Gene: IRS1

3667
HIRS-1
insulin receptor substrate 1
protein-coding
2q36.3
Ensembl:ENSG00000169047 MIM:147545 Vega:OTTHUMG00000133179 UniprotKB:P35568
NG_015830.1
PubMed
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.095e-1 (AD)  4.264e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg18018313chr2:227657192IRS15.750e-8Alcohol consumption der day27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GFOD10.914
PTPN40.909
THRB0.909
EPHA40.906
LMTK20.905
KLHL290.903
LUZP10.901
BHLHB90.9
KIAA1549L0.897
ATRNL10.896

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYL3-0.553
COPZ2-0.51
SNHG18-0.504
HEY2-0.484
CTNNA3-0.477
RAB13-0.474
RAI14-0.472
APOM-0.472
ACAP1-0.472
CSAG1-0.472

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB08513[4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACIDSmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in decreased expression of IRS1 mRNA"26377693
D0140131,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt"1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of IRS1 protein]"17458902
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of IRS1 mRNA"28903501
C52473317-ethynyl-5-androstene-3, 7, 17-triol"17-ethynyl-5-androstene-3, 7, 17-triol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IRS1 protein]"22384159
C0447551-methyl-4-phenyl-2,3-dihydropyridinium"1-methyl-4-phenyl-2,3-dihydropyridinium results in decreased expression of IRS1 mRNA"21856379
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of IRS1 mRNA"28433925
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of IRS1 mRNA"21346803
C0415253,3',4,5'-tetrahydroxystilbene"3,3',4,5'-tetrahydroxystilbene inhibits the reaction [Palmitic Acid inhibits the reaction [INS protein results in increased phosphorylation of IRS1 protein]]"25815690
C0415253,3',4,5'-tetrahydroxystilbene"tin protoporphyrin IX inhibits the reaction [3,3',4,5'-tetrahydroxystilbene inhibits the reaction [Palmitic Acid inhibits the reaction [INS protein results in increased phosphorylation of IRS1 protein]]]"25815690
C0415253,3',4,5'-tetrahydroxystilbene"3,3',4,5'-tetrahydroxystilbene inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased phosphorylation of IRS1 protein]"22298784
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of IRS1 mRNA"20959002
C0414773-hydroxyflavone3-hydroxyflavone inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of IRS1 protein]17458902
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRS1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRS1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRS1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRS1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRS1 mRNA"27188386
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in decreased expression of IRS1 mRNA"19561079
C4664205,10,15,20-tetrakis(4-sulfonatophenyl)porphyrinato iron(III) chloride"5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrinato iron(III) chloride inhibits the reaction [Dietary Fats inhibits the reaction [INS1 protein results in increased phosphorylation of IRS1 protein]]"19682478
C4664205,10,15,20-tetrakis(4-sulfonatophenyl)porphyrinato iron(III) chloride"5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrinato iron(III) chloride inhibits the reaction [Dietary Fats results in increased metabolism of IRS1 protein]"19682478
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRS1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRS1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRS1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRS1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRS1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of IRS1 mRNA21420995
D000082AcetaminophenAcetaminophen results in increased expression of IRS1 mRNA22230336
D000111AcetylcysteineAcetylcysteine inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of IRS1 protein]17458902
D020106AcrylamideAcrylamide results in decreased expression of IRS1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of IRS1 mRNA22100608|2715375
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of IRS1 gene27153756
D000493AllopurinolAllopurinol inhibits the reaction [Fructose results in decreased phosphorylation of IRS1 protein]22426011
D000496AlloxanAlloxan affects the phosphorylation of IRS1 protein26827782
D000496AlloxanPhycocyanin inhibits the reaction [Alloxan affects the phosphorylation of IRS1 protein]26827782
D000496AlloxanAlloxan results in decreased phosphorylation of IRS1 protein22138235
D000496AlloxanTaurine inhibits the reaction [Alloxan results in decreased phosphorylation of IRS1 protein]22138235
D000643Ammonium ChlorideAmmonium Chloride affects the expression of IRS1 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of IRS1 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in decreased expression of IRS1 mRNA20458559
C006632arsenic trioxideIRS1 mRNA affects the susceptibility to arsenic trioxide23911876
C015001arsenitearsenite results in decreased methylation of IRS1 promoter23974009
D001205Ascorbic Acid[Ascorbic Acid co-treated with Vitamin E] inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of IRS1 protein]21911000
D001205Ascorbic Acid[Ascorbic Acid co-treated with Vitamin E] inhibits the reaction [Diethylhexyl Phthalate results in decreased phosphorylation of IRS1 protein]21911000
D001241AspirinIRS1 polymorphism affects the susceptibility to Aspirin15066917
D001280AtrazineAtrazine affects the phosphorylation of IRS1 protein22378314
D001379AzathioprineAzathioprine results in increased phosphorylation of and results in decreased expression of IRS1 protein23958494
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of IRS1 mRNA26238291
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of IRS1 mRNA21632981
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased phosphorylation of IRS1 protein9683191
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of IRS1 mRNA21569818
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of IRS1 mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of IRS1 mRNA"20382639
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [INS1 protein results in decreased expression of IRS1 protein]24219910
D004958Estradiol"1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of IRS1 protein]"17458902
D004958Estradiol3-hydroxyflavone inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of IRS1 protein]17458902
D004958EstradiolAcetylcysteine inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of IRS1 protein]17458902
D004958Estradiol[Cycloheximide co-treated with Estradiol] results in increased expression of IRS1 mRNA15072547
D004958EstradiolEGF protein promotes the reaction [Estradiol results in increased expression of IRS1 mRNA]24758408
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of IRS1 mRNA15688983
D004958EstradiolEstradiol promotes the reaction [AKT1 protein modified form binds to IRS1 protein]19435893
D004958EstradiolEstradiol results in decreased phosphorylation of IRS1 protein15949379
D004958EstradiolEstradiol results in increased expression of IRS1 mRNA15072547|1568898
D004958EstradiolEstradiol results in increased expression of IRS1 protein modified form23810794
D004958EstradiolEstradiol results in increased phosphorylation of IRS1 protein23933164
D004958Estradiolfulvestrant inhibits the reaction [[Hexachlorobenzene co-treated with Estradiol] results in increased phosphorylation of IRS1 protein]19879930
D004958EstradiolGenistein inhibits the reaction [Estradiol results in increased phosphorylation of IRS1 protein]23933164
D004958Estradiol[Hexachlorobenzene co-treated with Estradiol] results in increased phosphorylation of IRS1 protein19879930
D004958Estradiol[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of IRS1 protein17458902
D004958EstradiolNVP-AEW541 inhibits the reaction [Estradiol promotes the reaction [AKT1 protein modified form binds to IRS1 protein]]19435893
D004958EstradiolPTEN protein affects the reaction [Estradiol promotes the reaction [AKT1 protein modified form binds to IRS1 protein]]19435893
D004958Estradiolresveratrol inhibits the reaction [Estradiol results in increased expression of IRS1 protein modified form]23810794
D004958EstradiolTetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of IRS1 mRNA]15688983
D004958EstradiolEstradiol results in increased phosphorylation of IRS1 protein15604210
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of IRS1 mRNA26496021
D004958EstradiolEstradiol results in decreased expression of IRS1 protein22142692
C511635bis(allixinato)oxovanadium(IV)bis(allixinato)oxovanadium(IV) results in increased phosphorylation of IRS1 protein17805585
C512927bis(alpha-furancarboxylato)oxovanadium(IV)bis(alpha-furancarboxylato)oxovanadium(IV) inhibits the reaction [Dexamethasone results in decreased expression of IRS1 mRNA]18812026
C006780bisphenol Abisphenol A results in increased expression of IRS1 mRNA16029874
C006780bisphenol Abisphenol A results in increased expression of IRS1 protein modified form23810794
C006780bisphenol Abisphenol A results in increased phosphorylation of IRS1 protein23933164
C006780bisphenol AGenistein inhibits the reaction [bisphenol A results in increased phosphorylation of IRS1 protein]23933164
C006780bisphenol Aresveratrol inhibits the reaction [bisphenol A results in increased expression of IRS1 protein modified form]23810794
C006780bisphenol Abisphenol A results in decreased expression of IRS1 mRNA26779933
C006780bisphenol Abisphenol A results in decreased phosphorylation of IRS1 protein25637671|2717670
C006780bisphenol Abisphenol A results in increased expression of IRS1 protein22470480
C006780bisphenol Abisphenol A results in increased phosphorylation of IRS1 protein26779933|2692323
C006780bisphenol A"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of IRS1 mRNA"28433925
C006780bisphenol Abisphenol A affects the expression of IRS1 mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of IRS1 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of and results in decreased phosphorylation of IRS1 protein28739533
C006780bisphenol Abisphenol A results in decreased expression of IRS1 protein22142692
C006780bisphenol Abisphenol A results in decreased phosphorylation of IRS1 protein28153594
C006780bisphenol Abisphenol A results in increased expression of IRS1 protein27836638
D000069286BortezomibBortezomib results in decreased degradation of IRS1 protein16227402
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of IRS1 mRNA22079614
D002104Cadmiummyricetin inhibits the reaction [[Streptozocin co-treated with Cadmium] results in decreased expression of IRS1 protein]24923654
D002104Cadmium[Streptozocin co-treated with Cadmium] results in decreased expression of IRS1 protein24923654
D019256Cadmium Chloride[Cadmium Chloride co-treated with methylmercuric chloride] results in decreased expression of IRS1 mRNA27814245
D019256Cadmium Chloride[Cadmium Chloride co-treated with methylmercuric chloride] results in increased phosphorylation of IRS1 protein27814245
C055494caffeic acid phenethyl estercaffeic acid phenethyl ester results in decreased expression of IRS1 mRNA21467634
D002211CapsaicinCapsaicin results in increased expression of IRS1 mRNA19798065
D002220CarbamazepineCarbamazepine affects the expression of IRS1 mRNA24752500
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of IRS1 mRNA17484886
D002330CarmustineCarmustine results in decreased expression of IRS1 mRNA15980968
D002392CatechinCatechin inhibits the reaction [Glucose results in decreased expression of IRS1 protein]24262486
D002392CatechinCatechin inhibits the reaction [Glucose results in decreased expression of IRS1 protein modified form]24262486
C523455CCG 1423CCG 1423 promotes the reaction [INS protein results in increased phosphorylation of IRS1 protein]21393865
D002737ChloropreneChloroprene results in decreased expression of IRS1 mRNA23125180
D002784CholesterolIRS1 gene polymorphism affects the abundance of Cholesterol10591678
D002791Cholesterol, Dietary"[Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of and results in decreased phosphorylation of IRS1 protein"19509184
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of IRS1 gene20938992
D002857ChromiumChromium inhibits the reaction [Dietary Fats results in decreased expression of IRS1 protein]20513351
D002857ChromiumChromium results in increased phosphorylation of IRS1 protein15516700
D002857ChromiumChromium affects the expression of IRS1 mRNA15862035
D002857ChromiumChromium promotes the reaction [INS1 protein results in increased phosphorylation of IRS1 protein]16424121
D017608Chromium CompoundsChromium Compounds results in decreased phosphorylation of IRS1 protein21472246
D017608Chromium CompoundsChromium Compounds results in increased phosphorylation of IRS1 protein21472246
C512471chromium (D-Phenylalanine)3chromium (D-Phenylalanine)3 results in decreased expression of IRS1 protein modified form18388893
C074702chromium hexavalent ionchromium hexavalent ion results in increased expression of IRS1 protein23748240
C074702chromium hexavalent ionMIR143 inhibits the reaction [chromium hexavalent ion results in increased expression of IRS1 protein]23748240
C074702chromium hexavalent ionchromium hexavalent ion results in decreased expression of and results in decreased phosphorylation of IRS1 protein28911802
C079689chromium tripicolinatechromium tripicolinate promotes the reaction [INS1 protein results in increased phosphorylation of IRS1 protein]16424121
C503589cis-9, trans-11-conjugated linoleic acid"cis-9, trans-11-conjugated linoleic acid inhibits the reaction [TNF protein results in decreased expression of IRS1 mRNA]"17327424
C503589cis-9, trans-11-conjugated linoleic acid"[trans-10,cis-12-conjugated linoleic acid co-treated with cis-9, trans-11-conjugated linoleic acid] results in decreased phosphorylation of IRS1 protein"17408517
C018021cobaltous chloridecobaltous chloride results in decreased expression of IRS1 mRNA19376846
D005576ColforsinColforsin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IRS1 mRNA]17407152
D019327Copper SulfateCopper Sulfate results in increased expression of IRS1 mRNA19549813
D003375Coumestrol[Coumestrol co-treated with ESR1 protein] results in increased expression of IRS1 mRNA18310284
D003375CoumestrolESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of IRS1 mRNA]18310284
C030973cupric oxidecupric oxide results in decreased expression of IRS1 mRNA22077320
D003474CurcuminCurcumin affects the phosphorylation of IRS1 protein27208389
D003474CurcuminCurcumin inhibits the reaction [Fructose affects the phosphorylation of IRS1 protein]26713546
D003513Cycloheximide[Cycloheximide co-treated with Estradiol] results in increased expression of IRS1 mRNA15072547
D003513CycloheximideCycloheximide results in decreased expression of IRS1 mRNA15072547
D003520Cyclophosphamide[Doxorubicin co-treated with Cyclophosphamide] affects the expression of IRS1 mRNA16322899
D016572CyclosporineCyclosporine results in decreased expression of IRS1 mRNA20106945
D016572CyclosporineCyclosporine results in decreased expression of IRS1 mRNA19770486
D016572CyclosporineCyclosporine results in decreased expression of IRS1 mRNA21865292
D003687DehydroepiandrosteroneDehydroepiandrosterone results in decreased phosphorylation of IRS1 protein27634381
D003687DehydroepiandrosteroneMetformin inhibits the reaction [Dehydroepiandrosterone results in decreased phosphorylation of IRS1 protein]27634381
D003687DehydroepiandrosteroneQuercetin inhibits the reaction [Dehydroepiandrosterone results in decreased phosphorylation of IRS1 protein]27634381
D003907Dexamethasone"3,3',4,5'-tetrahydroxystilbene inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased phosphorylation of IRS1 protein]"22298784
D003907Dexamethasonebis(alpha-furancarboxylato)oxovanadium(IV) inhibits the reaction [Dexamethasone results in decreased expression of IRS1 mRNA]18812026
D003907Dexamethasone[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased phosphorylation of IRS1 protein22298784
D003907DexamethasoneDexamethasone results in decreased expression of and results in increased phosphorylation of IRS1 protein22733784
D003907DexamethasoneDexamethasone results in decreased expression of IRS1 mRNA18812026
D003907DexamethasonePIK3R1 mutant form inhibits the reaction [Dexamethasone results in decreased expression of and results in increased phosphorylation of IRS1 protein]22733784
D003907DexamethasoneDexamethasone results in decreased expression of IRS1 mRNA20032058
D003907DexamethasoneTestosterone inhibits the reaction [Dexamethasone results in decreased expression of IRS1 mRNA]20032058
D003907DexamethasoneDexamethasone results in decreased expression of IRS1 mRNA19852296
D002945CisplatinCisplatin results in decreased expression of IRS1 mRNA19561079|2739243
D002945CisplatinIRS1 results in decreased susceptibility to Cisplatin21849418
D002945CisplatinCisplatin results in increased expression of IRS1 mRNA21151649
D004008DiclofenacDiclofenac affects the expression of IRS1 mRNA24752500
D004008DiclofenacDiclofenac affects the expression of IRS1 mRNA26934552
C000944dicrotophosdicrotophos results in increased expression of IRS1 mRNA28302478
D004040Dietary CarbohydratesDietary Carbohydrates results in decreased expression of IRS1 mRNA23872130
D004040Dietary CarbohydratesDietary Carbohydrates results in decreased expression of IRS1 protein23872130
D004041Dietary Fats"[Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of and results in decreased phosphorylation of IRS1 protein"19509184
D004041Dietary Fats"5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrinato iron(III) chloride inhibits the reaction [Dietary Fats inhibits the reaction [INS1 protein results in increased phosphorylation of IRS1 protein]]"19682478
D004041Dietary Fats"5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrinato iron(III) chloride inhibits the reaction [Dietary Fats results in increased metabolism of IRS1 protein]"19682478
D004041Dietary Fats[AGT protein affects the susceptibility to Dietary Fats] which affects the expression of IRS1 mRNA26704350
D004041Dietary FatsChromium inhibits the reaction [Dietary Fats results in decreased expression of IRS1 protein]20513351
D004041Dietary FatsDietary Fats inhibits the reaction [INS1 protein results in increased phosphorylation of IRS1 protein]19682478
D004041Dietary FatsDietary Fats results in decreased expression of IRS1 mRNA23954404
D004041Dietary FatsDietary Fats results in decreased expression of IRS1 protein20513351
D004041Dietary FatsDietary Fats results in decreased phosphorylation of IRS1 protein22198281
D004041Dietary FatsDietary Fats results in increased expression of IRS1 mRNA24398136
D004041Dietary FatsDietary Fats results in increased metabolism of IRS1 protein19682478
D004041Dietary Fatsnaringin inhibits the reaction [Dietary Fats results in decreased phosphorylation of IRS1 protein]22198281
D004041Dietary FatsSodium Selenite promotes the reaction [[Streptozocin co-treated with Dietary Fats] affects the phosphorylation of IRS1 protein]26522834
D004041Dietary Fats[Streptozocin co-treated with Dietary Fats] affects the phosphorylation of IRS1 protein26522834
D004051Diethylhexyl Phthalate"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of IRS1 mRNA"28433925
D004051Diethylhexyl Phthalate[Ascorbic Acid co-treated with Vitamin E] inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of IRS1 protein]21911000
D004051Diethylhexyl Phthalate[Ascorbic Acid co-treated with Vitamin E] inhibits the reaction [Diethylhexyl Phthalate results in decreased phosphorylation of IRS1 protein]21911000
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate affects the phosphorylation of IRS1 protein25280772
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate inhibits the reaction [INS1 protein results in increased phosphorylation of IRS1 protein]28526321
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of IRS1 protein21911000
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased phosphorylation of IRS1 protein21911000
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of IRS1 mRNA21911000
D004051Diethylhexyl Phthalate[INS1 protein co-treated with Diethylhexyl Phthalate] results in decreased expression of IRS1 protein28526321
D004052DiethylnitrosamineDiethylnitrosamine affects the expression of IRS1 mRNA20387270
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of IRS1 mRNA25242112
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of IRS1 protein25242112
D002117CalcitriolCalcitriol results in increased expression of IRS1 mRNA16002434|2648566
C076126disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate"disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate results in increased expression of IRS1 mRNA"20184727
D004317Doxorubicin[Doxorubicin co-treated with Cyclophosphamide] affects the expression of IRS1 mRNA16322899
D000431EthanolEthanol affects the phosphorylation of IRS1 protein18377926
D000431EthanolEthanol results in decreased phosphorylation of IRS1 protein28131861
D000431EthanolEthanol results in decreased phosphorylation of IRS1 protein12700235
D000431Ethanol[Ethanol results in decreased susceptibility to INS1 protein] which results in decreased expression of and results in decreased activity of IRS1 protein12700235
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of IRS1 mRNA29097150
D005227Fatty Acids[Fatty Acids co-treated with INS protein] affects the phosphorylation of IRS1 protein24648896
D005227Fatty AcidsQuercetin affects the reaction [[Fatty Acids co-treated with INS protein] affects the phosphorylation of IRS1 protein]24648896
D005227Fatty AcidsFatty Acids affects the expression of IRS1 mRNA17940560
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of IRS1 gene20938992
D005557FormaldehydeFormaldehyde results in decreased expression of IRS1 mRNA20655997|2766457
D005632Fructose"[Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of and results in decreased phosphorylation of IRS1 protein"19509184
D005632FructoseAllopurinol inhibits the reaction [Fructose results in decreased phosphorylation of IRS1 protein]22426011
D005632FructoseCurcumin inhibits the reaction [Fructose affects the phosphorylation of IRS1 protein]26713546
D005632FructoseFructose affects the phosphorylation of IRS1 protein26713546
D005632Fructose[Fructose co-treated with Oleanolic Acid] results in increased expression of IRS1 mRNA24704288
D005632Fructose[Fructose co-treated with Oleanolic Acid] results in increased expression of IRS1 protein24704288
D005632Fructose[Fructose co-treated with resveratrol] results in increased expression of IRS1 mRNA26488877
D005632FructoseFructose results in decreased expression of IRS1 mRNA19165636
D005632FructoseFructose results in decreased expression of IRS1 protein19008412
D005632FructoseFructose results in decreased phosphorylation of IRS1 protein22426011
D005632FructoseFructose results in increased phosphorylation of IRS1 protein24704288
D005632FructoseNOS3 protein inhibits the reaction [Fructose results in decreased expression of IRS1 protein]19008412
D005632FructoseOleanolic Acid inhibits the reaction [Fructose results in increased phosphorylation of IRS1 protein]24704288
D005632FructoseQuercetin inhibits the reaction [Fructose results in decreased phosphorylation of IRS1 protein]22426011
D005632FructoseRutin inhibits the reaction [Fructose results in decreased phosphorylation of IRS1 protein]22426011
C070081fulvestrantfulvestrant inhibits the reaction [[Hexachlorobenzene co-treated with Estradiol] results in increased phosphorylation of IRS1 protein]19879930
C070081fulvestrantfulvestrant inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of IRS1 protein]19879930
C070081fulvestrantfulvestrant results in decreased expression of IRS1 mRNA15072547
D019833GenisteinGenistein inhibits the reaction [bisphenol A results in increased phosphorylation of IRS1 protein]23933164
D019833GenisteinGenistein inhibits the reaction [Estradiol results in increased phosphorylation of IRS1 protein]23933164
D019833GenisteinGenistein results in increased expression of IRS1 mRNA22228119
C007845gingerolgingerol inhibits the reaction [sodium arsenite results in decreased expression of IRS1 mRNA]22285432
C007845gingerolgingerol inhibits the reaction [sodium arsenite results in decreased expression of IRS1 protein]22285432
C049864ginsenoside Reginsenoside Re inhibits the reaction [TNF protein results in increased phosphorylation of IRS1 protein]17885204
C049864ginsenoside Reginsenoside Re results in increased expression of IRS1 mRNA23545455
C049864ginsenoside Reginsenoside Re results in increased phosphorylation of IRS1 protein17885204
D005947GlucoseCatechin inhibits the reaction [Glucose results in decreased expression of IRS1 protein]24262486
D005947GlucoseCatechin inhibits the reaction [Glucose results in decreased expression of IRS1 protein modified form]24262486
D005947GlucoseGlucose promotes the reaction [PIK3R1 protein binds to IRS1 protein]10430617
D005947GlucoseGlucose results in decreased expression of IRS1 protein24262486
D005947GlucoseGlucose results in decreased expression of IRS1 protein modified form24262486
D005947GlucoseGlucose results in increased phosphorylation of IRS1 protein10430617
D005947GlucoseIRS1 protein polymorphism inhibits the reaction [Glucose results in increased secretion of INS protein]10430617
D005947GlucosePlant Extracts inhibits the reaction [Glucose results in decreased expression of IRS1 protein]24262486
D005947GlucosePlant Extracts inhibits the reaction [Glucose results in decreased expression of IRS1 protein modified form]24262486
D005905GlyburideIRS1 protein polymorphism inhibits the reaction [Glyburide results in increased secretion of INS protein]10430617
D006581Hexachlorobenzenefulvestrant inhibits the reaction [[Hexachlorobenzene co-treated with Estradiol] results in increased phosphorylation of IRS1 protein]19879930
D006581Hexachlorobenzenefulvestrant inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of IRS1 protein]19879930
D006581Hexachlorobenzene[Hexachlorobenzene co-treated with Estradiol] results in increased phosphorylation of IRS1 protein19879930
D006581HexachlorobenzeneHexachlorobenzene results in increased phosphorylation of IRS1 protein19879930
D006581HexachlorobenzeneHexachlorobenzene inhibits the reaction [Methylnitrosourea results in increased phosphorylation of IRS1 protein]16237195
D006581HexachlorobenzeneHexachlorobenzene results in increased expression of IRS1 protein16237195
D006581HexachlorobenzeneHexachlorobenzene results in increased phosphorylation of IRS1 protein16237195
D066248High Fructose Corn SyrupHigh Fructose Corn Syrup results in decreased expression of IRS1 mRNA25238689
D066248High Fructose Corn SyrupHigh Fructose Corn Syrup results in decreased expression of IRS1 protein25238689
D066248High Fructose Corn Syrupresveratrol inhibits the reaction [High Fructose Corn Syrup results in decreased expression of IRS1 mRNA]25238689
D066248High Fructose Corn Syrupresveratrol inhibits the reaction [High Fructose Corn Syrup results in decreased expression of IRS1 protein]25238689
D012701Serotonin[Ketanserin inhibits the reaction [Serotonin results in increased activity of AKT1 protein]] promotes the reaction [Serotonin inhibits the reaction [IRS1 protein binds to YWHAB protein]]22975078
D012701Serotonin[[Ketanserin inhibits the reaction [Serotonin results in increased activity of AKT1 protein]] promotes the reaction [Serotonin inhibits the reaction [IRS1 protein binds to YWHAB protein]]] which results in increased ubiquitination of and results in increased degradation of IRS1 protein22975078
D012701Serotonin[sarpogrelate results in increased activity of AKT1 protein] inhibits the reaction [Serotonin results in increased ubiquitination of and results in increased degradation of IRS1 protein]22975078
D012701SerotoninSerotonin affects the localization of and results in increased ubiquitination of and results in increased degradation of IRS1 protein22975078
D012701SerotoninSerotonin inhibits the reaction [IRS1 protein binds to YWHAB protein]22975078
C475919hydroxytamoxifenhydroxytamoxifen results in increased expression of IRS1 mRNA15072547
D0150561-Methyl-3-isobutylxanthine"3,3',4,5'-tetrahydroxystilbene inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased phosphorylation of IRS1 protein]"22298784
D0150561-Methyl-3-isobutylxanthine[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased phosphorylation of IRS1 protein22298784
D007545IsoproterenolIsoproterenol results in increased expression of IRS1 mRNA20003209
C515747isosteviol[isosteviol co-treated with Palmitic Acid] results in increased expression of IRS1 mRNA22479612
C515747isosteviolisosteviol results in increased expression of IRS1 mRNA22479612
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of IRS1 mRNA25307878|2743299
D007650Ketanserin[Ketanserin inhibits the reaction [Serotonin results in increased activity of AKT1 protein]] promotes the reaction [Serotonin inhibits the reaction [IRS1 protein binds to YWHAB protein]]22975078
D007650Ketanserin[[Ketanserin inhibits the reaction [Serotonin results in increased activity of AKT1 protein]] promotes the reaction [Serotonin inhibits the reaction [IRS1 protein binds to YWHAB protein]]] which results in increased ubiquitination of and results in increased degradation of IRS1 protein22975078
C045463leflunomideleflunomide results in increased expression of IRS1 mRNA28988120
C045463leflunomideleflunomide results in decreased expression of IRS1 mRNA19751817
C533894LG 100815LG 100815 results in decreased expression of IRS1 mRNA16951191
C027820ligustilideligustilide results in decreased phosphorylation of IRS1 protein23973442
C002385linsidominelinsidomine inhibits the reaction [INS1 protein results in increased phosphorylation of IRS1 protein]19682478
C002385linsidominelinsidomine results in increased metabolism of and results in decreased expression of IRS1 protein19682478
D008070Lipopolysaccharides"17-ethynyl-5-androstene-3, 7, 17-triol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IRS1 protein]"22384159
C042720mercuric bromidemercuric bromide results in increased expression of IRS1 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRS1 mRNA"27188386
D008687MetforminMetformin affects the reaction [Testosterone results in decreased expression of IRS1]19328476
D008687MetforminMetformin inhibits the reaction [Streptozocin results in decreased expression of IRS1 protein]23927877
D008687MetforminMetformin inhibits the reaction [Dehydroepiandrosterone results in decreased phosphorylation of IRS1 protein]27634381
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of IRS1 gene20938992
D008731MethoxychlorMethoxychlor results in increased methylation of IRS1 gene23303685
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of IRS1 mRNA23179753|2627250
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRS1 mRNA"27188386
C004925methylmercuric chloride[Cadmium Chloride co-treated with methylmercuric chloride] results in decreased expression of IRS1 mRNA27814245
C004925methylmercuric chloride[Cadmium Chloride co-treated with methylmercuric chloride] results in increased phosphorylation of IRS1 protein27814245
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of IRS1 mRNA"26251327
D008770MethylnitrosoureaHexachlorobenzene inhibits the reaction [Methylnitrosourea results in increased phosphorylation of IRS1 protein]16237195
D008770MethylnitrosoureaMethylnitrosourea results in increased phosphorylation of IRS1 protein16237195
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of IRS1 protein26364587
D0156551-Methyl-4-phenylpyridiniumINS protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of IRS1 protein]26364587
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of IRS1 mRNA25543134
C016599mono-(2-ethylhexyl)phthalate[INS1 protein co-treated with mono-(2-ethylhexyl)phthalate] results in decreased expression of IRS1 protein28526321
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of IRS1 protein24625837
C040015myricetinmyricetin inhibits the reaction [[Streptozocin co-treated with Cadmium] results in decreased expression of IRS1 protein]24923654
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of IRS1 mRNA"29244179
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IRS1 mRNA]17407152
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of IRS1 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of IRS1 mRNA"25554681|2562005
C005274naringinnaringin inhibits the reaction [Dietary Fats results in decreased phosphorylation of IRS1 protein]22198281
D009532NickelNickel results in decreased expression of IRS1 mRNA25583101
D009538NicotineNicotine results in decreased expression of IRS1 mRNA22265867
C002741N-nitrosomorpholineN-nitrosomorpholine results in increased expression of IRS1 protein21411721|9466558
C501177NVP-AEW541NVP-AEW541 inhibits the reaction [Estradiol promotes the reaction [AKT1 protein modified form binds to IRS1 protein]]19435893
C000594859nymphayolnymphayol results in increased phosphorylation of IRS1 protein25499137
C062198octa-2,4,6-trienoic acid"octa-2,4,6-trienoic acid results in decreased expression of IRS1 mRNA"16951191
D009828Oleanolic Acid[Fructose co-treated with Oleanolic Acid] results in increased expression of IRS1 mRNA24704288
D009828Oleanolic Acid[Fructose co-treated with Oleanolic Acid] results in increased expression of IRS1 protein24704288
D009828Oleanolic AcidOleanolic Acid inhibits the reaction [Fructose results in increased phosphorylation of IRS1 protein]24704288
D010168PalmitatesPalmitates inhibits the reaction [INS protein results in increased phosphorylation of IRS1 protein]23504962
D010168PalmitatesPalmitates results in increased phosphorylation of IRS1 protein23504962
D010168Palmitatesquercetin 3-O-glucuronide inhibits the reaction [Palmitates inhibits the reaction [INS protein results in increased phosphorylation of IRS1 protein]]23504962
D010168Palmitatesquercetin 3-O-glucuronide inhibits the reaction [Palmitates results in increased phosphorylation of IRS1 protein]23504962
D010168PalmitatesQuercetin inhibits the reaction [Palmitates inhibits the reaction [INS protein results in increased phosphorylation of IRS1 protein]]23504962
D010168PalmitatesQuercetin inhibits the reaction [Palmitates results in increased phosphorylation of IRS1 protein]23504962
D010168PalmitatesSodium Salicylate inhibits the reaction [Palmitates inhibits the reaction [INS protein results in increased phosphorylation of IRS1 protein]]23504962
D010168PalmitatesSodium Salicylate inhibits the reaction [Palmitates results in increased phosphorylation of IRS1 protein]23504962
D019308Palmitic Acid"3,3',4,5'-tetrahydroxystilbene inhibits the reaction [Palmitic Acid inhibits the reaction [INS protein results in increased phosphorylation of IRS1 protein]]"25815690
D019308Palmitic AcidPalmitic Acid inhibits the reaction [INS protein results in increased phosphorylation of IRS1 protein]25815690
D019308Palmitic Acid"tin protoporphyrin IX inhibits the reaction [3,3',4,5'-tetrahydroxystilbene inhibits the reaction [Palmitic Acid inhibits the reaction [INS protein results in increased phosphorylation of IRS1 protein]]]"25815690
D019308Palmitic Acid[isosteviol co-treated with Palmitic Acid] results in increased expression of IRS1 mRNA22479612
D010269ParaquatParaquat results in decreased expression of and results in increased phosphorylation of IRS1 protein23898955
D017374ParoxetineParoxetine affects the reaction [INS protein affects the phosphorylation of IRS1 protein]17728140
D017374ParoxetineParoxetine results in decreased activity of IRS1 protein17728140
D017374Paroxetinepyrazolanthrone inhibits the reaction [Paroxetine affects the reaction [INS protein affects the phosphorylation of IRS1 protein]]17728140
C522391perfluorododecanoic acidperfluorododecanoic acid results in decreased expression of IRS1 protein modified form23353032
C101816perfluoro-n-nonanoic acidperfluoro-n-nonanoic acid results in decreased expression of IRS1 protein modified form22387981
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of IRS1 mRNA26548598
C027579periodate-oxidized adenosineperiodate-oxidized adenosine affects the expression of IRS1 mRNA17097637
D026023Permethrin[Permethrin co-treated with INS protein] results in increased phosphorylation of IRS1 protein28866332
D010575PesticidesPesticides results in decreased methylation of IRS1 gene28396702
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRS1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of IRS1 mRNA26272509
D010705PhosgenePhosgene affects the expression of IRS1 mRNA16300373
D010798PhycocyaninPhycocyanin inhibits the reaction [Alloxan affects the phosphorylation of IRS1 protein]26827782
C006253pirinixic acidpirinixic acid results in decreased expression of IRS1 mRNA18445702
C006253pirinixic acidpirinixic acid results in increased expression of IRS1 mRNA18301758
D010936Plant ExtractsPlant Extracts inhibits the reaction [Glucose results in decreased expression of IRS1 protein]24262486
D010936Plant ExtractsPlant Extracts inhibits the reaction [Glucose results in decreased expression of IRS1 protein modified form]24262486
D010936Plant ExtractsPlant Extracts results in increased phosphorylation of IRS1 protein18534569
D028321Plant PreparationsPlant Preparations results in decreased expression of IRS1 mRNA23872130
D028321Plant PreparationsPlant Preparations results in decreased expression of IRS1 protein23872130
D011374ProgesteroneProgesterone results in decreased phosphorylation of IRS1 protein15949379
D011374ProgesteroneProgesterone results in increased phosphorylation of IRS1 protein15604210
C045950propiconazolepropiconazole results in increased expression of IRS1 mRNA21278054
C029658propionic acidpropionic acid results in decreased phosphorylation of IRS1 protein21472246
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [Paroxetine affects the reaction [INS protein affects the phosphorylation of IRS1 protein]]17728140
D011765PyruvaldehydePyruvaldehyde results in decreased phosphorylation of IRS1 protein23954466
D011794QuercetinQuercetin affects the reaction [[Fatty Acids co-treated with INS protein] affects the phosphorylation of IRS1 protein]24648896
D011794QuercetinQuercetin inhibits the reaction [Palmitates inhibits the reaction [INS protein results in increased phosphorylation of IRS1 protein]]23504962
D011794QuercetinQuercetin inhibits the reaction [Palmitates results in increased phosphorylation of IRS1 protein]23504962
D011794QuercetinQuercetin results in decreased expression of IRS1 mRNA21632981
D011794QuercetinQuercetin results in decreased expression of IRS1 protein12653748
D011794QuercetinQuercetin inhibits the reaction [IGF1 protein results in increased phosphorylation of IRS1 protein]24353828
D011794QuercetinQuercetin inhibits the reaction [Dehydroepiandrosterone results in decreased phosphorylation of IRS1 protein]27634381
D011794QuercetinQuercetin inhibits the reaction [Fructose results in decreased phosphorylation of IRS1 protein]22426011
D011794QuercetinQuercetin inhibits the reaction [TNF protein results in increased phosphorylation of IRS1 protein]20943792
C443401quercetin 3-O-glucuronidequercetin 3-O-glucuronide inhibits the reaction [Palmitates inhibits the reaction [INS protein results in increased phosphorylation of IRS1 protein]]23504962
C443401quercetin 3-O-glucuronidequercetin 3-O-glucuronide inhibits the reaction [Palmitates results in increased phosphorylation of IRS1 protein]23504962
C025474rebaudioside Arebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS1 mRNA]25554529
C059514resveratrolresveratrol inhibits the reaction [bisphenol A results in increased expression of IRS1 protein modified form]23810794
C059514resveratrolresveratrol inhibits the reaction [Estradiol results in increased expression of IRS1 protein modified form]23810794
C059514resveratrolresveratrol inhibits the reaction [IRS2 gene mutant form inhibits the reaction [INS protein results in increased phosphorylation of IRS1 protein]]25808216
C059514resveratrolresveratrol results in decreased activity of [IRS1 protein binds to PIK3R1 protein]17550345
C059514resveratrolresveratrol results in decreased expression of IRS1 protein18089832
C059514resveratrolresveratrol affects the phosphorylation of IRS1 protein20188786
C059514resveratrolresveratrol results in decreased expression of IRS1 mRNA22610192|2352548
C059514resveratrolresveratrol results in decreased expression of IRS1 protein18555852
C059514resveratrolresveratrol results in decreased phosphorylation of IRS1 protein22935344
C059514resveratrolresveratrol results in increased phosphorylation of IRS1 protein22309033
C059514resveratrol[Fructose co-treated with resveratrol] results in increased expression of IRS1 mRNA26488877
C059514resveratrolresveratrol inhibits the reaction [High Fructose Corn Syrup results in decreased expression of IRS1 mRNA]25238689
C059514resveratrolresveratrol inhibits the reaction [High Fructose Corn Syrup results in decreased expression of IRS1 protein]25238689
C059514resveratrolresveratrol inhibits the reaction [INS1 protein promotes the reaction [IRS1 protein binds to PIK3R1 protein]]16626303
C059514resveratrolresveratrol inhibits the reaction [Streptozocin results in decreased expression of IRS1 mRNA]26071184
C059514resveratrolresveratrol inhibits the reaction [Streptozocin results in decreased expression of IRS1 protein]26071184
C059514resveratrolresveratrol results in increased expression of IRS1 mRNA26071184|2648887
C059514resveratrolresveratrol results in increased expression of IRS1 protein26071184
C059514resveratrolresveratrol results in increased expression of IRS1 protein21575630|2173966
C059514resveratrolresveratrol inhibits the reaction [INS protein results in increased phosphorylation of IRS1 protein]21945106
C059514resveratrolresveratrol inhibits the reaction [TNF protein results in increased phosphorylation of IRS1 protein]20943792
C089730rosiglitazonerosiglitazone results in decreased expression of IRS1 mRNA21515302
D012431RutinRutin results in decreased expression of IRS1 protein20015448
D012431RutinRutin results in increased susceptibility to [Vitamin E results in decreased expression of IRS1 protein]20015448
D012431RutinVitamin E results in increased susceptibility to [Rutin results in decreased expression of IRS1 protein]20015448
D012431RutinRutin inhibits the reaction [Fructose results in decreased phosphorylation of IRS1 protein]22426011
C064294sarpogrelate[sarpogrelate results in increased activity of AKT1 protein] inhibits the reaction [Serotonin results in increased ubiquitination of and results in increased degradation of IRS1 protein]22975078
D020280SertralineSertraline affects the reaction [INS protein affects the phosphorylation of IRS1 protein]17728140
D020280SertralineSertraline results in decreased activity of IRS1 protein17728140
D012822Silicon DioxideSilicon Dioxide results in decreased expression of IRS1 mRNA23221170
D019821SimvastatinSimvastatin inhibits the reaction [IGF1 protein results in increased phosphorylation of IRS1 protein]27734117
D020123SirolimusSirolimus affects the phosphorylation of IRS1 protein17908691
D020123SirolimusSirolimus promotes the reaction [IGF1R protein binds to and results in increased phosphorylation of IRS1 protein]16227402
D020123SirolimusSirolimus promotes the reaction [IRS1 protein binds to PIK3R1 protein]17908691
D020123Sirolimus[Sirolimus results in decreased activity of RPS6KB1 protein] which results in increased activity of IRS1 protein17908691
D020123SirolimusSirolimus results in decreased degradation of IRS1 protein16227402|1790869
D020123SirolimusSirolimus results in decreased phosphorylation of IRS1 protein16227402
D020123SirolimusSirolimus inhibits the reaction [INS protein results in increased phosphorylation of IRS1 protein]18303120
D020123Sirolimus[Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [INS protein results in increased phosphorylation of IRS1 protein]18303120
C017947sodium arsenitesodium arsenite results in decreased expression of IRS1 mRNA24570342
C017947sodium arsenitesodium arsenite results in increased methylation of IRS1 gene24570342
C017947sodium arsenitegingerol inhibits the reaction [sodium arsenite results in decreased expression of IRS1 mRNA]22285432
C017947sodium arsenitegingerol inhibits the reaction [sodium arsenite results in decreased expression of IRS1 protein]22285432
C017947sodium arsenitesodium arsenite affects the expression of IRS125367288
C017947sodium arsenitesodium arsenite results in decreased expression of IRS1 mRNA22285432
C017947sodium arsenitesodium arsenite results in decreased expression of IRS1 protein22285432
D017673Sodium Chloride, Dietary"Sodium Chloride, Dietary results in increased phosphorylation of IRS1 protein"14670806
D012980Sodium SalicylateSodium Salicylate inhibits the reaction [Palmitates inhibits the reaction [INS protein results in increased phosphorylation of IRS1 protein]]23504962
D012980Sodium SalicylateSodium Salicylate inhibits the reaction [Palmitates results in increased phosphorylation of IRS1 protein]23504962
D018038Sodium SeleniteSodium Selenite promotes the reaction [[Streptozocin co-treated with Dietary Fats] affects the phosphorylation of IRS1 protein]26522834
D053260SootSoot results in decreased expression of IRS1 mRNA22461453
C012042steviolsteviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS1 mRNA]25554529
C012043steviosidestevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS1 mRNA]25554529
D013311StreptozocinMetformin inhibits the reaction [Streptozocin results in decreased expression of IRS1 protein]23927877
D013311StreptozocinSodium Selenite promotes the reaction [[Streptozocin co-treated with Dietary Fats] affects the phosphorylation of IRS1 protein]26522834
D013311Streptozocin[Streptozocin co-treated with Dietary Fats] affects the phosphorylation of IRS1 protein26522834
D013311StreptozocinStreptozocin results in decreased expression of IRS1 protein23927877
D013311Streptozocinmyricetin inhibits the reaction [[Streptozocin co-treated with Cadmium] results in decreased expression of IRS1 protein]24923654
D013311Streptozocinresveratrol inhibits the reaction [Streptozocin results in decreased expression of IRS1 mRNA]26071184
D013311Streptozocinresveratrol inhibits the reaction [Streptozocin results in decreased expression of IRS1 protein]26071184
D013311Streptozocin[Streptozocin co-treated with Cadmium] results in decreased expression of IRS1 protein24923654
D013311StreptozocinStreptozocin results in decreased expression of IRS1 mRNA26071184
D013311StreptozocinStreptozocin results in decreased expression of IRS1 protein26071184
D013629TamoxifenTamoxifen affects the expression of IRS1 mRNA14699072
D013654TaurineTaurine inhibits the reaction [Alloxan results in decreased phosphorylation of IRS1 protein]22138235
D013654TaurineTaurine results in increased phosphorylation of IRS1 protein22138235
C501413tesaglitazartesaglitazar results in decreased expression of IRS1 mRNA21515302
D013739TestosteroneMetformin affects the reaction [Testosterone results in decreased expression of IRS1]19328476
D013739TestosteroneTestosterone results in decreased expression of IRS119328476
D013739TestosteroneTestosterone results in increased expression of IRS1 mRNA20843997
D013739TestosteroneTestosterone inhibits the reaction [Dexamethasone results in decreased expression of IRS1 mRNA]20032058
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of IRS1 mRNA15688983
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of IRS1 mRNA]15688983
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of IRS1 mRNA21632981
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased phosphorylation of IRS1 protein9683191
D013749TetrachlorodibenzodioxinAHR protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of IRS1 mRNA]20181658
D013749TetrachlorodibenzodioxinColforsin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IRS1 mRNA]17407152
D013749TetrachlorodibenzodioxinMAPK8 protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of IRS1 protein]20181658
D013749TetrachlorodibenzodioxinN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IRS1 mRNA]17407152
D013749Tetrachlorodibenzodioxin"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of IRS1 mRNA"28433925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to IRS1 gene]21762485
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of IRS1 mRNA18691609|2018165
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of IRS1 protein20181658
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of IRS1 mRNA17407152
D013749TetrachlorodibenzodioxinTNF protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of IRS1 protein]20181658
D013749TetrachlorodibenzodioxinTNFRSF1A protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of IRS1 protein]20181658
D013749TetrachlorodibenzodioxinU 0126 inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of IRS1 protein]20181658
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [IGF1 protein results in increased phosphorylation of IRS1 protein]23639626
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of IRS1 mRNA20959002|2121527
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased phosphorylation of IRS1 protein23639626
D019284ThapsigarginThapsigargin affects the phosphorylation of and results in decreased expression of IRS1 protein22378314
D013806TheophyllineTheophylline results in increased expression of IRS1 mRNA16083514
C036680thorium nitratethorium nitrate analog results in increased phosphorylation of IRS1 protein24462957
C032628tin protoporphyrin IX"tin protoporphyrin IX inhibits the reaction [3,3',4,5'-tetrahydroxystilbene inhibits the reaction [Palmitic Acid inhibits the reaction [INS protein results in increased phosphorylation of IRS1 protein]]]"25815690
C009495titanium dioxidetitanium dioxide results in decreased expression of IRS1 mRNA23557971|2776080
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of IRS1 mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of IRS1 mRNA28111298
C496197trans-10,cis-12-conjugated linoleic acid"[trans-10,cis-12-conjugated linoleic acid co-treated with cis-9, trans-11-conjugated linoleic acid] results in decreased phosphorylation of IRS1 protein"17408517
D014212TretinoinTretinoin results in decreased expression of IRS1 mRNA23724009
C011559tributyltintributyltin results in decreased expression of and results in decreased phosphorylation of IRS1 protein28397090
D014241TrichloroethyleneTrichloroethylene results in decreased expression of IRS1 mRNA28973375
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRS1 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of IRS1 mRNA24935251|2627250
D014280TriglyceridesIRS1 gene polymorphism results in increased abundance of Triglycerides10591678
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of IRS1 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of IRS1 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of IRS1 mRNA21515302
D014415TunicamycinTunicamycin affects the phosphorylation of and results in decreased expression of IRS1 protein22378314
C113580U 0126U 0126 inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of IRS1 protein]20181658
D014520UrethaneUrethane results in decreased expression of IRS1 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRS1 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of IRS1 mRNA23179753|2627250
D014640VancomycinVancomycin results in increased expression of IRS1 mRNA18930951
D001335Vehicle EmissionsVehicle Emissions affects the expression of IRS1 mRNA23940539
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of IRS1 gene25560391
D014810Vitamin ERutin results in increased susceptibility to [Vitamin E results in decreased expression of IRS1 protein]20015448
D014810Vitamin EVitamin E results in decreased expression of IRS1 protein20015448
D014810Vitamin EVitamin E results in increased susceptibility to [Rutin results in decreased expression of IRS1 protein]20015448
D014810Vitamin E[Ascorbic Acid co-treated with Vitamin E] inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of IRS1 protein]21911000
D014810Vitamin E[Ascorbic Acid co-treated with Vitamin E] inhibits the reaction [Diethylhexyl Phthalate results in decreased phosphorylation of IRS1 protein]21911000
D015032ZincZinc results in decreased expression of IRS1 protein19913001
D015032ZincZinc results in increased phosphorylation of IRS1 protein15516700
D015032ZincZinc results in increased phosphorylation of IRS1 protein14644152

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001784phosphotyrosine residue binding-IPI20624904  
GO:0005068transmembrane receptor protein tyrosine kinase adaptor activity-ISS-  
GO:0005080protein kinase C binding-ISS-  
GO:0005088Ras guanyl-nucleotide exchange factor activity-TAS-  
GO:0005158insulin receptor binding-IBA21873635  
GO:0005158insulin receptor binding-IPI7493946  7537849  
GO:0005159insulin-like growth factor receptor binding-IPI7541045  
GO:0005515protein binding-IPI7513703  7542742  7559478  7680095  7680644  7935368  
8382612  8388384  8662806  9111084  9295312  9312143  
11018022  11063744  11403293  11416002  11694516  14632132  
16150444  16230374  16273093  16582879  18498745  18952604  
23643389  23770097  24008843  25814554  
GO:00163031-phosphatidylinositol-3-kinase activity-TAS-  
GO:0042169SH2 domain binding-ISS-  
GO:0043548phosphatidylinositol 3-kinase binding-IBA21873635  
GO:0043548phosphatidylinositol 3-kinase binding-IPI7782332  16043515  
GO:0043548phosphatidylinositol 3-kinase binding-ISS-  
GO:0046934phosphatidylinositol-4,5-bisphosphate 3-kinase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000165MAPK cascade-TAS-  
GO:0007165signal transduction-TAS1311924  
GO:0008284positive regulation of cell proliferation-NAS17925406  
GO:0008286insulin receptor signaling pathway-IBA21873635  
GO:0008286insulin receptor signaling pathway-IDA16516141  
GO:0008286insulin receptor signaling pathway-IMP16814735  
GO:0008286insulin receptor signaling pathway-IPI7537849  7559478  
GO:0010907positive regulation of glucose metabolic process-IMP16814735  
GO:0014065phosphatidylinositol 3-kinase signaling-IDA7782332  
GO:0019216regulation of lipid metabolic process-IBA21873635  
GO:0032000positive regulation of fatty acid beta-oxidation-IMP16814735  
GO:0032868response to insulin-IDA16516141  
GO:0032869cellular response to insulin stimulus-IMP16814735  
GO:0036092phosphatidylinositol-3-phosphate biosynthetic process-IEA-  
GO:0038111interleukin-7-mediated signaling pathway-TAS-  
GO:0042593glucose homeostasis-TAS16814735  
GO:0043434response to peptide hormone-ISS-  
GO:0043552positive regulation of phosphatidylinositol 3-kinase activity-ISS-  
GO:0045725positive regulation of glycogen biosynthetic process-IMP16814735  
GO:0045725positive regulation of glycogen biosynthetic process-NAS17925406  
GO:0046326positive regulation of glucose import-IMP16814735  
GO:0046627negative regulation of insulin receptor signaling pathway-ISS-  
GO:0046628positive regulation of insulin receptor signaling pathway-ISS-  
GO:0046676negative regulation of insulin secretion-IDA15572028  
GO:0046854phosphatidylinositol phosphorylation-IEA-  
GO:0048009insulin-like growth factor receptor signaling pathway-IPI7541045  
GO:0048015phosphatidylinositol-mediated signaling-TAS-  
GO:0051897positive regulation of protein kinase B signaling-TAS-  
GO:2001275positive regulation of glucose import in response to insulin stimulus-IDA7493946  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA-  
GO:0005634nucleus-ISS-  
GO:0005737cytoplasm-ISS-  
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-IDA-  
GO:0005886plasma membrane-TAS-  
GO:0005899insulin receptor complex-ISS-  
GO:0005901caveola-IDA15182363  
GO:0043231intracellular membrane-bounded organelle-ISS-  
KEGG ID KEGG Term
hsa04722Neurotrophin signaling pathway
hsa04910Insulin signaling pathway
hsa04920Adipocytokine signaling pathway
hsa04930Type II diabetes mellitus
hsa04960Aldosterone-regulated sodium reabsorption
Reactome ID Reactome Term Evidence
R-HSA-109704PI3K CascadeTAS
R-HSA-112399IRS-mediated signallingTAS
R-HSA-112399IRS-mediated signallingIEA
R-HSA-112412SOS-mediated signallingTAS
R-HSA-112412SOS-mediated signallingIEA
R-HSA-1257604PIP3 activates AKT signalingTAS
R-HSA-1266695Interleukin-7 signalingTAS
R-HSA-1280215Cytokine Signaling in Immune systemIEA
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-1643685DiseaseTAS
R-HSA-166520Signaling by NTRKsTAS
R-HSA-166520Signaling by NTRKsIEA
R-HSA-168256Immune SystemIEA
R-HSA-168256Immune SystemTAS
R-HSA-187037Signaling by NTRK1 (TRKA)TAS
R-HSA-187037Signaling by NTRK1 (TRKA)IEA
R-HSA-198203PI3K/AKT activationTAS
R-HSA-198203PI3K/AKT activationIEA
R-HSA-199418Negative regulation of the PI3K/AKT networkTAS
R-HSA-2219528PI3K/AKT Signaling in CancerTAS
R-HSA-2219530Constitutive Signaling by Aberrant PI3K in CancerTAS
R-HSA-2404192Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)TAS
R-HSA-2404192Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)IEA
R-HSA-2428924IGF1R signaling cascadeTAS
R-HSA-2428924IGF1R signaling cascadeIEA
R-HSA-2428928IRS-related events triggered by IGF1RTAS
R-HSA-2428928IRS-related events triggered by IGF1RIEA
R-HSA-2586552Signaling by LeptinIEA
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-5673001RAF/MAP kinase cascadeTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5684996MAPK1/MAPK3 signalingTAS
R-HSA-6811558PI5P, PP2A and IER3 Regulate PI3K/AKT SignalingTAS
R-HSA-74713IRS activationTAS
R-HSA-74749Signal attenuationTAS
R-HSA-74751Insulin receptor signalling cascadeTAS
R-HSA-74751Insulin receptor signalling cascadeIEA
R-HSA-74752Signaling by Insulin receptorTAS
R-HSA-74752Signaling by Insulin receptorIEA
R-HSA-9006925Intracellular signaling by second messengersTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesIEA
R-HSA-982772Growth hormone receptor signalingIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25557790An exon variant in insulin receptor gene is associated with susceptibility to colorectal cancer in women. (2015 May)Mahmoudi TTumour Biol
25799226Activation of AMPKalpha2 in adipocytes is essential for nicotine-induced insulin resistance in vivo. (2015 Apr)Wu YNat Med
26868433Is common genetic variation at IRS1, ENPP1 and TRIB3 loci associated with cardiometabolic phenotypes in type 2 diabetes? An exploratory analysis of the Verona Newly Diagnosed Type 2 Diabetes Study (VNDS) 5. (2016 Mar)Trombetta MNutr Metab Cardiovasc Dis