Gene info: ID 3654

Gene: IRAK1

GENE ID: 3654

Synonyms: IRAK|pelle

Description: interleukin 1 receptor associated kinase 1

Gene type: protein-coding

Location: Xq28

dbXrefs: Ensembl:ENSG00000184216 MIM:300283 Vega:OTTHUMG00000024228 UniprotKB:P51617

RefSeq: NG_008387.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 5

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : NA (AD) NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
AKT1	0.839
TFE3	0.834
DAB2IP	0.826
CSNK1G2	0.809
MAPK8IP1	0.808
HMGA1	0.806
TRAF7	0.804
PKIG	0.804
MGAT4B	0.801
KIFC3	0.8

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.717
OR4F29	-0.687
TRPV5	-0.212
TNFRSF13B	-0.196
C5orf64	-0.196
CTNNA3	-0.185
S100A12	-0.179
DTHD1	-0.172
OR7C1	-0.171
HBD	-0.169

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C003898	2-anisidine	2-anisidine results in decreased expression of IRAK1 mRNA	28089782
C035419	3,4-dihydroxybenzohydroxamic acid	"3,4-dihydroxybenzohydroxamic acid inhibits the reaction [Lipopolysaccharides results in increased expression of IRAK1 mRNA]"	25843059
C524042	3,5-bis(2-fluorobenzylidene)piperidin-4-one	"3,5-bis(2-fluorobenzylidene)piperidin-4-one inhibits the reaction [Oxygen deficiency results in increased expression of IRAK1 mRNA]"	23452621
C550091	9,10-dihydro-2,5-dimethoxyphenanthrene-1,7-diol	"9,10-dihydro-2,5-dimethoxyphenanthrene-1,7-diol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IRAK1 mRNA]"	20590609
C099958	acanthoic acid	acanthoic acid inhibits the reaction [Ethanol results in increased expression of IRAK1 protein]	28964808
D000082	Acetaminophen	Acetaminophen results in decreased expression of IRAK1 mRNA	21420995\|2669055
D000082	Acetaminophen	Acetaminophen affects the expression of IRAK1 mRNA	17562736
D020106	Acrylamide	Acrylamide results in increased expression of IRAK1 mRNA	28959563
D001149	Arsenates	[Atrazine co-treated with Arsenates] results in increased expression of IRAK1 mRNA	18585445
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of IRAK1 mRNA	23911876
D000069059	Atorvastatin Calcium	[Atorvastatin Calcium co-treated with Enalapril] results in decreased expression of IRAK1 mRNA	20524934
D000069059	Atorvastatin Calcium	[Atorvastatin Calcium co-treated with telmisartan] results in decreased expression of IRAK1 mRNA	20524934
D001280	Atrazine	[Atrazine co-treated with Arsenates] results in increased expression of IRAK1 mRNA	18585445
D001280	Atrazine	Atrazine results in decreased expression of IRAK1 mRNA	22378314
D001310	Auranofin	Auranofin inhibits the reaction [lipopolysaccharide A results in increased degradation of IRAK1 protein]	17034761
C012768	benzanthrone	benzanthrone results in increased expression of IRAK1 protein	28495615
D001564	Benzo(a)pyrene	Benzo(a)pyrene affects the expression of IRAK1 mRNA	21873647
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of IRAK1 mRNA"	20018196
D004958	Estradiol	Estradiol affects the expression of IRAK1 mRNA	21826169
C044887	beta-methylcholine	beta-methylcholine affects the expression of IRAK1 mRNA	21179406
C006780	bisphenol A	bisphenol A affects the expression of IRAK1 mRNA	21826169
C006780	bisphenol A	bisphenol A results in increased expression of IRAK1 mRNA	25181051
D000069286	Bortezomib	Bortezomib results in decreased expression of IRAK1 mRNA	20471514
C584509	C646 compound	C646 compound results in increased expression of IRAK1 mRNA	26191083
D019256	Cadmium Chloride	[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of IRAK1 mRNA	19840844
C058667	cadmium selenide	[cadmium selenide co-treated with zinc sulfide] results in increased expression of IRAK1 mRNA	22342292
D002110	Caffeine	"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of IRAK1 mRNA"	20230807
D002110	Caffeine	"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IRAK1 mRNA]"	20230807
D002185	Cannabidiol	"Cannabidiol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased degradation of IRAK1 protein]"	19910459
D002220	Carbamazepine	Carbamazepine affects the expression of IRAK1 mRNA	25979313
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of IRAK1 mRNA	17484886
C007095	cobaltiprotoporphyrin	cobaltiprotoporphyrin inhibits the reaction [IRAK1 protein binds to MYD88 protein]	25780291
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of IRAK1 mRNA	19320972\|1937684
C018021	cobaltous chloride	cobaltous chloride results in increased expression of IRAK1 mRNA	21925238
C018021	cobaltous chloride	cobaltous chloride results in increased expression of IRAK1 protein	21925238
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of IRAK1 mRNA	19549813
D003474	Curcumin	Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of IRAK1 mRNA]	23452621
D003474	Curcumin	Curcumin inhibits the reaction [Lipopolysaccharides results in increased degradation of IRAK1 protein]	16678799
D003474	Curcumin	Curcumin results in decreased expression of IRAK1	18462866
D016572	Cyclosporine	Cyclosporine results in increased expression of IRAK1 mRNA	20106945
D016572	Cyclosporine	Cyclosporine results in increased phosphorylation of IRAK1 protein	23958496
C007262	deoxynivalenol	"deoxynivalenol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of IRAK1 protein]"	26961612
D003911	Dextrans	[Dextrans co-treated with ferrite analog] results in decreased expression of IRAK1 mRNA	26576301
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of IRAK1 mRNA	21266533
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate affects the expression of IRAK1 mRNA	26924002
C015835	dimethyl-4-toluidine	dimethyl-4-toluidine results in decreased expression of IRAK1 mRNA	27638505
C024629	dimethyl phthalate	dimethyl phthalate affects the expression of IRAK1 mRNA	26924002
D004656	Enalapril	[Atorvastatin Calcium co-treated with Enalapril] results in decreased expression of IRAK1 mRNA	20524934
D004791	Enzyme Inhibitors	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of IRAK1 protein	23301498
D000069347	Erlotinib Hydrochloride	[Erlotinib Hydrochloride results in decreased susceptibility to Erlotinib Hydrochloride] which results in decreased expression of IRAK1 mRNA	27738319
D000431	Ethanol	acanthoic acid inhibits the reaction [Ethanol results in increased expression of IRAK1 protein]	28964808
D000431	Ethanol	Ethanol results in increased expression of IRAK1 protein	28964808
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of IRAK1 mRNA	17108234
C540355	fenamidone	fenamidone results in increased expression of IRAK1 mRNA	27029645
C001215	ferrite	[Dextrans co-treated with ferrite analog] results in decreased expression of IRAK1 mRNA	26576301
D018120	Finasteride	Finasteride results in increased expression of IRAK1 mRNA	24136188
D005419	Flavonoids	Flavonoids results in increased expression of IRAK1 mRNA	15465739
D005472	Fluorouracil	Fluorouracil results in increased expression of IRAK1 mRNA	15109396
D005472	Fluorouracil	IRAK1 affects the susceptibility to Fluorouracil	15067352
D005485	Flutamide	Flutamide results in increased expression of IRAK1 mRNA	24136188
D037741	Fullerenes	Fullerenes analog results in increased expression of IRAK1 mRNA	22342292
D005688	Galactosamine	"Glycyrrhetinic Acid inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactosamine] promotes the reaction [TRAF6 protein binds to IRAK1 protein]]"	28213090
D005688	Galactosamine	"[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactosamine] promotes the reaction [TRAF6 protein binds to IRAK1 protein]"	28213090
D005688	Galactosamine	"[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactosamine] results in increased expression of IRAK1 protein"	28213090
D019833	Genistein	Genistein inhibits the reaction [Oxygen deficiency results in increased expression of IRAK1 mRNA]	23452621
C049864	ginsenoside Re	ginsenoside Re inhibits the reaction [Lipopolysaccharides results in increased degradation of IRAK1 protein]	22849695
C049864	ginsenoside Re	ginsenoside Re inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IRAK1 protein]	22849695
D005897	Glafenine	Glafenine results in increased expression of IRAK1 mRNA	24136188
C475739	glutamyl-(2-(((3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl)oxy)carbonyl)-3-((2-(1H-indol-3-yl)ethyl)amino)-3-oxopropyl)-cysteinyl-glycine sodium salt	"glutamyl-(2-(((3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl)oxy)carbonyl)-3-((2-(1H-indol-3-yl)ethyl)amino)-3-oxopropyl)-cysteinyl-glycine sodium salt inhibits the reaction [[Lipopolysaccharides results in increased activity of IRAK1 protein] which results in increased phosphorylation of CHUK protein]"	21276822
C475739	glutamyl-(2-(((3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl)oxy)carbonyl)-3-((2-(1H-indol-3-yl)ethyl)amino)-3-oxopropyl)-cysteinyl-glycine sodium salt	"glutamyl-(2-(((3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl)oxy)carbonyl)-3-((2-(1H-indol-3-yl)ethyl)amino)-3-oxopropyl)-cysteinyl-glycine sodium salt inhibits the reaction [[Lipopolysaccharides results in increased activity of IRAK1 protein] which results in increased phosphorylation of IKBKB protein]"	21276822
D006034	Glycyrrhetinic Acid	"Glycyrrhetinic Acid inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactosamine] promotes the reaction [TRAF6 protein binds to IRAK1 protein]]"	28213090
C001329	helenalin	helenalin inhibits the reaction [Lipopolysaccharides results in increased degradation of IRAK1 protein]	16678799
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of IRAK1 mRNA	20044591
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of IRAK1 mRNA	23086925\|2429786
C045463	leflunomide	leflunomide results in increased expression of IRAK1 mRNA	24136188
C050016	lipoarabinomannan	lipoarabinomannan inhibits the reaction [IRAK1 protein binds to TRAF6 protein]	16263713
C082161	lipopolysaccharide A	Auranofin inhibits the reaction [lipopolysaccharide A results in increased degradation of IRAK1 protein]	17034761
C482199	lipopolysaccharide, E coli O55-B5	"9,10-dihydro-2,5-dimethoxyphenanthrene-1,7-diol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IRAK1 mRNA]"	20590609
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased expression of IRAK1 mRNA"	20590609
C482199	lipopolysaccharide, E coli O55-B5	"Cannabidiol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased degradation of IRAK1 protein]"	19910459
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased degradation of IRAK1 protein"	19910459
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased expression of IRAK1 protein"	20035708
C482199	lipopolysaccharide, E coli O55-B5	"resveratrol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IRAK1 protein]"	20035708
C440499	lipopolysaccharide, Escherichia coli O111 B4	"deoxynivalenol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of IRAK1 protein]"	26961612
C440499	lipopolysaccharide, Escherichia coli O111 B4	"Glycyrrhetinic Acid inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactosamine] promotes the reaction [TRAF6 protein binds to IRAK1 protein]]"	28213090
C440499	lipopolysaccharide, Escherichia coli O111 B4	"[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactosamine] promotes the reaction [TRAF6 protein binds to IRAK1 protein]"	28213090
C440499	lipopolysaccharide, Escherichia coli O111 B4	"[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactosamine] results in increased expression of IRAK1 protein"	28213090
C440499	lipopolysaccharide, Escherichia coli O111 B4	"lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of IRAK1 protein"	26961612
C442865	lipopolysaccharide, Helicobacter pylori	"IRAK1 protein promotes the reaction [lipopolysaccharide, Helicobacter pylori results in increased expression of CXCL8 mRNA]"	21220698
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased degradation of IRAK1 protein	17053167
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased phosphorylation of IRAK1 protein	17053167
D008070	Lipopolysaccharides	"3,4-dihydroxybenzohydroxamic acid inhibits the reaction [Lipopolysaccharides results in increased expression of IRAK1 mRNA]"	25843059
D008070	Lipopolysaccharides	Curcumin inhibits the reaction [Lipopolysaccharides results in increased degradation of IRAK1 protein]	16678799
D008070	Lipopolysaccharides	ginsenoside Re inhibits the reaction [Lipopolysaccharides results in increased degradation of IRAK1 protein]	22849695
D008070	Lipopolysaccharides	ginsenoside Re inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IRAK1 protein]	22849695
D008070	Lipopolysaccharides	"glutamyl-(2-(((3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl)oxy)carbonyl)-3-((2-(1H-indol-3-yl)ethyl)amino)-3-oxopropyl)-cysteinyl-glycine sodium salt inhibits the reaction [[Lipopolysaccharides results in increased activity of IRAK1 protein] which results in increased phosphorylation of CHUK protein]"	21276822
D008070	Lipopolysaccharides	"glutamyl-(2-(((3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl)oxy)carbonyl)-3-((2-(1H-indol-3-yl)ethyl)amino)-3-oxopropyl)-cysteinyl-glycine sodium salt inhibits the reaction [[Lipopolysaccharides results in increased activity of IRAK1 protein] which results in increased phosphorylation of IKBKB protein]"	21276822
D008070	Lipopolysaccharides	helenalin inhibits the reaction [Lipopolysaccharides results in increased degradation of IRAK1 protein]	16678799
D008070	Lipopolysaccharides	IRAK1 protein promotes the reaction [Lipopolysaccharides inhibits the reaction [TGFB1 protein results in increased expression of SMAD6 mRNA]]	21295571
D008070	Lipopolysaccharides	IRAK1 protein promotes the reaction [Lipopolysaccharides results in increased phosphorylation of SMAD3 protein]	21295571
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of IRAK1 mRNA	25890327
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased activity of IRAK1 protein	21276822
D008070	Lipopolysaccharides	[Lipopolysaccharides results in increased activity of IRAK1 protein] which results in increased phosphorylation of CHUK protein	21276822
D008070	Lipopolysaccharides	[Lipopolysaccharides results in increased activity of IRAK1 protein] which results in increased phosphorylation of IKBKB protein	21276822
D008070	Lipopolysaccharides	[Lipopolysaccharides results in increased activity of IRAK1 protein] which results in increased phosphorylation of TAK1 protein	21276822
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased degradation of IRAK1 protein	15933225\|1667879
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of IRAK1 mRNA	25843059
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased phosphorylation of and results in increased activity of IRAK1 protein	19159680
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased phosphorylation of and results in increased ubiquitination of and results in increased degradation of IRAK1 protein	21232528
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased phosphorylation of IRAK1 protein	22849695
D008070	Lipopolysaccharides	Xanthones inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased ubiquitination of and results in increased degradation of IRAK1 protein]	21232528
D008070	Lipopolysaccharides	[Lipopolysaccharides co-treated with Titanium] results in decreased expression of IRAK1 mRNA	21308757
D008727	Methotrexate	Methotrexate results in increased expression of IRAK1 mRNA	21678067
D008769	Methylnitronitrosoguanidine	[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of IRAK1 mRNA	19840844
D008769	Methylnitronitrosoguanidine	[Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of IRAK1 mRNA	19840844
D008769	Methylnitronitrosoguanidine	[Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IRAK1 mRNA	19840844
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in increased expression of IRAK1 mRNA	24810058
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IRAK1 mRNA"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of IRAK1 mRNA"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IRAK1 mRNA]"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of IRAK1 mRNA"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IRAK1 mRNA]"	20230807
C406082	monomethylarsonous acid	monomethylarsonous acid results in increased expression of IRAK1 mRNA	20024957
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of IRAK1 mRNA	26924002
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of IRAK1 mRNA"	25620056
C051752	nefazodone	nefazodone results in increased expression of IRAK1 mRNA	24136188
D009538	Nicotine	"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of IRAK1 mRNA"	20230807
D009538	Nicotine	"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IRAK1 mRNA]"	20230807
C012655	nimesulide	nimesulide results in increased expression of IRAK1 mRNA	24136188
C464660	obeticholic acid	obeticholic acid results in decreased expression of IRAK1 mRNA	27939613
D019319	Okadaic Acid	[Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of IRAK1 mRNA	19840844
D010100	Oxygen	"3,5-bis(2-fluorobenzylidene)piperidin-4-one inhibits the reaction [Oxygen deficiency results in increased expression of IRAK1 mRNA]"	23452621
D010100	Oxygen	Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of IRAK1 mRNA]	23452621
D010100	Oxygen	Genistein inhibits the reaction [Oxygen deficiency results in increased expression of IRAK1 mRNA]	23452621
D010100	Oxygen	Oxygen deficiency results in increased expression of IRAK1 mRNA	23452621
D010100	Oxygen	Plant Extracts inhibits the reaction [Oxygen deficiency results in increased expression of IRAK1 mRNA]	23452621
D010100	Oxygen	resveratrol inhibits the reaction [Oxygen deficiency results in increased expression of IRAK1 mRNA]	23452621
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of IRAK1 mRNA	23892564
C006253	pirinixic acid	pirinixic acid results in increased expression of IRAK1 mRNA	18301758
D010936	Plant Extracts	Plant Extracts inhibits the reaction [Oxygen deficiency results in increased expression of IRAK1 mRNA]	23452621
D010936	Plant Extracts	Plant Extracts results in increased expression of IRAK1 mRNA	15465739
D059808	Polyphenols	Polyphenols results in increased expression of IRAK1 mRNA	15465739
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of IRAK1 mRNA	22714537
D011374	Progesterone	Progesterone results in increased expression of IRAK1 mRNA	17701593
D011374	Progesterone	Progesterone results in decreased expression of IRAK1 mRNA	19690047
D011794	Quercetin	Quercetin results in decreased expression of IRAK1 mRNA	23727915
C059514	resveratrol	resveratrol inhibits the reaction [Oxygen deficiency results in increased expression of IRAK1 mRNA]	23452621
C059514	resveratrol	"resveratrol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IRAK1 protein]"	20035708
C059514	resveratrol	resveratrol results in decreased expression of IRAK1 protein	20035708
C547874	SAR 020106	SAR 020106 results in decreased activity of IRAK1 protein	22111927
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of IRAK1 mRNA	25895662
D012834	Silver	Silver results in increased expression of IRAK1 mRNA	22342292
D016559	Tacrolimus	Tacrolimus results in increased phosphorylation of IRAK1 protein	23958496
C084178	telmisartan	[Atorvastatin Calcium co-treated with telmisartan] results in decreased expression of IRAK1 mRNA	20524934
C020806	tetrabromobisphenol A	tetrabromobisphenol A results in increased expression of IRAK1 mRNA	25461914
D013755	Tetradecanoylphorbol Acetate	IRAK1 mutant form inhibits the reaction [[Vitallium analog co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CXCL8 mRNA]	23680697
D013755	Tetradecanoylphorbol Acetate	IRAK1 mutant form inhibits the reaction [[Vitallium analog co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of CXCL8 protein]	23680697
D013755	Tetradecanoylphorbol Acetate	[Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IRAK1 mRNA	19840844
D014025	Titanium	[Lipopolysaccharides co-treated with Titanium] results in decreased expression of IRAK1 mRNA	21308757
C009495	titanium dioxide	titanium dioxide results in increased expression of IRAK1 mRNA	22342292
D014118	Toxins, Biological	"Toxins, Biological affects the expression of IRAK1 mRNA"	19682533
C004218	tylophorine	tylophorine analog results in increased expression of IRAK1 mRNA	19284764
C406224	valdecoxib	valdecoxib results in increased expression of IRAK1 mRNA	24136188
D014635	Valproic Acid	Valproic Acid affects the expression of IRAK1 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of IRAK1 mRNA	19101580\|2317975
D014635	Valproic Acid	Valproic Acid results in increased methylation of IRAK1 gene	29154799
D014800	Vitallium	IRAK1 mutant form inhibits the reaction [[Vitallium analog co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CXCL8 mRNA]	23680697
D014800	Vitallium	IRAK1 mutant form inhibits the reaction [[Vitallium analog co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of CXCL8 protein]	23680697
C111237	vorinostat	vorinostat results in decreased expression of IRAK1 mRNA	27188386
D044004	Xanthones	Xanthones inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased ubiquitination of and results in increased degradation of IRAK1 protein]	21232528
D015034	Zinc Oxide	[Zinc Oxide analog co-treated with OVAL protein] results in increased expression of IRAK1 protein	25127755
C017803	zinc protoporphyrin	zinc protoporphyrin promotes the reaction [IRAK1 protein binds to MYD88 protein]	25780291
C031238	zinc sulfide	[cadmium selenide co-treated with zinc sulfide] results in increased expression of IRAK1 mRNA	22342292

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004672	protein kinase activity	-	IDA	12054681
GO:0004672	protein kinase activity	-	TAS	-
GO:0004674	protein serine/threonine kinase activity	-	EXP	11960013
GO:0004674	protein serine/threonine kinase activity	-	IBA	21873635
GO:0004674	protein serine/threonine kinase activity	-	NAS	11397809
GO:0004674	protein serine/threonine kinase activity	-	TAS	-
GO:0004704	NF-kappaB-inducing kinase activity	-	TAS	8599092
GO:0005515	protein binding	-	IPI	10383454 11397809 11518704 12242293 12496252 12860405 12874243 12925853 16203735 16884718 17567694 19081057 19264966 21743479 21903422 22037600 28436939
GO:0005524	ATP binding	-	IEA	-
GO:0016301	kinase activity	-	IDA	12054681
GO:0031072	heat shock protein binding	-	IEA	-
GO:0042803	protein homodimerization activity	-	IPI	10383454
GO:0042803	protein homodimerization activity	-	NAS	11397809
GO:0046982	protein heterodimerization activity	-	IPI	10383454

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000187	activation of MAPK activity	-	TAS	-
GO:0001959	regulation of cytokine-mediated signaling pathway	-	IMP	10383454
GO:0002224	toll-like receptor signaling pathway	-	IBA	21873635
GO:0002224	toll-like receptor signaling pathway	-	TAS	-
GO:0002755	MyD88-dependent toll-like receptor signaling pathway	-	TAS	10383454
GO:0006468	protein phosphorylation	-	TAS	8599092
GO:0007165	signal transduction	-	NAS	10854325
GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	-	NAS	11397809
GO:0007250	activation of NF-kappaB-inducing kinase activity	-	IDA	11397809
GO:0007254	JNK cascade	-	TAS	-
GO:0007568	aging	-	IEA	-
GO:0016032	viral process	-	IEA	-
GO:0019221	cytokine-mediated signaling pathway	-	IBA	21873635
GO:0031663	lipopolysaccharide-mediated signaling pathway	-	IMP	10383454
GO:0032088	negative regulation of NF-kappaB transcription factor activity	-	IMP	10383454
GO:0032481	positive regulation of type I interferon production	-	IMP	23633945
GO:0032496	response to lipopolysaccharide	-	IMP	10383454
GO:0034134	toll-like receptor 2 signaling pathway	-	IMP	10383454
GO:0034142	toll-like receptor 4 signaling pathway	-	IBA	21873635
GO:0034162	toll-like receptor 9 signaling pathway	-	TAS	-
GO:0034605	cellular response to heat	-	IEA	-
GO:0035556	intracellular signal transduction	-	IBA	21873635
GO:0043066	negative regulation of apoptotic process	-	TAS	-
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	-	IBA	21873635
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	-	IMP	22158417
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	-	TAS	-
GO:0043406	positive regulation of MAP kinase activity	-	IBA	21873635
GO:0045893	positive regulation of transcription, DNA-templated	-	NAS	11397809
GO:0046777	protein autophosphorylation	-	IDA	10383454 12054681
GO:0046777	protein autophosphorylation	-	NAS	11397809
GO:0048661	positive regulation of smooth muscle cell proliferation	-	IEA	-
GO:0051092	positive regulation of NF-kappaB transcription factor activity	-	IBA	21873635
GO:0051092	positive regulation of NF-kappaB transcription factor activity	-	IDA	10383454
GO:0051092	positive regulation of NF-kappaB transcription factor activity	-	TAS	-
GO:0051259	protein complex oligomerization	-	IMP	16831874
GO:0060337	type I interferon signaling pathway	-	IMP	23633945
GO:0070423	nucleotide-binding oligomerization domain containing signaling pathway	-	TAS	-
GO:0070498	interleukin-1-mediated signaling pathway	-	IBA	21873635
GO:0070498	interleukin-1-mediated signaling pathway	-	IMP	10383454
GO:0070498	interleukin-1-mediated signaling pathway	-	TAS	-
GO:0070555	response to interleukin-1	-	IMP	10383454
GO:0071456	cellular response to hypoxia	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IBA	21873635
GO:0005634	nucleus	-	IDA	-
GO:0005737	cytoplasm	-	IBA	21873635
GO:0005811	lipid droplet	-	ISS	-
GO:0005829	cytosol	-	IDA	-
GO:0005829	cytosol	-	TAS	-
GO:0005886	plasma membrane	-	IBA	21873635
GO:0005886	plasma membrane	-	TAS	-
GO:0010008	endosome membrane	-	TAS	-
GO:0045323	interleukin-1 receptor complex	-	NAS	10854325

KEGG ID	KEGG Term
hsa04210	Apoptosis
hsa04620	Toll-like receptor signaling pathway
hsa04722	Neurotrophin signaling pathway
hsa05140	Leishmaniasis
hsa05142	Chagas disease (American trypanosomiasis)
hsa05145	Toxoplasmosis

Reactome ID	Reactome Term	Evidence
R-HSA-1257604	PIP3 activates AKT signaling	TAS
R-HSA-1280215	Cytokine Signaling in Immune system	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-162582	Signal Transduction	IEA
R-HSA-166016	Toll Like Receptor 4 (TLR4) Cascade	TAS
R-HSA-166058	MyD88:Mal cascade initiated on plasma membrane	TAS
R-HSA-166166	MyD88-independent TLR4 cascade	TAS
R-HSA-168138	Toll Like Receptor 9 (TLR9) Cascade	TAS
R-HSA-168142	Toll Like Receptor 10 (TLR10) Cascade	TAS
R-HSA-168164	Toll Like Receptor 3 (TLR3) Cascade	TAS
R-HSA-168176	Toll Like Receptor 5 (TLR5) Cascade	TAS
R-HSA-168179	Toll Like Receptor TLR1:TLR2 Cascade	TAS
R-HSA-168181	Toll Like Receptor 7/8 (TLR7/8) Cascade	TAS
R-HSA-168188	Toll Like Receptor TLR6:TLR2 Cascade	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-168638	NOD1/2 Signaling Pathway	TAS
R-HSA-168643	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	TAS
R-HSA-168898	Toll-Like Receptors Cascades	TAS
R-HSA-181438	Toll Like Receptor 2 (TLR2) Cascade	TAS
R-HSA-193639	p75NTR signals via NF-kB	TAS
R-HSA-193639	p75NTR signals via NF-kB	IEA
R-HSA-193704	p75 NTR receptor-mediated signalling	TAS
R-HSA-193704	p75 NTR receptor-mediated signalling	IEA
R-HSA-199418	Negative regulation of the PI3K/AKT network	TAS
R-HSA-209543	p75NTR recruits signalling complexes	TAS
R-HSA-209543	p75NTR recruits signalling complexes	IEA
R-HSA-209560	NF-kB is activated and signals survival	TAS
R-HSA-445989	TAK1 activates NFkB by phosphorylation and activation of IKKs complex	TAS
R-HSA-446652	Interleukin-1 family signaling	TAS
R-HSA-448424	Interleukin-17 signaling	TAS
R-HSA-449147	Signaling by Interleukins	TAS
R-HSA-450294	MAP kinase activation	TAS
R-HSA-450302	activated TAK1 mediates p38 MAPK activation	TAS
R-HSA-450321	JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	TAS
R-HSA-6811558	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	TAS
R-HSA-73887	Death Receptor Signalling	TAS
R-HSA-73887	Death Receptor Signalling	IEA
R-HSA-9006925	Intracellular signaling by second messengers	TAS
R-HSA-9020702	Interleukin-1 signaling	TAS
R-HSA-937039	IRAK1 recruits IKK complex	TAS
R-HSA-937061	TRIF(TICAM1)-mediated TLR4 signaling	TAS
R-HSA-975110	TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	TAS
R-HSA-975138	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	TAS
R-HSA-975144	IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	TAS
R-HSA-975155	MyD88 dependent cascade initiated on endosome	TAS
R-HSA-975871	MyD88 cascade initiated on plasma membrane	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
17382928	The association between innate immunity gene (IRAK1) and C-reactive protein in the Diabetes Heart Study. (2007 Jun)	Lakoski SG	Exp Mol Pathol
28115805	Hsa-mir-499 rs3746444 T/C Polymorphism is Associated with Increased Risk of Coronary Artery Disease in a Chinese Population. (2017 Jan)	Chen W	Acta Cardiol Sin
21933552	Functional polymorphism in exon 5 and variant haplotype of the interleukin-1 receptor-associated kinase 1 gene are associated with susceptibility to and severity of sepsis in the Chinese population. (2011 Aug)	Fang Y	Chin Med J (Engl)
26371589	A toll-like receptor 9 (rs352140) variant is associated with placental inflammation in newborn infants. (2016)	Karody V	J Matern Fetal Neonatal Med
24144839	A common polymorphism in pre-microRNA-146a is associated with lung cancer risk in a Korean population. (2014 Jan 15)	Jeon HS	Gene