Gene: IRF3

3661
IIAE7
interferon regulatory factor 3
protein-coding
19q13.33
Ensembl:ENSG00000126456 MIM:603734 Vega:OTTHUMG00000183287 UniprotKB:Q14653
NG_031810.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  4.540e-1 (ND)   (Frontal_Cortex)
6.675e-1 (AD)  5.455e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MGAT10.87
SNRPA0.87
HSF10.869
PPP4C0.866
AUP10.864
CLK30.863
BAX0.862
TRIM280.86
CNPY30.859
POLR2H0.856

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.675
OR4F29-0.652
AMPD1-0.212
OR4F16-0.206
MYL1-0.199
XIRP2-0.189
TTLL10-AS1-0.185
MTRNR2L6-0.182
DSG1-0.182
TBX4-0.18

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of IRF3 mRNA"25614096
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of IRF3 mRNA"21394737
C0700552,3',4,4',5-pentachlorobiphenyl"[2,3',4,4',5-pentachlorobiphenyl co-treated with Lipopolysaccharides] results in increased phosphorylation of and affects the localization of IRF3 protein"22906770
C0700552,3',4,4',5-pentachlorobiphenyl"IRF3 mutant form inhibits the reaction [[2,3',4,4',5-pentachlorobiphenyl co-treated with Lipopolysaccharides] results in decreased expression of OCLN protein]"22906770
C0700552,3',4,4',5-pentachlorobiphenyl"IRF3 results in increased susceptibility to [2,3',4,4',5-pentachlorobiphenyl co-treated with Lipopolysaccharides]"22906770
C5859122,4-dihydroxy-N-(4-hydroxyphenyl)benzamide"2,4-dihydroxy-N-(4-hydroxyphenyl)benzamide results in decreased phosphorylation of IRF3 protein"24144632
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased activity of IRF3 protein]19627980
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IRF3 protein]19627980
D000082AcetaminophenAcetaminophen results in decreased expression of IRF3 mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of IRF3 mRNA17562736
C006632arsenic trioxidearsenic trioxide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IRF3 protein]23106696
D001310AuranofinAuranofin inhibits the reaction [lipopolysaccharide A results in increased activity of IRF3 protein]17034761
D001310AuranofinAuranofin inhibits the reaction [lipopolysaccharide A results in increased phosphorylation of IRF3 protein]17034761
D001310AuranofinAuranofin inhibits the reaction [TBK1 protein results in increased activity of IRF3 protein]17034761
D001310AuranofinAuranofin inhibits the reaction [TICAM1 protein results in increased activity of IRF3 protein]17034761
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of IRF3 mRNA21964900
C006780bisphenol Abisphenol A results in decreased expression of IRF3 mRNA26595511
C006780bisphenol Abisphenol A results in decreased expression of IRF3 mRNA26982218
C006780bisphenol Abisphenol A results in increased expression of IRF3 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of IRF3 gene28505145
C043561chrysinchrysin inhibits the reaction [Poly I-C results in increased expression of IRF3 mRNA]19426678
C012843cinnamic aldehydecinnamic aldehyde inhibits the reaction [Lipopolysaccharides results in increased activity of IRF3 protein]17920563
C007095cobaltiprotoporphyrincobaltiprotoporphyrin results in decreased phosphorylation of IRF3 protein25780291
D003474CurcuminCurcumin inhibits the reaction [[Lipopolysaccharides binds to TLR4 protein] which results in increased activity of IRF3 protein]16678799
D003474CurcuminCurcumin inhibits the reaction [Lipopolysaccharides results in increased activity of IRF3 protein]16678799
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of IRF3 mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of IRF3 mRNA21266533
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the phosphorylation of IRF3 protein]"23178662
D004785Environmental PollutantsEnvironmental Pollutants affects the expression of IRF3 mRNA19118595
C007619eriodictyoleriodictyol inhibits the reaction [Poly I-C results in increased expression of IRF3 mRNA]19426678
D000431EthanolEthanol results in increased expression of IRF3 mRNA26858005
D000431Ethanol[Fructose co-treated with Ethanol] results in increased expression of IRF3 protein26858005
D000431EthanolFructose promotes the reaction [Ethanol results in increased expression of IRF3 mRNA]26858005
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of IRF3 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of IRF3 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of IRF3 mRNA17942748
C100807ethyl N-allyl-N-(2-methyl-3-(4-(4-amidinophenoxycarbonyl)phenyl)propenoyl)aminoacetate methanesulfonateethyl N-allyl-N-(2-methyl-3-(4-(4-amidinophenoxycarbonyl)phenyl)propenoyl)aminoacetate methanesulfonate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of IRF3 protein]20023007
C100807ethyl N-allyl-N-(2-methyl-3-(4-(4-amidinophenoxycarbonyl)phenyl)propenoyl)aminoacetate methanesulfonateethyl N-allyl-N-(2-methyl-3-(4-(4-amidinophenoxycarbonyl)phenyl)propenoyl)aminoacetate methanesulfonate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IRF3 protein]20023007
D005632Fructose[Fructose co-treated with Ethanol] results in increased expression of IRF3 protein26858005
D005632FructoseFructose promotes the reaction [Ethanol results in increased expression of IRF3 mRNA]26858005
D005690Galactose"[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactose] results in increased phosphorylation of IRF3 protein"23535186
D005690Galactose"scoparone inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactose] results in increased phosphorylation of IRF3 protein]"23535186
C056507gemcitabinegemcitabine results in decreased expression of IRF3 mRNA17039268
D005839GentamicinsGentamicins results in increased expression of IRF3 mRNA22061828
D006418HemeHeme metabolite results in decreased expression of IRF3 mRNA19191707
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IRF3 mRNA25613284
C082161lipopolysaccharide AAuranofin inhibits the reaction [lipopolysaccharide A results in increased activity of IRF3 protein]17034761
C082161lipopolysaccharide AAuranofin inhibits the reaction [lipopolysaccharide A results in increased phosphorylation of IRF3 protein]17034761
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased activity of IRF3 protein"25680285
C440499lipopolysaccharide, Escherichia coli O111 B4"CLIC4 protein inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of IRF3 protein]"21469130
C440499lipopolysaccharide, Escherichia coli O111 B4"Drugs, Chinese Herbal affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the phosphorylation of IRF3 protein]"23178662
C440499lipopolysaccharide, Escherichia coli O111 B4"lipopolysaccharide, Escherichia coli O111 B4 affects the phosphorylation of IRF3 protein"23178662
C440499lipopolysaccharide, Escherichia coli O111 B4"[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactose] results in increased phosphorylation of IRF3 protein"23535186
C440499lipopolysaccharide, Escherichia coli O111 B4"lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of IRF3 protein"21469130|2849961
C440499lipopolysaccharide, Escherichia coli O111 B4"scoparone inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactose] results in increased phosphorylation of IRF3 protein]"23535186
C440499lipopolysaccharide, Escherichia coli O111 B4"zingerone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of IRF3 protein]"29289488
D008070Lipopolysaccharides"[2,3',4,4',5-pentachlorobiphenyl co-treated with Lipopolysaccharides] results in increased phosphorylation of and affects the localization of IRF3 protein"22906770
D008070Lipopolysaccharides"IRF3 mutant form inhibits the reaction [[2,3',4,4',5-pentachlorobiphenyl co-treated with Lipopolysaccharides] results in decreased expression of OCLN protein]"22906770
D008070Lipopolysaccharides"IRF3 results in increased susceptibility to [2,3',4,4',5-pentachlorobiphenyl co-treated with Lipopolysaccharides]"22906770
D008070Lipopolysaccharides4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased activity of IRF3 protein]19627980
D008070Lipopolysaccharides4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IRF3 protein]19627980
D008070Lipopolysaccharidesarsenic trioxide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IRF3 protein]23106696
D008070Lipopolysaccharidescinnamic aldehyde inhibits the reaction [Lipopolysaccharides results in increased activity of IRF3 protein]17920563
D008070LipopolysaccharidesCurcumin inhibits the reaction [[Lipopolysaccharides binds to TLR4 protein] which results in increased activity of IRF3 protein]16678799
D008070LipopolysaccharidesCurcumin inhibits the reaction [Lipopolysaccharides results in increased activity of IRF3 protein]16678799
D008070Lipopolysaccharidesethyl N-allyl-N-(2-methyl-3-(4-(4-amidinophenoxycarbonyl)phenyl)propenoyl)aminoacetate methanesulfonate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of IRF3 protein]20023007
D008070Lipopolysaccharidesethyl N-allyl-N-(2-methyl-3-(4-(4-amidinophenoxycarbonyl)phenyl)propenoyl)aminoacetate methanesulfonate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IRF3 protein]20023007
D008070Lipopolysaccharides[Lipopolysaccharides binds to TLR4 protein] which results in increased activity of IRF3 protein16678799
D008070LipopolysaccharidesLipopolysaccharides promotes the reaction [IRF3 protein binds to IRF3 protein]19426678
D008070LipopolysaccharidesLipopolysaccharides results in increased activity of IRF3 protein16678799|1792056
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of IRF3 mRNA24056979|2589696
D008070LipopolysaccharidesLipopolysaccharides results in increased phosphorylation of and results in increased activity of IRF3 protein16116226|2002300
D008070LipopolysaccharidesLipopolysaccharides results in increased phosphorylation of IRF3 protein18323514|1942667
D008070LipopolysaccharidesLuteolin inhibits the reaction [Lipopolysaccharides promotes the reaction [IRF3 protein binds to IRF3 protein]]19426678
D008070LipopolysaccharidesLuteolin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IRF3 protein]19426678
D008070LipopolysaccharidesMAPKAPK2 protein affects the reaction [Lipopolysaccharides results in increased phosphorylation of IRF3 protein]21586572
D008070Lipopolysaccharidesmethyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased expression of IRF3 mRNA]24056979
D008070Lipopolysaccharidespitavastatin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IRF3 protein]18323514
D008070Lipopolysaccharidesresveratrol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of IRF3 protein]16116226
D008070LipopolysaccharidesSodium Selenite inhibits the reaction [Lipopolysaccharides results in increased activity of IRF3 protein]18279804
D008070LipopolysaccharidesSodium Selenite inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IRF3 protein]18279804
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of IRF3 mRNA19426678
D008070LipopolysaccharidesLuteolin inhibits the reaction [Lipopolysaccharides results in increased expression of IRF3 mRNA]19426678
D047311LuteolinLuteolin inhibits the reaction [Lipopolysaccharides promotes the reaction [IRF3 protein binds to IRF3 protein]]19426678
D047311LuteolinLuteolin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IRF3 protein]19426678
D047311LuteolinLuteolin inhibits the reaction [Lipopolysaccharides results in increased expression of IRF3 mRNA]19426678
D047311LuteolinLuteolin inhibits the reaction [Poly I-C results in increased expression of IRF3 mRNA]19426678
D047311LuteolinLuteolin inhibits the reaction [TBK1 protein results in increased expression of IRF3 mRNA]19426678
C018091maduramicinmaduramicin results in increased expression of IRF3 mRNA29128925
C008435methyldithiocarbamatemethyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased expression of IRF3 mRNA]24056979
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of IRF3 mRNA"29244179
C022838nickel chlorideIRF3 protein inhibits the reaction [nickel chloride results in decreased expression of TP63 mRNA alternative form]21466819
C022838nickel chloridenickel chloride results in decreased expression of IRF3 mRNA21466819
D019308Palmitic AcidPalmitic Acid results in increased phosphorylation of IRF3 protein18323514
D019308Palmitic Acidpitavastatin inhibits the reaction [Palmitic Acid results in increased phosphorylation of IRF3 protein]18323514
D019308Palmitic AcidPravastatin inhibits the reaction [Palmitic Acid results in increased phosphorylation of IRF3 protein]18323514
D010416PentachlorophenolPentachlorophenol results in increased expression of IRF3 mRNA23892564
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of IRF3 mRNA19162173
C006253pirinixic acidpirinixic acid results in decreased expression of IRF3 mRNA18445702
C006253pirinixic acidpirinixic acid results in decreased expression of IRF3 mRNA19162173
C108475pitavastatinpitavastatin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IRF3 protein]18323514
C108475pitavastatinpitavastatin inhibits the reaction [Palmitic Acid results in increased phosphorylation of IRF3 protein]18323514
D011070Poly I-CPoly I-C results in increased phosphorylation of IRF3 protein18779317
D011070Poly I-CTP53 protein affects the reaction [Poly I-C results in increased phosphorylation of IRF3 protein]18779317
D011070Poly I-C[Vehicle Emissions analog co-treated with Poly I-C] affects the localization of IRF3 protein16399790
D011070Poly I-Cchrysin inhibits the reaction [Poly I-C results in increased expression of IRF3 mRNA]19426678
D011070Poly I-Ceriodictyol inhibits the reaction [Poly I-C results in increased expression of IRF3 mRNA]19426678
D011070Poly I-CQuercetin inhibits the reaction [Poly I-C results in increased expression of IRF3 mRNA]19426678
D011070Poly I-CSodium Selenite inhibits the reaction [Poly I-C results in increased activity of IRF3 protein]18279804
D011070Poly I-CLuteolin inhibits the reaction [Poly I-C results in increased expression of IRF3 mRNA]19426678
D011070Poly I-CPoly I-C results in increased expression of IRF3 mRNA19426678
D017035PravastatinPravastatin inhibits the reaction [Palmitic Acid results in increased phosphorylation of IRF3 protein]18323514
D011794QuercetinQuercetin results in increased expression of IRF3 mRNA21632981
D011794QuercetinQuercetin inhibits the reaction [Poly I-C results in increased expression of IRF3 mRNA]19426678
C059514resveratrolresveratrol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of IRF3 protein]16116226
C059514resveratrolresveratrol inhibits the reaction [TBK1 protein results in increased activity of IRF3 protein]16678799
C059514resveratrolresveratrol inhibits the reaction [TBK1 protein results in increased phosphorylation of IRF3 protein]16116226
C059514resveratrolresveratrol results in decreased phosphorylation of IRF3 protein22118570
C018145scoparone"scoparone inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactose] results in increased phosphorylation of IRF3 protein]"23535186
D012643SeleniumSelenium results in increased expression of IRF3 mRNA19244175
C017947sodium arsenitesodium arsenite results in decreased expression of IRF3 mRNA16014739
D018038Sodium SeleniteSodium Selenite inhibits the reaction [Lipopolysaccharides results in increased activity of IRF3 protein]18279804
D018038Sodium SeleniteSodium Selenite inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IRF3 protein]18279804
D018038Sodium SeleniteSodium Selenite inhibits the reaction [Poly I-C results in increased activity of IRF3 protein]18279804
D018038Sodium SeleniteSodium Selenite inhibits the reaction [TBK1 protein results in increased activity of IRF3 protein]18279804
D018038Sodium SeleniteSodium Selenite inhibits the reaction [TICAM1 protein results in increased activity of IRF3 protein]18279804
D013629TamoxifenTamoxifen affects the expression of IRF3 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [[AHR protein binds to RELB protein] which binds to IRF3 promoter]17900530
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin results in increased activity of AHR protein] which results in increased expression of IRF3 mRNA17900530
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of IRF3 mRNA21570461|2405805
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of IRF3 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of IRF3 mRNA23798565
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of IRF3 mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IRF3 mRNA25613284
D013853ThioacetamideThioacetamide results in decreased expression of IRF3 mRNA23411599
D014212TretinoinTretinoin results in increased expression of IRF3 mRNA23724009
D014635Valproic AcidValproic Acid results in increased methylation of IRF3 gene29154799
D001335Vehicle Emissions[Vehicle Emissions analog co-treated with Poly I-C] affects the localization of IRF3 protein16399790
C025643vinclozolinvinclozolin results in increased expression of IRF3 mRNA23034163
C013738zingerone"zingerone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of IRF3 protein]"29289488

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IMP17560375  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IC-  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IMP17560375  
GO:0001078transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IC-  
GO:0003677DNA binding-NAS12062447  
GO:0003712transcription coregulator activity-TAS8524823  
GO:0005515protein binding-IPI15841462  16154084  16362036  17599067  18309294  18583960  
18711448  19153231  20308324  20581830  21903422  21988832  
22908223  23746807  24807708  26347139  
GO:0019904protein domain specific binding-IPI11583620  
GO:0042802identical protein binding-IPI15841462  16301520  18725644  19416887  19454348  20403326  
20581830  21102435  21782231  22000020  22728658  23746807  
25609649  
GO:0042803protein homodimerization activity-IPI12062447  
GO:0043565sequence-specific DNA binding-IDA23332764  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IEA-  
GO:0006366transcription by RNA polymerase II-TAS8524823  
GO:0006915apoptotic process-TAS20049431  
GO:0006974cellular response to DNA damage stimulus-TAS16979567  
GO:0016032viral process-IEA-  
GO:0031663lipopolysaccharide-mediated signaling pathway-IEA-  
GO:0032479regulation of type I interferon production-TAS-  
GO:0032480negative regulation of type I interferon production-TAS-  
GO:0032481positive regulation of type I interferon production-TAS-  
GO:0032727positive regulation of interferon-alpha production-ISS-  
GO:0032728positive regulation of interferon-beta production-ISS-  
GO:0032728positive regulation of interferon-beta production-TAS16979567  
GO:0035666TRIF-dependent toll-like receptor signaling pathway-TAS-  
GO:0039530MDA-5 signaling pathway-TAS16979567  
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling-IEA-  
GO:0043330response to exogenous dsRNA-IEA-  
GO:0045351type I interferon biosynthetic process-IEA-  
GO:0045358negative regulation of interferon-beta biosynthetic process-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA9660935  
GO:0045944positive regulation of transcription by RNA polymerase II-IMP17560375  
GO:0050689negative regulation of defense response to virus by host-IEA-  
GO:0050715positive regulation of cytokine secretion-IEA-  
GO:0051607defense response to virus-ISS-  
GO:0060333interferon-gamma-mediated signaling pathway-TAS-  
GO:0060337type I interferon signaling pathway-TAS-  
GO:0060340positive regulation of type I interferon-mediated signaling pathway-IEA-  
GO:0071359cellular response to dsRNA-IEA-  
GO:0071888macrophage apoptotic process-TAS16846591  
GO:0097300programmed necrotic cell death-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA17079289  18818105  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IDA17079289  18818105  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa04620Toll-like receptor signaling pathway
hsa04622RIG-I-like receptor signaling pathway
hsa04623Cytosolic DNA-sensing pathway
hsa05160Hepatitis C
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-1169408ISG15 antiviral mechanismTAS
R-HSA-1169410Antiviral mechanism by IFN-stimulated genesTAS
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1606322ZBP1(DAI) mediated induction of type I IFNsTAS
R-HSA-1606322ZBP1(DAI) mediated induction of type I IFNsIEA
R-HSA-1606341IRF3 mediated activation of type 1 IFNTAS
R-HSA-1606341IRF3 mediated activation of type 1 IFNIEA
R-HSA-166016Toll Like Receptor 4 (TLR4) CascadeTAS
R-HSA-166166MyD88-independent TLR4 cascade TAS
R-HSA-168164Toll Like Receptor 3 (TLR3) CascadeTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168249Innate Immune SystemIEA
R-HSA-168256Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-168898Toll-Like Receptors CascadesTAS
R-HSA-168928DDX58/IFIH1-mediated induction of interferon-alpha/betaTAS
R-HSA-1834941STING mediated induction of host immune responsesTAS
R-HSA-1834949Cytosolic sensors of pathogen-associated DNA TAS
R-HSA-1834949Cytosolic sensors of pathogen-associated DNA IEA
R-HSA-3134973LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN productionTAS
R-HSA-3134975Regulation of innate immune responses to cytosolic DNATAS
R-HSA-3270619IRF3-mediated induction of type I IFNTAS
R-HSA-877300Interferon gamma signalingTAS
R-HSA-9013973TICAM1-dependent activation of IRF3/IRF7TAS
R-HSA-909733Interferon alpha/beta signalingTAS
R-HSA-913531Interferon SignalingTAS
R-HSA-918233TRAF3-dependent IRF activation pathwayTAS
R-HSA-933541TRAF6 mediated IRF7 activationTAS
R-HSA-936440Negative regulators of DDX58/IFIH1 signalingTAS
R-HSA-936964Activation of IRF3/IRF7 mediated by TBK1/IKK epsilonTAS
R-HSA-937061TRIF(TICAM1)-mediated TLR4 signaling TAS
R-HSA-983231Factors involved in megakaryocyte development and platelet productionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21859832Interferon-signaling pathway: associations with colon and rectal cancer risk and subsequent survival. (2011 Nov)Slattery MLCarcinogenesis