Gene: IREB2

3658
ACO3|IRE-BP 2|IRE-BP2|IRP2|IRP2AD
iron responsive element binding protein 2
protein-coding
15q25.1
Ensembl:ENSG00000136381 MIM:147582 Vega:OTTHUMG00000143861 UniprotKB:P48200
NC_000015.10
PubMed|SNP Mapped
ND
16   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.055e-1 (AD)  1.000e-12 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs17484235chr15:78469072 (GRCh38.p7)C>A / C>G / C>Tnicotine dependenceSNV(Single Nucleotide Variation)
rs17405217chr15:78438807 (GRCh38.p7)C>G / C>Tnicotine dependenceSNV(Single Nucleotide Variation)
rs17483548chr15:78437971 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NUP1530.933
UBR10.933
ARFGEF10.924
COG50.924
TRAPPC110.922
RAB3GAP20.922
SEC24B0.922
RINT10.921
DHX360.919
FBXW20.918

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.515
OR4F29-0.468
S100A1-0.295
CSAG1-0.29
MTRNR2L6-0.288
APOA1-0.28
TNFRSF13B-0.277
NR0B1-0.275
MTRNR2L9-0.273
MTRNR2L10-0.267

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of IREB2 mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of IREB2 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of IREB2 mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of IREB2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of IREB2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of IREB2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of IREB2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of IREB2 mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of IREB2 mRNA17562736
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Zinc deficiency results in increased expression of IREB2 protein]18073202
D020106AcrylamideAcrylamide results in increased expression of IREB2 mRNA28959563
D000643Ammonium ChlorideAmmonium Chloride affects the expression of IREB2 mRNA16483693
D001205Ascorbic Acid[Ascorbic Acid co-treated with CAT protein] inhibits the reaction [Zinc deficiency results in increased expression of IREB2 protein]18073202
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of IREB2 mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of IREB2 mRNA"19150397
C006780bisphenol Abisphenol A affects the expression of IREB2 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of IREB2 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of IREB2 mRNA26079696
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of IREB2 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of IREB2 mRNA26272509
D002994ClofibrateClofibrate inhibits the reaction [Iron deficiency results in increased activity of IREB2 protein]11969379
C018021cobaltous chloridecobaltous chloride results in decreased degradation of IREB2 protein12972033
D003300CopperCopper deficiency results in increased expression of IREB2 mRNA24024382
D016572CyclosporineCyclosporine results in decreased expression of IREB2 mRNA25562108
D003676DeferoxamineDeferoxamine results in increased activity of IREB2 protein11054110|1807320
D003676DeferoxamineDeferoxamine results in increased expression of and results in increased activity of IREB2 protein16568477
D003676DeferoxamineDeferoxamine results in increased expression of IREB2 protein17469137
D003676DeferoxamineDeferoxamine inhibits the reaction [Hemin results in decreased expression of IREB2 protein]12972033
D003676DeferoxamineDeferoxamine inhibits the reaction [Nitroprusside results in decreased expression of IREB2 protein]12972033
D003676DeferoxamineDeferoxamine results in increased expression of IREB2 protein12972033
D003703DemecolcineDemecolcine results in increased expression of IREB2 mRNA23649840
D004317DoxorubicinDoxorubicin results in decreased activity of IREB2 protein16770644
D004317DoxorubicinDoxorubicin results in decreased activity of IREB2 protein11731422
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of IREB2 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of IREB2 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of IREB2 mRNA29097150
C007687etironetiron promotes the reaction [Zinc deficiency results in increased expression of IREB2 protein]18073202
C013531ferric ammonium citrateferric ammonium citrate results in decreased activity of IREB2 protein11054110|1807320
C013531ferric ammonium citrateferric ammonium citrate results in decreased expression of IREB2 protein17469137
D018120FinasterideFinasteride results in increased expression of IREB2 mRNA24136188
D005419FlavonoidsFlavonoids results in decreased expression of IREB2 mRNA18035473
D005472FluorouracilFluorouracil results in increased expression of IREB2 mRNA16584549
D005485FlutamideFlutamide results in increased expression of IREB2 mRNA24136188
D005557FormaldehydeFormaldehyde results in decreased expression of IREB2 mRNA20655997
C039281furanfuran results in increased methylation of IREB2 gene22079235
D006418Heme[succinylacetone results in decreased chemical synthesis of Heme] inhibits the reaction [Iron results in increased degradation of IREB2 protein]12972033
D006427HeminHemin results in decreased expression of and results in decreased activity of IREB2 protein16568477
D006427HeminDeferoxamine inhibits the reaction [Hemin results in decreased expression of IREB2 protein]12972033
D006427HeminHemin results in decreased expression of IREB2 protein12972033
D006427Heminsuccinylacetone inhibits the reaction [Hemin results in decreased expression of IREB2 protein]12972033
C492448ICG 001ICG 001 results in decreased expression of IREB2 mRNA26191083
D007501IronIREB2 protein affects the metabolism of Iron17194590
D007501IronClofibrate inhibits the reaction [Iron deficiency results in increased activity of IREB2 protein]11969379
D007501IronIron deficiency results in increased activity of IREB2 protein11969379
D007501IronIREB2 protein binds to Iron12972033
D007501IronIron deficiency results in increased stability of IREB2 protein12972033
D007501IronIron results in increased degradation of IREB2 protein12972033
D007501IronIron results in increased oxidation of and results in increased cleavage of IREB2 protein12972033
D007501IronIron results in increased ubiquitination of IREB2 protein12972033
D007501Iron[succinylacetone results in decreased chemical synthesis of Heme] inhibits the reaction [Iron results in increased degradation of IREB2 protein]12972033
C544151jinfukangjinfukang results in decreased expression of IREB2 mRNA27392435
C410337K 7174K 7174 results in increased expression of IREB2 mRNA24086573
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with IFNG protein] results in decreased activity of IREB2 protein11054110
D008070LipopolysaccharidesLipopolysaccharides results in decreased activity of IREB2 protein11054110
D008345ManganeseManganese results in decreased activity of IREB2 protein16568477
D008345ManganeseManganese results in increased expression of IREB2 protein17469137
C025340manganese chloridemanganese chloride results in decreased activity of IREB2 protein16568477
C025340manganese chloridemanganese chloride results in increased activity of IREB2 protein15893546
D008701MethapyrileneMethapyrilene affects the expression of IREB2 mRNA28935588
D008746Methylazoxymethanol AcetateMethylazoxymethanol Acetate results in increased expression of IREB2 mRNA28349193
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of IREB2 mRNA28001369
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of IREB2 protein24625837
C496401N-((3-(aminomethyl)phenyl)methyl)ethanimidamideN-((3-(aminomethyl)phenyl)methyl)ethanimidamide promotes the reaction [Zinc deficiency results in increased expression of IREB2 protein]18073202
C051752nefazodonenefazodone results in increased expression of IREB2 mRNA24136188
D009599NitroprussideDeferoxamine inhibits the reaction [Nitroprusside results in decreased expression of IREB2 protein]12972033
D009599NitroprussideNitroprusside results in decreased expression of IREB2 protein12972033
D010100OxygenOxygen deficiency affects the stability of and affects the activity of IREB2 protein12972033
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of IREB2 mRNA19162173
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of IREB2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of IREB2 mRNA26272509
C018637phoronephorone affects the expression of IREB2 mRNA18198479
D010795Phthalic AcidsPhthalic Acids results in increased expression of IREB2 mRNA21061450
C006253pirinixic acidpirinixic acid results in increased expression of IREB2 mRNA17426115
D010936Plant ExtractsPlant Extracts results in increased expression of IREB2 mRNA23557933
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of IREB2 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of IREB2 mRNA22079256
D011192Potassium DichromatePotassium Dichromate results in increased expression of IREB2 protein23718831
C020804succinylacetonesuccinylacetone inhibits the reaction [Hemin results in decreased expression of IREB2 protein]12972033
C020804succinylacetone[succinylacetone results in decreased chemical synthesis of Heme] inhibits the reaction [Iron results in increased degradation of IREB2 protein]12972033
C001803tempoltempol results in increased expression of IREB2 protein18073202
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of IREB2 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of IREB2 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to IREB2 gene]28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of IREB2 mRNA18163543|2821309
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of IREB2 protein28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of IREB2 mRNA22298810
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of IREB2 mRNA28973375
D014241TrichloroethyleneTrichloroethylene results in decreased expression of IREB2 mRNA19448997
D014241TrichloroethyleneTrichloroethylene results in increased expression of IREB2 mRNA19448997
D014635Valproic AcidValproic Acid results in decreased expression of IREB2 mRNA23179753
D014635Valproic AcidValproic Acid results in decreased methylation of IREB2 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of IREB2 mRNA28001369
C025643vinclozolinvinclozolin results in increased expression of IREB2 mRNA23555832
D014750VincristineVincristine results in increased expression of IREB2 mRNA23649840
D015032ZincAcetylcysteine inhibits the reaction [Zinc deficiency results in increased expression of IREB2 protein]18073202
D015032Zinc[Ascorbic Acid co-treated with CAT protein] inhibits the reaction [Zinc deficiency results in increased expression of IREB2 protein]18073202
D015032Zincetiron promotes the reaction [Zinc deficiency results in increased expression of IREB2 protein]18073202
D015032ZincN-((3-(aminomethyl)phenyl)methyl)ethanimidamide promotes the reaction [Zinc deficiency results in increased expression of IREB2 protein]18073202
D015032ZincZinc deficiency results in increased expression of and results in increased activity of IREB2 protein18073202
C016837zinc chloridezinc chloride results in increased expression of IREB2 mRNA18947441
C088658zoledronic acidzoledronic acid results in increased expression of IREB2 mRNA20977926

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-IDA7983023  
GO:0003723RNA binding-TAS9924025  
GO:0005515protein binding-IPI19762596  19762597  
GO:0030350iron-responsive element binding-TAS9924025  
GO:0030371translation repressor activity-IEA-  
GO:0046872metal ion binding-IEA-  
GO:00515394 iron, 4 sulfur cluster binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006826iron ion transport-TAS9924025  
GO:0006879cellular iron ion homeostasis-TAS-  
GO:0008152metabolic process-IEA-  
GO:0017148negative regulation of translation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-NAS7983023  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-382551Transport of small moleculesTAS
R-HSA-917937Iron uptake and transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22914670Association of IREB2 and CHRNA3/5 polymorphisms with COPD and COPD-related phenotypes in a Chinese Han population. (2012 Nov 26)Zhou HJ Hum Genet
26762739Focused Analysis of Exome Sequencing Data for Rare Germline Mutations in Familial and Sporadic Lung Cancer. (2016 Jan)Liu YJ Thorac Oncol
28287180Functional interactors of three genome-wide association study genes are differentially expressed in severe chronic obstructive pulmonary disease lung tissue. (2017 Mar 13)Morrow JDSci Rep
27021816Pathways to smoking behaviours: biological insights from the Tobacco and Genetics Consortium meta-analysis. (2017 Jan)Minica CCMol Psychiatry
22539604Association of the 15q25 and 5p15 lung cancer susceptibility regions with gene expression in lung tumor tissue. (2012 Jul)Fehringer GCancer Epidemiol Biomarkers Prev
21320324The role of IREB2 and transforming growth factor beta-1 genetic variants in COPD: a replication case-control study. (2011 Feb 14)Chappell SLBMC Med Genet
26310313Susceptibility loci in lung cancer and COPD: association of IREB2 and FAM13A with pulmonary diseases. (2015 Aug 27)Ziolkowska-Suchanek ISci Rep
22080838A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13. (2012 Feb 15)Cho MHHum Mol Genet
26220977A multiancestry study identifies novel genetic associations with CHRNA5 methylation in human brain and risk of nicotine dependence. (2015 Oct 15)Hancock DBHum Mol Genet
22837378Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction. (2012 Oct 1)Wilk JBAm J Respir Crit Care Med
20656943Loci identified by genome-wide association studies influence different disease-related phenotypes in chronic obstructive pulmonary disease. (2010 Dec 15)Pillai SGAm J Respir Crit Care Med
22356581Association of IREB2 and CHRNA3 polymorphisms with airflow obstruction in severe alpha-1 antitrypsin deficiency. (2012 Feb 22)Kim WJRespir Res
19800047Integration of genomic and genetic approaches implicates IREB2 as a COPD susceptibility gene. (2009 Oct)DeMeo DLAm J Hum Genet
29422661Understanding the role of the chromosome 15q25.1 in COPD through epigenetics and transcriptomics. (2018 May)Nedeljkovic IEur J Hum Genet
22461431CHRNA3/5, IREB2, and ADCY2 are associated with severe chronic obstructive pulmonary disease in Poland. (2012 Aug)Hardin MAm J Respir Cell Mol Biol
25101718IREB2 and GALC are associated with pulmonary artery enlargement in chronic obstructive pulmonary disease. (2015 Mar)Lee JHAm J Respir Cell Mol Biol