Gene: ITGA1

3672
CD49a|VLA1
integrin subunit alpha 1
protein-coding
5q11.2
Ensembl:ENSG00000213949 MIM:192968 Vega:OTTHUMG00000131163 UniprotKB:P56199
NC_000005.10
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.340e-1 (AD)  6.335e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ELOVL70.91
IRAK30.881
ERG0.857
MECOM0.855
CFH0.854
CYYR10.854
RBMS20.85
ACSL50.847
TGFBR20.846
NEDD40.843

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HAS1-0.581
TMEM121-0.573
MAGIX-0.569
DLK2-0.563
SLC7A4-0.563
MARCH4-0.552
TMEM179-0.55
SMIM18-0.548
PIP5KL1-0.547
CORT-0.543

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of ITGA1 mRNA"28903501
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in decreased expression of ITGA1 mRNA"20406850
C5779422-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide"2-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide inhibits the reaction [TGFB1 protein results in increased expression of ITGA1 mRNA]"26644586
C5779422-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide"2-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide results in decreased expression of ITGA1 mRNA"26644586
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of ITGA1 mRNA"23196670
C0144643,4-dichloroaniline"3,4-dichloroaniline results in increased expression of ITGA1 mRNA"24172598
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ITGA1 mRNA"25670856
D020106AcrylamideAcrylamide results in decreased expression of ITGA1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of ITGA1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ITGA1 mRNA19770486
D000537Aluminum OxideAluminum Oxide results in increased expression of ITGA1 mRNA19464052
D000499AllylamineAllylamine results in increased expression of ITGA1 mRNA15910882
D000499AllylamineAllylamine results in increased expression of ITGA1 protein15910882
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ITGA1 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of ITGA1 mRNA24449571
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of ITGA1 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of ITGA1 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ITGA1 mRNA22316170|2623829
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of ITGA1 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ITGA1 mRNA19770486|2156981
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ITGA1 mRNA22610609
D001599BerberineBerberine results in increased expression of ITGA1 mRNA26478571
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of ITGA1 protein11507064
D004958EstradiolPGR protein affects the reaction [[Estradiol co-treated with Progesterone] results in increased expression of ITGA1]11507064
D004958Estradiolresveratrol inhibits the reaction [[Estradiol co-treated with Progesterone] results in increased expression of ITGA1 protein]11507064
D004958Estradiolresveratrol inhibits the reaction [PGR protein affects the reaction [[Estradiol co-treated with Progesterone] results in increased expression of ITGA1]]11507064
D004958EstradiolEstradiol results in decreased expression of ITGA1 mRNA25210133
C006780bisphenol Abisphenol A results in increased expression of ITGA1 mRNA26063408
C006780bisphenol Abisphenol A results in increased expression of ITGA1 mRNA25181051|2909715
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of ITGA1 mRNA26472689
D000074262Canola OilCanola Oil metabolite results in decreased expression of ITGA1 mRNA27363782
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of ITGA1 mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of ITGA1 mRNA12734012
D002713Chlorine[Ozone co-treated with Chlorine] results in decreased expression of ITGA1 mRNA18636392
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of ITGA1 mRNA27858113
C018021cobaltous chloridecobaltous chloride results in increased expression of ITGA1 mRNA19320972
D005576ColforsinITGA1 protein affects the susceptibility to Colforsin15836982
D003345CorticosteroneCorticosterone results in decreased expression of ITGA1 mRNA15755911
C014347decitabinedecitabine affects the methylation of ITGA1 gene17669516
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ITGA1 mRNA17361019|2126653
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of ITGA1 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of ITGA1 mRNA27392435
D002945CisplatinITGA1 mRNA results in increased susceptibility to Cisplatin25199881
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of ITGA1 mRNA20920545
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of ITGA1 protein20920545
D004237DiuronDiuron metabolite results in increased expression of ITGA1 mRNA24172598
D004237DiuronDiuron results in increased expression of ITGA1 mRNA21551480
D004317DoxorubicinITGA1 mRNA results in increased susceptibility to Doxorubicin25199881
C118739entinostatentinostat results in increased expression of ITGA1 mRNA26272509
D000431EthanolEthanol results in decreased expression of ITGA1 mRNA16098508
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ITGA1 mRNA15576828|2909715
D005620Freund's Adjuvant[Urethane co-treated with Freund's Adjuvant] results in decreased expression of ITGA1 mRNA12400877
C001277geldanamycingeldanamycin results in increased expression of ITGA1 mRNA26705709
D019833GenisteinGenistein results in decreased expression of ITGA1 mRNA21048042
C568713GSK1210151AGSK1210151A inhibits the reaction [TGFB1 protein results in increased expression of ITGA1 mRNA]26644586
C568713GSK1210151AGSK1210151A results in decreased expression of ITGA1 mRNA26644586
D007213IndomethacinIndomethacin results in increased expression of ITGA1 mRNA16771604
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of ITGA1 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of ITGA1 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of ITGA1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [TGFB1 protein results in increased expression of ITGA1 mRNA]26644586
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ITGA1 mRNA26644586
C045463leflunomideleflunomide results in increased expression of ITGA1 mRNA28988120
D017258Medroxyprogesterone AcetateMedroxyprogesterone Acetate results in decreased expression of ITGA1 mRNA20843944
D008694MethamphetamineMethamphetamine results in increased methylation of ITGA1 promoter26307267
D008727MethotrexateITGA1 mRNA results in increased susceptibility to Methotrexate25199881
D008727MethotrexateMethotrexate results in increased expression of ITGA1 mRNA17400583
D008746Methylazoxymethanol AcetateMethylazoxymethanol Acetate results in increased expression of ITGA1 mRNA28349193
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ITGA1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ITGA1 mRNA"25554681
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of ITGA1 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of ITGA1 mRNA25729387
D010100OxygenOxygen deficiency results in decreased expression of ITGA1 mRNA20880076
D010126Ozone[Ozone co-treated with Chlorine] results in decreased expression of ITGA1 mRNA18636392
D017239PaclitaxelITGA1 mRNA results in increased susceptibility to Paclitaxel25199881
D052638Particulate MatterParticulate Matter results in increased expression of ITGA1 mRNA24769257
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of ITGA1 protein26879310
D010634PhenobarbitalPhenobarbital results in decreased expression of ITGA1 mRNA23091169
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of ITGA1 mRNA26272509
D010862PilocarpinePilocarpine results in increased expression of ITGA1 protein12851778
C006253pirinixic acidpirinixic acid results in decreased expression of ITGA1 mRNA23811191
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of ITGA1 protein11507064
D011374ProgesteronePGR protein affects the reaction [[Estradiol co-treated with Progesterone] results in increased expression of ITGA1]11507064
D011374Progesteroneresveratrol inhibits the reaction [[Estradiol co-treated with Progesterone] results in increased expression of ITGA1 protein]11507064
D011374Progesteroneresveratrol inhibits the reaction [PGR protein affects the reaction [[Estradiol co-treated with Progesterone] results in increased expression of ITGA1]]11507064
C513428pyrachlostrobinpyrachlostrobin results in increased expression of ITGA1 mRNA27029645
C502851quinocetonequinocetone results in increased expression of ITGA1 mRNA27046791
C059514resveratrolresveratrol inhibits the reaction [[Estradiol co-treated with Progesterone] results in increased expression of ITGA1 protein]11507064
C059514resveratrolresveratrol inhibits the reaction [PGR protein affects the reaction [[Estradiol co-treated with Progesterone] results in increased expression of ITGA1]]11507064
D012822Silicon DioxideSilicon Dioxide results in decreased expression of ITGA1 mRNA22431001
D012834SilverSilver results in decreased expression of ITGA1 mRNA27131904
C009277sodium arsenatesodium arsenate results in increased expression of ITGA1 mRNA21795629
D018038Sodium SeleniteSodium Selenite results in increased expression of ITGA1 mRNA18175754
D053260SootSoot results in decreased expression of ITGA1 mRNA26551751
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ITGA1 mRNA26238291|2791314
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ITGA1 mRNA16054898
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ITGA1 mRNA19490992
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of ITGA1 mRNA25613284
C009495titanium dioxidetitanium dioxide affects the expression of ITGA1 mRNA17656681|2355797
C009495titanium dioxidetitanium dioxide results in decreased expression of ITGA1 mRNA27760801
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of ITGA1 mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased methylation of ITGA1 gene26756918
D014050TolueneToluene results in increased expression of ITGA1 mRNA22967744
D019772TopotecanITGA1 mRNA results in increased susceptibility to Topotecan25199881
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of ITGA1 mRNA25729387
D019772TopotecanTopotecan results in increased expression of ITGA1 mRNA25729387
D014212TretinoinTretinoin results in increased expression of ITGA1 mRNA16012519|2372400
C012589trichostatin Atrichostatin A affects the expression of ITGA1 mRNA28542535
C012589trichostatin Atrichostatin A results in increased expression of ITGA1 mRNA26705709
D014520Urethane[Urethane co-treated with Freund's Adjuvant] results in decreased expression of ITGA1 mRNA12400877
D014520UrethaneUrethane results in decreased expression of ITGA1 mRNA12400877
D014635Valproic AcidValproic Acid results in increased expression of ITGA1 mRNA23179753|2627250
C025643vinclozolinvinclozolin affects the expression of ITGA1 mRNA19015723
D014750VincristineITGA1 mRNA results in increased susceptibility to Vincristine25199881
D015032ZincZinc affects the expression of ITGA1 mRNA16979875
C088658zoledronic acidzoledronic acid results in increased expression of ITGA1 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005102signaling receptor binding-IEA-  
GO:0005515protein binding-IPI16754661  18587047  
GO:0005518collagen binding-TAS8428973  
GO:0019903protein phosphatase binding-IPI15592458  
GO:0046872metal ion binding-IEA-  
GO:0098639collagen binding involved in cell-matrix adhesion-IMP24823363  
GO ID GO Term Qualifier Evidence PubMed
GO:0000187activation of MAPK activity-IEA-  
GO:0006936muscle contraction-TAS-  
GO:0007160cell-matrix adhesion-IMP24823363  
GO:0007229integrin-mediated signaling pathway-IEA-  
GO:0008285negative regulation of cell proliferation-IMP15592458  
GO:0030198extracellular matrix organization-TAS-  
GO:0030593neutrophil chemotaxis-IEA-  
GO:0032516positive regulation of phosphoprotein phosphatase activity-IDA15592458  
GO:0042059negative regulation of epidermal growth factor receptor signaling pathway-ISS-  
GO:0042311vasodilation-IEA-  
GO:0043525positive regulation of neuron apoptotic process-IEA-  
GO:0045123cellular extravasation-IEA-  
GO:0048812neuron projection morphogenesis-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001669acrosomal vesicle-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0005925focal adhesion-HDA21423176  
GO:0005925focal adhesion-IDA11518510  
GO:0008305integrin complex-TAS8428973  
GO:0009897external side of plasma membrane-IEA-  
GO:0009986cell surface-HDA19581412  23658023  
GO:0009986cell surface-IDA19933311  20563599  
GO:0016020membrane-HDA19946888  
GO:0034665integrin alpha1-beta1 complex-IDA24823363  
GO:0043005neuron projection-IEA-  
GO:0043204perikaryon-IEA-  
GO:0045121membrane raft-IEA-  
GO:0045178basal part of cell-IEA-  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
hsa04510Focal adhesion
hsa04512ECM-receptor interaction
hsa04640Hematopoietic cell lineage
hsa04810Regulation of actin cytoskeleton
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
hsa05414Dilated cardiomyopathy
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisIEA
R-HSA-1266738Developmental BiologyIEA
R-HSA-1474244Extracellular matrix organizationIEA
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-216083Integrin cell surface interactionsIEA
R-HSA-216083Integrin cell surface interactionsTAS
R-HSA-3000157Laminin interactionsIEA
R-HSA-373755Semaphorin interactionsIEA
R-HSA-373760L1CAM interactionsIEA
R-HSA-397014Muscle contractionTAS
R-HSA-416700Other semaphorin interactionsIEA
R-HSA-422475Axon guidanceIEA
R-HSA-445355Smooth Muscle ContractionTAS
R-HSA-447041CHL1 interactionsIEA
R-HSA-75892Platelet Adhesion to exposed collagenIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29577422NOTCH4 is a possible novel susceptibility gene for dilated cardiomyopathy in the Chinese population: A case-control study. (2018 Mar 26)Shi XJ Clin Lab Anal
27143927Integrin and gene network analysis reveals that ITGA5 and ITGB1 are prognostic in non-small-cell lung cancer. (2016)Zheng WOnco Targets Ther