Gene info: ID 3658

Gene: IREB2

GENE ID: 3658

Synonyms: ACO3|IRE-BP 2|IRE-BP2|IRP2|IRP2AD

Description: iron responsive element binding protein 2

Gene type: protein-coding

Location: 15q25.1

dbXrefs: Ensembl:ENSG00000136381 MIM:147582 Vega:OTTHUMG00000143861 UniprotKB:P48200

RefSeq: NC_000015.10

Retrived from: PubMed|SNP Mapped

SNPs: 3 ANCO-SNPs

Phenotype: ND

# Publications: 16

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 7.055e-1 (AD) 1.000e-12 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs17484235	chr15:78469072 (GRCh38.p7)	C>A / C>G / C>T	nicotine dependence	SNV(Single Nucleotide Variation)
rs17405217	chr15:78438807 (GRCh38.p7)	C>G / C>T	nicotine dependence	SNV(Single Nucleotide Variation)
rs17483548	chr15:78437971 (GRCh38.p7)	G>A	nicotine dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
NUP153	0.933
UBR1	0.933
ARFGEF1	0.924
COG5	0.924
TRAPPC11	0.922
RAB3GAP2	0.922
SEC24B	0.922
RINT1	0.921
DHX36	0.919
FBXW2	0.918

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.515
OR4F29	-0.468
S100A1	-0.295
CSAG1	-0.29
MTRNR2L6	-0.288
APOA1	-0.28
TNFRSF13B	-0.277
NR0B1	-0.275
MTRNR2L9	-0.273
MTRNR2L10	-0.267

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of IREB2 mRNA"	19114083
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of IREB2 mRNA"	21346803
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of IREB2 mRNA"	21346803
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of IREB2 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of IREB2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of IREB2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of IREB2 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in decreased expression of IREB2 mRNA	21420995
D000082	Acetaminophen	Acetaminophen affects the expression of IREB2 mRNA	17562736
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Zinc deficiency results in increased expression of IREB2 protein]	18073202
D020106	Acrylamide	Acrylamide results in increased expression of IREB2 mRNA	28959563
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of IREB2 mRNA	16483693
D001205	Ascorbic Acid	[Ascorbic Acid co-treated with CAT protein] inhibits the reaction [Zinc deficiency results in increased expression of IREB2 protein]	18073202
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of IREB2 mRNA	19770486
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of IREB2 mRNA"	19150397
C006780	bisphenol A	bisphenol A affects the expression of IREB2 mRNA	21786754
C006780	bisphenol A	bisphenol A affects the expression of IREB2 mRNA	25181051
C018475	butyraldehyde	butyraldehyde results in decreased expression of IREB2 mRNA	26079696
D020245	p-Chloromercuribenzoic Acid	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of IREB2 mRNA"	27188386
D020245	p-Chloromercuribenzoic Acid	p-Chloromercuribenzoic Acid results in decreased expression of IREB2 mRNA	26272509
D002994	Clofibrate	Clofibrate inhibits the reaction [Iron deficiency results in increased activity of IREB2 protein]	11969379
C018021	cobaltous chloride	cobaltous chloride results in decreased degradation of IREB2 protein	12972033
D003300	Copper	Copper deficiency results in increased expression of IREB2 mRNA	24024382
D016572	Cyclosporine	Cyclosporine results in decreased expression of IREB2 mRNA	25562108
D003676	Deferoxamine	Deferoxamine results in increased activity of IREB2 protein	11054110\|1807320
D003676	Deferoxamine	Deferoxamine results in increased expression of and results in increased activity of IREB2 protein	16568477
D003676	Deferoxamine	Deferoxamine results in increased expression of IREB2 protein	17469137
D003676	Deferoxamine	Deferoxamine inhibits the reaction [Hemin results in decreased expression of IREB2 protein]	12972033
D003676	Deferoxamine	Deferoxamine inhibits the reaction [Nitroprusside results in decreased expression of IREB2 protein]	12972033
D003676	Deferoxamine	Deferoxamine results in increased expression of IREB2 protein	12972033
D003703	Demecolcine	Demecolcine results in increased expression of IREB2 mRNA	23649840
D004317	Doxorubicin	Doxorubicin results in decreased activity of IREB2 protein	16770644
D004317	Doxorubicin	Doxorubicin results in decreased activity of IREB2 protein	11731422
C045651	epigallocatechin gallate	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of IREB2 mRNA	22079256
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of IREB2 mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of IREB2 mRNA	29097150
C007687	etiron	etiron promotes the reaction [Zinc deficiency results in increased expression of IREB2 protein]	18073202
C013531	ferric ammonium citrate	ferric ammonium citrate results in decreased activity of IREB2 protein	11054110\|1807320
C013531	ferric ammonium citrate	ferric ammonium citrate results in decreased expression of IREB2 protein	17469137
D018120	Finasteride	Finasteride results in increased expression of IREB2 mRNA	24136188
D005419	Flavonoids	Flavonoids results in decreased expression of IREB2 mRNA	18035473
D005472	Fluorouracil	Fluorouracil results in increased expression of IREB2 mRNA	16584549
D005485	Flutamide	Flutamide results in increased expression of IREB2 mRNA	24136188
D005557	Formaldehyde	Formaldehyde results in decreased expression of IREB2 mRNA	20655997
C039281	furan	furan results in increased methylation of IREB2 gene	22079235
D006418	Heme	[succinylacetone results in decreased chemical synthesis of Heme] inhibits the reaction [Iron results in increased degradation of IREB2 protein]	12972033
D006427	Hemin	Hemin results in decreased expression of and results in decreased activity of IREB2 protein	16568477
D006427	Hemin	Deferoxamine inhibits the reaction [Hemin results in decreased expression of IREB2 protein]	12972033
D006427	Hemin	Hemin results in decreased expression of IREB2 protein	12972033
D006427	Hemin	succinylacetone inhibits the reaction [Hemin results in decreased expression of IREB2 protein]	12972033
C492448	ICG 001	ICG 001 results in decreased expression of IREB2 mRNA	26191083
D007501	Iron	IREB2 protein affects the metabolism of Iron	17194590
D007501	Iron	Clofibrate inhibits the reaction [Iron deficiency results in increased activity of IREB2 protein]	11969379
D007501	Iron	Iron deficiency results in increased activity of IREB2 protein	11969379
D007501	Iron	IREB2 protein binds to Iron	12972033
D007501	Iron	Iron deficiency results in increased stability of IREB2 protein	12972033
D007501	Iron	Iron results in increased degradation of IREB2 protein	12972033
D007501	Iron	Iron results in increased oxidation of and results in increased cleavage of IREB2 protein	12972033
D007501	Iron	Iron results in increased ubiquitination of IREB2 protein	12972033
D007501	Iron	[succinylacetone results in decreased chemical synthesis of Heme] inhibits the reaction [Iron results in increased degradation of IREB2 protein]	12972033
C544151	jinfukang	jinfukang results in decreased expression of IREB2 mRNA	27392435
C410337	K 7174	K 7174 results in increased expression of IREB2 mRNA	24086573
D008070	Lipopolysaccharides	[Lipopolysaccharides co-treated with IFNG protein] results in decreased activity of IREB2 protein	11054110
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased activity of IREB2 protein	11054110
D008345	Manganese	Manganese results in decreased activity of IREB2 protein	16568477
D008345	Manganese	Manganese results in increased expression of IREB2 protein	17469137
C025340	manganese chloride	manganese chloride results in decreased activity of IREB2 protein	16568477
C025340	manganese chloride	manganese chloride results in increased activity of IREB2 protein	15893546
D008701	Methapyrilene	Methapyrilene affects the expression of IREB2 mRNA	28935588
D008746	Methylazoxymethanol Acetate	Methylazoxymethanol Acetate results in increased expression of IREB2 mRNA	28349193
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of IREB2 mRNA	28001369
C406082	monomethylarsonous acid	monomethylarsonous acid results in increased expression of IREB2 protein	24625837
C496401	N-((3-(aminomethyl)phenyl)methyl)ethanimidamide	N-((3-(aminomethyl)phenyl)methyl)ethanimidamide promotes the reaction [Zinc deficiency results in increased expression of IREB2 protein]	18073202
C051752	nefazodone	nefazodone results in increased expression of IREB2 mRNA	24136188
D009599	Nitroprusside	Deferoxamine inhibits the reaction [Nitroprusside results in decreased expression of IREB2 protein]	12972033
D009599	Nitroprusside	Nitroprusside results in decreased expression of IREB2 protein	12972033
D010100	Oxygen	Oxygen deficiency affects the stability of and affects the activity of IREB2 protein	12972033
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of IREB2 mRNA	19162173
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of IREB2 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in decreased expression of IREB2 mRNA	26272509
C018637	phorone	phorone affects the expression of IREB2 mRNA	18198479
D010795	Phthalic Acids	Phthalic Acids results in increased expression of IREB2 mRNA	21061450
C006253	pirinixic acid	pirinixic acid results in increased expression of IREB2 mRNA	17426115
D010936	Plant Extracts	Plant Extracts results in increased expression of IREB2 mRNA	23557933
C027373	potassium chromate(VI)	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of IREB2 mRNA	22079256
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of IREB2 mRNA	22079256
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of IREB2 protein	23718831
C020804	succinylacetone	succinylacetone inhibits the reaction [Hemin results in decreased expression of IREB2 protein]	12972033
C020804	succinylacetone	[succinylacetone results in decreased chemical synthesis of Heme] inhibits the reaction [Iron results in increased degradation of IREB2 protein]	12972033
C001803	tempol	tempol results in increased expression of IREB2 protein	18073202
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of IREB2 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of IREB2 mRNA	25975270
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to IREB2 gene]	28213091
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of IREB2 mRNA	18163543\|2821309
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of IREB2 protein	28213091
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of IREB2 mRNA	22298810
D013750	Tetrachloroethylene	Tetrachloroethylene results in increased expression of IREB2 mRNA	28973375
D014241	Trichloroethylene	Trichloroethylene results in decreased expression of IREB2 mRNA	19448997
D014241	Trichloroethylene	Trichloroethylene results in increased expression of IREB2 mRNA	19448997
D014635	Valproic Acid	Valproic Acid results in decreased expression of IREB2 mRNA	23179753
D014635	Valproic Acid	Valproic Acid results in decreased methylation of IREB2 gene	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of IREB2 mRNA	28001369
C025643	vinclozolin	vinclozolin results in increased expression of IREB2 mRNA	23555832
D014750	Vincristine	Vincristine results in increased expression of IREB2 mRNA	23649840
D015032	Zinc	Acetylcysteine inhibits the reaction [Zinc deficiency results in increased expression of IREB2 protein]	18073202
D015032	Zinc	[Ascorbic Acid co-treated with CAT protein] inhibits the reaction [Zinc deficiency results in increased expression of IREB2 protein]	18073202
D015032	Zinc	etiron promotes the reaction [Zinc deficiency results in increased expression of IREB2 protein]	18073202
D015032	Zinc	N-((3-(aminomethyl)phenyl)methyl)ethanimidamide promotes the reaction [Zinc deficiency results in increased expression of IREB2 protein]	18073202
D015032	Zinc	Zinc deficiency results in increased expression of and results in increased activity of IREB2 protein	18073202
C016837	zinc chloride	zinc chloride results in increased expression of IREB2 mRNA	18947441
C088658	zoledronic acid	zoledronic acid results in increased expression of IREB2 mRNA	20977926

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003723	RNA binding	-	IDA	7983023
GO:0003723	RNA binding	-	TAS	9924025
GO:0005515	protein binding	-	IPI	19762596 19762597
GO:0030350	iron-responsive element binding	-	TAS	9924025
GO:0030371	translation repressor activity	-	IEA	-
GO:0046872	metal ion binding	-	IEA	-
GO:0051539	4 iron, 4 sulfur cluster binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006826	iron ion transport	-	TAS	9924025
GO:0006879	cellular iron ion homeostasis	-	TAS	-
GO:0008152	metabolic process	-	IEA	-
GO:0017148	negative regulation of translation	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005737	cytoplasm	-	NAS	7983023
GO:0005829	cytosol	-	TAS	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-382551	Transport of small molecules	TAS
R-HSA-917937	Iron uptake and transport	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
22914670	Association of IREB2 and CHRNA3/5 polymorphisms with COPD and COPD-related phenotypes in a Chinese Han population. (2012 Nov 26)	Zhou H	J Hum Genet
26762739	Focused Analysis of Exome Sequencing Data for Rare Germline Mutations in Familial and Sporadic Lung Cancer. (2016 Jan)	Liu Y	J Thorac Oncol
28287180	Functional interactors of three genome-wide association study genes are differentially expressed in severe chronic obstructive pulmonary disease lung tissue. (2017 Mar 13)	Morrow JD	Sci Rep
27021816	Pathways to smoking behaviours: biological insights from the Tobacco and Genetics Consortium meta-analysis. (2017 Jan)	Minica CC	Mol Psychiatry
22539604	Association of the 15q25 and 5p15 lung cancer susceptibility regions with gene expression in lung tumor tissue. (2012 Jul)	Fehringer G	Cancer Epidemiol Biomarkers Prev
21320324	The role of IREB2 and transforming growth factor beta-1 genetic variants in COPD: a replication case-control study. (2011 Feb 14)	Chappell SL	BMC Med Genet
26310313	Susceptibility loci in lung cancer and COPD: association of IREB2 and FAM13A with pulmonary diseases. (2015 Aug 27)	Ziolkowska-Suchanek I	Sci Rep
22080838	A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13. (2012 Feb 15)	Cho MH	Hum Mol Genet
26220977	A multiancestry study identifies novel genetic associations with CHRNA5 methylation in human brain and risk of nicotine dependence. (2015 Oct 15)	Hancock DB	Hum Mol Genet
22837378	Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction. (2012 Oct 1)	Wilk JB	Am J Respir Crit Care Med
20656943	Loci identified by genome-wide association studies influence different disease-related phenotypes in chronic obstructive pulmonary disease. (2010 Dec 15)	Pillai SG	Am J Respir Crit Care Med
22356581	Association of IREB2 and CHRNA3 polymorphisms with airflow obstruction in severe alpha-1 antitrypsin deficiency. (2012 Feb 22)	Kim WJ	Respir Res
19800047	Integration of genomic and genetic approaches implicates IREB2 as a COPD susceptibility gene. (2009 Oct)	DeMeo DL	Am J Hum Genet
29422661	Understanding the role of the chromosome 15q25.1 in COPD through epigenetics and transcriptomics. (2018 May)	Nedeljkovic I	Eur J Hum Genet
22461431	CHRNA3/5, IREB2, and ADCY2 are associated with severe chronic obstructive pulmonary disease in Poland. (2012 Aug)	Hardin M	Am J Respir Cell Mol Biol
25101718	IREB2 and GALC are associated with pulmonary artery enlargement in chronic obstructive pulmonary disease. (2015 Mar)	Lee JH	Am J Respir Cell Mol Biol