Gene: INSR

3643
CD220|HHF5
insulin receptor
protein-coding
19p13.2
Ensembl:ENSG00000171105 MIM:147670 Vega:OTTHUMG00000181992 UniprotKB:P06213
NG_008852.2
PubMed|SNP Mapped
ND|AD
7   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.327e-1 (AD)  9.129e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10500204chr19:7182952 (GRCh38.p7)A>Calcohol dependenceSNV(Single Nucleotide Variation)
rs1864193chr19:7114202 (GRCh38.p7)C>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NUP2140.826
RAF10.815
PPP6R30.813
ACIN10.813
DPF20.808
TXLNA0.803
SYVN10.8
LRRFIP20.798
PHF120.798
NUP1880.796

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.62
OR4F29-0.606
CCNYL3-0.19
RERGL-0.185
FAM25A-0.181
OR2A2-0.175
CRH-0.173
LCE1A-0.172
SPANXA2-0.165
KRT78-0.165

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00030Insulin HumanBiotechDrug11061-68-0Approved|InvestigationalTarget
DB00046Insulin LisproBiotechDrug133107-64-9ApprovedTarget
DB00047Insulin GlargineBiotechDrug160337-95-1ApprovedTarget
DB00071Insulin PorkBiotechDrug12584-58-6ApprovedTarget
DB01277MecaserminBiotechDrug68562-41-4Approved|InvestigationalTarget
DB01306Insulin AspartBiotechDrug116094-23-6ApprovedTarget
DB01307Insulin DetemirBiotechDrug169148-63-4ApprovedTarget
DB01309Insulin GlulisineBiotechDrug207748-29-6ApprovedTarget
DB03909Adenosine-5'-[Beta, Gamma-Methylene]TriphosphateSmall MoleculeExperimentalTarget
DB05115NN344Small Molecule-InvestigationalTarget
DB05120AT1391Small Molecule-InvestigationalTarget
DB08513[4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACIDSmall MoleculeExperimentalTarget
DB09129Chromic chlorideSmall Molecule10025-73-7ApprovedTarget
DB09564Insulin DegludecBiotechDrug844439-96-9ApprovedTarget
DB12267BrigatinibSmall Molecule1197953-54-0Approved|InvestigationalTarget
ID Drug Name Action PubMed
C5616191-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea results in increased phosphorylation of INSR protein23576437
C5616191-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)ureaINS protein promotes the reaction [1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea results in increased phosphorylation of INSR protein]23576437
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of INSR mRNA"29112739
C5112952,2',4,4'-tetrabromodiphenyl ether"ESR1 gene mutant form inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of INSR mRNA]"29112739
C5290542-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol"[2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol co-treated with vildagliptin] inhibits the reaction [Dietary Fats results in decreased phosphorylation of INSR protein]"28807765
C5290542-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol"2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol inhibits the reaction [Dietary Fats results in decreased phosphorylation of INSR protein]"28807765
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of INSR mRNA"28433925
C0415253,3',4,5'-tetrahydroxystilbene"3,3',4,5'-tetrahydroxystilbene results in decreased activity of INSR protein"22298784
C0415253,3',4,5'-tetrahydroxystilbene"3,3',4,5'-tetrahydroxystilbene inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased phosphorylation of INSR protein]"22298784
C0415253,3',4,5'-tetrahydroxystilbene"3,3',4,5'-tetrahydroxystilbene binds to INSR protein"22298784
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of INSR mRNA]"19467301
C4340033-(4-methylphenylsulfonyl)-2-propenenitrile3-(4-methylphenylsulfonyl)-2-propenenitrile results in increased expression of INSR protein15564333
C4411283-N-1(spermine)-7, 24-dihydroxy-5-cholestane 24-sulfate"3-N-1(spermine)-7, 24-dihydroxy-5-cholestane 24-sulfate promotes the reaction [INS protein results in increased phosphorylation of INSR protein]"20075852
C4411283-N-1(spermine)-7, 24-dihydroxy-5-cholestane 24-sulfate"3-N-1(spermine)-7, 24-dihydroxy-5-cholestane 24-sulfate promotes the reaction [INS protein results in increased phosphorylation of INSR protein]"20075852
C5756314-(4-(2,4-dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy)-3-trifluoromethylbenzonitrile"4-(4-(2,4-dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy)-3-trifluoromethylbenzonitrile affects the expression of INSR mRNA"21218783
C4664205,10,15,20-tetrakis(4-sulfonatophenyl)porphyrinato iron(III) chloride"5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrinato iron(III) chloride inhibits the reaction [Dietary Fats inhibits the reaction [INS1 protein results in increased phosphorylation of INSR protein]]"19682478
C4664205,10,15,20-tetrakis(4-sulfonatophenyl)porphyrinato iron(III) chloride"5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrinato iron(III) chloride inhibits the reaction [Dietary Fats results in increased metabolism of INSR protein]"19682478
C0579285'-amino-5'-deoxyadenosine5'-amino-5'-deoxyadenosine inhibits the reaction [AICA ribonucleotide results in decreased activity of INSR promoter]15694368
C0579285'-amino-5'-deoxyadenosine5'-amino-5'-deoxyadenosine inhibits the reaction [AICA ribonucleotide results in decreased expression of INSR mRNA]15694368
C0579285'-amino-5'-deoxyadenosine5'-amino-5'-deoxyadenosine inhibits the reaction [AICA ribonucleotide results in decreased expression of INSR protein]15694368
C5622359-ethyl-6,6-dimethyl-8-(4-oxetan-3-ylpiperazin-1-yl)-11-oxo-6,11-dihydro-5H-benzo(b)carbazole-3-carbonitrile"9-ethyl-6,6-dimethyl-8-(4-oxetan-3-ylpiperazin-1-yl)-11-oxo-6,11-dihydro-5H-benzo(b)carbazole-3-carbonitrile affects the activity of INSR protein"21823617
D000082AcetaminophenAcetaminophen results in decreased expression of INSR mRNA21420995|2906747
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Pyruvaldehyde results in decreased phosphorylation of INSR protein]22917016
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Chromium results in decreased phosphorylation of INSR protein]18569013
D016604Aflatoxin B1Aflatoxin B1 affects the expression of INSR protein20106945
C031143AICA ribonucleotide5'-amino-5'-deoxyadenosine inhibits the reaction [AICA ribonucleotide results in decreased activity of INSR promoter]15694368
C031143AICA ribonucleotide5'-amino-5'-deoxyadenosine inhibits the reaction [AICA ribonucleotide results in decreased expression of INSR mRNA]15694368
C031143AICA ribonucleotide5'-amino-5'-deoxyadenosine inhibits the reaction [AICA ribonucleotide results in decreased expression of INSR protein]15694368
C031143AICA ribonucleotideAICA ribonucleotide results in decreased activity of INSR promoter15694368
C031143AICA ribonucleotideAICA ribonucleotide results in decreased expression of INSR mRNA15694368
C031143AICA ribonucleotideAICA ribonucleotide results in decreased expression of INSR protein15694368
C031143AICA ribonucleotideDipyridamole inhibits the reaction [AICA ribonucleotide results in decreased activity of INSR promoter]15694368
C031143AICA ribonucleotideDipyridamole inhibits the reaction [AICA ribonucleotide results in decreased expression of INSR mRNA]15694368
C031143AICA ribonucleotideDipyridamole inhibits the reaction [AICA ribonucleotide results in decreased expression of INSR protein]15694368
C103303alitretinoinalitretinoin results in increased phosphorylation of INSR protein18063688
D000493AllopurinolAllopurinol inhibits the reaction [Fructose results in decreased phosphorylation of INSR protein]22426011|2449131
D000496AlloxanAlloxan results in decreased phosphorylation of INSR protein22138235
D000496AlloxanTaurine inhibits the reaction [Alloxan results in decreased phosphorylation of INSR protein]22138235
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of INSR mRNA28522335
D000880AnthraquinonesAnthraquinones analog results in decreased activity of INSR protein27473261
D001151ArsenicArsenic affects the expression of INSR protein24675094
C015001arsenite[arsenite co-treated with Benzo(a)pyrene] results in increased expression of INSR mRNA15894712
C015001arsenitearsenite results in increased expression of INSR mRNA15894712
D001205Ascorbic Acid[Ascorbic Acid co-treated with Vitamin E] inhibits the reaction [Diethylhexyl Phthalate results in increased expression of INSR mRNA]21911000
D001280AtrazineAtrazine results in increased expression of INSR mRNA25929836
D019817Benzoic AcidBenzoic Acid analog results in increased phosphorylation of INSR protein24287560
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of INSR mRNA17879257
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of INSR gene25435355
D001564Benzo(a)pyrene[arsenite co-treated with Benzo(a)pyrene] results in increased expression of INSR mRNA15894712
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of INSR mRNA15894712
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of INSR mRNA"20382639
D004958EstradiolEstradiol affects the phosphorylation of INSR protein17068109
D004958EstradiolEstradiol affects the reaction [Streptozocin affects the expression of INSR protein]17068109
D004958EstradiolEstradiol results in decreased expression of INSR protein22142692
C543008bis(4-hydroxyphenyl)sulfone[Dietary Fats co-treated with bis(4-hydroxyphenyl)sulfone] affects the expression of INSR mRNA27241191
C006780bisphenol Abisphenol A inhibits the reaction [INS1 protein results in increased phosphorylation of INSR protein]24349194
C006780bisphenol Apyrazolanthrone inhibits the reaction [bisphenol A inhibits the reaction [INS1 protein results in increased phosphorylation of INSR protein]]24349194
C006780bisphenol Abisphenol A results in decreased expression of INSR mRNA23376180|2677993
C006780bisphenol Abisphenol A results in decreased expression of INSR protein23376180
C006780bisphenol Abisphenol A results in decreased phosphorylation of INSR protein25637671|2677993
C006780bisphenol A"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of INSR mRNA"28433925
C006780bisphenol Abisphenol A promotes the reaction [Dietary Fats results in decreased phosphorylation of INSR protein]25112833
C006780bisphenol Abisphenol A results in decreased expression of and results in decreased phosphorylation of INSR protein28153594|2873953
C006780bisphenol Abisphenol A results in decreased expression of INSR protein22142692|2342420
C006780bisphenol Abisphenol A results in decreased phosphorylation of INSR protein25112833
C006780bisphenol Abisphenol A results in increased expression of INSR protein27836638
C006780bisphenol Abisphenol A results in increased methylation of INSR gene28505145
C006780bisphenol ADietary Fats promotes the reaction [bisphenol A results in decreased phosphorylation of INSR protein]25112833
D002079ButterButter inhibits the reaction [Dietary Fats results in decreased expression of INSR mRNA]24450870
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of INSR promoter22457795
D002110CaffeineCaffeine results in decreased expression of INSR mRNA22583948
D002220CarbamazepineCarbamazepine affects the expression of INSR mRNA24752500
D002392CatechinCatechin inhibits the reaction [Glucose results in decreased expression of INSR protein]24262486
D002392CatechinCatechin inhibits the reaction [Glucose results in decreased expression of INSR protein modified form]24262486
D002791Cholesterol, Dietary"[Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in decreased phosphorylation of INSR protein"19509184
D002794CholineCholine deficiency results in decreased expression of INSR protein3554467
D002794CholineCholine deficiency results in increased activity of INSR protein3554467
C022990chromic chloridechromic chloride results in increased expression of INSR mRNA19283340
D002857ChromiumAcetylcysteine inhibits the reaction [Chromium results in decreased phosphorylation of INSR protein]18569013
D002857ChromiumChromium promotes the reaction [INS1 protein results in increased phosphorylation of INSR protein]16842748
D002857ChromiumChromium promotes the reaction [Zinc results in increased phosphorylation of INSR protein]15516700
D002857ChromiumChromium results in decreased phosphorylation of INSR protein18569013
D002857ChromiumChromium results in increased phosphorylation of INSR protein15516700
D002857ChromiumZinc promotes the reaction [Chromium results in increased phosphorylation of INSR protein]15516700
D017608Chromium CompoundsChromium Compounds promotes the reaction [INS1 protein results in increased phosphorylation of INSR protein]16842748
D017608Chromium CompoundsChromium Compounds results in increased expression of INSR mRNA21935427
D017608Chromium CompoundsChromium Compounds results in increased phosphorylation of INSR protein21935427
C074702chromium hexavalent ionchromium hexavalent ion results in decreased expression of INSR protein28911802
C503589cis-9, trans-11-conjugated linoleic acid"cis-9, trans-11-conjugated linoleic acid affects the expression of INSR protein"17327424
D003035Cobalt[Cobalt co-treated with INS1 protein] results in increased phosphorylation of INSR protein1321133
D016572CyclosporineCyclosporine results in decreased expression of INSR mRNA20106945|2556210
D0174851-Deoxynojirimycin[1-Deoxynojirimycin co-treated with Polysaccharides] inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of INSR protein]25446853
D003907Dexamethasone"3,3',4,5'-tetrahydroxystilbene inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased phosphorylation of INSR protein]"22298784
D003907Dexamethasone[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased phosphorylation of INSR protein22298784
D004008DiclofenacDiclofenac affects the expression of INSR mRNA24752500
D004040Dietary CarbohydratesDietary Carbohydrates results in decreased expression of INSR mRNA17490981
D004041Dietary Fats"[Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in decreased phosphorylation of INSR protein"19509184
D004041Dietary Fats[1-Deoxynojirimycin co-treated with Polysaccharides] inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of INSR protein]25446853
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of INSR mRNA]"19467301
D004041Dietary Fats"5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrinato iron(III) chloride inhibits the reaction [Dietary Fats inhibits the reaction [INS1 protein results in increased phosphorylation of INSR protein]]"19682478
D004041Dietary Fats"5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrinato iron(III) chloride inhibits the reaction [Dietary Fats results in increased metabolism of INSR protein]"19682478
D004041Dietary Fats[Dietary Fats co-treated with bis(4-hydroxyphenyl)sulfone] affects the expression of INSR mRNA27241191
D004041Dietary Fats[Dietary Fats co-treated with Streptozocin] results in increased expression of INSR protein25446853
D004041Dietary FatsDietary Fats inhibits the reaction [INS1 protein results in increased phosphorylation of INSR protein]19682478
D004041Dietary FatsDietary Fats results in decreased expression of INSR mRNA26519255
D004041Dietary FatsDietary Fats results in increased expression of INSR mRNA19467301|2439813
D004041Dietary FatsDietary Fats results in increased metabolism of INSR protein19682478
D004041Dietary Fats[Streptozocin co-treated with Dietary Fats] results in decreased phosphorylation of INSR protein26522834
D004041Dietary Fats"[2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol co-treated with vildagliptin] inhibits the reaction [Dietary Fats results in decreased phosphorylation of INSR protein]"28807765
D004041Dietary Fats"2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol inhibits the reaction [Dietary Fats results in decreased phosphorylation of INSR protein]"28807765
D004041Dietary Fatsbisphenol A promotes the reaction [Dietary Fats results in decreased phosphorylation of INSR protein]25112833
D004041Dietary FatsButter inhibits the reaction [Dietary Fats results in decreased expression of INSR mRNA]24450870
D004041Dietary Fats[Dietary Fats co-treated with Streptozocin co-treated with Quercetin] affects the expression of INSR mRNA21439094
D004041Dietary FatsDietary Fats promotes the reaction [bisphenol A results in decreased phosphorylation of INSR protein]25112833
D004041Dietary FatsDietary Fats results in decreased expression of INSR mRNA24450870
D004041Dietary FatsDietary Fats results in decreased phosphorylation of INSR protein25112833|2880776
D004041Dietary FatsMargarine inhibits the reaction [Dietary Fats results in decreased expression of INSR mRNA]24450870
D004041Dietary FatsOlive Oil inhibits the reaction [Dietary Fats results in decreased expression of INSR mRNA]24450870
D004041Dietary Fatsvildagliptin inhibits the reaction [Dietary Fats results in decreased phosphorylation of INSR protein]28807765
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of INSR protein28025108
D004051Diethylhexyl Phthalate"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of INSR mRNA"28433925
D004051Diethylhexyl Phthalate[Ascorbic Acid co-treated with Vitamin E] inhibits the reaction [Diethylhexyl Phthalate results in increased expression of INSR mRNA]21911000
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of and results in decreased phosphorylation of INSR protein25280772
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of INSR mRNA25280772
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of INSR protein21911000|2802510
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of INSR mRNA21911000
D004051Diethylhexyl Phthalate[INS1 protein co-treated with Diethylhexyl Phthalate] results in decreased expression of and results in decreased phosphorylation of INSR protein28526321
D004052DiethylnitrosamineDiethylnitrosamine affects the expression of INSR mRNA20387270
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of INSR protein19542621
D004176DipyridamoleDipyridamole inhibits the reaction [AICA ribonucleotide results in decreased activity of INSR promoter]15694368
D004176DipyridamoleDipyridamole inhibits the reaction [AICA ribonucleotide results in decreased expression of INSR mRNA]15694368
D004176DipyridamoleDipyridamole inhibits the reaction [AICA ribonucleotide results in decreased expression of INSR protein]15694368
C076126disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate"disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate results in increased expression of INSR mRNA"20184727
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased activity of INSR protein"25856345
C074283estradiol 3-benzoateestradiol 3-benzoate results in increased expression of INSR mRNA21323755
D000431EthanolEthanol results in decreased phosphorylation of INSR protein18377926
D000431EthanolEthanol results in decreased phosphorylation of INSR protein12700235
D004997Ethinyl EstradiolESR1 gene mutant form inhibits the reaction [Ethinyl Estradiol results in increased expression of INSR mRNA]29112739
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of INSR mRNA29112739
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of INSR gene18056790
D005411Flame RetardantsESR1 gene mutant form inhibits the reaction [Flame Retardants results in increased expression of INSR mRNA]29112739
D005411Flame RetardantsFlame Retardants results in increased expression of INSR mRNA29112739
D005632Fructose"[Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in decreased phosphorylation of INSR protein"19509184
D005632FructoseAllopurinol inhibits the reaction [Fructose results in decreased phosphorylation of INSR protein]22426011|2449131
D005632Fructose[Fructose co-treated with Oleanolic Acid] results in increased expression of INSR mRNA24704288
D005632Fructose"[Fructose co-treated with Sodium Chloride, Dietary deficiency] results in decreased expression of INSR mRNA"14633139
D005632Fructose"[Fructose co-treated with Sodium Chloride, Dietary deficiency] results in decreased expression of INSR protein"14633139
D005632FructoseFructose results in decreased expression of INSR mRNA14573337
D005632FructoseFructose results in decreased expression of INSR protein14573337
D005632FructoseFructose results in decreased phosphorylation of INSR protein22426011|2449131
D005632FructoseQuercetin inhibits the reaction [Fructose results in decreased phosphorylation of INSR protein]22426011|2449131
D005632FructoseRutin inhibits the reaction [Fructose results in decreased phosphorylation of INSR protein]22426011
C070081fulvestrantfulvestrant inhibits the reaction [resveratrol results in increased phosphorylation of INSR protein]18426865
C000599091fumosorinonefumosorinone results in increased phosphorylation of INSR protein modified form25796170
C000599091fumosorinonefumosorinone results in increased phosphorylation of INSR protein modified form25796170
D005947GlucoseCatechin inhibits the reaction [Glucose results in decreased expression of INSR protein]24262486
D005947GlucoseCatechin inhibits the reaction [Glucose results in decreased expression of INSR protein modified form]24262486
D005947GlucoseGlucose results in decreased degradation of INSR mRNA7826318
D005947GlucoseGlucose results in decreased expression of INSR protein24262486
D005947GlucoseGlucose results in decreased expression of INSR protein modified form24262486
D005947GlucoseGlucose results in increased expression of INSR mRNA7826318
D005947GlucoseGlucose results in increased phosphorylation of INSR protein7826318
D005947GlucosePlant Extracts inhibits the reaction [Glucose results in decreased expression of INSR protein]24262486
D005947GlucosePlant Extracts inhibits the reaction [Glucose results in decreased expression of INSR protein modified form]24262486
C015240glucose tolerance factorglucose tolerance factor results in increased activity of INSR protein10824953
D006581HexachlorobenzeneHexachlorobenzene results in increased expression of INSR protein19879930
D006581HexachlorobenzeneHexachlorobenzene results in increased expression of INSR protein16237195
D006861Hydrogen PeroxideFANCA protein affects the reaction [Hydrogen Peroxide results in increased phosphorylation of INSR protein]22482891
D006861Hydrogen PeroxideFANCC protein affects the reaction [Hydrogen Peroxide results in increased phosphorylation of INSR protein]22482891
D006861Hydrogen PeroxideHydrogen Peroxide results in increased phosphorylation of INSR protein22482891
D000069036Insulin GlargineInsulin Glargine results in increased phosphorylation of INSR protein27884723
D0150561-Methyl-3-isobutylxanthine"3,3',4,5'-tetrahydroxystilbene inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased phosphorylation of INSR protein]"22298784
D0150561-Methyl-3-isobutylxanthine[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased phosphorylation of INSR protein22298784
C040920isoliquiritigeninisoliquiritigenin inhibits the reaction [INS1 protein results in increased phosphorylation of INSR protein]27117918
C515747isosteviolisosteviol results in increased expression of INSR mRNA22479612
C045463leflunomideleflunomide results in increased expression of INSR mRNA24136188
C002385linsidominelinsidomine inhibits the reaction [INS1 protein results in increased phosphorylation of INSR protein]19682478
C002385linsidominelinsidomine results in increased metabolism of INSR protein19682478
D008148LovastatinLovastatin promotes the reaction [INS protein results in increased phosphorylation of INSR protein]19741129
D047311LuteolinLuteolin inhibits the reaction [INS1 protein results in increased phosphorylation of INSR protein]18591783
D008274Magnesium[Magnesium co-treated with INS protein] results in increased phosphorylation of and results in increased activity of INSR protein2542339
D008274Magnesium[Manganese co-treated with Magnesium co-treated with INS protein] results in increased phosphorylation of and results in increased activity of INSR protein2542339
D008274Magnesium[Polylysine co-treated with Manganese co-treated with Magnesium] promotes the reaction [INS protein results in increased phosphorylation of and results in increased activity of INSR protein]2542339
D008274Magnesium[Polylysine co-treated with Manganese co-treated with Magnesium] promotes the reaction [INS protein results in increased phosphorylation of and results in increased activity of INSR protein modified form]2542339
D008345Manganese[Manganese co-treated with Magnesium co-treated with INS protein] results in increased phosphorylation of and results in increased activity of INSR protein2542339
D008345Manganese[Polylysine co-treated with Manganese co-treated with Magnesium] promotes the reaction [INS protein results in increased phosphorylation of and results in increased activity of INSR protein]2542339
D008345Manganese[Polylysine co-treated with Manganese co-treated with Magnesium] promotes the reaction [INS protein results in increased phosphorylation of and results in increased activity of INSR protein modified form]2542339
D008345Manganese[Manganese co-treated with INS1 protein] results in increased phosphorylation of INSR protein1321133
D008345ManganeseManganese deficiency results in decreased expression of INSR protein2204694
C025340manganese chloridemanganese chloride results in decreased expression of INSR mRNA19276553
C025340manganese chloridemanganese chloride results in increased phosphorylation of INSR protein2475105
D008383MargarineMargarine inhibits the reaction [Dietary Fats results in decreased expression of INSR mRNA]24450870
D008550MelatoninMelatonin inhibits the reaction [Streptozocin results in decreased expression of INSR protein]19705549
D008687Metformin[Metformin co-treated with IGF1 protein] results in decreased expression of INSR mRNA21664031
D008687Metformin[Metformin co-treated with IGF2 protein] results in decreased expression of INSR mRNA21664031
D008687Metformin[Metformin co-treated with INS protein] results in decreased expression of INSR mRNA21664031
D008687MetforminMetformin inhibits the reaction [Streptozocin results in decreased expression of INSR mRNA]23927877
D008694MethamphetamineMethamphetamine results in increased expression of INSR mRNA26307267
D008727MethotrexateMethotrexate results in increased expression of INSR mRNA17400583
D008731MethoxychlorMethoxychlor results in decreased expression of INSR mRNA23303685
D008770MethylnitrosoureaMethylnitrosourea results in increased expression of INSR protein16237195
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of INSR protein26364587
D0156551-Methyl-4-phenylpyridiniumINS protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of INSR protein]26364587
D008825MiconazoleMiconazole results in decreased expression of INSR mRNA22262564
C044659molybdate[molybdate co-treated with INS1 protein] results in increased phosphorylation of INSR protein1321133
C044659molybdate[molybdate co-treated with Vanadates co-treated with INS1 protein] results in increased phosphorylation of INSR protein1321133
C016599mono-(2-ethylhexyl)phthalate[INS1 protein co-treated with mono-(2-ethylhexyl)phthalate] results in decreased expression of and results in decreased phosphorylation of INSR protein28526321
D009151Mustard GasMustard Gas results in increased expression of INSR mRNA18955075
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of INSR mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of INSR mRNA"25554681
D009532NickelNickel results in decreased expression of INSR mRNA24768652
D009532Nickel[Nickel co-treated with INS1 protein] results in increased phosphorylation of INSR protein1321133
D009538NicotineNicotine results in decreased expression of INSR mRNA22265867
D009538NicotineNicotine results in decreased expression of INSR protein20960268
C007350nitrofennitrofen results in decreased expression of INSR mRNA20438933|2143327
C007350nitrofennitrofen results in decreased expression of INSR protein20438933
C007350nitrofenTretinoin inhibits the reaction [nitrofen results in decreased expression of INSR mRNA]21433279
C002741N-nitrosomorpholineN-nitrosomorpholine results in increased expression of INSR protein21411721
D019787Linoleic AcidLinoleic Acid analog results in increased expression of INSR mRNA27939595
D009828Oleanolic Acid[Fructose co-treated with Oleanolic Acid] results in increased expression of INSR mRNA24704288
C108709oleoyl-estroneoleoyl-estrone results in decreased expression of INSR mRNA20184727
C488250oleoylethanolamideMAPK8 protein promotes the reaction [oleoylethanolamide affects the phosphorylation of and affects the activity of INSR protein]19345745
C488250oleoylethanolamideoleoylethanolamide affects the phosphorylation of and affects the activity of INSR protein19345745
C488250oleoylethanolamide[oleoylethanolamide binds to and results in increased activity of PPARA protein] which results in decreased activity of INSR protein19345745
C488250oleoylethanolamidepyrazolanthrone inhibits the reaction [oleoylethanolamide affects the phosphorylation of and affects the activity of INSR protein]19345745
C488250oleoylethanolamideSB 203580 inhibits the reaction [oleoylethanolamide affects the phosphorylation of and affects the activity of INSR protein]19345745
D009844OligosaccharidesOligosaccharides results in increased expression of INSR mRNA21935427
D009844OligosaccharidesOligosaccharides results in increased phosphorylation of INSR protein21935427
D000069463Olive OilOlive Oil inhibits the reaction [Dietary Fats results in decreased expression of INSR mRNA]24450870
C029341oxophenylarsineoxophenylarsine promotes the reaction [Vanadates results in increased phosphorylation of INSR protein]2458350
D010100OxygenOxygen deficiency results in increased expression of INSR mRNA26516004
D010100OxygenOxygen deficiency results in increased expression of INSR protein25352008
D010100Oxygenresveratrol inhibits the reaction [Oxygen deficiency results in increased expression of INSR protein]25352008
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of INSR mRNA24667235
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of INSR mRNA26548598
C076715pervanadateINS1 protein promotes the reaction [pervanadate results in increased phosphorylation of INSR protein]8404595
C076715pervanadatepervanadate results in increased phosphorylation of INSR protein8404595
D010672PhenytoinPhenytoin results in increased expression of INSR mRNA14741686
C030614picolinic acidpicolinic acid results in increased expression of INSR mRNA19283340
D010936Plant ExtractsPlant Extracts inhibits the reaction [Glucose results in decreased expression of INSR protein]24262486
D010936Plant ExtractsPlant Extracts inhibits the reaction [Glucose results in decreased expression of INSR protein modified form]24262486
D010936Plant ExtractsPlant Extracts results in increased phosphorylation of INSR protein18534569
D011107Polylysine[Polylysine co-treated with Manganese co-treated with Magnesium] promotes the reaction [INS protein results in increased phosphorylation of and results in increased activity of INSR protein]2542339
D011107Polylysine[Polylysine co-treated with Manganese co-treated with Magnesium] promotes the reaction [INS protein results in increased phosphorylation of and results in increased activity of INSR protein modified form]2542339
D011134Polysaccharides[1-Deoxynojirimycin co-treated with Polysaccharides] inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of INSR protein]25446853
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of INSR mRNA22714537
D011374ProgesteroneProgesterone results in increased expression of INSR mRNA20864642
D011374ProgesteroneProgesterone affects the reaction [Streptozocin affects the expression of INSR protein]17068109
D011374ProgesteroneProgesterone results in decreased phosphorylation of INSR protein17068109
C033607puerarinpuerarin inhibits the reaction [Streptozocin results in decreased expression of INSR mRNA]23927877
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [bisphenol A inhibits the reaction [INS1 protein results in increased phosphorylation of INSR protein]]24349194
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [oleoylethanolamide affects the phosphorylation of and affects the activity of INSR protein]19345745
D011765PyruvaldehydeAcetylcysteine inhibits the reaction [Pyruvaldehyde results in decreased phosphorylation of INSR protein]22917016
D011765PyruvaldehydePyruvaldehyde results in decreased phosphorylation of INSR protein22917016
D011765Pyruvaldehyderesveratrol inhibits the reaction [Pyruvaldehyde results in decreased phosphorylation of INSR protein]22917016
D011765Pyruvaldehyderosiglitazone inhibits the reaction [Pyruvaldehyde results in decreased phosphorylation of INSR protein]22917016
D011794Quercetin[Dietary Fats co-treated with Streptozocin co-treated with Quercetin] affects the expression of INSR mRNA21439094
D011794QuercetinQuercetin inhibits the reaction [Fructose results in decreased phosphorylation of INSR protein]22426011|2449131
D011794QuercetinQuercetin results in decreased activity of INSR protein1324726
C012526quercitrinquercitrin affects the expression of INSR mRNA25193878
C025474rebaudioside Arebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of INSR mRNA]25554529
C059514resveratrolresveratrol inhibits the reaction [IRS2 gene mutant form inhibits the reaction [INS protein results in increased phosphorylation of INSR protein]]25808216
C059514resveratrolresveratrol inhibits the reaction [Pyruvaldehyde results in decreased phosphorylation of INSR protein]22917016
C059514resveratrolresveratrol inhibits the reaction [Streptozocin inhibits the reaction [INS protein results in increased phosphorylation of INSR protein]]25808216
C059514resveratrolresveratrol binds to and results in decreased phosphorylation of and results in decreased activity of INSR protein22935344
C059514resveratrolESR1 protein promotes the reaction [resveratrol results in increased phosphorylation of INSR protein]18426865
C059514resveratrolfulvestrant inhibits the reaction [resveratrol results in increased phosphorylation of INSR protein]18426865
C059514resveratrolresveratrol inhibits the reaction [Oxygen deficiency results in increased expression of INSR protein]25352008
C059514resveratrolresveratrol results in increased phosphorylation of INSR protein18426865
C089730rosiglitazonerosiglitazone inhibits the reaction [Pyruvaldehyde results in decreased phosphorylation of INSR protein]22917016
C089730rosiglitazonerosiglitazone results in increased phosphorylation of INSR protein modified form25796170
C089730rosiglitazonerosiglitazone results in increased expression of INSR protein14595539
C022850rutamarinrutamarin promotes the reaction [INS protein results in increased phosphorylation of INSR protein]22384078
C022850rutamarinrutamarin results in increased phosphorylation of INSR protein22384078
C022850rutamarinrutamarin promotes the reaction [INS protein results in increased phosphorylation of INSR protein]22384078
D012431RutinRutin inhibits the reaction [Fructose results in decreased phosphorylation of INSR protein]22426011
C093642SB 203580SB 203580 inhibits the reaction [oleoylethanolamide affects the phosphorylation of and affects the activity of INSR protein]19345745
D012715Sesame OilSesame Oil results in increased expression of INSR mRNA29191790
C017947sodium arsenitesodium arsenite affects the methylation of INSR gene28589171
C017947sodium arsenitesodium arsenite inhibits the reaction [INS protein results in increased phosphorylation of INSR protein]24535192
C017947sodium arsenitesodium arsenite results in increased phosphorylation of INSR protein20043101
C017947sodium arsenitesodium arsenite results in increased expression of INSR mRNA26876454
D017673Sodium Chloride, Dietary"[Fructose co-treated with Sodium Chloride, Dietary deficiency] results in decreased expression of INSR mRNA"14633139
D017673Sodium Chloride, Dietary"[Fructose co-treated with Sodium Chloride, Dietary deficiency] results in decreased expression of INSR protein"14633139
D017673Sodium Chloride, Dietary"Sodium Chloride, Dietary results in decreased expression of INSR mRNA"14633139
D017673Sodium Chloride, Dietary"Sodium Chloride, Dietary results in decreased expression of INSR protein"14633139
D012999SomanSoman results in increased expression of INSR mRNA19281266
C012042steviolsteviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of INSR mRNA]25554529
C012043steviosidestevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of INSR mRNA]25554529
D013311Streptozocinresveratrol inhibits the reaction [Streptozocin inhibits the reaction [INS protein results in increased phosphorylation of INSR protein]]25808216
D013311StreptozocinStreptozocin inhibits the reaction [INS protein results in increased phosphorylation of INSR protein]25808216
D013311Streptozocin[1-Deoxynojirimycin co-treated with Polysaccharides] inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of INSR protein]25446853
D013311Streptozocin[Dietary Fats co-treated with Streptozocin] results in increased expression of INSR protein25446853
D013311StreptozocinMetformin inhibits the reaction [Streptozocin results in decreased expression of INSR mRNA]23927877
D013311Streptozocinpuerarin inhibits the reaction [Streptozocin results in decreased expression of INSR mRNA]23927877
D013311Streptozocin[Streptozocin co-treated with Dietary Fats] results in decreased phosphorylation of INSR protein26522834
D013311StreptozocinStreptozocin results in decreased expression of INSR mRNA23927877
D013311Streptozocin[Dietary Fats co-treated with Streptozocin co-treated with Quercetin] affects the expression of INSR mRNA21439094
D013311StreptozocinEstradiol affects the reaction [Streptozocin affects the expression of INSR protein]17068109
D013311StreptozocinMelatonin inhibits the reaction [Streptozocin results in decreased expression of INSR protein]19705549
D013311StreptozocinProgesterone affects the reaction [Streptozocin affects the expression of INSR protein]17068109
D013311StreptozocinStreptozocin affects the expression of INSR protein17068109
D013311StreptozocinStreptozocin results in decreased expression of INSR protein19705549|2356251
D013311StreptozocinStreptozocin results in decreased phosphorylation of INSR protein18331706
D013311StreptozocinStreptozocin results in increased expression of INSR mRNA9243097
D013311Streptozocinxanthoceraside inhibits the reaction [Streptozocin results in decreased expression of INSR protein]23562514
D012460SulfasalazineSulfasalazine results in increased expression of INSR protein15564333
D013654TaurineTaurine inhibits the reaction [Alloxan results in decreased phosphorylation of INSR protein]22138235
D013654TaurineTaurine results in increased phosphorylation of INSR protein22138235
D013739TestosteroneTestosterone results in increased expression of INSR mRNA17618942
D013739TestosteroneTestosterone affects the expression of INSR17162844
D013739TestosteroneTestosterone results in decreased expression of INSR mRNA20843997
D043343Testosterone PropionateTestosterone Propionate results in increased expression of INSR mRNA23457541
D013749TetrachlorodibenzodioxinAHR protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of INSR mRNA]20181658
D013749TetrachlorodibenzodioxinMAPK8 protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of INSR protein]20181658
D013749Tetrachlorodibenzodioxin"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of INSR mRNA"28433925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of INSR mRNA20181658
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of INSR protein20181658
D013749TetrachlorodibenzodioxinTNF protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of INSR protein]20181658
D013749TetrachlorodibenzodioxinTNFRSF1A protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of INSR protein]20181658
D013749TetrachlorodibenzodioxinU 0126 inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of INSR protein]20181658
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of INSR mRNA15977195
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with LEP protein] affects the expression of INSR mRNA15977195
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of INSR mRNA28973375
D053778ThiazolidinesThiazolidines analog results in increased phosphorylation of INSR protein24287560
D014118Toxins, Biological"Toxins, Biological affects the expression of INSR mRNA"19682533
D014212TretinoinTretinoin results in increased expression of INSR mRNA23830798
D014212TretinoinTretinoin inhibits the reaction [nitrofen results in decreased expression of INSR mRNA]21433279
D014212TretinoinTretinoin results in increased expression of INSR protein21433279
C032910triadimefontriadimefon results in decreased expression of INSR mRNA26790661
C403535triaquaoxohexakis(propionato)trichromium(III)triaquaoxohexakis(propionato)trichromium(III) results in increased activity of INSR protein12203022|1507341
C011559tributyltintributyltin affects the methylation of INSR gene28011154
C011559tributyltintributyltin results in decreased expression of and results in decreased phosphorylation of INSR protein28397090
C005445triphenyl phosphate"ESR1 gene mutant form inhibits the reaction [[tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in increased expression of INSR mRNA]"29112739
C005445triphenyl phosphate"[tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in increased expression of INSR mRNA"29112739
C016805tris(1,3-dichloro-2-propyl)phosphate"ESR1 gene mutant form inhibits the reaction [[tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in increased expression of INSR mRNA]"29112739
C016805tris(1,3-dichloro-2-propyl)phosphate"[tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in increased expression of INSR mRNA"29112739
D014317Tritolyl Phosphates"ESR1 gene mutant form inhibits the reaction [[tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in increased expression of INSR mRNA]"29112739
D014317Tritolyl Phosphates"[tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in increased expression of INSR mRNA"29112739
C057693troglitazonetroglitazone results in decreased expression of INSR mRNA28973697
C057693troglitazonetroglitazone promotes the reaction [INS protein promotes the reaction [INSR protein results in increased phosphorylation of INSR protein]]10813377
C079836tyrphostin 25tyrphostin 25 inhibits the reaction [INS1 protein results in increased phosphorylation of INSR protein]14511371
C113580U 0126U 0126 inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of INSR protein]20181658
D014520UrethaneUrethane results in increased expression of INSR mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of INSR mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of INSR mRNA24935251
D014635Valproic AcidValproic Acid affects the expression of INSR mRNA17963808
D014638VanadatesVanadates results in decreased expression of INSR mRNA22714537
D014638Vanadatesoxophenylarsine promotes the reaction [Vanadates results in increased phosphorylation of INSR protein]2458350
D014638VanadatesVanadates promotes the reaction [INS1 protein results in increased phosphorylation of INSR protein]16842748
D014638VanadatesVanadates results in increased phosphorylation of INSR protein2458350
D014638Vanadates[molybdate co-treated with Vanadates co-treated with INS1 protein] results in increased phosphorylation of INSR protein1321133
D014638Vanadates[Vanadates co-treated with INS1 protein] results in increased phosphorylation of INSR protein1321133
D014638VanadatesVanadates results in increased expression of INSR protein17874149
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of INSR gene25560391
C502012vildagliptin"[2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol co-treated with vildagliptin] inhibits the reaction [Dietary Fats results in decreased phosphorylation of INSR protein]"28807765
C502012vildagliptinvildagliptin inhibits the reaction [Dietary Fats results in decreased phosphorylation of INSR protein]28807765
D014810Vitamin E[Ascorbic Acid co-treated with Vitamin E] inhibits the reaction [Diethylhexyl Phthalate results in increased expression of INSR mRNA]21911000
C548611xanthocerasidexanthoceraside inhibits the reaction [Streptozocin results in decreased expression of INSR protein]23562514
D015032ZincChromium promotes the reaction [Zinc results in increased phosphorylation of INSR protein]15516700
D015032ZincZinc promotes the reaction [Chromium results in increased phosphorylation of INSR protein]15516700
D015032ZincZinc results in increased phosphorylation of INSR protein15516700
D015032ZincZinc affects the expression of INSR mRNA16413754
D015032Zinc[Zinc co-treated with INS1 protein] results in increased phosphorylation of INSR protein1321133
D015032ZincZinc deficiency results in decreased expression of INSR mRNA21893222
D015032ZincZinc deficiency results in decreased expression of INSR protein21893222
C016837zinc chloridezinc chloride results in increased phosphorylation of INSR protein11340092

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001540amyloid-beta binding-IPI19406747  
GO:0004709MAP kinase kinase kinase activity-IBA21873635  
GO:0004713protein tyrosine kinase activity-IBA21873635  
GO:0004713protein tyrosine kinase activity-IDA8496180  
GO:0004713protein tyrosine kinase activity-IMP7537849  
GO:0004714transmembrane receptor protein tyrosine kinase activity-IBA21873635  
GO:0004888transmembrane signaling receptor activity-IBA21873635  
GO:0005009insulin-activated receptor activity-IBA21873635  
GO:0005009insulin-activated receptor activity-IDA6849137  8440175  
GO:0005159insulin-like growth factor receptor binding-IDA8452530  
GO:0005515protein binding-IPI7493946  7537849  7935368  8452530  8662806  8702689  
8999839  9506989  9593725  9742218  10500481  10660596  
11136729  11163213  11279102  11289049  11374898  11506178  
11579209  11796522  12237455  12634852  14568990  14722096  
15588987  15629149  16582879  16926280  17092689  17135270  
17159996  17481567  19029027  21720388  21806020  25416956  
GO:0005524ATP binding-IDA6849137  
GO:0005525GTP binding-IDA9092559  
GO:0019904protein domain specific binding-IPI16246733  
GO:0031434mitogen-activated protein kinase kinase binding-IBA21873635  
GO:0031994insulin-like growth factor I binding-IPI8452530  
GO:0031995insulin-like growth factor II binding-IPI12138094  
GO:0043548phosphatidylinositol 3-kinase binding-IPI7537849  8276809  
GO:0043559insulin binding-IDA8440175  
GO:0043559insulin binding-IPI8452530  
GO:0043560insulin receptor substrate binding-IBA21873635  
GO:0043560insulin receptor substrate binding-IPI7493946  7537849  7559478  
GO:0044877protein-containing complex binding-IPI19406747  
GO:0051425PTB domain binding-IPI7559478  
GO ID GO Term Qualifier Evidence PubMed
GO:0000187activation of MAPK activity-IMP17001305  
GO:0001934positive regulation of protein phosphorylation-IBA21873635  
GO:0001934positive regulation of protein phosphorylation-IDA7556070  
GO:0003007heart morphogenesis-IMP7693131  
GO:0005975carbohydrate metabolic process-IEA-  
GO:0006355regulation of transcription, DNA-templated-IMP12881524  
GO:0006468protein phosphorylation-TAS19188609  
GO:0007186G-protein coupled receptor signaling pathway-IDA9092559  
GO:0007275multicellular organism development-IBA21873635  
GO:0007612learning-TAS19188609  
GO:0007613memory-TAS19188609  
GO:0008284positive regulation of cell proliferation-IC11500939  
GO:0008284positive regulation of cell proliferation-IDA17925406  
GO:0008284positive regulation of cell proliferation-IMP12138094  
GO:0008286insulin receptor signaling pathway-IDA6849137  8440175  20455999  
GO:0008286insulin receptor signaling pathway-ISS19406747  
GO:0008286insulin receptor signaling pathway-TAS-  
GO:0008544epidermis development-IEA-  
GO:0008584male gonad development-IEA-  
GO:0009968negative regulation of signal transduction-IBA21873635  
GO:0018108peptidyl-tyrosine phosphorylation-IDA8496180  
GO:0019087transformation of host cell by virus-IMP17001305  
GO:0030154cell differentiation-IBA21873635  
GO:0030238male sex determination-IEA-  
GO:0030325adrenal gland development-IEA-  
GO:0030335positive regulation of cell migration-IMP12138094  
GO:0031017exocrine pancreas development-IEA-  
GO:0032147activation of protein kinase activity-IMP9819385  
GO:0032148activation of protein kinase B activity-IDA7556070  
GO:0032869cellular response to insulin stimulus-IDA8440175  
GO:0033674positive regulation of kinase activity-IBA21873635  
GO:0038083peptidyl-tyrosine autophosphorylation-IEA-  
GO:0042593glucose homeostasis-IBA21873635  
GO:0042593glucose homeostasis-IMP7693131  
GO:0043066negative regulation of apoptotic process-IBA21873635  
GO:0043243positive regulation of protein complex disassembly-ISS19406747  
GO:0043410positive regulation of MAPK cascade-IDA20455999  
GO:0043410positive regulation of MAPK cascade-IMP11500939  
GO:0045429positive regulation of nitric oxide biosynthetic process-IMP10747347  
GO:0045725positive regulation of glycogen biosynthetic process-IDA17925406  
GO:0045821positive regulation of glycolytic process-IMP7693131  
GO:0045840positive regulation of mitotic nuclear division-IMP11500939  
GO:0045893positive regulation of transcription, DNA-templated-IEA-  
GO:0045995regulation of embryonic development-IMP7693131  
GO:0046326positive regulation of glucose import-IDA3518947  
GO:0046326positive regulation of glucose import-NAS11001060  
GO:0046777protein autophosphorylation-IDA6849137  8496180  
GO:0046777protein autophosphorylation-IMP7537849  
GO:0048639positive regulation of developmental growth-IMP7693131  
GO:0051290protein heterotetramerization-IDA1898103  
GO:0051446positive regulation of meiotic cell cycle-IEA-  
GO:0051897positive regulation of protein kinase B signaling-IMP11500939  
GO:0060267positive regulation of respiratory burst-IDA9092559  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IBA21873635  
GO:0071363cellular response to growth factor stimulus-IEA-  
GO:0097062dendritic spine maintenance-ISS19406747  
GO:0097242amyloid-beta clearance-ISS19406747  
GO:1990535neuron projection maintenance-ISS-  
GO:2000194regulation of female gonad development-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005622intracellular-ISS-  
GO:0005635nuclear envelopecolocalizes_withIDA19406747  
GO:0005737cytoplasm-IBA21873635  
GO:0005886plasma membrane-IC6849137  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-IDA9092559  
GO:0005899insulin receptor complex-IBA21873635  
GO:0005899insulin receptor complex-IMP15069075  
GO:0005901caveola-IDA15182363  
GO:0009897external side of plasma membrane-ISS-  
GO:0010008endosome membrane-TAS-  
GO:0016020membrane-IDA8452530  
GO:0030424axon-IBA21873635  
GO:0031981nuclear lumencolocalizes_withIDA19406747  
GO:0032590dendrite membrane-ISS-  
GO:0032809neuronal cell body membrane-ISS-  
GO:0043235receptor complex-IBA21873635  
GO:0043235receptor complex-IDA23382219  
GO:0070062extracellular exosome-HDA20458337  
KEGG ID KEGG Term
hsa04520Adherens junction
hsa04910Insulin signaling pathway
hsa04930Type II diabetes mellitus
hsa04960Aldosterone-regulated sodium reabsorption
Reactome ID Reactome Term Evidence
R-HSA-1257604PIP3 activates AKT signalingTAS
R-HSA-162582Signal TransductionTAS
R-HSA-199418Negative regulation of the PI3K/AKT networkTAS
R-HSA-6811558PI5P, PP2A and IER3 Regulate PI3K/AKT SignalingTAS
R-HSA-74713IRS activationTAS
R-HSA-74749Signal attenuationTAS
R-HSA-74751Insulin receptor signalling cascadeTAS
R-HSA-74752Signaling by Insulin receptorTAS
R-HSA-77387Insulin receptor recyclingTAS
R-HSA-9006925Intracellular signaling by second messengersTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19948975Integrative predictive model of coronary artery calcification in atherosclerosis. (2009 Dec 15)McGeachie MCirculation
22705438Association between insulin receptor gene polymorphism and the metabolic syndrome in Han and Yi Chinese. (2012)Wang CAsia Pac J Clin Nutr
25557790An exon variant in insulin receptor gene is associated with susceptibility to colorectal cancer in women. (2015 May)Mahmoudi TTumour Biol
24175768Is there an association between variants in candidate insulin pathway genes IGF-I, IGFBP-3, INSR, and IRS2 and risk of colorectal cancer in the Iranian population? (2013)Karimi KAsian Pac J Cancer Prev
28592245In silico identification of potential key regulatory factors in smoking-induced lung cancer. (2017 Jun 7)El-Aarag SABMC Med Genomics
26077721Insulin receptor variants and obesity-related cancers in the Framingham Heart Study. (2015 Aug)Parekh NCancer Causes Control
27296149Association of MMP-8 with obesity, smoking and insulin resistance. (2016 Sep)Lauhio AEur J Clin Invest