Gene: INSL3

3640
RLF|RLNL|ley-I-L
insulin like 3
protein-coding
19p13.11
Ensembl:ENSG00000248099 MIM:146738 Vega:OTTHUMG00000183481 UniprotKB:P51460
NG_012092.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.759e-1 (AD)  3.103e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
JDP20.499
PSPN0.482
SIRT40.479
ASGR10.474
GLIS10.466
QRICH20.464
TDRG10.451
FOXD4L10.45
SPR0.446
P4HA20.443

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SETD9-0.365
LRRCC1-0.335
CHST9-0.33
C5orf64-0.322
CTNNA3-0.306
MYOT-0.302
SLCO1A2-0.298
NEK7-0.295
SEPT10-0.292
OR2K2-0.292

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0192732,2-bis(4-glycidyloxyphenyl)propane"2,2-bis(4-glycidyloxyphenyl)propane results in increased expression of INSL3 protein"28482050
D000082AcetaminophenAcetaminophen results in decreased expression of INSL3 mRNA22230336
D020106AcrylamideAcrylamide results in increased expression of INSL3 mRNA22459607
D000447AldehydesAldehydes results in increased expression of INSL3 mRNA25014914
D000643Ammonium ChlorideAmmonium Chloride affects the expression of INSL3 mRNA16483693
D001280AtrazineAtrazine results in increased expression of INSL3 mRNA18585445
D001280Atrazine[Atrazine co-treated with Bucladesine] results in increased expression of INSL3 mRNA23200735
D001280AtrazineAtrazine inhibits the reaction [Bucladesine results in increased expression of INSL3 mRNA]21693180
D001280AtrazineAtrazine results in increased expression of INSL3 mRNA23200735
D001280AtrazineQuercetin inhibits the reaction [[Atrazine co-treated with Bucladesine] results in increased expression of INSL3 mRNA]23200735
D001280AtrazineQuercetin inhibits the reaction [Atrazine results in increased expression of INSL3 mRNA]23200735
D004958EstradiolEstradiol results in decreased expression of INSL3 mRNA19428929
D004958EstradiolTestosterone inhibits the reaction [Estradiol results in decreased expression of INSL3 mRNA]19428929
D004958EstradiolEstradiol results in decreased expression of INSL3 mRNA19428929
D001688Biological ProductsBiological Products results in decreased expression of INSL3 mRNA26055946
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in increased expression of INSL3 protein28482050
C006780bisphenol Abisphenol A results in decreased expression of INSL3 mRNA23284716
C006780bisphenol Abisphenol A results in increased expression of INSL3 protein28482050
C492482bisphenol Bbisphenol B results in increased expression of INSL3 protein28482050
C027561butylbenzyl phthalatebutylbenzyl phthalate results in decreased expression of INSL3 mRNA14687758|1610213
C018475butyraldehydebutyraldehyde results in increased expression of INSL3 mRNA26079696
D002330CarmustineCarmustine results in decreased expression of INSL3 mRNA15980968
C062876cetrorelix[cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of INSL3 mRNA18160741
C062876cetrorelix[cetrorelix co-treated with testosterone enanthate] results in decreased expression of INSL3 mRNA18160741
C018021cobaltous chloridecobaltous chloride results in decreased expression of INSL3 mRNA24612858
D019327Copper SulfateCopper Sulfate results in increased expression of INSL3 mRNA19549813
C017160cypermethrincypermethrin results in decreased expression of INSL3 mRNA24810582
D017135Desogestrel[cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of INSL3 mRNA18160741
C088674dibromoacetic aciddibromoacetic acid results in decreased expression of INSL3 mRNA21046364
D003993Dibutyl Phthalate[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate] results in decreased expression of INSL317400582
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of INSL3 mRNA14687758|1610213
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of INSL3 protein16037377|2174549
D003994Bucladesine[Atrazine co-treated with Bucladesine] results in increased expression of INSL3 mRNA23200735
D003994BucladesineAtrazine inhibits the reaction [Bucladesine results in increased expression of INSL3 mRNA]21693180
D003994BucladesineBucladesine results in increased expression of INSL3 mRNA21458522|2169318
D003994BucladesineQuercetin inhibits the reaction [[Atrazine co-treated with Bucladesine] results in increased expression of INSL3 mRNA]23200735
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of INSL3 mRNA20335514|2812309
D004051Diethylhexyl Phthalate[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate] results in decreased expression of INSL317400582
D004051Diethylhexyl Phthalate[Diethylhexyl Phthalate co-treated with ethylene dimethanesulfonate] results in decreased expression of INSL3 mRNA23064086
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of INSL3 mRNA14687758|1610213
C089799diheptyl phthalatediheptyl phthalate results in decreased expression of INSL3 mRNA22112501
C025605diisobutyl phthalatediisobutyl phthalate results in decreased expression of INSL3 mRNA22112501
C012125diisononyl phthalatediisononyl phthalate results in decreased expression of INSL3 mRNA22112501|2544572
C012125diisononyl phthalatediisononyl phthalate results in decreased expression of INSL3 protein25445723
C027387di-n-hexyl phthalatedi-n-hexyl phthalate results in decreased expression of INSL3 mRNA22112501
C034171di-n-pentyl phthalatedi-n-pentyl phthalate results in decreased expression of INSL3 mRNA21177253|2163311
C034171di-n-pentyl phthalate[Simvastatin co-treated with di-n-pentyl phthalate] results in decreased expression of INSL3 mRNA25055962
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of INSL3 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of INSL3 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of INSL3 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of INSL3 mRNA15834898
C002994ethylene dimethanesulfonate[Diethylhexyl Phthalate co-treated with ethylene dimethanesulfonate] results in decreased expression of INSL3 mRNA23064086
D005419FlavonoidsFlavonoids results in decreased expression of INSL3 mRNA18035473
D019833Genistein[Genistein co-treated with mono-(2-ethylhexyl)phthalate] results in decreased expression of INSL3 mRNA27181934
D055768Halogenated Diphenyl Ethers[Halogenated Diphenyl Ethers co-treated with hexabromocyclododecane] results in decreased expression of INSL3 mRNA26607716
C089796hexabromocyclododecane[Halogenated Diphenyl Ethers co-treated with hexabromocyclododecane] results in decreased expression of INSL3 mRNA26607716
D007220Industrial WasteIndustrial Waste results in decreased expression of INSL3 mRNA26055946
C016599mono-(2-ethylhexyl)phthalate[Genistein co-treated with mono-(2-ethylhexyl)phthalate] results in decreased expression of INSL3 mRNA27181934
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of INSL3 mRNA22087261
C028577monobutyl phthalatemonobutyl phthalate results in decreased expression of INSL3 mRNA16338306
D016912Levonorgestrel[testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of INSL3 mRNA19074003
C046012pentanalpentanal results in increased expression of INSL3 mRNA26079696
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of INSL3 protein28126411
D010795Phthalic AcidsPhthalic Acids results in decreased expression of INSL3 mRNA15728792|1831571
C005556propionaldehydepropionaldehyde results in increased expression of INSL3 mRNA26079696
C428725pyridabenpyridaben results in decreased expression of INSL3 mRNA22563483
D011794QuercetinQuercetin inhibits the reaction [[Atrazine co-treated with Bucladesine] results in increased expression of INSL3 mRNA]23200735
D011794QuercetinQuercetin inhibits the reaction [Atrazine results in increased expression of INSL3 mRNA]23200735
D019821Simvastatin[Simvastatin co-treated with di-n-pentyl phthalate] results in decreased expression of INSL3 mRNA25055962
C009277sodium arsenatesodium arsenate results in decreased expression of INSL3 mRNA23922661
D013629TamoxifenTamoxifen affects the expression of INSL3 mRNA17555576
D013739TestosteroneTestosterone inhibits the reaction [Estradiol results in decreased expression of INSL3 mRNA]19428929
D013739TestosteroneTestosterone results in increased expression of INSL3 mRNA19428929
D013739TestosteroneTestosterone results in increased expression of INSL3 mRNA19428929
C004648testosterone enanthate[cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of INSL3 mRNA18160741
C004648testosterone enanthate[cetrorelix co-treated with testosterone enanthate] results in decreased expression of INSL3 mRNA18160741
C004648testosterone enanthatetestosterone enanthate results in decreased expression of INSL3 mRNA25603467
C010792testosterone undecanoate[testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of INSL3 mRNA19074003
C010792testosterone undecanoatetestosterone undecanoate results in decreased expression of INSL3 mRNA19074003
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of INSL3 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of INSL3 mRNA20059583
D014212TretinoinTretinoin results in decreased expression of INSL3 mRNA23724009
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in decreased expression of INSL3 mRNA23537331
D014635Valproic AcidValproic Acid results in increased methylation of INSL3 gene29154799
C025643vinclozolinvinclozolin results in increased expression of INSL3 mRNA20566332

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001664G-protein coupled receptor binding-IBA21873635  
GO:0002020protease binding-IPI20082125  
GO:0005102signaling receptor binding-TAS8020942  
GO:0005158insulin receptor binding-TAS8253799  
GO:0005179hormone activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway-IBA21873635  
GO:0007267cell-cell signaling-TAS8253799  
GO:0007283spermatogenesis-TAS8253799  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0010634positive regulation of epithelial cell migration-IDA23539510  
GO:0090303positive regulation of wound healing-IDA23539510  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375276Peptide ligand-binding receptorsTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418555G alpha (s) signalling eventsTAS
R-HSA-444821Relaxin receptorsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19178527Demographic, physical and lifestyle factors associated with androgen status: the Florey Adelaide Male Ageing Study (FAMAS). (2009 Aug)Atlantis EClin Endocrinol (Oxf)
29740335Amniotic Fluid INSL3 Measured During the Critical Time Window in Human Pregnancy Relates to Cryptorchidism, Hypospadias, and Phthalate Load: A Large Case-Control Study. (2018)Anand-Ivell RFront Physiol