Gene: IRF6

3664
LPS|OFC6|PIT|PPS|PPS1|VWS|VWS1
interferon regulatory factor 6
protein-coding
1q32.2
Ensembl:ENSG00000117595 MIM:607199 Vega:OTTHUMG00000036521 UniprotKB:O14896
NG_007081.2
PubMed
0   ANCO-SNPs
ND
5   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.304e-1 (AD)  4.712e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BMX0.904
TRABD2B0.843
BMP50.838
FOXD20.83
MYOCD0.828
CHMP4C0.819
TBX180.818
OGN0.817
COL8A10.812
ALX40.807

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ASPDH-0.392
HHATL-0.391
SORCS2-0.378
KLHL26-0.375
EPHB1-0.374
NDP-0.373
FUT9-0.372
FEZF2-0.37
RHCG-0.369
GRM3-0.367

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of IRF6 mRNA"23829299
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the expression of IRF6 mRNA"19414516
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of IRF6 mRNA]"19414516
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [FSHB protein affects the expression of IRF6 mRNA]"19414516
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of IRF6 mRNA"19167446
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of IRF6 mRNA"21346803
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in decreased expression of IRF6 mRNA25088246
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of IRF6 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRF6 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRF6 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRF6 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRF6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRF6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRF6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRF6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRF6 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of IRF6 mRNA26690555|2906747
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of IRF6 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of IRF6 mRNA]17585979
D020106AcrylamideAcrylamide results in increased expression of IRF6 mRNA28959563
D000242Cyclic AMP"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of IRF6 mRNA]"19414516
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of IRF6 mRNA19770486
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of IRF6 mRNA24449571
C006632arsenic trioxideIRF6 protein results in decreased susceptibility to arsenic trioxide20707922
D001280AtrazineAtrazine results in increased expression of IRF6 mRNA25929836
D004958EstradiolEstradiol results in decreased expression of IRF6 mRNA20106945
D004958EstradiolEstradiol results in increased expression of IRF6 mRNA19484750
D004958EstradiolEstradiol results in decreased expression of IRF6 mRNA14664709
D004958EstradiolEstradiol results in increased expression of IRF6 mRNA19484750
C006780bisphenol Abisphenol A affects the methylation of IRF6 promoter27334623
C006780bisphenol Abisphenol A results in increased methylation of IRF6 promoter27312807
C006780bisphenol Abisphenol A affects the expression of IRF6 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of IRF6 gene28505145
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of IRF6 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of IRF6 mRNA]17585979
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of IRF6 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in decreased expression of IRF6 mRNA19167446
D003375CoumestrolCoumestrol results in decreased expression of IRF6 mRNA19167446
D003471CuprizoneCuprizone results in increased expression of IRF6 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of IRF6 mRNA20106945
C093628cyproconazolecyproconazole results in increased expression of IRF6 mRNA22664269
C014347decitabinedecitabine results in decreased expression of IRF6 mRNA27915011
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of IRF6 mRNA21266533
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of IRF6 mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein inhibits the reaction [Diethylhexyl Phthalate results in increased expression of IRF6 mRNA]19850644
D002117CalcitriolCalcitriol results in increased expression of IRF6 mRNA26485663
D004147DioxinsDioxins affects the expression of IRF6 mRNA20463971
C061365flusilazoleflusilazole results in increased expression of IRF6 mRNA22664269|2826382
D005897GlafenineGlafenine results in decreased expression of IRF6 mRNA24136188
D017313FenretinideFenretinide results in increased expression of IRF6 mRNA28973697
D007213IndomethacinIndomethacin results in decreased expression of IRF6 mRNA28201806
D007657Ketone BodiesKetone Bodies results in decreased expression of IRF6 mRNA16807920
C018091maduramicinmaduramicin results in increased expression of IRF6 mRNA29128925
D008727MethotrexateIRF6 protein affects the susceptibility to Methotrexate16217747
D008727MethotrexateMethotrexate affects the expression of IRF6 mRNA18502557
D008752Methylene ChlorideMethylene Chloride results in decreased expression of IRF6 mRNA28392392
C030589methylmercury cysteinemethylmercury cysteine results in decreased expression of IRF6 mRNA19465457
C517284monomethyl phthalatemonomethyl phthalate affects the expression of IRF6 mRNA26924002
D009151Mustard GasMustard Gas results in increased expression of IRF6 mRNA25102026
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of IRF6 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of IRF6 mRNA"25620056
C051752nefazodonenefazodone results in decreased expression of IRF6 mRNA24136188
C012655nimesulidenimesulide results in decreased expression of IRF6 mRNA24136188
D010126OzoneOzone results in decreased expression of IRF6 mRNA16183385
D010126Ozone"[Water Pollutants, Chemical co-treated with Ozone] results in increased expression of IRF6 mRNA"23246600
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRF6 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of IRF6 mRNA26272509
D052638Particulate Matter[IRF6 gene mutant form affects the susceptibility to Particulate Matter] which results in decreased expression of IRF6 mRNA21222557|2122255
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of IRF6 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in decreased expression of IRF6 mRNA19270015|1948288
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRF6 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of IRF6 mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of IRF6 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of IRF6 mRNA18445702
D011374ProgesteroneProgesterone results in increased expression of IRF6 mRNA23018184
D011374ProgesteroneProgesterone results in increased expression of IRF6 mRNA20864642
D011441PropylthiouracilPropylthiouracil results in decreased expression of IRF6 mRNA24780913
C059514resveratrol[Coumestrol co-treated with resveratrol] results in decreased expression of IRF6 mRNA19167446
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of IRF6 mRNA21427059
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of IRF6 mRNA23806026
D012906SmokeSmoke results in decreased expression of IRF6 mRNA21095227
C009277sodium arsenatesodium arsenate results in increased expression of IRF6 mRNA23922661
D013629TamoxifenTamoxifen affects the expression of IRF6 mRNA20937368
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of IRF6 mRNA21570461|2405805
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of IRF6 mRNA17586704
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of IRF6 mRNA18796159
D014212TretinoinTretinoin results in decreased expression of IRF6 mRNA23724009
D014212TretinoinTretinoin results in increased expression of IRF6 mRNA20488242
C032910triadimefontriadimefon results in increased expression of IRF6 mRNA22664269
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRF6 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of IRF6 mRNA24935251|2627250
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRF6 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased methylation of IRF6 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of IRF6 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased expression of IRF6 mRNA21427059
D001335Vehicle Emissions[IRF6 gene mutant form affects the susceptibility to Vehicle Emissions] which results in decreased expression of IRF6 mRNA21222557|2122255
D014874Water Pollutants, Chemical"[Water Pollutants, Chemical co-treated with Ozone] results in increased expression of IRF6 mRNA"23246600

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IC-  
GO:0003677DNA binding-ISS-  
GO:0003700DNA-binding transcription factor activity-ISS-  
GO:0005515protein binding-IPI16049006  21903422  
GO:0043565sequence-specific DNA binding-IDA28473536  
GO:0044212transcription regulatory region DNA binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0007050cell cycle arrest-IDA18212048  
GO:0008285negative regulation of cell proliferation-IDA18212048  
GO:0030216keratinocyte differentiation-IEA-  
GO:0043616keratinocyte proliferation-IEA-  
GO:0045893positive regulation of transcription, DNA-templated-ISS-  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA21807998  
GO:0048468cell development-IEA-  
GO:0060333interferon-gamma-mediated signaling pathway-TAS-  
GO:0060337type I interferon signaling pathway-TAS-  
GO:0060644mammary gland epithelial cell differentiation-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA-  
GO:0005737cytoplasm-IDA16049006  18212048  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0030054cell junction-IDA-  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-168256Immune SystemTAS
R-HSA-877300Interferon gamma signalingTAS
R-HSA-909733Interferon alpha/beta signalingTAS
R-HSA-913531Interferon SignalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19388848Association among IRF6 polymorphism, environmental factors, and nonsyndromic orofacial clefts in western china. (2009 May)Jia ZLDNA Cell Biol
18218836Unraveling human cleft lip and palate research. (2008 Feb)Vieira ARJ Dent Res
23512105Confirming genes influencing risk to cleft lip with/without cleft palate in a case-parent trio study. (2013 Jul)Beaty THHum Genet
26710774[Significant association between nonsyndromic cleft lip with or without cleft palate and IRF6rs2235371 polymorphism in Iranian familiar population]. (2015 Nov-Dec)Jafary FMol Biol (Mosk)
21859832Interferon-signaling pathway: associations with colon and rectal cancer risk and subsequent survival. (2011 Nov)Slattery MLCarcinogenesis