Gene: IRF7

3665
IMD39|IRF-7H|IRF7A|IRF7B|IRF7C|IRF7H
interferon regulatory factor 7
protein-coding
11p15.5
Ensembl:ENSG00000185507 MIM:605047 Vega:OTTHUMG00000132019 UniprotKB:Q92985
NG_029106.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.182e-1 (AD)  8.443e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TAP10.889
HELZ20.849
IFI350.846
PARP90.845
PSMB80.839
CLIC10.836
DTX3L0.835
NLRC50.833
SP1100.831
IFITM10.826

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MARCH4-0.481
PPEF1-0.473
ABCC12-0.465
SLC7A4-0.463
KIT-0.463
NEUROD6-0.452
CASC15-0.452
GRIN3A-0.452
XKR4-0.451
HAPLN1-0.447

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0700461,2-dioleoyloxy-3-(trimethylammonium)propane"[Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of IRF7 mRNA"22129739
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene affects the expression of IRF7 mRNA"18281256
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of IRF7 mRNA"25614096
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of IRF7 mRNA"27188386
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of IRF7 mRNA19191707
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of IRF7 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of IRF7 mRNA21420995|2906747
D000082AcetaminophenAcetaminophen affects the expression of IRF7 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 affects the expression of IRF7 protein20106945
C412373AG 1879AG 1879 inhibits the reaction [chromium hexavalent ion results in increased expression of IRF7 mRNA]19994902
D001151ArsenicArsenic results in increased methylation of IRF7 gene27838757
D001379AzathioprineAzathioprine results in decreased expression of IRF7 mRNA19192274
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of IRF7 mRNA26377693
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of IRF7 mRNA26377693
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of IRF7 mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of IRF7 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of IRF7 mRNA19770486|2071347
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of IRF7 mRNA"19150397
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of IRF7 mRNA19619570
D004958EstradiolEstradiol results in increased expression of IRF7 mRNA19619570
D004958EstradiolEstradiol results in increased expression of IRF7 mRNA15289156|1948475
C006780bisphenol Abisphenol A affects the methylation of IRF7 promoter27334623
C006780bisphenol Abisphenol A affects the expression of IRF7 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of IRF7 mRNA25181051
C518299BIX 01294BIX 01294 promotes the reaction [IFNA2 protein alternative form results in increased expression of IRF7 mRNA]25079219
C518299BIX 01294BIX 01294 results in increased expression of IRF7 protein25079219
D002065BuspironeBuspirone results in decreased expression of IRF7 mRNA24136188
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of IRF7 mRNA14729362|1500399
D019256Cadmium ChlorideCadmium Chloride results in increased expression of IRF7 mRNA25993096
D000074262Canola OilCanola Oil metabolite results in decreased expression of IRF7 mRNA27363782
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of IRF7 mRNA17484886
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of IRF7 mRNA16934159
D002737ChloropreneChloroprene results in decreased expression of IRF7 mRNA23125180
D002784Cholesterol"[Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of IRF7 mRNA"22129739
C074702chromium hexavalent ionAG 1879 inhibits the reaction [chromium hexavalent ion results in increased expression of IRF7 mRNA]19994902
C074702chromium hexavalent ionchromium hexavalent ion results in increased expression of IRF7 mRNA19994902
C074702chromium hexavalent ionFYN protein promotes the reaction [chromium hexavalent ion results in increased expression of IRF7 mRNA]19994902
C074702chromium hexavalent ionSTAT1 protein affects the reaction [chromium hexavalent ion results in increased expression of IRF7 mRNA]19994902
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of IRF7 mRNA28472532
C074702chromium hexavalent ionchromium hexavalent ion results in increased expression of IRF7 mRNA19994902
D016572CyclosporineCyclosporine results in decreased expression of IRF7 mRNA19770486
D016047Zalcitabine"[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of IRF7 mRNA"18606552
C014347decitabinedecitabine results in increased expression of IRF7 mRNA17785578
C014347decitabinedecitabine results in increased expression of IRF7 protein19117987
C014347decitabineTNF protein promotes the reaction [decitabine results in increased expression of IRF7 protein]19117987
C014347decitabinedecitabine results in increased expression of IRF7 mRNA27923600
C016366dibenzothiophenedibenzothiophene results in increased expression of IRF7 mRNA23656968
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of IRF7 mRNA28962523
D004008DiclofenacDiclofenac results in decreased expression of IRF7 mRNA19192274
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of IRF7 mRNA27405655
C058705diethyl malatediethyl malate affects the expression of IRF7 mRNA24814887
C014476diethyl maleatediethyl maleate results in decreased expression of IRF7 mRNA21161181
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of IRF7 mRNA18164116
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of IRF7 mRNA15289156
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of IRF7 mRNA21658437
D002117CalcitriolCalcitriol results in increased expression of IRF7 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of IRF7 mRNA21592394
D0198131,2-Dimethylhydrazine"1,2-Dimethylhydrazine results in increased expression of IRF7 mRNA"27840820
D0198131,2-Dimethylhydrazine"APC protein affects the reaction [1,2-Dimethylhydrazine results in increased expression of IRF7 mRNA]"27840820
D004391DustDust results in decreased expression of IRF7 mRNA17805423
D000431EthanolEthanol results in increased expression of IRF7 protein26858005
D000431Ethanol[Fructose co-treated with Ethanol] results in increased expression of IRF7 protein26858005
D000431Ethanol[Fish Oils co-treated with Ethanol] results in increased expression of IRF7 mRNA17347304
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of IRF7 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of IRF7 mRNA16174780|1794274
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of IRF7 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of IRF7 mRNA16174780|1755790
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of IRF7 mRNA23649840
D011345FenofibrateFenofibrate results in increased expression of IRF7 mRNA25572481
C000499ferric oxideferric oxide analog results in decreased expression of IRF7 mRNA25086211
D018120FinasterideFinasteride results in decreased expression of IRF7 mRNA24136188
D005395Fish Oils[Fish Oils co-treated with Ethanol] results in increased expression of IRF7 mRNA17347304
D005557FormaldehydeFormaldehyde results in increased expression of IRF7 mRNA23649840
D005632Fructose[Fructose co-treated with Ethanol] results in increased expression of IRF7 protein26858005
D005632FructoseFructose results in increased expression of IRF7 protein26858005
C069837fullerene C60fullerene C60 results in decreased expression of IRF7 mRNA19167457
C039281furanfuran results in decreased expression of IRF7 mRNA25539665
D019833GenisteinGenistein results in increased expression of IRF7 mRNA18847459
D019833GenisteinGenistein results in increased expression of IRF7 mRNA15289156
D005839GentamicinsGentamicins results in increased expression of IRF7 mRNA22061828
C010974glyphosateglyphosate results in increased expression of IRF7 mRNA25636363
D006052Gold Sodium ThiomalateGold Sodium Thiomalate results in decreased expression of IRF7 mRNA19192274
C514793gp120 protein, Human immunodeficiency virus 1"[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of IRF7 mRNA"18606552
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of IRF7 mRNA17183730
C540383INCB018424INCB018424 results in decreased expression of IRF7 mRNA22941906
D007213IndomethacinIndomethacin results in increased expression of IRF7 mRNA28201806
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of IRF7 mRNA25613284
D007529IsoflavonesIsoflavones affects the expression of IRF7 mRNA16365062
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of IRF7 mRNA24796395|2530787
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of IRF7 mRNA]25890327|2658214
D008070Lipopolysaccharides(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of IRF7 mRNA]25890327|2658214
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of IRF7 mRNA24056979|2589032
D008070Lipopolysaccharidesmethyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased expression of IRF7 mRNA]24056979
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of IRF7 mRNA26378955
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of IRF7 mRNA21641980
C008435methyldithiocarbamatemethyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased expression of IRF7 mRNA]24056979
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of IRF7 mRNA23649840
D008775MethylprednisoloneMethylprednisolone results in decreased expression of IRF7 mRNA19192274
D008942MitoxantroneIRF7 protein affects the susceptibility to Mitoxantrone16217747
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of IRF7 mRNA22108045
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of IRF7 mRNA"29244179
C510788N4-(2,2-dimethyl-3-oxo-4H-pyrid(1,4)oxazin-6-yl)-5-fluoro-N2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine"N4-(2,2-dimethyl-3-oxo-4H-pyrid(1,4)oxazin-6-yl)-5-fluoro-N2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine results in decreased expression of IRF7 mRNA"25487280
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of IRF7 mRNA"23845593
D037742Nanotubes, Carbon"Nanotubes, Carbon analog affects the expression of IRF7 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of IRF7 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of IRF7 mRNA"25554681
D009532NickelNickel results in increased expression of IRF7 mRNA25583101
C022838nickel chloridenickel chloride results in decreased expression of IRF7 mRNA21466819
C028007nickel monoxidenickel monoxide affects the expression of IRF7 mRNA19167457
C002741N-nitrosomorpholineN-nitrosomorpholine results in increased expression of IRF7 mRNA19716841
D009966OrphenadrineOrphenadrine affects the expression of IRF7 mRNA23665939
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of IRF7 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of IRF7 mRNA25729387
C030110oxaliplatin[Topotecan co-treated with oxaliplatin] results in increased expression of IRF7 mRNA25729387
D010081OxazoloneOxazolone results in increased expression of IRF7 mRNA21893156
D017239PaclitaxelPaclitaxel results in increased expression of IRF7 mRNA15585946
D010416PentachlorophenolPentachlorophenol results in increased expression of IRF7 mRNA23892564
D010634PhenobarbitalPhenobarbital results in decreased expression of IRF7 mRNA19162173
D010656PhenylephrinePhenylephrine results in decreased expression of IRF7 mRNA18158353
C006253pirinixic acidpirinixic acid results in decreased expression of IRF7 mRNA20059764|2381119
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in decreased expression of IRF7 mRNA]20059764
C006253pirinixic acidpirinixic acid results in decreased expression of IRF7 mRNA12832660|1916217
D011239PrednisolonePrednisolone results in decreased expression of IRF7 mRNA19192274
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of IRF7 mRNA19162173
D011441PropylthiouracilPropylthiouracil results in increased expression of IRF7 mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in increased expression of IRF7 mRNA27029645
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of IRF7 mRNA16079270
D012402RotenoneRotenone results in decreased expression of IRF7 mRNA19013527
D017655Silicon CompoundsSilicon Compounds results in increased expression of IRF7 mRNA20513754
D017655Silicon CompoundsSilicon Compounds results in increased expression of IRF7 protein20513754
D012834SilverSilver affects the expression of IRF7 mRNA27131904
D012999SomanSoman results in increased expression of IRF7 mRNA19281266
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of IRF7 mRNA26378955
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of IRF7 mRNA21641980
D013467SulindacSulindac results in decreased expression of IRF7 mRNA24136188
C061133tamibarotenetamibarotene results in increased expression of IRF7 mRNA15498508
D013629TamoxifenTamoxifen affects the expression of IRF7 mRNA17555576
C501413tesaglitazartesaglitazar results in decreased expression of IRF7 mRNA21515302
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of IRF7 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of IRF7 mRNA21592394
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of IRF7 mRNA27914987
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of IRF7 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of IRF7 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of IRF7 mRNA16704738
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of IRF7 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of IRF7 mRNA19770486|2323856
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of IRF7 mRNA23798565|2405805
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of IRF7 mRNA23238561
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of IRF7 mRNA25613284
D019284ThapsigarginThapsigargin results in increased expression of IRF7 mRNA22378314
D013806TheophyllineTheophylline results in decreased expression of IRF7 mRNA16083514
D013853ThioacetamideThioacetamide results in decreased expression of IRF7 mRNA23411599
C009495titanium dioxidetitanium dioxide results in increased expression of IRF7 mRNA23557971|2776080
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of IRF7 mRNA20133372
C479163tofacitinibtofacitinib results in decreased expression of IRF7 mRNA22941906|2548728
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of IRF7 mRNA25729387
D019772Topotecan[Topotecan co-treated with oxaliplatin] results in increased expression of IRF7 mRNA25729387
D019772TopotecanTopotecan results in increased expression of IRF7 mRNA25729387
D014212TretinoinTretinoin affects the expression of IRF7 mRNA15498508
D014212TretinoinTretinoin results in increased expression of IRF7 mRNA15894607
C012589trichostatin Atrichostatin A results in increased expression of IRF7 mRNA15901671
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of IRF7 mRNA21893156
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of IRF7 mRNA"26743178
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of IRF7 mRNA"26179874
C057693troglitazonetroglitazone results in increased expression of IRF7 mRNA25572481
D014415TunicamycinTunicamycin results in increased expression of IRF7 mRNA22378314
D014635Valproic AcidValproic Acid results in increased expression of IRF7 mRNA15901671
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of IRF7 mRNA17183730
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of IRF7 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of IRF7 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of IRF7 mRNA23179753|2627250
D014635Valproic AcidValproic Acid results in increased methylation of IRF7 gene29154799
C025643vinclozolinvinclozolin affects the expression of IRF7 mRNA19015723
C025643vinclozolinvinclozolin results in increased expression of IRF7 mRNA23034163
C029297vinylidene chloridevinylidene chloride results in increased expression of IRF7 mRNA26682919
D015215Zidovudine[Zidovudine co-treated with IFNA1 protein] results in increased expression of IRF7 mRNA20370541

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA17404045  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0000982transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IDA17404045  
GO:0003677DNA binding-IMP12374802  
GO:0005515protein binding-IPI11943871  17599067  18922877  19176627  20392859  21903422  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-TAS9315633  
GO:0002819regulation of adaptive immune response-IDA17404045  
GO:0006366transcription by RNA polymerase II-TAS9315633  
GO:0006974cellular response to DNA damage stimulus-TAS16979567  
GO:0009615response to virus-TAS21490621  
GO:0016064immunoglobulin mediated immune response-IEA-  
GO:0019043establishment of viral latency-TAS21490621  
GO:0032479regulation of type I interferon production-TAS21490621  
GO:0032481positive regulation of type I interferon production-TAS-  
GO:0032607interferon-alpha production-ISS-  
GO:0032608interferon-beta production-ISS-  
GO:0032727positive regulation of interferon-alpha production-IDA16127453  
GO:0032727positive regulation of interferon-alpha production-TAS16979567  
GO:0032728positive regulation of interferon-beta production-IMP22065573  
GO:0032728positive regulation of interferon-beta production-TAS16979567  
GO:0034124regulation of MyD88-dependent toll-like receptor signaling pathway-ISS-  
GO:0034127regulation of MyD88-independent toll-like receptor signaling pathway-ISS-  
GO:0035666TRIF-dependent toll-like receptor signaling pathway-TAS-  
GO:0039530MDA-5 signaling pathway-TAS16979567  
GO:0045087innate immune response-TAS17404045  
GO:0045351type I interferon biosynthetic process-IEA-  
GO:0045655regulation of monocyte differentiation-TAS21490621  
GO:0045893positive regulation of transcription, DNA-templated-IMP12374802  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA16127453  17404045  
GO:0050776regulation of immune response-TAS21490621  
GO:0051607defense response to virus-IDA21478870  
GO:0060333interferon-gamma-mediated signaling pathway-TAS-  
GO:0060337type I interferon signaling pathway-TAS-  
GO:0060340positive regulation of type I interferon-mediated signaling pathway-IEA-  
GO:2000110negative regulation of macrophage apoptotic process-TAS21490621  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA22065573  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IDA19176627  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0010008endosome membrane-TAS-  
KEGG ID KEGG Term
hsa04620Toll-like receptor signaling pathway
hsa04622RIG-I-like receptor signaling pathway
hsa04623Cytosolic DNA-sensing pathway
hsa05160Hepatitis C
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-166016Toll Like Receptor 4 (TLR4) CascadeTAS
R-HSA-166166MyD88-independent TLR4 cascade TAS
R-HSA-168138Toll Like Receptor 9 (TLR9) CascadeTAS
R-HSA-168164Toll Like Receptor 3 (TLR3) CascadeTAS
R-HSA-168181Toll Like Receptor 7/8 (TLR7/8) CascadeTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-168898Toll-Like Receptors CascadesTAS
R-HSA-168928DDX58/IFIH1-mediated induction of interferon-alpha/betaTAS
R-HSA-1834949Cytosolic sensors of pathogen-associated DNA TAS
R-HSA-3134963DEx/H-box helicases activate type I IFN and inflammatory cytokines production TAS
R-HSA-877300Interferon gamma signalingTAS
R-HSA-9013973TICAM1-dependent activation of IRF3/IRF7TAS
R-HSA-909733Interferon alpha/beta signalingTAS
R-HSA-913531Interferon SignalingTAS
R-HSA-918233TRAF3-dependent IRF activation pathwayTAS
R-HSA-933541TRAF6 mediated IRF7 activationTAS
R-HSA-936964Activation of IRF3/IRF7 mediated by TBK1/IKK epsilonTAS
R-HSA-937061TRIF(TICAM1)-mediated TLR4 signaling TAS
R-HSA-975110TRAF6 mediated IRF7 activation in TLR7/8 or 9 signalingTAS
R-HSA-975155MyD88 dependent cascade initiated on endosomeTAS
R-HSA-983231Factors involved in megakaryocyte development and platelet productionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22261033Cigarette smoke induction of osteopontin (SPP1) mediates T(H)17 inflammation in human and experimental emphysema. (2012 Jan 18)Shan MSci Transl Med
19880818Reduced expression of IRF7 in nasal epithelial cells from smokers after infection with influenza. (2010 Sep)Jaspers IAm J Respir Cell Mol Biol