
C012589trichostatin Atrichostatin A affects the expression of INPPL1 mRNA28542535
D014635Valproic AcidValproic Acid affects the expression of INPPL1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of INPPL1 mRNA23179753|2800136
D014635Valproic AcidValproic Acid results in increased methylation of INPPL1 gene29154799
C025643vinclozolinvinclozolin results in increased expression of INPPL1 mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003779actin binding-IEA-  
GO:0005515protein binding-IPI10871282  11158326  12504111  16302969  18692052  20368287  
20933011  21712384  24728074  
GO:0017124SH3 domain binding-IEA-  
GO:0034485phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity-TAS-  
GO:0042169SH2 domain binding-IPI5668240  
GO:0052659inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001958endochondral ossification-IMP23273569  
GO:0002376immune system process-IEA-  
GO:0006006glucose metabolic process-IEA-  
GO:0006661phosphatidylinositol biosynthetic process-TAS-  
GO:0006897endocytosis-IMP15668240  
GO:0007015actin filament organization-IMP15668240  
GO:0007155cell adhesion-TAS15668240  
GO:0008285negative regulation of cell proliferation-IEA-  
GO:0009791post-embryonic development-IEA-  
GO:0010629negative regulation of gene expression-IEA-  
GO:0019221cytokine-mediated signaling pathway-TAS-  
GO:0032868response to insulin-IEA-  
GO:0043647inositol phosphate metabolic process-TAS-  
GO:0046856phosphatidylinositol dephosphorylation-IEA-  
GO:0097178ruffle assembly-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005794Golgi apparatus-IDA-  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005856cytoskeleton-IEA-  
GO:0005886plasma membrane-IEA-  
GO:0030027lamellipodium-IEA-  
GO:0030175filopodium-IEA-  
KEGG ID KEGG Term
hsa00562Inositol phosphate metabolism
hsa01100Metabolic pathways
hsa04070Phosphatidylinositol signaling system
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1430728MetabolismTAS
R-HSA-1483249Inositol phosphate metabolismTAS
R-HSA-1483255PI MetabolismTAS
R-HSA-1483257Phospholipid metabolismTAS
R-HSA-1660499Synthesis of PIPs at the plasma membraneTAS
R-HSA-168256Immune SystemTAS
R-HSA-1855204Synthesis of IP3 and IP4 in the cytosolTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-451927Interleukin-2 family signalingTAS
R-HSA-512988Interleukin-3, 5 and GM-CSF signalingTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-912526Interleukin receptor SHC signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22486725INPPL1 is associated with the metabolic syndrome in men with Type 1 diabetes, but not with diabetic nephropathy. (2012 Dec)Hyvonen MEDiabet Med