Gene: PDX1

3651
GSF|IDX-1|IPF1|IUF1|MODY4|PAGEN1|PDX-1|STF-1
pancreatic and duodenal homeobox 1
protein-coding
13q12.2
Ensembl:ENSG00000139515 MIM:600733 Vega:OTTHUMG00000016638 UniprotKB:P52945
NG_008183.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.421e-2 (AD)  8.660e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR2Z10.646
OR14A160.556
ATOH10.545
OR2A40.539
OR5H140.538
OR5D130.534
OR6C680.533
GSTA30.533
TMCO5A0.532
UGT3A10.527

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYBPC1-0.24
PARS2-0.221
PIH1D2-0.21
NMNAT1-0.191
ZBTB3-0.188
USP51-0.185
TMEM229A-0.181
MIP-0.181
TSPEAR-0.18
PIGV-0.179

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1053511-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene"1-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene results in increased expression of PDX1"26980118
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Glucose affects the localization of PDX1 protein]9873045
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Glucose results in increased phosphorylation of and results in increased activity of PDX1 protein]9873045
C0757734-phenylbutyric acid4-phenylbutyric acid inhibits the reaction [LEPR gene mutant form results in decreased expression of PDX1 mRNA]23274897
C5505476-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide"6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [SIRT1 protein promotes the reaction [resveratrol results in increased expression of PDX1 mRNA]]"21163946
C103303alitretinoinalitretinoin results in decreased expression of PDX1 mRNA21670153
C103303alitretinoinalitretinoin results in decreased expression of PDX1 mRNA21115832
D000584AmilorideAmiloride results in decreased uptake of PDX1 protein16405074
D001152ArsenicalsArsenicals results in decreased methylation of PDX1 promoter23315758
C015001arsenitearsenite results in increased methylation of PDX1 promoter23974009
D001554BenzeneBenzene results in increased expression of PDX1 protein15468289
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PDX1 mRNA22316170
D004958EstradiolEstradiol results in decreased expression of PDX1 mRNA22946080
D001629BezafibrateBezafibrate results in decreased expression of PDX1 mRNA11527545
D001629BezafibrateDiazoxide inhibits the reaction [Bezafibrate results in decreased expression of PDX1 mRNA]11527545
C006780bisphenol Abisphenol A results in increased expression of PDX1 mRNA27623287|2877489
C006780bisphenol Abisphenol A results in increased expression of PDX1 protein28774890
C006780bisphenol AGPER1 protein affects the reaction [bisphenol A results in increased expression of PDX1 mRNA]28774890
C006780bisphenol APDX1 protein affects the reaction [bisphenol A promotes the reaction [Glucose results in increased secretion of INS protein]]28774890
C006780bisphenol Abisphenol A results in decreased expression of PDX1 mRNA22946080|2518105
C059041calyculin Acalyculin A inhibits the reaction [Glucose affects the localization of PDX1 protein]11574405
C059041calyculin Acalyculin A inhibits the reaction [Glucose affects the localization of PDX1 protein]11574405
D002211CapsaicinCapsaicin results in decreased expression of PDX1 mRNA16278290
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PDX1 gene20938992
C030865copper bis(3,5-diisopropylsalicylate)"[copper bis(3,5-diisopropylsalicylate) co-treated with Glucose] results in increased expression of PDX1 protein"23795780
D015638Cytochalasin DCytochalasin D results in decreased uptake of PDX1 protein16405074
D003907DexamethasoneDexamethasone results in decreased expression of PDX1 mRNA25851902
D003981DiazoxideDiazoxide inhibits the reaction [Bezafibrate results in decreased expression of PDX1 mRNA]11527545
D004041Dietary FatsDietary Fats results in decreased expression of PDX1 mRNA25228148
D004041Dietary FatsDietary Fats results in decreased expression of PDX1 protein25228148
D004041Dietary Fatsresveratrol inhibits the reaction [Dietary Fats results in decreased expression of PDX1 mRNA]25228148
D004041Dietary Fatsresveratrol inhibits the reaction [Dietary Fats results in decreased expression of PDX1 protein]25228148
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of PDX1 mRNA25280772
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of PDX1 protein25280772
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of PDX1 mRNA22946080
C042986ebselen[ebselen co-treated with Glucose] results in increased expression of PDX1 protein23795780
D005419FlavonoidsFlavonoids results in increased expression of PDX1 mRNA18035473
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PDX1 gene20938992
D004397FonofosFonofos results in increased methylation of PDX1 promoter22847954
D005632FructoseFructose results in increased expression of PDX1 mRNA23533474
D005632FructoseFructose results in increased expression of PDX1 protein23533474
D005632FructoseQuercetin inhibits the reaction [Fructose results in increased expression of PDX1 protein]23533474
C039281furanfuran results in increased expression of PDX1 mRNA27387713
D005707Gallic AcidGallic Acid results in increased expression of PDX1 protein24036142
C007835geniposidegeniposide inhibits the reaction [Palmitic Acid results in decreased expression of PDX1 protein]22819839
D005947Glucose2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Glucose affects the localization of PDX1 protein]9873045
D005947Glucose2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Glucose results in increased phosphorylation of and results in increased activity of PDX1 protein]9873045
D005947Glucosecalyculin A inhibits the reaction [Glucose affects the localization of PDX1 protein]11574405
D005947GlucoseGlucose affects the localization of PDX1 protein11574405|2255838
D005947Glucose[Glucose co-treated with INS protein] affects the localization of PDX1 protein11574405
D005947Glucose[Glucose co-treated with sodium arsenite] affects the localization of PDX1 protein11574405
D005947GlucoseGlucose results in increased phosphorylation of and results in increased activity of PDX1 protein9873045
D005947GlucoseOkadaic Acid inhibits the reaction [Glucose affects the localization of PDX1 protein]11574405
D005947GlucosePalmitic Acid inhibits the reaction [Glucose affects the localization of PDX1 protein]22558381
D005947Glucose[SB 203580 co-treated with INS protein] inhibits the reaction [Glucose affects the localization of PDX1 protein]11574405
D005947GlucoseSB 203580 inhibits the reaction [Glucose affects the localization of PDX1 protein]11574405|9873045
D005947GlucoseSB 203580 inhibits the reaction [[Glucose co-treated with sodium arsenite] affects the localization of PDX1 protein]11574405
D005947GlucoseSB 203580 inhibits the reaction [Glucose results in increased phosphorylation of and results in increased activity of PDX1 protein]9873045
D005947Glucose[wortmannin co-treated with INS protein] inhibits the reaction [Glucose affects the localization of PDX1 protein]11574405
D005947Glucosewortmannin inhibits the reaction [Glucose affects the localization of PDX1 protein]11574405|9873045
D005947Glucosewortmannin inhibits the reaction [Glucose results in increased phosphorylation of and results in increased activity of PDX1 protein]9873045
D005947Glucosecalyculin A inhibits the reaction [Glucose affects the localization of PDX1 protein]11574405
D005947Glucose"[copper bis(3,5-diisopropylsalicylate) co-treated with Glucose] results in increased expression of PDX1 protein"23795780
D005947Glucose[ebselen co-treated with Glucose] results in increased expression of PDX1 protein23795780
D005947GlucoseGlucose affects the localization of PDX1 protein11574405|9873045
D005947Glucose[Glucose co-treated with INS1 protein] affects the localization of PDX1 protein11574405
D005947Glucose[Glucose co-treated with sodium arsenite] affects the localization of PDX1 protein11574405
D005947GlucoseGlucose results in increased activity of PDX1 promoter16489446
D005947GlucoseGlucose results in increased expression of PDX1 mRNA22558381
D005947GlucoseGlucose results in increased phosphorylation of and results in increased activity of PDX1 protein9873045
D005947GlucoseIL1B protein inhibits the reaction [Glucose results in increased expression of PDX1 mRNA]22558381
D005947Glucose"lipopolysaccharide, Escherichia coli O111 B4 inhibits the reaction [Glucose results in increased expression of PDX1 mRNA]"22558381
D005947Glucose[Metformin co-treated with Glucose] affects the localization of PDX1 protein16489446
D005947GlucoseOkadaic Acid inhibits the reaction [Glucose affects the localization of PDX1 protein]11574405
D005947GlucosePalmitic Acid inhibits the reaction [Glucose results in increased expression of PDX1 mRNA]22558381
D005947GlucosePDX1 protein affects the reaction [bisphenol A promotes the reaction [Glucose results in increased secretion of INS protein]]28774890
D005947Glucoserosiglitazone promotes the reaction [Glucose results in increased activity of PDX1 promoter]16489446
D005947GlucoseSB 203580 inhibits the reaction [Glucose affects the localization of PDX1 protein]11574405
D005947GlucoseSB 203580 inhibits the reaction [[Glucose co-treated with sodium arsenite] affects the localization of PDX1 protein]11574405
D005947Glucose"TLR4 affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 inhibits the reaction [Glucose results in increased expression of PDX1 mRNA]]"22558381
D005947Glucosewortmannin inhibits the reaction [Glucose affects the localization of PDX1 protein]11574405
D005947GlucoseGlucose affects the expression of PDX1 mRNA24349266
D005947GlucoseGlucose results in decreased expression of PDX1 protein24349266
D005947GlucoseGlucose results in increased expression of PDX1 mRNA22558381
D005947Glucose"lipopolysaccharide, Escherichia coli O111 B4 inhibits the reaction [Glucose results in increased expression of PDX1 mRNA]"22558381
C500810GW8510GW8510 results in increased expression of PDX1 mRNA22242153
D006247HarmineHarmine results in increased expression of PDX1 mRNA25751815
D006247HarmineHarmine results in increased expression of PDX1 protein25751815
C440499lipopolysaccharide, Escherichia coli O111 B4"lipopolysaccharide, Escherichia coli O111 B4 inhibits the reaction [Glucose results in increased expression of PDX1 mRNA]"22558381
C440499lipopolysaccharide, Escherichia coli O111 B4"TLR4 affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 inhibits the reaction [Glucose results in increased expression of PDX1 mRNA]]"22558381
C440499lipopolysaccharide, Escherichia coli O111 B4"lipopolysaccharide, Escherichia coli O111 B4 inhibits the reaction [Glucose results in increased expression of PDX1 mRNA]"22558381
C005498magnolol[magnolol co-treated with Pyruvaldehyde] results in increased expression of PDX1 mRNA28919305
D008687Metformin[Metformin co-treated with Glucose] affects the localization of PDX1 protein16489446
D008687MetforminMetformin results in increased expression of PDX1 protein16489446
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PDX1 gene20938992
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of PDX1 mRNA26011545
C025256nonylphenolnonylphenol results in decreased expression of PDX1 mRNA22946080
C474055octylphenoloctylphenol inhibits the reaction [Streptozocin results in decreased expression of PDX1 mRNA]24781736
C474055octylphenoloctylphenol results in increased expression of PDX1 mRNA24781736
C474055octylphenoloctylphenol results in decreased expression of PDX1 mRNA22946080
D019319Okadaic AcidOkadaic Acid inhibits the reaction [Glucose affects the localization of PDX1 protein]11574405
D019319Okadaic AcidOkadaic Acid inhibits the reaction [Glucose affects the localization of PDX1 protein]11574405
D019308Palmitic AcidPalmitic Acid inhibits the reaction [Glucose affects the localization of PDX1 protein]22558381
D019308Palmitic AcidPalmitic Acid results in decreased expression of PDX1 mRNA18155663
D019308Palmitic AcidPalmitic Acid inhibits the reaction [Glucose results in increased expression of PDX1 mRNA]22558381
D019308Palmitic Acidgeniposide inhibits the reaction [Palmitic Acid results in decreased expression of PDX1 protein]22819839
D019308Palmitic AcidPalmitic Acid results in decreased expression of PDX1 protein22819839
D010278ParathionParathion results in increased methylation of PDX1 promoter22847954
D010936Plant ExtractsPlant Extracts results in increased expression of PDX1 protein24036142
D011192Potassium DichromatePotassium Dichromate results in increased expression of PDX1 mRNA23608068
D011765Pyruvaldehyde[magnolol co-treated with Pyruvaldehyde] results in increased expression of PDX1 mRNA28919305
D011794QuercetinQuercetin inhibits the reaction [Fructose results in increased expression of PDX1 protein]23533474
D017382Reactive Oxygen SpeciesATP6 protein affects the reaction [PDX1 protein affects the abundance of Reactive Oxygen Species]18273840
D017382Reactive Oxygen SpeciesPDX1 protein affects the abundance of Reactive Oxygen Species18273840
C059514resveratrol"6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [SIRT1 protein promotes the reaction [resveratrol results in increased expression of PDX1 mRNA]]"21163946
C059514resveratrolresveratrol results in increased expression of PDX1 mRNA21163946
C059514resveratrolSIRT1 protein promotes the reaction [resveratrol results in increased expression of PDX1 mRNA]21163946
C059514resveratrolresveratrol results in increased expression of PDX1 protein24036142
C059514resveratrolresveratrol inhibits the reaction [Dietary Fats results in decreased expression of PDX1 mRNA]25228148
C059514resveratrolresveratrol inhibits the reaction [Dietary Fats results in decreased expression of PDX1 protein]25228148
C089730rosiglitazonerosiglitazone affects the localization of PDX1 protein16489446
C089730rosiglitazonerosiglitazone promotes the reaction [Glucose results in increased activity of PDX1 promoter]16489446
C089730rosiglitazonerosiglitazone results in increased expression of PDX1 protein16489446
C093642SB 203580[SB 203580 co-treated with INS protein] inhibits the reaction [Glucose affects the localization of PDX1 protein]11574405
C093642SB 203580SB 203580 inhibits the reaction [Glucose affects the localization of PDX1 protein]11574405|9873045
C093642SB 203580SB 203580 inhibits the reaction [[Glucose co-treated with sodium arsenite] affects the localization of PDX1 protein]11574405
C093642SB 203580SB 203580 inhibits the reaction [Glucose results in increased phosphorylation of and results in increased activity of PDX1 protein]9873045
C093642SB 203580SB 203580 inhibits the reaction [sodium arsenite affects the localization of PDX1 protein]9873045
C093642SB 203580SB 203580 inhibits the reaction [sodium arsenite results in increased phosphorylation of and results in increased activity of PDX1 protein]9873045
C093642SB 203580SB 203580 inhibits the reaction [Glucose affects the localization of PDX1 protein]11574405
C093642SB 203580SB 203580 inhibits the reaction [[Glucose co-treated with sodium arsenite] affects the localization of PDX1 protein]11574405
D020123SirolimusSirolimus results in decreased expression of PDX1 mRNA20622751
C017947sodium arsenite[Glucose co-treated with sodium arsenite] affects the localization of PDX1 protein11574405
C017947sodium arseniteSB 203580 inhibits the reaction [[Glucose co-treated with sodium arsenite] affects the localization of PDX1 protein]11574405
C017947sodium arseniteSB 203580 inhibits the reaction [sodium arsenite affects the localization of PDX1 protein]9873045
C017947sodium arseniteSB 203580 inhibits the reaction [sodium arsenite results in increased phosphorylation of and results in increased activity of PDX1 protein]9873045
C017947sodium arsenitesodium arsenite affects the localization of PDX1 protein9873045
C017947sodium arsenitesodium arsenite results in increased phosphorylation of and results in increased activity of PDX1 protein9873045
C017947sodium arsenite[Glucose co-treated with sodium arsenite] affects the localization of PDX1 protein11574405
C017947sodium arseniteSB 203580 inhibits the reaction [[Glucose co-treated with sodium arsenite] affects the localization of PDX1 protein]11574405
D013311Streptozocinoctylphenol inhibits the reaction [Streptozocin results in decreased expression of PDX1 mRNA]24781736
D013311StreptozocinStreptozocin results in decreased expression of PDX1 mRNA24781736
C105686SU 5402SU 5402 results in decreased expression of PDX1 mRNA16326079
C105686SU 5402SU 5402 results in increased expression of PDX1 mRNA16326079
C012568terbufosterbufos results in increased methylation of PDX1 promoter22847954
D043343Testosterone PropionateTestosterone Propionate results in increased expression of PDX1 mRNA23457541
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PDX1 mRNA21570461|2405805
D014118Toxins, Biological"Toxins, Biological affects the expression of PDX1 mRNA"19682533
D014212TretinoinTretinoin results in increased expression of PDX1 protein17244022
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PDX1 gene25560391
D014801Vitamin A[Vitamin A co-treated with INHBA protein] results in increased expression of PDX1 mRNA17244017
C009687wortmannin[wortmannin co-treated with INS protein] inhibits the reaction [Glucose affects the localization of PDX1 protein]11574405
C009687wortmanninwortmannin inhibits the reaction [Glucose affects the localization of PDX1 protein]11574405|9873045
C009687wortmanninwortmannin inhibits the reaction [Glucose results in increased phosphorylation of and results in increased activity of PDX1 protein]9873045
C009687wortmanninwortmannin inhibits the reaction [Glucose affects the localization of PDX1 protein]11574405

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IBA21873635  
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0003682chromatin binding-IEA-  
GO:0003700DNA-binding transcription factor activity-IBA21873635  
GO:0003700DNA-binding transcription factor activity-TAS17941991  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IEA-  
GO:0001889liver development-IEA-  
GO:0003309type B pancreatic cell differentiation-IBA21873635  
GO:0003309type B pancreatic cell differentiation-IDA12124776  24567802  
GO:0003309type B pancreatic cell differentiation-ISS-  
GO:0006006glucose metabolic process-IEA-  
GO:0006091generation of precursor metabolites and energy-TAS8954967  
GO:0006366transcription by RNA polymerase II-TAS8954967  
GO:0007263nitric oxide mediated signal transduction-IDA17941991  
GO:0008284positive regulation of cell proliferation-IEA-  
GO:0008285negative regulation of cell proliferation-IEA-  
GO:0009887animal organ morphogenesis-TAS8988180  
GO:0016331morphogenesis of embryonic epithelium-IEA-  
GO:0030073insulin secretion-IDA17941991  
GO:0031017exocrine pancreas development-IEA-  
GO:0031018endocrine pancreas development-IBA21873635  
GO:0035774positive regulation of insulin secretion involved in cellular response to glucose stimulus-IEA-  
GO:0042593glucose homeostasis-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-IBA21873635  
GO:0045944positive regulation of transcription by RNA polymerase II-ISS-  
GO:0048565digestive tract development-IEA-  
GO:0051594detection of glucose-ISS-  
GO:1902236negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway-IEA-  
GO:2000675negative regulation of type B pancreatic cell apoptotic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005654nucleoplasm-IDA-  
GO:0005829cytosol-IEA-  
GO:0016607nuclear speck-IEA-  
KEGG ID KEGG Term
hsa04930Type II diabetes mellitus
hsa04950Maturity onset diabetes of the young
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyIEA
R-HSA-186712Regulation of beta-cell developmentIEA
R-HSA-210745Regulation of gene expression in beta cellsIEA
R-HSA-210747Regulation of gene expression in early pancreatic precursor cellsIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25813534Association of genetic variants with hypertension in a longitudinal population-based genetic epidemiological study. (2015 May)Yamada YInt J Mol Med