C026486 | 1,2,5,6-dibenzanthracene | "1,2,5,6-dibenzanthracene results in decreased expression of IRS1 mRNA" | 26377693 |
D014013 | 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt | "1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of IRS1 protein]" | 17458902 |
C028474 | 1,4-bis(2-(3,5-dichloropyridyloxy))benzene | "1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of IRS1 mRNA" | 28903501 |
C524733 | 17-ethynyl-5-androstene-3, 7, 17-triol | "17-ethynyl-5-androstene-3, 7, 17-triol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IRS1 protein]" | 22384159 |
C044755 | 1-methyl-4-phenyl-2,3-dihydropyridinium | "1-methyl-4-phenyl-2,3-dihydropyridinium results in decreased expression of IRS1 mRNA" | 21856379 |
C014024 | 2,4,5,2',4',5'-hexachlorobiphenyl | "[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of IRS1 mRNA" | 28433925 |
C016403 | 2,4-dinitrotoluene | "2,4-dinitrotoluene affects the expression of IRS1 mRNA" | 21346803 |
C041525 | 3,3',4,5'-tetrahydroxystilbene | "3,3',4,5'-tetrahydroxystilbene inhibits the reaction [Palmitic Acid inhibits the reaction [INS protein results in increased phosphorylation of IRS1 protein]]" | 25815690 |
C041525 | 3,3',4,5'-tetrahydroxystilbene | "tin protoporphyrin IX inhibits the reaction [3,3',4,5'-tetrahydroxystilbene inhibits the reaction [Palmitic Acid inhibits the reaction [INS protein results in increased phosphorylation of IRS1 protein]]]" | 25815690 |
C041525 | 3,3',4,5'-tetrahydroxystilbene | "3,3',4,5'-tetrahydroxystilbene inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased phosphorylation of IRS1 protein]" | 22298784 |
C023035 | 3,4,5,3',4'-pentachlorobiphenyl | "3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of IRS1 mRNA" | 20959002 |
C041477 | 3-hydroxyflavone | 3-hydroxyflavone inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of IRS1 protein] | 17458902 |
C459179 | 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide | "[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRS1 mRNA" | 27188386 |
C459179 | 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide | "[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRS1 mRNA" | 27188386 |
C459179 | 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide | "[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRS1 mRNA" | 27188386 |
C459179 | 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide | "[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRS1 mRNA" | 27188386 |
C459179 | 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide | "[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRS1 mRNA" | 27188386 |
C517041 | (4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) | "(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in decreased expression of IRS1 mRNA" | 19561079 |
C466420 | 5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrinato iron(III) chloride | "5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrinato iron(III) chloride inhibits the reaction [Dietary Fats inhibits the reaction [INS1 protein results in increased phosphorylation of IRS1 protein]]" | 19682478 |
C466420 | 5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrinato iron(III) chloride | "5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrinato iron(III) chloride inhibits the reaction [Dietary Fats results in increased metabolism of IRS1 protein]" | 19682478 |
C516138 | (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine | "[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRS1 mRNA" | 27188386 |
C516138 | (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine | "[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRS1 mRNA" | 27188386 |
C516138 | (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine | "[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRS1 mRNA" | 27188386 |
C516138 | (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine | "[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRS1 mRNA" | 27188386 |
C516138 | (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine | "[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRS1 mRNA" | 27188386 |
D000082 | Acetaminophen | Acetaminophen results in decreased expression of IRS1 mRNA | 21420995 |
D000082 | Acetaminophen | Acetaminophen results in increased expression of IRS1 mRNA | 22230336 |
D000111 | Acetylcysteine | Acetylcysteine inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of IRS1 protein] | 17458902 |
D020106 | Acrylamide | Acrylamide results in decreased expression of IRS1 mRNA | 28959563 |
D016604 | Aflatoxin B1 | Aflatoxin B1 results in decreased expression of IRS1 mRNA | 22100608|2715375 |
D016604 | Aflatoxin B1 | Aflatoxin B1 results in decreased methylation of IRS1 gene | 27153756 |
D000493 | Allopurinol | Allopurinol inhibits the reaction [Fructose results in decreased phosphorylation of IRS1 protein] | 22426011 |
D000496 | Alloxan | Alloxan affects the phosphorylation of IRS1 protein | 26827782 |
D000496 | Alloxan | Phycocyanin inhibits the reaction [Alloxan affects the phosphorylation of IRS1 protein] | 26827782 |
D000496 | Alloxan | Alloxan results in decreased phosphorylation of IRS1 protein | 22138235 |
D000496 | Alloxan | Taurine inhibits the reaction [Alloxan results in decreased phosphorylation of IRS1 protein] | 22138235 |
D000643 | Ammonium Chloride | Ammonium Chloride affects the expression of IRS1 mRNA | 16483693 |
D018501 | Antirheumatic Agents | Antirheumatic Agents results in increased expression of IRS1 mRNA | 24449571 |
C006632 | arsenic trioxide | arsenic trioxide results in decreased expression of IRS1 mRNA | 20458559 |
C006632 | arsenic trioxide | IRS1 mRNA affects the susceptibility to arsenic trioxide | 23911876 |
C015001 | arsenite | arsenite results in decreased methylation of IRS1 promoter | 23974009 |
D001205 | Ascorbic Acid | [Ascorbic Acid co-treated with Vitamin E] inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of IRS1 protein] | 21911000 |
D001205 | Ascorbic Acid | [Ascorbic Acid co-treated with Vitamin E] inhibits the reaction [Diethylhexyl Phthalate results in decreased phosphorylation of IRS1 protein] | 21911000 |
D001241 | Aspirin | IRS1 polymorphism affects the susceptibility to Aspirin | 15066917 |
D001280 | Atrazine | Atrazine affects the phosphorylation of IRS1 protein | 22378314 |
D001379 | Azathioprine | Azathioprine results in increased phosphorylation of and results in decreased expression of IRS1 protein | 23958494 |
D001564 | Benzo(a)pyrene | Benzo(a)pyrene results in decreased expression of IRS1 mRNA | 26238291 |
D001564 | Benzo(a)pyrene | Benzo(a)pyrene results in increased expression of IRS1 mRNA | 21632981 |
D001564 | Benzo(a)pyrene | Benzo(a)pyrene results in increased phosphorylation of IRS1 protein | 9683191 |
D001564 | Benzo(a)pyrene | Benzo(a)pyrene results in decreased expression of IRS1 mRNA | 21569818 |
D001564 | Benzo(a)pyrene | Benzo(a)pyrene results in increased expression of IRS1 mRNA | 19770486 |
D015123 | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide | "7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of IRS1 mRNA" | 20382639 |
C072553 | benzyloxycarbonylleucyl-leucyl-leucine aldehyde | benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [INS1 protein results in decreased expression of IRS1 protein] | 24219910 |
D004958 | Estradiol | "1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of IRS1 protein]" | 17458902 |
D004958 | Estradiol | 3-hydroxyflavone inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of IRS1 protein] | 17458902 |
D004958 | Estradiol | Acetylcysteine inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of IRS1 protein] | 17458902 |
D004958 | Estradiol | [Cycloheximide co-treated with Estradiol] results in increased expression of IRS1 mRNA | 15072547 |
D004958 | Estradiol | EGF protein promotes the reaction [Estradiol results in increased expression of IRS1 mRNA] | 24758408 |
D004958 | Estradiol | [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of IRS1 mRNA | 15688983 |
D004958 | Estradiol | Estradiol promotes the reaction [AKT1 protein modified form binds to IRS1 protein] | 19435893 |
D004958 | Estradiol | Estradiol results in decreased phosphorylation of IRS1 protein | 15949379 |
D004958 | Estradiol | Estradiol results in increased expression of IRS1 mRNA | 15072547|1568898 |
D004958 | Estradiol | Estradiol results in increased expression of IRS1 protein modified form | 23810794 |
D004958 | Estradiol | Estradiol results in increased phosphorylation of IRS1 protein | 23933164 |
D004958 | Estradiol | fulvestrant inhibits the reaction [[Hexachlorobenzene co-treated with Estradiol] results in increased phosphorylation of IRS1 protein] | 19879930 |
D004958 | Estradiol | Genistein inhibits the reaction [Estradiol results in increased phosphorylation of IRS1 protein] | 23933164 |
D004958 | Estradiol | [Hexachlorobenzene co-treated with Estradiol] results in increased phosphorylation of IRS1 protein | 19879930 |
D004958 | Estradiol | [IGF1 protein co-treated with Estradiol] results in increased phosphorylation of IRS1 protein | 17458902 |
D004958 | Estradiol | NVP-AEW541 inhibits the reaction [Estradiol promotes the reaction [AKT1 protein modified form binds to IRS1 protein]] | 19435893 |
D004958 | Estradiol | PTEN protein affects the reaction [Estradiol promotes the reaction [AKT1 protein modified form binds to IRS1 protein]] | 19435893 |
D004958 | Estradiol | resveratrol inhibits the reaction [Estradiol results in increased expression of IRS1 protein modified form] | 23810794 |
D004958 | Estradiol | Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of IRS1 mRNA] | 15688983 |
D004958 | Estradiol | Estradiol results in increased phosphorylation of IRS1 protein | 15604210 |
D004958 | Estradiol | [bisphenol A co-treated with Estradiol] results in increased expression of IRS1 mRNA | 26496021 |
D004958 | Estradiol | Estradiol results in decreased expression of IRS1 protein | 22142692 |
C511635 | bis(allixinato)oxovanadium(IV) | bis(allixinato)oxovanadium(IV) results in increased phosphorylation of IRS1 protein | 17805585 |
C512927 | bis(alpha-furancarboxylato)oxovanadium(IV) | bis(alpha-furancarboxylato)oxovanadium(IV) inhibits the reaction [Dexamethasone results in decreased expression of IRS1 mRNA] | 18812026 |
C006780 | bisphenol A | bisphenol A results in increased expression of IRS1 mRNA | 16029874 |
C006780 | bisphenol A | bisphenol A results in increased expression of IRS1 protein modified form | 23810794 |
C006780 | bisphenol A | bisphenol A results in increased phosphorylation of IRS1 protein | 23933164 |
C006780 | bisphenol A | Genistein inhibits the reaction [bisphenol A results in increased phosphorylation of IRS1 protein] | 23933164 |
C006780 | bisphenol A | resveratrol inhibits the reaction [bisphenol A results in increased expression of IRS1 protein modified form] | 23810794 |
C006780 | bisphenol A | bisphenol A results in decreased expression of IRS1 mRNA | 26779933 |
C006780 | bisphenol A | bisphenol A results in decreased phosphorylation of IRS1 protein | 25637671|2717670 |
C006780 | bisphenol A | bisphenol A results in increased expression of IRS1 protein | 22470480 |
C006780 | bisphenol A | bisphenol A results in increased phosphorylation of IRS1 protein | 26779933|2692323 |
C006780 | bisphenol A | "[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of IRS1 mRNA" | 28433925 |
C006780 | bisphenol A | bisphenol A affects the expression of IRS1 mRNA | 25181051 |
C006780 | bisphenol A | [bisphenol A co-treated with Estradiol] results in increased expression of IRS1 mRNA | 26496021 |
C006780 | bisphenol A | bisphenol A results in decreased expression of and results in decreased phosphorylation of IRS1 protein | 28739533 |
C006780 | bisphenol A | bisphenol A results in decreased expression of IRS1 protein | 22142692 |
C006780 | bisphenol A | bisphenol A results in decreased phosphorylation of IRS1 protein | 28153594 |
C006780 | bisphenol A | bisphenol A results in increased expression of IRS1 protein | 27836638 |
D000069286 | Bortezomib | Bortezomib results in decreased degradation of IRS1 protein | 16227402 |
D015124 | 8-Bromo Cyclic Adenosine Monophosphate | 8-Bromo Cyclic Adenosine Monophosphate results in increased expression of IRS1 mRNA | 22079614 |
D002104 | Cadmium | myricetin inhibits the reaction [[Streptozocin co-treated with Cadmium] results in decreased expression of IRS1 protein] | 24923654 |
D002104 | Cadmium | [Streptozocin co-treated with Cadmium] results in decreased expression of IRS1 protein | 24923654 |
D019256 | Cadmium Chloride | [Cadmium Chloride co-treated with methylmercuric chloride] results in decreased expression of IRS1 mRNA | 27814245 |
D019256 | Cadmium Chloride | [Cadmium Chloride co-treated with methylmercuric chloride] results in increased phosphorylation of IRS1 protein | 27814245 |
C055494 | caffeic acid phenethyl ester | caffeic acid phenethyl ester results in decreased expression of IRS1 mRNA | 21467634 |
D002211 | Capsaicin | Capsaicin results in increased expression of IRS1 mRNA | 19798065 |
D002220 | Carbamazepine | Carbamazepine affects the expression of IRS1 mRNA | 24752500 |
D002251 | Carbon Tetrachloride | Carbon Tetrachloride affects the expression of IRS1 mRNA | 17484886 |
D002330 | Carmustine | Carmustine results in decreased expression of IRS1 mRNA | 15980968 |
D002392 | Catechin | Catechin inhibits the reaction [Glucose results in decreased expression of IRS1 protein] | 24262486 |
D002392 | Catechin | Catechin inhibits the reaction [Glucose results in decreased expression of IRS1 protein modified form] | 24262486 |
C523455 | CCG 1423 | CCG 1423 promotes the reaction [INS protein results in increased phosphorylation of IRS1 protein] | 21393865 |
D002737 | Chloroprene | Chloroprene results in decreased expression of IRS1 mRNA | 23125180 |
D002784 | Cholesterol | IRS1 gene polymorphism affects the abundance of Cholesterol | 10591678 |
D002791 | Cholesterol, Dietary | "[Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of and results in decreased phosphorylation of IRS1 protein" | 19509184 |
D002794 | Choline | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of IRS1 gene | 20938992 |
D002857 | Chromium | Chromium inhibits the reaction [Dietary Fats results in decreased expression of IRS1 protein] | 20513351 |
D002857 | Chromium | Chromium results in increased phosphorylation of IRS1 protein | 15516700 |
D002857 | Chromium | Chromium affects the expression of IRS1 mRNA | 15862035 |
D002857 | Chromium | Chromium promotes the reaction [INS1 protein results in increased phosphorylation of IRS1 protein] | 16424121 |
D017608 | Chromium Compounds | Chromium Compounds results in decreased phosphorylation of IRS1 protein | 21472246 |
D017608 | Chromium Compounds | Chromium Compounds results in increased phosphorylation of IRS1 protein | 21472246 |
C512471 | chromium (D-Phenylalanine)3 | chromium (D-Phenylalanine)3 results in decreased expression of IRS1 protein modified form | 18388893 |
C074702 | chromium hexavalent ion | chromium hexavalent ion results in increased expression of IRS1 protein | 23748240 |
C074702 | chromium hexavalent ion | MIR143 inhibits the reaction [chromium hexavalent ion results in increased expression of IRS1 protein] | 23748240 |
C074702 | chromium hexavalent ion | chromium hexavalent ion results in decreased expression of and results in decreased phosphorylation of IRS1 protein | 28911802 |
C079689 | chromium tripicolinate | chromium tripicolinate promotes the reaction [INS1 protein results in increased phosphorylation of IRS1 protein] | 16424121 |
C503589 | cis-9, trans-11-conjugated linoleic acid | "cis-9, trans-11-conjugated linoleic acid inhibits the reaction [TNF protein results in decreased expression of IRS1 mRNA]" | 17327424 |
C503589 | cis-9, trans-11-conjugated linoleic acid | "[trans-10,cis-12-conjugated linoleic acid co-treated with cis-9, trans-11-conjugated linoleic acid] results in decreased phosphorylation of IRS1 protein" | 17408517 |
C018021 | cobaltous chloride | cobaltous chloride results in decreased expression of IRS1 mRNA | 19376846 |
D005576 | Colforsin | Colforsin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IRS1 mRNA] | 17407152 |
D019327 | Copper Sulfate | Copper Sulfate results in increased expression of IRS1 mRNA | 19549813 |
D003375 | Coumestrol | [Coumestrol co-treated with ESR1 protein] results in increased expression of IRS1 mRNA | 18310284 |
D003375 | Coumestrol | ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of IRS1 mRNA] | 18310284 |
C030973 | cupric oxide | cupric oxide results in decreased expression of IRS1 mRNA | 22077320 |
D003474 | Curcumin | Curcumin affects the phosphorylation of IRS1 protein | 27208389 |
D003474 | Curcumin | Curcumin inhibits the reaction [Fructose affects the phosphorylation of IRS1 protein] | 26713546 |
D003513 | Cycloheximide | [Cycloheximide co-treated with Estradiol] results in increased expression of IRS1 mRNA | 15072547 |
D003513 | Cycloheximide | Cycloheximide results in decreased expression of IRS1 mRNA | 15072547 |
D003520 | Cyclophosphamide | [Doxorubicin co-treated with Cyclophosphamide] affects the expression of IRS1 mRNA | 16322899 |
D016572 | Cyclosporine | Cyclosporine results in decreased expression of IRS1 mRNA | 20106945 |
D016572 | Cyclosporine | Cyclosporine results in decreased expression of IRS1 mRNA | 19770486 |
D016572 | Cyclosporine | Cyclosporine results in decreased expression of IRS1 mRNA | 21865292 |
D003687 | Dehydroepiandrosterone | Dehydroepiandrosterone results in decreased phosphorylation of IRS1 protein | 27634381 |
D003687 | Dehydroepiandrosterone | Metformin inhibits the reaction [Dehydroepiandrosterone results in decreased phosphorylation of IRS1 protein] | 27634381 |
D003687 | Dehydroepiandrosterone | Quercetin inhibits the reaction [Dehydroepiandrosterone results in decreased phosphorylation of IRS1 protein] | 27634381 |
D003907 | Dexamethasone | "3,3',4,5'-tetrahydroxystilbene inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased phosphorylation of IRS1 protein]" | 22298784 |
D003907 | Dexamethasone | bis(alpha-furancarboxylato)oxovanadium(IV) inhibits the reaction [Dexamethasone results in decreased expression of IRS1 mRNA] | 18812026 |
D003907 | Dexamethasone | [Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased phosphorylation of IRS1 protein | 22298784 |
D003907 | Dexamethasone | Dexamethasone results in decreased expression of and results in increased phosphorylation of IRS1 protein | 22733784 |
D003907 | Dexamethasone | Dexamethasone results in decreased expression of IRS1 mRNA | 18812026 |
D003907 | Dexamethasone | PIK3R1 mutant form inhibits the reaction [Dexamethasone results in decreased expression of and results in increased phosphorylation of IRS1 protein] | 22733784 |
D003907 | Dexamethasone | Dexamethasone results in decreased expression of IRS1 mRNA | 20032058 |
D003907 | Dexamethasone | Testosterone inhibits the reaction [Dexamethasone results in decreased expression of IRS1 mRNA] | 20032058 |
D003907 | Dexamethasone | Dexamethasone results in decreased expression of IRS1 mRNA | 19852296 |
D002945 | Cisplatin | Cisplatin results in decreased expression of IRS1 mRNA | 19561079|2739243 |
D002945 | Cisplatin | IRS1 results in decreased susceptibility to Cisplatin | 21849418 |
D002945 | Cisplatin | Cisplatin results in increased expression of IRS1 mRNA | 21151649 |
D004008 | Diclofenac | Diclofenac affects the expression of IRS1 mRNA | 24752500 |
D004008 | Diclofenac | Diclofenac affects the expression of IRS1 mRNA | 26934552 |
C000944 | dicrotophos | dicrotophos results in increased expression of IRS1 mRNA | 28302478 |
D004040 | Dietary Carbohydrates | Dietary Carbohydrates results in decreased expression of IRS1 mRNA | 23872130 |
D004040 | Dietary Carbohydrates | Dietary Carbohydrates results in decreased expression of IRS1 protein | 23872130 |
D004041 | Dietary Fats | "[Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of and results in decreased phosphorylation of IRS1 protein" | 19509184 |
D004041 | Dietary Fats | "5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrinato iron(III) chloride inhibits the reaction [Dietary Fats inhibits the reaction [INS1 protein results in increased phosphorylation of IRS1 protein]]" | 19682478 |
D004041 | Dietary Fats | "5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrinato iron(III) chloride inhibits the reaction [Dietary Fats results in increased metabolism of IRS1 protein]" | 19682478 |
D004041 | Dietary Fats | [AGT protein affects the susceptibility to Dietary Fats] which affects the expression of IRS1 mRNA | 26704350 |
D004041 | Dietary Fats | Chromium inhibits the reaction [Dietary Fats results in decreased expression of IRS1 protein] | 20513351 |
D004041 | Dietary Fats | Dietary Fats inhibits the reaction [INS1 protein results in increased phosphorylation of IRS1 protein] | 19682478 |
D004041 | Dietary Fats | Dietary Fats results in decreased expression of IRS1 mRNA | 23954404 |
D004041 | Dietary Fats | Dietary Fats results in decreased expression of IRS1 protein | 20513351 |
D004041 | Dietary Fats | Dietary Fats results in decreased phosphorylation of IRS1 protein | 22198281 |
D004041 | Dietary Fats | Dietary Fats results in increased expression of IRS1 mRNA | 24398136 |
D004041 | Dietary Fats | Dietary Fats results in increased metabolism of IRS1 protein | 19682478 |
D004041 | Dietary Fats | naringin inhibits the reaction [Dietary Fats results in decreased phosphorylation of IRS1 protein] | 22198281 |
D004041 | Dietary Fats | Sodium Selenite promotes the reaction [[Streptozocin co-treated with Dietary Fats] affects the phosphorylation of IRS1 protein] | 26522834 |
D004041 | Dietary Fats | [Streptozocin co-treated with Dietary Fats] affects the phosphorylation of IRS1 protein | 26522834 |
D004051 | Diethylhexyl Phthalate | "[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of IRS1 mRNA" | 28433925 |
D004051 | Diethylhexyl Phthalate | [Ascorbic Acid co-treated with Vitamin E] inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of IRS1 protein] | 21911000 |
D004051 | Diethylhexyl Phthalate | [Ascorbic Acid co-treated with Vitamin E] inhibits the reaction [Diethylhexyl Phthalate results in decreased phosphorylation of IRS1 protein] | 21911000 |
D004051 | Diethylhexyl Phthalate | Diethylhexyl Phthalate affects the phosphorylation of IRS1 protein | 25280772 |
D004051 | Diethylhexyl Phthalate | Diethylhexyl Phthalate inhibits the reaction [INS1 protein results in increased phosphorylation of IRS1 protein] | 28526321 |
D004051 | Diethylhexyl Phthalate | Diethylhexyl Phthalate results in decreased expression of IRS1 protein | 21911000 |
D004051 | Diethylhexyl Phthalate | Diethylhexyl Phthalate results in decreased phosphorylation of IRS1 protein | 21911000 |
D004051 | Diethylhexyl Phthalate | Diethylhexyl Phthalate results in increased expression of IRS1 mRNA | 21911000 |
D004051 | Diethylhexyl Phthalate | [INS1 protein co-treated with Diethylhexyl Phthalate] results in decreased expression of IRS1 protein | 28526321 |
D004052 | Diethylnitrosamine | Diethylnitrosamine affects the expression of IRS1 mRNA | 20387270 |
D004054 | Diethylstilbestrol | Diethylstilbestrol results in decreased expression of IRS1 mRNA | 25242112 |
D004054 | Diethylstilbestrol | Diethylstilbestrol results in decreased expression of IRS1 protein | 25242112 |
D002117 | Calcitriol | Calcitriol results in increased expression of IRS1 mRNA | 16002434|2648566 |
C076126 | disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate | "disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate results in increased expression of IRS1 mRNA" | 20184727 |
D004317 | Doxorubicin | [Doxorubicin co-treated with Cyclophosphamide] affects the expression of IRS1 mRNA | 16322899 |
D000431 | Ethanol | Ethanol affects the phosphorylation of IRS1 protein | 18377926 |
D000431 | Ethanol | Ethanol results in decreased phosphorylation of IRS1 protein | 28131861 |
D000431 | Ethanol | Ethanol results in decreased phosphorylation of IRS1 protein | 12700235 |
D000431 | Ethanol | [Ethanol results in decreased susceptibility to INS1 protein] which results in decreased expression of and results in decreased activity of IRS1 protein | 12700235 |
D004997 | Ethinyl Estradiol | Ethinyl Estradiol results in increased expression of IRS1 mRNA | 29097150 |
D005227 | Fatty Acids | [Fatty Acids co-treated with INS protein] affects the phosphorylation of IRS1 protein | 24648896 |
D005227 | Fatty Acids | Quercetin affects the reaction [[Fatty Acids co-treated with INS protein] affects the phosphorylation of IRS1 protein] | 24648896 |
D005227 | Fatty Acids | Fatty Acids affects the expression of IRS1 mRNA | 17940560 |
D005492 | Folic Acid | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of IRS1 gene | 20938992 |
D005557 | Formaldehyde | Formaldehyde results in decreased expression of IRS1 mRNA | 20655997|2766457 |
D005632 | Fructose | "[Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of and results in decreased phosphorylation of IRS1 protein" | 19509184 |
D005632 | Fructose | Allopurinol inhibits the reaction [Fructose results in decreased phosphorylation of IRS1 protein] | 22426011 |
D005632 | Fructose | Curcumin inhibits the reaction [Fructose affects the phosphorylation of IRS1 protein] | 26713546 |
D005632 | Fructose | Fructose affects the phosphorylation of IRS1 protein | 26713546 |
D005632 | Fructose | [Fructose co-treated with Oleanolic Acid] results in increased expression of IRS1 mRNA | 24704288 |
D005632 | Fructose | [Fructose co-treated with Oleanolic Acid] results in increased expression of IRS1 protein | 24704288 |
D005632 | Fructose | [Fructose co-treated with resveratrol] results in increased expression of IRS1 mRNA | 26488877 |
D005632 | Fructose | Fructose results in decreased expression of IRS1 mRNA | 19165636 |
D005632 | Fructose | Fructose results in decreased expression of IRS1 protein | 19008412 |
D005632 | Fructose | Fructose results in decreased phosphorylation of IRS1 protein | 22426011 |
D005632 | Fructose | Fructose results in increased phosphorylation of IRS1 protein | 24704288 |
D005632 | Fructose | NOS3 protein inhibits the reaction [Fructose results in decreased expression of IRS1 protein] | 19008412 |
D005632 | Fructose | Oleanolic Acid inhibits the reaction [Fructose results in increased phosphorylation of IRS1 protein] | 24704288 |
D005632 | Fructose | Quercetin inhibits the reaction [Fructose results in decreased phosphorylation of IRS1 protein] | 22426011 |
D005632 | Fructose | Rutin inhibits the reaction [Fructose results in decreased phosphorylation of IRS1 protein] | 22426011 |
C070081 | fulvestrant | fulvestrant inhibits the reaction [[Hexachlorobenzene co-treated with Estradiol] results in increased phosphorylation of IRS1 protein] | 19879930 |
C070081 | fulvestrant | fulvestrant inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of IRS1 protein] | 19879930 |
C070081 | fulvestrant | fulvestrant results in decreased expression of IRS1 mRNA | 15072547 |
D019833 | Genistein | Genistein inhibits the reaction [bisphenol A results in increased phosphorylation of IRS1 protein] | 23933164 |
D019833 | Genistein | Genistein inhibits the reaction [Estradiol results in increased phosphorylation of IRS1 protein] | 23933164 |
D019833 | Genistein | Genistein results in increased expression of IRS1 mRNA | 22228119 |
C007845 | gingerol | gingerol inhibits the reaction [sodium arsenite results in decreased expression of IRS1 mRNA] | 22285432 |
C007845 | gingerol | gingerol inhibits the reaction [sodium arsenite results in decreased expression of IRS1 protein] | 22285432 |
C049864 | ginsenoside Re | ginsenoside Re inhibits the reaction [TNF protein results in increased phosphorylation of IRS1 protein] | 17885204 |
C049864 | ginsenoside Re | ginsenoside Re results in increased expression of IRS1 mRNA | 23545455 |
C049864 | ginsenoside Re | ginsenoside Re results in increased phosphorylation of IRS1 protein | 17885204 |
D005947 | Glucose | Catechin inhibits the reaction [Glucose results in decreased expression of IRS1 protein] | 24262486 |
D005947 | Glucose | Catechin inhibits the reaction [Glucose results in decreased expression of IRS1 protein modified form] | 24262486 |
D005947 | Glucose | Glucose promotes the reaction [PIK3R1 protein binds to IRS1 protein] | 10430617 |
D005947 | Glucose | Glucose results in decreased expression of IRS1 protein | 24262486 |
D005947 | Glucose | Glucose results in decreased expression of IRS1 protein modified form | 24262486 |
D005947 | Glucose | Glucose results in increased phosphorylation of IRS1 protein | 10430617 |
D005947 | Glucose | IRS1 protein polymorphism inhibits the reaction [Glucose results in increased secretion of INS protein] | 10430617 |
D005947 | Glucose | Plant Extracts inhibits the reaction [Glucose results in decreased expression of IRS1 protein] | 24262486 |
D005947 | Glucose | Plant Extracts inhibits the reaction [Glucose results in decreased expression of IRS1 protein modified form] | 24262486 |
D005905 | Glyburide | IRS1 protein polymorphism inhibits the reaction [Glyburide results in increased secretion of INS protein] | 10430617 |
D006581 | Hexachlorobenzene | fulvestrant inhibits the reaction [[Hexachlorobenzene co-treated with Estradiol] results in increased phosphorylation of IRS1 protein] | 19879930 |
D006581 | Hexachlorobenzene | fulvestrant inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of IRS1 protein] | 19879930 |
D006581 | Hexachlorobenzene | [Hexachlorobenzene co-treated with Estradiol] results in increased phosphorylation of IRS1 protein | 19879930 |
D006581 | Hexachlorobenzene | Hexachlorobenzene results in increased phosphorylation of IRS1 protein | 19879930 |
D006581 | Hexachlorobenzene | Hexachlorobenzene inhibits the reaction [Methylnitrosourea results in increased phosphorylation of IRS1 protein] | 16237195 |
D006581 | Hexachlorobenzene | Hexachlorobenzene results in increased expression of IRS1 protein | 16237195 |
D006581 | Hexachlorobenzene | Hexachlorobenzene results in increased phosphorylation of IRS1 protein | 16237195 |
D066248 | High Fructose Corn Syrup | High Fructose Corn Syrup results in decreased expression of IRS1 mRNA | 25238689 |
D066248 | High Fructose Corn Syrup | High Fructose Corn Syrup results in decreased expression of IRS1 protein | 25238689 |
D066248 | High Fructose Corn Syrup | resveratrol inhibits the reaction [High Fructose Corn Syrup results in decreased expression of IRS1 mRNA] | 25238689 |
D066248 | High Fructose Corn Syrup | resveratrol inhibits the reaction [High Fructose Corn Syrup results in decreased expression of IRS1 protein] | 25238689 |
D012701 | Serotonin | [Ketanserin inhibits the reaction [Serotonin results in increased activity of AKT1 protein]] promotes the reaction [Serotonin inhibits the reaction [IRS1 protein binds to YWHAB protein]] | 22975078 |
D012701 | Serotonin | [[Ketanserin inhibits the reaction [Serotonin results in increased activity of AKT1 protein]] promotes the reaction [Serotonin inhibits the reaction [IRS1 protein binds to YWHAB protein]]] which results in increased ubiquitination of and results in increased degradation of IRS1 protein | 22975078 |
D012701 | Serotonin | [sarpogrelate results in increased activity of AKT1 protein] inhibits the reaction [Serotonin results in increased ubiquitination of and results in increased degradation of IRS1 protein] | 22975078 |
D012701 | Serotonin | Serotonin affects the localization of and results in increased ubiquitination of and results in increased degradation of IRS1 protein | 22975078 |
D012701 | Serotonin | Serotonin inhibits the reaction [IRS1 protein binds to YWHAB protein] | 22975078 |
C475919 | hydroxytamoxifen | hydroxytamoxifen results in increased expression of IRS1 mRNA | 15072547 |
D015056 | 1-Methyl-3-isobutylxanthine | "3,3',4,5'-tetrahydroxystilbene inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased phosphorylation of IRS1 protein]" | 22298784 |
D015056 | 1-Methyl-3-isobutylxanthine | [Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased phosphorylation of IRS1 protein | 22298784 |
D007545 | Isoproterenol | Isoproterenol results in increased expression of IRS1 mRNA | 20003209 |
C515747 | isosteviol | [isosteviol co-treated with Palmitic Acid] results in increased expression of IRS1 mRNA | 22479612 |
C515747 | isosteviol | isosteviol results in increased expression of IRS1 mRNA | 22479612 |
C561695 | (+)-JQ1 compound | (+)-JQ1 compound results in decreased expression of IRS1 mRNA | 25307878|2743299 |
D007650 | Ketanserin | [Ketanserin inhibits the reaction [Serotonin results in increased activity of AKT1 protein]] promotes the reaction [Serotonin inhibits the reaction [IRS1 protein binds to YWHAB protein]] | 22975078 |
D007650 | Ketanserin | [[Ketanserin inhibits the reaction [Serotonin results in increased activity of AKT1 protein]] promotes the reaction [Serotonin inhibits the reaction [IRS1 protein binds to YWHAB protein]]] which results in increased ubiquitination of and results in increased degradation of IRS1 protein | 22975078 |
C045463 | leflunomide | leflunomide results in increased expression of IRS1 mRNA | 28988120 |
C045463 | leflunomide | leflunomide results in decreased expression of IRS1 mRNA | 19751817 |
C533894 | LG 100815 | LG 100815 results in decreased expression of IRS1 mRNA | 16951191 |
C027820 | ligustilide | ligustilide results in decreased phosphorylation of IRS1 protein | 23973442 |
C002385 | linsidomine | linsidomine inhibits the reaction [INS1 protein results in increased phosphorylation of IRS1 protein] | 19682478 |
C002385 | linsidomine | linsidomine results in increased metabolism of and results in decreased expression of IRS1 protein | 19682478 |
D008070 | Lipopolysaccharides | "17-ethynyl-5-androstene-3, 7, 17-triol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IRS1 protein]" | 22384159 |
C042720 | mercuric bromide | mercuric bromide results in increased expression of IRS1 mRNA | 26272509 |
C042720 | mercuric bromide | "[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRS1 mRNA" | 27188386 |
D008687 | Metformin | Metformin affects the reaction [Testosterone results in decreased expression of IRS1] | 19328476 |
D008687 | Metformin | Metformin inhibits the reaction [Streptozocin results in decreased expression of IRS1 protein] | 23927877 |
D008687 | Metformin | Metformin inhibits the reaction [Dehydroepiandrosterone results in decreased phosphorylation of IRS1 protein] | 27634381 |
D008715 | Methionine | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of IRS1 gene | 20938992 |
D008731 | Methoxychlor | Methoxychlor results in increased methylation of IRS1 gene | 23303685 |
C004925 | methylmercuric chloride | methylmercuric chloride results in increased expression of IRS1 mRNA | 23179753|2627250 |
C004925 | methylmercuric chloride | "[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRS1 mRNA" | 27188386 |
C004925 | methylmercuric chloride | [Cadmium Chloride co-treated with methylmercuric chloride] results in decreased expression of IRS1 mRNA | 27814245 |
C004925 | methylmercuric chloride | [Cadmium Chloride co-treated with methylmercuric chloride] results in increased phosphorylation of IRS1 protein | 27814245 |
D018817 | N-Methyl-3,4-methylenedioxyamphetamine | "N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of IRS1 mRNA" | 26251327 |
D008770 | Methylnitrosourea | Hexachlorobenzene inhibits the reaction [Methylnitrosourea results in increased phosphorylation of IRS1 protein] | 16237195 |
D008770 | Methylnitrosourea | Methylnitrosourea results in increased phosphorylation of IRS1 protein | 16237195 |
D015655 | 1-Methyl-4-phenylpyridinium | 1-Methyl-4-phenylpyridinium results in decreased expression of IRS1 protein | 26364587 |
D015655 | 1-Methyl-4-phenylpyridinium | INS protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of IRS1 protein] | 26364587 |
C016599 | mono-(2-ethylhexyl)phthalate | mono-(2-ethylhexyl)phthalate results in decreased expression of IRS1 mRNA | 25543134 |
C016599 | mono-(2-ethylhexyl)phthalate | [INS1 protein co-treated with mono-(2-ethylhexyl)phthalate] results in decreased expression of IRS1 protein | 28526321 |
C406082 | monomethylarsonous acid | monomethylarsonous acid results in increased expression of IRS1 protein | 24625837 |
C040015 | myricetin | myricetin inhibits the reaction [[Streptozocin co-treated with Cadmium] results in decreased expression of IRS1 protein] | 24923654 |
C583365 | N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide | "N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of IRS1 mRNA" | 29244179 |
C063509 | N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide | N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IRS1 mRNA] | 17407152 |
D037742 | Nanotubes, Carbon | "Nanotubes, Carbon analog results in decreased expression of IRS1 mRNA" | 25554681|2562005 |
D037742 | Nanotubes, Carbon | "Nanotubes, Carbon results in decreased expression of IRS1 mRNA" | 25554681|2562005 |
C005274 | naringin | naringin inhibits the reaction [Dietary Fats results in decreased phosphorylation of IRS1 protein] | 22198281 |
D009532 | Nickel | Nickel results in decreased expression of IRS1 mRNA | 25583101 |
D009538 | Nicotine | Nicotine results in decreased expression of IRS1 mRNA | 22265867 |
C002741 | N-nitrosomorpholine | N-nitrosomorpholine results in increased expression of IRS1 protein | 21411721|9466558 |
C501177 | NVP-AEW541 | NVP-AEW541 inhibits the reaction [Estradiol promotes the reaction [AKT1 protein modified form binds to IRS1 protein]] | 19435893 |
C000594859 | nymphayol | nymphayol results in increased phosphorylation of IRS1 protein | 25499137 |
C062198 | octa-2,4,6-trienoic acid | "octa-2,4,6-trienoic acid results in decreased expression of IRS1 mRNA" | 16951191 |
D009828 | Oleanolic Acid | [Fructose co-treated with Oleanolic Acid] results in increased expression of IRS1 mRNA | 24704288 |
D009828 | Oleanolic Acid | [Fructose co-treated with Oleanolic Acid] results in increased expression of IRS1 protein | 24704288 |
D009828 | Oleanolic Acid | Oleanolic Acid inhibits the reaction [Fructose results in increased phosphorylation of IRS1 protein] | 24704288 |
D010168 | Palmitates | Palmitates inhibits the reaction [INS protein results in increased phosphorylation of IRS1 protein] | 23504962 |
D010168 | Palmitates | Palmitates results in increased phosphorylation of IRS1 protein | 23504962 |
D010168 | Palmitates | quercetin 3-O-glucuronide inhibits the reaction [Palmitates inhibits the reaction [INS protein results in increased phosphorylation of IRS1 protein]] | 23504962 |
D010168 | Palmitates | quercetin 3-O-glucuronide inhibits the reaction [Palmitates results in increased phosphorylation of IRS1 protein] | 23504962 |
D010168 | Palmitates | Quercetin inhibits the reaction [Palmitates inhibits the reaction [INS protein results in increased phosphorylation of IRS1 protein]] | 23504962 |
D010168 | Palmitates | Quercetin inhibits the reaction [Palmitates results in increased phosphorylation of IRS1 protein] | 23504962 |
D010168 | Palmitates | Sodium Salicylate inhibits the reaction [Palmitates inhibits the reaction [INS protein results in increased phosphorylation of IRS1 protein]] | 23504962 |
D010168 | Palmitates | Sodium Salicylate inhibits the reaction [Palmitates results in increased phosphorylation of IRS1 protein] | 23504962 |
D019308 | Palmitic Acid | "3,3',4,5'-tetrahydroxystilbene inhibits the reaction [Palmitic Acid inhibits the reaction [INS protein results in increased phosphorylation of IRS1 protein]]" | 25815690 |
D019308 | Palmitic Acid | Palmitic Acid inhibits the reaction [INS protein results in increased phosphorylation of IRS1 protein] | 25815690 |
D019308 | Palmitic Acid | "tin protoporphyrin IX inhibits the reaction [3,3',4,5'-tetrahydroxystilbene inhibits the reaction [Palmitic Acid inhibits the reaction [INS protein results in increased phosphorylation of IRS1 protein]]]" | 25815690 |
D019308 | Palmitic Acid | [isosteviol co-treated with Palmitic Acid] results in increased expression of IRS1 mRNA | 22479612 |
D010269 | Paraquat | Paraquat results in decreased expression of and results in increased phosphorylation of IRS1 protein | 23898955 |
D017374 | Paroxetine | Paroxetine affects the reaction [INS protein affects the phosphorylation of IRS1 protein] | 17728140 |
D017374 | Paroxetine | Paroxetine results in decreased activity of IRS1 protein | 17728140 |
D017374 | Paroxetine | pyrazolanthrone inhibits the reaction [Paroxetine affects the reaction [INS protein affects the phosphorylation of IRS1 protein]] | 17728140 |
C522391 | perfluorododecanoic acid | perfluorododecanoic acid results in decreased expression of IRS1 protein modified form | 23353032 |
C101816 | perfluoro-n-nonanoic acid | perfluoro-n-nonanoic acid results in decreased expression of IRS1 protein modified form | 22387981 |
C076994 | perfluorooctane sulfonic acid | perfluorooctane sulfonic acid results in increased expression of IRS1 mRNA | 26548598 |
C027579 | periodate-oxidized adenosine | periodate-oxidized adenosine affects the expression of IRS1 mRNA | 17097637 |
D026023 | Permethrin | [Permethrin co-treated with INS protein] results in increased phosphorylation of IRS1 protein | 28866332 |
D010575 | Pesticides | Pesticides results in decreased methylation of IRS1 gene | 28396702 |
D010662 | Phenylmercuric Acetate | "[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRS1 mRNA" | 27188386 |
D010662 | Phenylmercuric Acetate | Phenylmercuric Acetate results in increased expression of IRS1 mRNA | 26272509 |
D010705 | Phosgene | Phosgene affects the expression of IRS1 mRNA | 16300373 |
D010798 | Phycocyanin | Phycocyanin inhibits the reaction [Alloxan affects the phosphorylation of IRS1 protein] | 26827782 |
C006253 | pirinixic acid | pirinixic acid results in decreased expression of IRS1 mRNA | 18445702 |
C006253 | pirinixic acid | pirinixic acid results in increased expression of IRS1 mRNA | 18301758 |
D010936 | Plant Extracts | Plant Extracts inhibits the reaction [Glucose results in decreased expression of IRS1 protein] | 24262486 |
D010936 | Plant Extracts | Plant Extracts inhibits the reaction [Glucose results in decreased expression of IRS1 protein modified form] | 24262486 |
D010936 | Plant Extracts | Plant Extracts results in increased phosphorylation of IRS1 protein | 18534569 |
D028321 | Plant Preparations | Plant Preparations results in decreased expression of IRS1 mRNA | 23872130 |
D028321 | Plant Preparations | Plant Preparations results in decreased expression of IRS1 protein | 23872130 |
D011374 | Progesterone | Progesterone results in decreased phosphorylation of IRS1 protein | 15949379 |
D011374 | Progesterone | Progesterone results in increased phosphorylation of IRS1 protein | 15604210 |
C045950 | propiconazole | propiconazole results in increased expression of IRS1 mRNA | 21278054 |
C029658 | propionic acid | propionic acid results in decreased phosphorylation of IRS1 protein | 21472246 |
C432165 | pyrazolanthrone | pyrazolanthrone inhibits the reaction [Paroxetine affects the reaction [INS protein affects the phosphorylation of IRS1 protein]] | 17728140 |
D011765 | Pyruvaldehyde | Pyruvaldehyde results in decreased phosphorylation of IRS1 protein | 23954466 |
D011794 | Quercetin | Quercetin affects the reaction [[Fatty Acids co-treated with INS protein] affects the phosphorylation of IRS1 protein] | 24648896 |
D011794 | Quercetin | Quercetin inhibits the reaction [Palmitates inhibits the reaction [INS protein results in increased phosphorylation of IRS1 protein]] | 23504962 |
D011794 | Quercetin | Quercetin inhibits the reaction [Palmitates results in increased phosphorylation of IRS1 protein] | 23504962 |
D011794 | Quercetin | Quercetin results in decreased expression of IRS1 mRNA | 21632981 |
D011794 | Quercetin | Quercetin results in decreased expression of IRS1 protein | 12653748 |
D011794 | Quercetin | Quercetin inhibits the reaction [IGF1 protein results in increased phosphorylation of IRS1 protein] | 24353828 |
D011794 | Quercetin | Quercetin inhibits the reaction [Dehydroepiandrosterone results in decreased phosphorylation of IRS1 protein] | 27634381 |
D011794 | Quercetin | Quercetin inhibits the reaction [Fructose results in decreased phosphorylation of IRS1 protein] | 22426011 |
D011794 | Quercetin | Quercetin inhibits the reaction [TNF protein results in increased phosphorylation of IRS1 protein] | 20943792 |
C443401 | quercetin 3-O-glucuronide | quercetin 3-O-glucuronide inhibits the reaction [Palmitates inhibits the reaction [INS protein results in increased phosphorylation of IRS1 protein]] | 23504962 |
C443401 | quercetin 3-O-glucuronide | quercetin 3-O-glucuronide inhibits the reaction [Palmitates results in increased phosphorylation of IRS1 protein] | 23504962 |
C025474 | rebaudioside A | rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS1 mRNA] | 25554529 |
C059514 | resveratrol | resveratrol inhibits the reaction [bisphenol A results in increased expression of IRS1 protein modified form] | 23810794 |
C059514 | resveratrol | resveratrol inhibits the reaction [Estradiol results in increased expression of IRS1 protein modified form] | 23810794 |
C059514 | resveratrol | resveratrol inhibits the reaction [IRS2 gene mutant form inhibits the reaction [INS protein results in increased phosphorylation of IRS1 protein]] | 25808216 |
C059514 | resveratrol | resveratrol results in decreased activity of [IRS1 protein binds to PIK3R1 protein] | 17550345 |
C059514 | resveratrol | resveratrol results in decreased expression of IRS1 protein | 18089832 |
C059514 | resveratrol | resveratrol affects the phosphorylation of IRS1 protein | 20188786 |
C059514 | resveratrol | resveratrol results in decreased expression of IRS1 mRNA | 22610192|2352548 |
C059514 | resveratrol | resveratrol results in decreased expression of IRS1 protein | 18555852 |
C059514 | resveratrol | resveratrol results in decreased phosphorylation of IRS1 protein | 22935344 |
C059514 | resveratrol | resveratrol results in increased phosphorylation of IRS1 protein | 22309033 |
C059514 | resveratrol | [Fructose co-treated with resveratrol] results in increased expression of IRS1 mRNA | 26488877 |
C059514 | resveratrol | resveratrol inhibits the reaction [High Fructose Corn Syrup results in decreased expression of IRS1 mRNA] | 25238689 |
C059514 | resveratrol | resveratrol inhibits the reaction [High Fructose Corn Syrup results in decreased expression of IRS1 protein] | 25238689 |
C059514 | resveratrol | resveratrol inhibits the reaction [INS1 protein promotes the reaction [IRS1 protein binds to PIK3R1 protein]] | 16626303 |
C059514 | resveratrol | resveratrol inhibits the reaction [Streptozocin results in decreased expression of IRS1 mRNA] | 26071184 |
C059514 | resveratrol | resveratrol inhibits the reaction [Streptozocin results in decreased expression of IRS1 protein] | 26071184 |
C059514 | resveratrol | resveratrol results in increased expression of IRS1 mRNA | 26071184|2648887 |
C059514 | resveratrol | resveratrol results in increased expression of IRS1 protein | 26071184 |
C059514 | resveratrol | resveratrol results in increased expression of IRS1 protein | 21575630|2173966 |
C059514 | resveratrol | resveratrol inhibits the reaction [INS protein results in increased phosphorylation of IRS1 protein] | 21945106 |
C059514 | resveratrol | resveratrol inhibits the reaction [TNF protein results in increased phosphorylation of IRS1 protein] | 20943792 |
C089730 | rosiglitazone | rosiglitazone results in decreased expression of IRS1 mRNA | 21515302 |
D012431 | Rutin | Rutin results in decreased expression of IRS1 protein | 20015448 |
D012431 | Rutin | Rutin results in increased susceptibility to [Vitamin E results in decreased expression of IRS1 protein] | 20015448 |
D012431 | Rutin | Vitamin E results in increased susceptibility to [Rutin results in decreased expression of IRS1 protein] | 20015448 |
D012431 | Rutin | Rutin inhibits the reaction [Fructose results in decreased phosphorylation of IRS1 protein] | 22426011 |
C064294 | sarpogrelate | [sarpogrelate results in increased activity of AKT1 protein] inhibits the reaction [Serotonin results in increased ubiquitination of and results in increased degradation of IRS1 protein] | 22975078 |
D020280 | Sertraline | Sertraline affects the reaction [INS protein affects the phosphorylation of IRS1 protein] | 17728140 |
D020280 | Sertraline | Sertraline results in decreased activity of IRS1 protein | 17728140 |
D012822 | Silicon Dioxide | Silicon Dioxide results in decreased expression of IRS1 mRNA | 23221170 |
D019821 | Simvastatin | Simvastatin inhibits the reaction [IGF1 protein results in increased phosphorylation of IRS1 protein] | 27734117 |
D020123 | Sirolimus | Sirolimus affects the phosphorylation of IRS1 protein | 17908691 |
D020123 | Sirolimus | Sirolimus promotes the reaction [IGF1R protein binds to and results in increased phosphorylation of IRS1 protein] | 16227402 |
D020123 | Sirolimus | Sirolimus promotes the reaction [IRS1 protein binds to PIK3R1 protein] | 17908691 |
D020123 | Sirolimus | [Sirolimus results in decreased activity of RPS6KB1 protein] which results in increased activity of IRS1 protein | 17908691 |
D020123 | Sirolimus | Sirolimus results in decreased degradation of IRS1 protein | 16227402|1790869 |
D020123 | Sirolimus | Sirolimus results in decreased phosphorylation of IRS1 protein | 16227402 |
D020123 | Sirolimus | Sirolimus inhibits the reaction [INS protein results in increased phosphorylation of IRS1 protein] | 18303120 |
D020123 | Sirolimus | [Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [INS protein results in increased phosphorylation of IRS1 protein] | 18303120 |
C017947 | sodium arsenite | sodium arsenite results in decreased expression of IRS1 mRNA | 24570342 |
C017947 | sodium arsenite | sodium arsenite results in increased methylation of IRS1 gene | 24570342 |
C017947 | sodium arsenite | gingerol inhibits the reaction [sodium arsenite results in decreased expression of IRS1 mRNA] | 22285432 |
C017947 | sodium arsenite | gingerol inhibits the reaction [sodium arsenite results in decreased expression of IRS1 protein] | 22285432 |
C017947 | sodium arsenite | sodium arsenite affects the expression of IRS1 | 25367288 |
C017947 | sodium arsenite | sodium arsenite results in decreased expression of IRS1 mRNA | 22285432 |
C017947 | sodium arsenite | sodium arsenite results in decreased expression of IRS1 protein | 22285432 |
D017673 | Sodium Chloride, Dietary | "Sodium Chloride, Dietary results in increased phosphorylation of IRS1 protein" | 14670806 |
D012980 | Sodium Salicylate | Sodium Salicylate inhibits the reaction [Palmitates inhibits the reaction [INS protein results in increased phosphorylation of IRS1 protein]] | 23504962 |
D012980 | Sodium Salicylate | Sodium Salicylate inhibits the reaction [Palmitates results in increased phosphorylation of IRS1 protein] | 23504962 |
D018038 | Sodium Selenite | Sodium Selenite promotes the reaction [[Streptozocin co-treated with Dietary Fats] affects the phosphorylation of IRS1 protein] | 26522834 |
D053260 | Soot | Soot results in decreased expression of IRS1 mRNA | 22461453 |
C012042 | steviol | steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS1 mRNA] | 25554529 |
C012043 | stevioside | stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS1 mRNA] | 25554529 |
D013311 | Streptozocin | Metformin inhibits the reaction [Streptozocin results in decreased expression of IRS1 protein] | 23927877 |
D013311 | Streptozocin | Sodium Selenite promotes the reaction [[Streptozocin co-treated with Dietary Fats] affects the phosphorylation of IRS1 protein] | 26522834 |
D013311 | Streptozocin | [Streptozocin co-treated with Dietary Fats] affects the phosphorylation of IRS1 protein | 26522834 |
D013311 | Streptozocin | Streptozocin results in decreased expression of IRS1 protein | 23927877 |
D013311 | Streptozocin | myricetin inhibits the reaction [[Streptozocin co-treated with Cadmium] results in decreased expression of IRS1 protein] | 24923654 |
D013311 | Streptozocin | resveratrol inhibits the reaction [Streptozocin results in decreased expression of IRS1 mRNA] | 26071184 |
D013311 | Streptozocin | resveratrol inhibits the reaction [Streptozocin results in decreased expression of IRS1 protein] | 26071184 |
D013311 | Streptozocin | [Streptozocin co-treated with Cadmium] results in decreased expression of IRS1 protein | 24923654 |
D013311 | Streptozocin | Streptozocin results in decreased expression of IRS1 mRNA | 26071184 |
D013311 | Streptozocin | Streptozocin results in decreased expression of IRS1 protein | 26071184 |
D013629 | Tamoxifen | Tamoxifen affects the expression of IRS1 mRNA | 14699072 |
D013654 | Taurine | Taurine inhibits the reaction [Alloxan results in decreased phosphorylation of IRS1 protein] | 22138235 |
D013654 | Taurine | Taurine results in increased phosphorylation of IRS1 protein | 22138235 |
C501413 | tesaglitazar | tesaglitazar results in decreased expression of IRS1 mRNA | 21515302 |
D013739 | Testosterone | Metformin affects the reaction [Testosterone results in decreased expression of IRS1] | 19328476 |
D013739 | Testosterone | Testosterone results in decreased expression of IRS1 | 19328476 |
D013739 | Testosterone | Testosterone results in increased expression of IRS1 mRNA | 20843997 |
D013739 | Testosterone | Testosterone inhibits the reaction [Dexamethasone results in decreased expression of IRS1 mRNA] | 20032058 |
D013749 | Tetrachlorodibenzodioxin | [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of IRS1 mRNA | 15688983 |
D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of IRS1 mRNA] | 15688983 |
D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin results in increased expression of IRS1 mRNA | 21632981 |
D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin results in increased phosphorylation of IRS1 protein | 9683191 |
D013749 | Tetrachlorodibenzodioxin | AHR protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of IRS1 mRNA] | 20181658 |
D013749 | Tetrachlorodibenzodioxin | Colforsin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IRS1 mRNA] | 17407152 |
D013749 | Tetrachlorodibenzodioxin | MAPK8 protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of IRS1 protein] | 20181658 |
D013749 | Tetrachlorodibenzodioxin | N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IRS1 mRNA] | 17407152 |
D013749 | Tetrachlorodibenzodioxin | "[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of IRS1 mRNA" | 28433925 |
D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to IRS1 gene] | 21762485 |
D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin results in decreased expression of IRS1 mRNA | 18691609|2018165 |
D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin results in decreased expression of IRS1 protein | 20181658 |
D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin results in increased expression of IRS1 mRNA | 17407152 |
D013749 | Tetrachlorodibenzodioxin | TNF protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of IRS1 protein] | 20181658 |
D013749 | Tetrachlorodibenzodioxin | TNFRSF1A protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of IRS1 protein] | 20181658 |
D013749 | Tetrachlorodibenzodioxin | U 0126 inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of IRS1 protein] | 20181658 |
D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin inhibits the reaction [IGF1 protein results in increased phosphorylation of IRS1 protein] | 23639626 |
D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin results in decreased expression of IRS1 mRNA | 20959002|2121527 |
D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin results in decreased phosphorylation of IRS1 protein | 23639626 |
D019284 | Thapsigargin | Thapsigargin affects the phosphorylation of and results in decreased expression of IRS1 protein | 22378314 |
D013806 | Theophylline | Theophylline results in increased expression of IRS1 mRNA | 16083514 |
C036680 | thorium nitrate | thorium nitrate analog results in increased phosphorylation of IRS1 protein | 24462957 |
C032628 | tin protoporphyrin IX | "tin protoporphyrin IX inhibits the reaction [3,3',4,5'-tetrahydroxystilbene inhibits the reaction [Palmitic Acid inhibits the reaction [INS protein results in increased phosphorylation of IRS1 protein]]]" | 25815690 |
C009495 | titanium dioxide | titanium dioxide results in decreased expression of IRS1 mRNA | 23557971|2776080 |
D014028 | Tobacco Smoke Pollution | Tobacco Smoke Pollution results in decreased expression of IRS1 mRNA | 28065790 |
D014028 | Tobacco Smoke Pollution | Tobacco Smoke Pollution results in decreased expression of IRS1 mRNA | 28111298 |
C496197 | trans-10,cis-12-conjugated linoleic acid | "[trans-10,cis-12-conjugated linoleic acid co-treated with cis-9, trans-11-conjugated linoleic acid] results in decreased phosphorylation of IRS1 protein" | 17408517 |
D014212 | Tretinoin | Tretinoin results in decreased expression of IRS1 mRNA | 23724009 |
C011559 | tributyltin | tributyltin results in decreased expression of and results in decreased phosphorylation of IRS1 protein | 28397090 |
D014241 | Trichloroethylene | Trichloroethylene results in decreased expression of IRS1 mRNA | 28973375 |
C012589 | trichostatin A | "[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRS1 mRNA" | 27188386 |
C012589 | trichostatin A | trichostatin A results in increased expression of IRS1 mRNA | 24935251|2627250 |
D014280 | Triglycerides | IRS1 gene polymorphism results in increased abundance of Triglycerides | 10591678 |
C015559 | trimellitic anhydride | trimellitic anhydride results in decreased expression of IRS1 mRNA | 19042947 |
C016805 | tris(1,3-dichloro-2-propyl)phosphate | "tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of IRS1 mRNA" | 26179874 |
C057693 | troglitazone | troglitazone results in decreased expression of IRS1 mRNA | 21515302 |
D014415 | Tunicamycin | Tunicamycin affects the phosphorylation of and results in decreased expression of IRS1 protein | 22378314 |
C113580 | U 0126 | U 0126 inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of IRS1 protein] | 20181658 |
D014520 | Urethane | Urethane results in decreased expression of IRS1 mRNA | 28818685 |
D014635 | Valproic Acid | "[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRS1 mRNA" | 27188386 |
D014635 | Valproic Acid | Valproic Acid results in increased expression of IRS1 mRNA | 23179753|2627250 |
D014640 | Vancomycin | Vancomycin results in increased expression of IRS1 mRNA | 18930951 |
D001335 | Vehicle Emissions | Vehicle Emissions affects the expression of IRS1 mRNA | 23940539 |
D001335 | Vehicle Emissions | Vehicle Emissions results in increased methylation of IRS1 gene | 25560391 |
D014810 | Vitamin E | Rutin results in increased susceptibility to [Vitamin E results in decreased expression of IRS1 protein] | 20015448 |
D014810 | Vitamin E | Vitamin E results in decreased expression of IRS1 protein | 20015448 |
D014810 | Vitamin E | Vitamin E results in increased susceptibility to [Rutin results in decreased expression of IRS1 protein] | 20015448 |
D014810 | Vitamin E | [Ascorbic Acid co-treated with Vitamin E] inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of IRS1 protein] | 21911000 |
D014810 | Vitamin E | [Ascorbic Acid co-treated with Vitamin E] inhibits the reaction [Diethylhexyl Phthalate results in decreased phosphorylation of IRS1 protein] | 21911000 |
D015032 | Zinc | Zinc results in decreased expression of IRS1 protein | 19913001 |
D015032 | Zinc | Zinc results in increased phosphorylation of IRS1 protein | 15516700 |
D015032 | Zinc | Zinc results in increased phosphorylation of IRS1 protein | 14644152 |