Gene: IRF5

3663
SLEB10
interferon regulatory factor 5
protein-coding
7q32.1
Ensembl:ENSG00000128604 MIM:607218 Vega:OTTHUMG00000158410 UniprotKB:Q13568
NG_012306.1
PubMed
0   ANCO-SNPs
ND
5   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.592e-2 (AD)  4.729e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg13914531chr7:128579876IRF57.600e-11Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DEF60.879
BTK0.879
NCKAP1L0.877
BIN20.876
FGD20.871
APBB1IP0.87
LAPTM50.869
LAIR10.868
CD680.865
CYTH40.865

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HES5-0.342
ATP2C2-0.333
ARSF-0.316
WNT7A-0.311
KCNIP3-0.279
CPLX3-0.273
FAM180B-0.263
FEZF2-0.262
NXPH3-0.258
HPDL-0.257

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of IRF5 mRNA"22698814
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of IRF5 mRNA"27291303
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of IRF5 mRNA"18648102
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of IRF5 mRNA"21346803
D000082AcetaminophenAcetaminophen affects the expression of IRF5 mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of IRF5 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of IRF5 mRNA]17585979
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of IRF5 mRNA24449571
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of IRF5 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of IRF5 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of IRF5 mRNA21569818
C006780bisphenol Abisphenol A affects the expression of IRF5 mRNA21786754
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of IRF5 mRNA28628672
C006780bisphenol Abisphenol A affects the methylation of IRF5 promoter27334623
C006780bisphenol Abisphenol A affects the expression of IRF5 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of IRF5 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of IRF5 mRNA28628672
D002101Cacodylic AcidCacodylic Acid results in decreased expression of IRF5 mRNA17720352
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of IRF5 mRNA17585979
D002994ClofibrateClofibrate results in decreased expression of IRF5 mRNA23811191
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of IRF5 mRNA]17585979
D019327Copper SulfateCopper Sulfate results in decreased expression of IRF5 mRNA19549813
D003474CurcuminCurcumin analog results in increased expression of IRF5 mRNA26409325
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of IRF5 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of IRF5 mRNA28628672
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of IRF5 mRNA28962523
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of IRF5 mRNA27392435
D002945CisplatinCisplatin results in increased expression of IRF5 mRNA27392435
D004041Dietary FatsDietary Fats results in decreased expression of IRF5 mRNA18042831
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of IRF5 mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein promotes the reaction [Diethylhexyl Phthalate results in decreased expression of IRF5 mRNA]19850644
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of IRF5 mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of IRF5 mRNA23649840
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of IRF5 mRNA20044591
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of IRF5 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of IRF5 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of IRF5 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of IRF5 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of IRF5 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of IRF5 mRNA27392435
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of IRF5 mRNA26918785
D008070Lipopolysaccharides"methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate promotes the reaction [Lipopolysaccharides results in increased expression of IRF5 mRNA]"26918785
D008070LipopolysaccharidesLipopolysaccharides affects the expression of IRF5 mRNA24056979
D008070Lipopolysaccharidesmethyldithiocarbamate inhibits the reaction [Lipopolysaccharides affects the expression of IRF5 mRNA]24056979
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of IRF5 mRNA25613284
D008727MethotrexateMethotrexate results in increased expression of IRF5 mRNA24449571
C445068methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate"methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate promotes the reaction [Lipopolysaccharides results in increased expression of IRF5 mRNA]"26918785
C008435methyldithiocarbamatemethyldithiocarbamate inhibits the reaction [Lipopolysaccharides affects the expression of IRF5 mRNA]24056979
D008752Methylene ChlorideMethylene Chloride results in decreased expression of IRF5 mRNA28392392
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of IRF5 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of IRF5 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of IRF5 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of IRF5 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of IRF5 mRNA"25554681
D009532NickelNickel results in increased expression of IRF5 mRNA25583101
C029938nickel sulfatenickel sulfate results in increased expression of IRF5 mRNA16780908
D000073878Palm OilPalm Oil results in decreased expression of IRF5 mRNA18042831
D010416PentachlorophenolPentachlorophenol results in increased expression of IRF5 mRNA24642059
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of IRF5 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of IRF5 mRNA20059764|2381119
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in decreased expression of IRF5 mRNA]20059764
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of IRF5 mRNA28903501
D011441PropylthiouracilPropylthiouracil results in decreased expression of IRF5 mRNA24780913
D047428Protein Kinase Inhibitors[Protein Kinase Inhibitors results in decreased activity of IRAK4 protein] inhibits the reaction [resiquimod promotes the reaction [IRF5 protein binds to CXCL10 promoter]]28924041
D047428Protein Kinase Inhibitors[Protein Kinase Inhibitors results in decreased activity of IRAK4 protein] inhibits the reaction [resiquimod promotes the reaction [IRF5 protein binds to TNF promoter]]28924041
C402365resiquimod[Protein Kinase Inhibitors results in decreased activity of IRAK4 protein] inhibits the reaction [resiquimod promotes the reaction [IRF5 protein binds to CXCL10 promoter]]28924041
C402365resiquimod[Protein Kinase Inhibitors results in decreased activity of IRAK4 protein] inhibits the reaction [resiquimod promotes the reaction [IRF5 protein binds to TNF promoter]]28924041
C402365resiquimodresiquimod promotes the reaction [IRF5 protein binds to CXCL10 promoter]28924041
C402365resiquimodresiquimod promotes the reaction [IRF5 protein binds to TNF promoter]28924041
C471405sorafenibsorafenib results in increased expression of IRF5 mRNA26409325
D013629TamoxifenTamoxifen results in decreased expression of IRF5 mRNA25123088
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of IRF5 mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of IRF5 mRNA21570461|2405805
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of IRF5 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of IRF5 mRNA15328365
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of IRF5 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of IRF5 mRNA26232522
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of IRF5 mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of IRF5 mRNA20133372
D014118Toxins, Biological"Toxins, Biological affects the expression of IRF5 mRNA"19682533
D014241TrichloroethyleneTrichloroethylene results in decreased expression of IRF5 mRNA25549359
D014635Valproic AcidValproic Acid results in increased methylation of IRF5 gene29154799
D014635Valproic AcidValproic Acid affects the expression of IRF5 mRNA17963808
D024483Vitamin K 3Vitamin K 3 affects the expression of IRF5 mRNA20044591

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IC-  
GO:0005515protein binding-IPI18836453  20237317  21903422  21988832  
GO:0042802identical protein binding-IPI18836453  
GO:0043565sequence-specific DNA binding-IMP23332764  
GO:0044212transcription regulatory region DNA binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0032494response to peptidoglycan-IDA22412986  
GO:0032495response to muramyl dipeptide-IDA22412986  
GO:0032727positive regulation of interferon-alpha production-IC22412986  
GO:0032728positive regulation of interferon-beta production-IC22412986  
GO:0032735positive regulation of interleukin-12 production-IC22412986  
GO:0043065positive regulation of apoptotic process-IMP22412986  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA12600985  22412986  
GO:0051607defense response to virus-IEA-  
GO:0060333interferon-gamma-mediated signaling pathway-TAS-  
GO:0060337type I interferon signaling pathway-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA22412986  
GO:0005737cytoplasm-IDA22412986  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa04620Toll-like receptor signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-168256Immune SystemTAS
R-HSA-877300Interferon gamma signalingTAS
R-HSA-909733Interferon alpha/beta signalingTAS
R-HSA-913531Interferon SignalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23288628Genetics of rheumatoid arthritis - a comprehensive review. (2013 Oct)Kurko JClin Rev Allergy Immunol
25263394A large candidate-gene association study suggests genetic variants at IRF5 and PRDM1 to be associated with aggressive periodontitis. (2014 Dec)Schaefer ASJ Clin Periodontol
25011482Interferon regulatory factor 5 genetic variants are associated with cardiovascular disease in patients with rheumatoid arthritis. (2014 Jul 10)Garcia-Bermudez MArthritis Res Ther
20439292Genetic variants in the prediction of rheumatoid arthritis. (2010 Sep)van der Helm-van Mil AHAnn Rheum Dis
20046016[Is rheumatoid arthritis without anti-citrullinated peptide antibody a genetically distinct subset?]. (2009 Dec)Ohmura KNihon Rinsho Meneki Gakkai Kaishi