Gene: AQP7

364
AQP7L|AQPap|GLYCQTL
aquaporin 7
protein-coding
9p13.3
Ensembl:ENSG00000165269 MIM:602974 Vega:OTTHUMG00000019773 UniprotKB:O14520
NG_027764.1
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.967e-1 (AD)  1.542e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs17251987chr9:33388291 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ACE0.523
PLCB40.523
KLF80.498
GDF70.491
RASGRP20.467
SLC16A140.466
CACNG20.464
DNAH10OS0.459
KLHL380.456
INCENP0.453

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LRAT-0.319
MASP1-0.311
RHPN2-0.306
TLCD1-0.302
C11orf88-0.297
S100A1-0.295
FAM181A-0.295
S100A16-0.293
ADA-0.29
RFX4-0.29

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0291412,2,5,7,8-pentamethyl-1-hydroxychroman"2,2,5,7,8-pentamethyl-1-hydroxychroman results in increased expression of AQP7 mRNA"21920950
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of AQP7 mRNA"19114083
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of AQP7 mRNA"25380136
D000082AcetaminophenAcetaminophen results in decreased expression of AQP7 mRNA26690555|2906747
D000082AcetaminophenAcetaminophen results in increased expression of AQP7 mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of AQP7 mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of AQP7 mRNA23630614
D000643Ammonium ChlorideAmmonium Chloride affects the expression of AQP7 mRNA16483693
C526219apple polyphenol extractapple polyphenol extract inhibits the reaction [[Dietary Sucrose co-treated with Dietary Fats] results in decreased methylation of AQP7 promoter]23529981
C526219apple polyphenol extract[Dietary Sucrose co-treated with Dietary Fats co-treated with apple polyphenol extract] results in increased expression of AQP7 mRNA23529981
C015001arseniteAQP7 protein results in increased uptake of arsenite11972053
D001280AtrazineAtrazine results in increased expression of AQP7 mRNA25929836
D001280AtrazineAtrazine results in increased expression of AQP7 mRNA22378314
C547126AZM551248AZM551248 results in decreased expression of AQP7 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of AQP7 mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of AQP7 gene25435355
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of AQP7 mRNA28341573
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of AQP7 protein28341573
D004958EstradiolEstradiol results in increased expression of AQP7 mRNA28341573
D004958Estradiol[Quercetin co-treated with Estradiol] affects the expression of AQP7 protein28341573
D004958EstradiolQuercetin inhibits the reaction [[Estradiol co-treated with Progesterone] results in increased expression of AQP7 mRNA]28341573
D004958EstradiolQuercetin inhibits the reaction [[Estradiol co-treated with Progesterone] results in increased expression of AQP7 protein]28341573
D004958EstradiolQuercetin promotes the reaction [Estradiol results in increased expression of AQP7 mRNA]28341573
C095105bexarotene[bexarotene co-treated with Tamoxifen] results in increased expression of AQP7 mRNA17630414
C095105bexarotenebexarotene results in decreased expression of AQP7 mRNA16648578
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in increased expression of AQP7 mRNA27685785
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of AQP7 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of AQP7 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of AQP7 mRNA25594700
C006780bisphenol Abisphenol A results in decreased expression of AQP7 mRNA25181051
D002101Cacodylic AcidCacodylic Acid results in increased expression of AQP7 mRNA17720352
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of AQP7 mRNA20938992
D016572CyclosporineCyclosporine results in increased expression of AQP7 mRNA25562108
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of AQP7 mRNA]27941970
D003907DexamethasoneDexamethasone results in increased expression of AQP7 mRNA19853017|2504701
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of AQP7 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of AQP7 mRNA28628672
D003907DexamethasoneDexamethasone results in increased expression of AQP7 mRNA14618091
D003976DiazinonDiazinon results in decreased methylation of AQP7 gene22964155
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of AQP7 mRNA27392435
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of AQP7 mRNA26924002
D004041Dietary FatsDietary Fats results in decreased expression of AQP7 mRNA18042831
D004041Dietary FatsDietary Fats results in increased expression of AQP7 mRNA18457598
D004041Dietary Fatsapple polyphenol extract inhibits the reaction [[Dietary Sucrose co-treated with Dietary Fats] results in decreased methylation of AQP7 promoter]23529981
D004041Dietary Fats[Dietary Sucrose co-treated with Dietary Fats co-treated with apple polyphenol extract] results in increased expression of AQP7 mRNA23529981
D004041Dietary Fats[Dietary Sucrose co-treated with Dietary Fats] results in decreased methylation of AQP7 promoter23529981
D019422Dietary Sucroseapple polyphenol extract inhibits the reaction [[Dietary Sucrose co-treated with Dietary Fats] results in decreased methylation of AQP7 promoter]23529981
D019422Dietary Sucrose[Dietary Sucrose co-treated with Dietary Fats co-treated with apple polyphenol extract] results in increased expression of AQP7 mRNA23529981
D019422Dietary Sucrose[Dietary Sucrose co-treated with Dietary Fats] results in decreased methylation of AQP7 promoter23529981
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of AQP7 mRNA24535843
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of AQP7 mRNA19638242
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of AQP7 mRNA17072980|2538013
C024629dimethyl phthalatedimethyl phthalate results in decreased expression of AQP7 mRNA26924002
D004237DiuronDiuron results in decreased expression of AQP7 mRNA25152437
D004837EpinephrineEpinephrine affects the localization of AQP7 protein10777495
D004837EpinephrineEpinephrine results in increased expression of AQP7 mRNA10777495
D004837EpinephrineINS1 inhibits the reaction [Epinephrine results in increased expression of AQP7 mRNA]10777495
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of AQP7 mRNA17942748
D005419FlavonoidsFlavonoids results in increased expression of AQP7 mRNA18035473
D005485FlutamideFlutamide results in decreased expression of AQP7 mRNA24793618
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of AQP7 mRNA20938992
C039281furanfuran results in increased expression of AQP7 mRNA25539665
D005990GlycerolAQP7 protein affects the metabolism of Glycerol19840149
D005990GlycerolAQP7 protein results in increased transport of Glycerol9252401
D005990GlycerolAQP7 protein results in increased uptake of Glycerol19585522
D005990GlycerolAQP7 protein results in increased transport of Glycerol9514918
D017313FenretinideFenretinide results in decreased expression of AQP7 mRNA28973697
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of AQP7 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of AQP7 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of AQP7 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of AQP7 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of AQP7 mRNA27392435
D008623MercaptoethanolMercaptoethanol inhibits the reaction [Mercuric Chloride results in decreased activity of AQP7 protein]10777495
D008627Mercuric ChlorideMercaptoethanol inhibits the reaction [Mercuric Chloride results in decreased activity of AQP7 protein]10777495
D008627Mercuric ChlorideMercuric Chloride results in decreased activity of AQP7 protein10777495
D008627Mercuric ChlorideMercuric Chloride results in decreased expression of AQP7 protein25854323
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of AQP7 mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of AQP7 protein25854323
C517284monomethyl phthalatemonomethyl phthalate affects the expression of AQP7 mRNA26924002
C500085muraglitazarmuraglitazar results in increased expression of AQP7 mRNA21515302
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of AQP7 mRNA25380136
D009532NickelNickel results in decreased expression of AQP7 mRNA25583101
C028007nickel monoxidenickel monoxide results in decreased expression of AQP7 mRNA19167457
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of AQP7 mRNA27935865
D000073878Palm OilPalm Oil results in decreased expression of AQP7 mRNA18042831
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of AQP7 mRNA19162173
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of AQP7 mRNA24535843
C047088phenylamilphenylamil results in increased expression of AQP7 mRNA20519739
C047088phenylamilPPARG protein promotes the reaction [phenylamil results in increased expression of AQP7 mRNA]20519739
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of AQP7 mRNA27935865
C006253pirinixic acidpirinixic acid results in increased expression of AQP7 mRNA18301758|2081375
C006253pirinixic acidpirinixic acid results in increased expression of AQP7 mRNA19162173|2248451
D010936Plant ExtractsPlant Extracts results in decreased expression of AQP7 mRNA23557933
D028321Plant PreparationsPlant Preparations results in increased expression of AQP7 mRNA26945725
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of AQP7 mRNA19162173
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of AQP7 mRNA28341573
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of AQP7 protein28341573
D011374ProgesteroneQuercetin inhibits the reaction [[Estradiol co-treated with Progesterone] results in increased expression of AQP7 mRNA]28341573
D011374ProgesteroneQuercetin inhibits the reaction [[Estradiol co-treated with Progesterone] results in increased expression of AQP7 protein]28341573
D011794Quercetin[Quercetin co-treated with Estradiol] affects the expression of AQP7 protein28341573
D011794QuercetinQuercetin inhibits the reaction [[Estradiol co-treated with Progesterone] results in increased expression of AQP7 mRNA]28341573
D011794QuercetinQuercetin inhibits the reaction [[Estradiol co-treated with Progesterone] results in increased expression of AQP7 protein]28341573
D011794QuercetinQuercetin promotes the reaction [Estradiol results in increased expression of AQP7 mRNA]28341573
C089730rosiglitazonerosiglitazone results in increased expression of AQP7 mRNA21515302
C016104sodium bichromatesodium bichromate results in decreased expression of AQP7 mRNA22561333
C016104sodium bichromatesodium bichromate results in increased expression of AQP7 mRNA25993096
D012969Sodium FluorideSodium Fluoride results in increased expression of AQP7 protein28918527
D013311StreptozocinStreptozocin results in increased expression of AQP7 mRNA16684804
D013311Streptozocinvanadyl sulfate inhibits the reaction [Streptozocin results in increased expression of AQP7 mRNA]16684804
C061133tamibarotenetamibarotene affects the expression of AQP7 mRNA15498508
D013629Tamoxifen[bexarotene co-treated with Tamoxifen] results in increased expression of AQP7 mRNA17630414
C501413tesaglitazartesaglitazar results in increased expression of AQP7 mRNA21515302
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of AQP7 mRNA21570461|2637764
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of AQP7 mRNA17942748
D013853ThioacetamideThioacetamide results in increased expression of AQP7 mRNA23411599
C009495titanium dioxidetitanium dioxide results in increased expression of AQP7 mRNA23557971
D014212TretinoinTretinoin affects the expression of AQP7 mRNA15498508
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of AQP7 mRNA"26743178
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of AQP7 mRNA"26179874
C057693troglitazonetroglitazone results in increased expression of AQP7 mRNA12732648
C057693troglitazonetroglitazone results in increased expression of AQP7 mRNA21515302
C057693troglitazone[TNF protein co-treated with troglitazone] results in decreased expression of AQP7 mRNA12732648
D014508UreaAQP7 protein results in increased transport of Urea9252401
D014508UreaAQP7 protein results in increased uptake of Urea19585522
D014635Valproic AcidValproic Acid results in increased methylation of AQP7 gene29154799
C034028vanadyl sulfatevanadyl sulfate inhibits the reaction [Streptozocin results in increased expression of AQP7 mRNA]16684804
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of AQP7 gene25560391
D014867WaterAQP7 protein affects the transport of Water18059526
D014867WaterAQP7 protein results in increased transport of Water9252401

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0015204urea transmembrane transporter activity-IBA21873635  
GO:0015250water channel activity-EXP1373524  1510932  7530250  9369468  9405233  9806845  
9829975  10318966  10510269  10564231  11001937  11034202  
11076974  11573934  12084581  14701836  15948717  16596446  
17178220  18202181  18501347  18511455  18762715  21251984  
GO:0015254glycerol channel activity-EXP9369468  9405233  10510269  10564231  11573934  12084581  
16596446  18762715  
GO ID GO Term Qualifier Evidence PubMed
GO:0006091generation of precursor metabolites and energy-TAS9405233  
GO:0006833water transport-TAS-  
GO:0007588excretion-TAS9405233  
GO:0015793glycerol transport-TAS-  
GO:0055085transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA18718702  
GO:0005886plasma membrane-IDA18718702  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS9405233  
GO:0005911cell-cell junction-IDA18718702  
KEGG ID KEGG Term
hsa03320PPAR signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-382551Transport of small moleculesTAS
R-HSA-432030Transport of glycerol from adipocytes to the liver by AquaporinsTAS
R-HSA-432047Passive transport by AquaporinsTAS
R-HSA-445717Aquaporin-mediated transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25541553Adiposity is associated with DNA methylation profile in adipose tissue. (2015 Aug)Agha GInt J Epidemiol