Gene: IRF2

3660
IRF-2
interferon regulatory factor 2
protein-coding
4q35.1
Ensembl:ENSG00000168310 MIM:147576 Vega:OTTHUMG00000160606 UniprotKB:P14316
NC_000004.12
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.685e-1 (AD)  7.763e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GNAI30.855
LAPTM4A0.846
NFE2L20.841
RNF1140.82
HNRNPF0.818
G3BP10.817
SH3GLB10.815
MCMBP0.814
CTDSP20.81
LMAN10.809

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.602
OR4F29-0.57
ADRA1D-0.267
ABCC12-0.258
HCRTR1-0.256
RHO-0.25
CRH-0.249
NMU-0.247
CACNA1S-0.234
PPEF1-0.233

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of IRF2 mRNA"21354444
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of IRF2 mRNA28329830
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of IRF2 mRNA"18648102
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of IRF2 mRNA"21346803
D000082AcetaminophenAcetaminophen results in decreased expression of IRF2 mRNA21420995|2776149
D000082AcetaminophenAcetaminophen results in increased expression of IRF2 mRNA22230336
D020106AcrylamideAcrylamide results in decreased expression of IRF2 mRNA28959563
C016601afimoxifeneafimoxifene inhibits the reaction [Estrogens results in decreased expression of IRF2 mRNA]21233418
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of IRF2 gene27153756
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of IRF2 mRNA"23195993
D001280AtrazineAtrazine results in increased expression of IRF2 mRNA25929836
D001280AtrazineAtrazine results in increased expression of IRF2 mRNA22378314
C547126AZM551248AZM551248 results in decreased expression of IRF2 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of IRF2 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of IRF2 mRNA"19150397|2038263
C006780bisphenol Abisphenol A affects the expression of IRF2 mRNA21786754
C006780bisphenol Abisphenol A affects the methylation of IRF2 promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of IRF2 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of IRF2 promoter22457795
D002994ClofibrateClofibrate results in decreased expression of IRF2 mRNA23811191
D016572CyclosporineCyclosporine results in decreased expression of IRF2 mRNA20106945|2556210
D003907DexamethasoneDexamethasone results in increased expression of IRF2 mRNA22733784
D002945CisplatinCisplatin results in increased expression of IRF2 mRNA27392435
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of IRF2 mRNA22079256
D004967Estrogensafimoxifene inhibits the reaction [Estrogens results in decreased expression of IRF2 mRNA]21233418
D004967EstrogensEstrogens results in decreased expression of IRF2 mRNA21233418
D005419FlavonoidsFlavonoids results in increased expression of IRF2 mRNA15465739
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of IRF2 mRNA28329830
C002469fusarenon-Xfusarenon-X results in increased expression of IRF2 mRNA24983900
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of IRF2 mRNA25613284
C029310lardlard results in decreased expression of IRF2 mRNA26115784
D008070LipopolysaccharidesIRF2 protein affects the reaction [IFNG protein promotes the reaction [Lipopolysaccharides results in increased expression of IL12B mRNA]]10415056
D008070LipopolysaccharidesIRF2 protein affects the reaction [Lipopolysaccharides results in increased expression of IL12B mRNA]10415056
D008070LipopolysaccharidesIRF2 protein affects the reaction [Lipopolysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]]10415056
D008070LipopolysaccharidesIRF2 protein affects the reaction [Lipopolysaccharides results in increased secretion of IL12B protein]10415056
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of IRF2 mRNA10975854
D008558MelphalanMelphalan results in decreased expression of IRF2 mRNA22363485
D008731MethoxychlorMethoxychlor results in increased methylation of IRF2 gene23303685
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of IRF2 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of IRF2 mRNA"20188158
D009532NickelNickel results in decreased expression of IRF2 mRNA23195993
C022838nickel chloridenickel chloride results in increased expression of IRF2 mRNA17312168
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of IRF2 mRNA25729387
D010634PhenobarbitalPhenobarbital affects the expression of IRF2 mRNA19136022
C006253pirinixic acidNCF1 protein promotes the reaction [pirinixic acid results in decreased expression of IRF2 mRNA]17950772
C006253pirinixic acidpirinixic acid affects the expression of IRF2 mRNA17950772|1913602
C006253pirinixic acidpirinixic acid results in decreased expression of IRF2 mRNA17950772|2381119
D010936Plant ExtractsPlant Extracts results in increased expression of IRF2 mRNA15465739
D059808PolyphenolsPolyphenols results in increased expression of IRF2 mRNA15465739
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of IRF2 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of IRF2 mRNA22079256
C045362prochlorazprochloraz results in increased expression of IRF2 mRNA21470553
D012524SarinSarin results in decreased expression of IRF2 mRNA19522546
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of IRF2 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in decreased expression of IRF2 mRNA19073995
D012999SomanSoman results in increased expression of IRF2 mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of IRF2 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of IRF2 mRNA24058054
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of IRF2 mRNA28973375
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of IRF2 mRNA25613284
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of IRF2 mRNA25729387
D014241TrichloroethyleneTrichloroethylene results in increased methylation of IRF2 gene27618143
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of IRF2 mRNA29024780
D014635Valproic AcidValproic Acid affects the expression of IRF2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of IRF2 mRNA23179753|2915479
D014635Valproic AcidValproic Acid results in decreased methylation of IRF2 gene29154799
D015215Zidovudine[Zidovudine co-treated with IFNA1 protein] results in increased expression of IRF2 mRNA20370541
C088658zoledronic acidzoledronic acid results in increased expression of IRF2 mRNA24714768
D015054ZymosanIRF2 protein affects the reaction [Zymosan affects the expression of [IL12A protein binds to IL12B protein]]10415056

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IMP9540062  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IMP9540062  
GO:0003677DNA binding-IDA9540062  
GO:0003700DNA-binding transcription factor activity-IMP9540062  
GO:0005515protein binding-IPI9540062  21903422  25609649  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-TAS7507207  
GO:0006355regulation of transcription, DNA-templated-IMP9540062  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0007596blood coagulation-TAS-  
GO:0008283cell proliferation-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-IMP9540062  
GO:0051607defense response to virus-IDA21478870  
GO:0060333interferon-gamma-mediated signaling pathway-TAS-  
GO:0060337type I interferon signaling pathway-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005925focal adhesion-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-168928DDX58/IFIH1-mediated induction of interferon-alpha/betaTAS
R-HSA-877300Interferon gamma signalingTAS
R-HSA-909733Interferon alpha/beta signalingTAS
R-HSA-913531Interferon SignalingTAS
R-HSA-933541TRAF6 mediated IRF7 activationTAS
R-HSA-983231Factors involved in megakaryocyte development and platelet productionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26202054Interaction between smoking history and gene expression levels impacts survival of breast cancer patients. (2015 Aug)Andres SABreast Cancer Res Treat
21859832Interferon-signaling pathway: associations with colon and rectal cancer risk and subsequent survival. (2011 Nov)Slattery MLCarcinogenesis