Gene: IRF4

3662
LSIRF|MUM1|NF-EM5|SHEP8
interferon regulatory factor 4
protein-coding
6p25.3
Ensembl:ENSG00000137265 MIM:601900 Vega:OTTHUMG00000016294 UniprotKB:Q15306
NG_027728.1
PubMed
0   ANCO-SNPs
ND
5   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.592e-1 (AD)  6.995e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLAMF70.628
CYTIP0.624
NOD20.597
MYO1G0.594
CCL50.589
PARP150.587
IL150.585
FASLG0.583
PATL20.583
ARHGAP150.574

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ARSF-0.359
WNT7A-0.35
NANOS3-0.321
SLC29A4-0.311
ZNF835-0.307
KCNIP3-0.307
PYGM-0.302
NEUROD6-0.292
FRMPD1-0.288
FNDC5-0.288

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of IRF4 mRNA22230336
D020106AcrylamideAcrylamide results in decreased expression of IRF4 mRNA28959563
D001151ArsenicArsenic results in increased methylation of IRF4 gene27838757
C006632arsenic trioxidearsenic trioxide affects the methylation of IRF4 promoter26046465
C015001arsenitearsenite results in increased methylation of IRF4 promoter23974009
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of IRF4 mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of IRF4 mRNA21569818
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of IRF4 mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of IRF4 mRNA27685785
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of IRF4 mRNA28628672
C006780bisphenol Abisphenol A affects the methylation of IRF4 promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of IRF4 mRNA25181051
D002392CatechinCatechin results in decreased expression of IRF4 mRNA15465739
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of IRF4 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of IRF4 mRNA28628672
D004041Dietary FatsDietary Fats results in decreased expression of IRF4 mRNA18042831
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of IRF4 mRNA21041162
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of IRF4 mRNA23649840
D005419FlavonoidsFlavonoids results in decreased expression of IRF4 mRNA15465739
D006418HemeHeme metabolite results in increased expression of IRF4 mRNA19191707
D017313FenretinideFenretinide results in increased expression of IRF4 mRNA28973697
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of IRF4 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of IRF4 mRNA28628672
D015759Ionomycinpyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IRF4 mRNA]15477007
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IRF4 mRNA15477007
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IRF4 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of IRF4 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of IRF4 mRNA28628672
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of IRF4 mRNA23582323
C008261lead acetatelead acetate results in decreased expression of IRF4 mRNA21829687
D008070LipopolysaccharidesLipopolysaccharides affects the expression of IRF4 mRNA24056979
D008070Lipopolysaccharidesmethyldithiocarbamate inhibits the reaction [Lipopolysaccharides affects the expression of IRF4 mRNA]24056979
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of IRF4 mRNA21641980
C008435methyldithiocarbamatemethyldithiocarbamate inhibits the reaction [Lipopolysaccharides affects the expression of IRF4 mRNA]24056979
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of IRF4 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog affects the expression of IRF4 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of IRF4 mRNA"25554681
D009532NickelNickel results in increased expression of IRF4 mRNA25583101
C507134ON 01910ON 01910 affects the expression of IRF4 mRNA22351695
D010126OzoneOzone results in decreased expression of IRF4 mRNA28623178
D000073878Palm OilPalm Oil results in decreased expression of IRF4 mRNA18042831
D010936Plant ExtractsPlant Extracts results in decreased expression of IRF4 mRNA15465739
D059808PolyphenolsPolyphenols results in decreased expression of IRF4 mRNA15465739
C020972pyrrolidine dithiocarbamic acidpyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IRF4 mRNA]15477007
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of IRF4 mRNA23806026
D019821SimvastatinSimvastatin results in decreased expression of IRF4 protein21856936
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of IRF4 mRNA21641980
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of IRF4 mRNA12377990
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of IRF4 mRNA24058054
D013755Tetradecanoylphorbol Acetatepyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IRF4 mRNA]15477007
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IRF4 mRNA15477007
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IRF4 mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of IRF4 mRNA23557971
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of IRF4 mRNA19042947
D014635Valproic AcidValproic Acid results in increased expression of IRF4 mRNA28001369
D015215ZidovudineIRF4 protein results in decreased susceptibility to [Zidovudine co-treated with IFNA1 protein]17138822
D015032ZincZinc deficiency results in increased expression of IRF4 mRNA22171008
D019287Zinc SulfateZinc Sulfate results in increased expression of IRF4 mRNA27215404

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA12374808  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IDA12374808  
GO:0003700DNA-binding transcription factor activity-ISS-  
GO:0003700DNA-binding transcription factor activity-NAS12374808  
GO:0005515protein binding-IPI21903422  
GO:0008134transcription factor binding-NAS12374808  
GO:0016279protein-lysine N-methyltransferase activity-IEA-  
GO:0043565sequence-specific DNA binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0018022peptidyl-lysine methylation-IEA-  
GO:0019221cytokine-mediated signaling pathway-TAS-  
GO:0034122negative regulation of toll-like receptor signaling pathway-IEA-  
GO:0042110T cell activation-NAS12374808  
GO:0042832defense response to protozoan-ISS-  
GO:0043011myeloid dendritic cell differentiation-IEA-  
GO:0043388positive regulation of DNA binding-IEA-  
GO:0043966histone H3 acetylation-IEA-  
GO:0043967histone H4 acetylation-IEA-  
GO:0045082positive regulation of interleukin-10 biosynthetic process-IDA12374808  
GO:0045086positive regulation of interleukin-2 biosynthetic process-IDA12374808  
GO:0045368positive regulation of interleukin-13 biosynthetic process-IDA12374808  
GO:0045404positive regulation of interleukin-4 biosynthetic process-IDA12374808  
GO:0045622regulation of T-helper cell differentiation-NAS12374808  
GO:0045893positive regulation of transcription, DNA-templated-IDA12374808  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA12374808  
GO:0060333interferon-gamma-mediated signaling pathway-TAS-  
GO:0060337type I interferon signaling pathway-TAS-  
GO:0072540T-helper 17 cell lineage commitment-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000788nuclear nucleosome-IEA-  
GO:0005634nucleus-IC12374808  
GO:0005654nucleoplasm-IDA-  
GO:0005829cytosol-TAS-  
GO:0016020membrane-HDA19946888  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-168256Immune SystemTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-6785807Interleukin-4 and 13 signalingTAS
R-HSA-877300Interferon gamma signalingTAS
R-HSA-909733Interferon alpha/beta signalingTAS
R-HSA-913531Interferon SignalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27453436Methylation of a panel of genes in peripheral blood leukocytes is associated with colorectal cancer. (2016 Jul 25)Luo XSci Rep
23303382Genome-wide association study of serum albumin:globulin ratio in Korean populations. (2013 Mar)Hong KWJ Hum Genet
27113098CPEB4 and IRF4 expression in peripheral mononuclear cells are potential prognostic factors for advanced lung cancer. (2017 Feb)Wu YYJ Formos Med Assoc
21859832Interferon-signaling pathway: associations with colon and rectal cancer risk and subsequent survival. (2011 Nov)Slattery MLCarcinogenesis
27459457Epidemiological Assessments of Skin Outcomes in the Nurses' Health Studies. (2016 Sep)Li WQAm J Public Health