Gene: ITGA2

3673
BR|CD49B|GPIa|HPA-5|VLA-2|VLAA2
integrin subunit alpha 2
protein-coding
5q11.2
Ensembl:ENSG00000164171 MIM:192974 Vega:OTTHUMG00000131165 UniprotKB:P17301
NG_008330.1
PubMed
0   ANCO-SNPs
ND|AD
6   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.462e-1 (AD)  2.646e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PLD10.817
PRRG10.814
SH3TC20.813
LGR50.811
TMEM63A0.809
MYO1D0.807
PCSK60.804
PIK3C2B0.8
GALNT60.8
FRYL0.799

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC29A4-0.42
HES5-0.416
DIO2-0.386
TNNT1-0.385
WNT7B-0.382
PLA2G5-0.363
ARSF-0.358
SLC13A5-0.354
PRTN3-0.34
POU3F1-0.331

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5815721-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea results in increased expression of ITGA2 mRNA25827057
C5815721-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea[Carbon Tetrachloride co-treated with 1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea] results in increased expression of ITGA2 mRNA25827057
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of ITGA2 mRNA"19167446
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in increased expression of ITGA2 mRNA]28655636
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in increased expression of ITGA2 mRNA]28655636
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITGA2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITGA2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of ITGA2 mRNA29067470
D000111AcetylcysteineAcetylcysteine inhibits the reaction [benz(a)anthracene results in increased expression of ITGA2 mRNA]21635667
D000111AcetylcysteineAcetylcysteine inhibits the reaction [benzo(k)fluoranthene results in increased expression of ITGA2 mRNA]21635667
D000111Acetylcysteine"Acetylcysteine inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of ITGA2 mRNA]"21635667
D000244Adenosine DiphosphateITGA2 gene SNP affects the susceptibility to [Aspirin co-treated with clopidogrel co-treated with Adenosine Diphosphate]16214444
D016604Aflatoxin B1Aflatoxin B1 affects the expression of ITGA2 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of ITGA2 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of ITGA2 mRNA27153756
D020875Enkephalin, Ala(2)-MePhe(4)-Gly(5)-"Enkephalin, Ala(2)-MePhe(4)-Gly(5)- inhibits the reaction [Carbon Tetrachloride results in increased expression of ITGA2 mRNA]"17299060
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of ITGA2 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ITGA2 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of ITGA2 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in decreased expression of ITGA2 mRNA25258189
C006632arsenic trioxideITGA2 protein results in decreased susceptibility to arsenic trioxide20707922
D001241AspirinITGA2 gene SNP affects the susceptibility to [Aspirin co-treated with clopidogrel]15205592|1621444
D001241AspirinITGA2 gene SNP affects the susceptibility to [Aspirin co-treated with clopidogrel co-treated with Adenosine Diphosphate]16214444
D001241AspirinITGA2 gene SNP affects the susceptibility to [Aspirin co-treated with clopidogrel co-treated with Epinephrine]16214444
D001241AspirinITGA2 polymorphism results in decreased susceptibility to Aspirin18231737
C547126AZM551248AZM551248 results in decreased expression of ITGA2 mRNA22323515
C487081belinostatbelinostat results in increased expression of ITGA2 mRNA27188386
C030935benz(a)anthraceneAcetylcysteine inhibits the reaction [benz(a)anthracene results in increased expression of ITGA2 mRNA]21635667
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of ITGA2 mRNA21635667
C030935benz(a)anthraceneSB 203580 inhibits the reaction [benz(a)anthracene results in increased expression of ITGA2 mRNA]21635667
C022921benzo(k)fluorantheneAcetylcysteine inhibits the reaction [benzo(k)fluoranthene results in increased expression of ITGA2 mRNA]21635667
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in increased expression of ITGA2 mRNA21635667
C022921benzo(k)fluorantheneSB 203580 inhibits the reaction [benzo(k)fluoranthene results in increased expression of ITGA2 mRNA]21635667
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ITGA2 mRNA21632981|2187194
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of ITGA2 mRNA"26238291
D004958EstradiolEstradiol affects the expression of ITGA2 mRNA22574217
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of ITGA2 mRNA20660070
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of ITGA2 mRNA19619570
D004958EstradiolEstradiol results in increased expression of ITGA2 mRNA19619570|2118537
D004958EstradiolEstradiol results in increased expression of ITGA2 protein16912569
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of ITGA2 mRNA20147733
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of ITGA2 mRNA12766906
C584509C646 compoundC646 compound results in decreased expression of ITGA2 mRNA26191083
D002104CadmiumCadmium results in increased expression of ITGA2 mRNA22562489
D000001Calcimycinfulvic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of ITGA2 mRNA]21331654
D000001Calcimycin[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of ITGA2 mRNA21331654
D002118CalciumITGA2 protein promotes the reaction [[Dinoprostone co-treated with Serotonin] results in increased import of Calcium]18234883
D002118CalciumTRPV4 protein promotes the reaction [ITGA2 protein promotes the reaction [[Dinoprostone co-treated with Serotonin] results in increased import of Calcium]]18234883
D002220CarbamazepineCarbamazepine affects the expression of ITGA2 mRNA24752500|2597931
D002251Carbon Tetrachloride[Carbon Tetrachloride co-treated with 1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea] results in increased expression of ITGA2 mRNA25827057
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ITGA2 mRNA17299060|2582705
D002251Carbon Tetrachloride"Enkephalin, Ala(2)-MePhe(4)-Gly(5)- inhibits the reaction [Carbon Tetrachloride results in increased expression of ITGA2 mRNA]"17299060
D007464ClioquinolITGA2 protein promotes the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of EGFR protein]18346929
C055162clopidogrelITGA2 gene SNP affects the susceptibility to [Aspirin co-treated with clopidogrel]15205592|1621444
C055162clopidogrelITGA2 gene SNP affects the susceptibility to [Aspirin co-treated with clopidogrel co-treated with Adenosine Diphosphate]16214444
C055162clopidogrelITGA2 gene SNP affects the susceptibility to [Aspirin co-treated with clopidogrel co-treated with Epinephrine]16214444
C018021cobaltous chloridecobaltous chloride results in decreased expression of ITGA2 mRNA19320972
C018021cobaltous chloridecobaltous chloride results in increased expression of ITGA2 protein16798617
D003300CopperITGA2 protein promotes the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of EGFR protein]18346929
D003300CopperCopper deficiency results in increased expression of ITGA2 mRNA26033743
D019327Copper SulfateCopper Sulfate results in increased expression of ITGA2 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of ITGA2 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in decreased expression of ITGA2 mRNA19167446
D016572CyclosporineCyclosporine results in decreased expression of ITGA2 mRNA27989131
D016572CyclosporineCyclosporine results in increased expression of ITGA2 mRNA20106945|2163298
D004008DiclofenacDiclofenac affects the expression of ITGA2 mRNA24752500
D004041Dietary FatsDietary Fats results in decreased expression of ITGA2 mRNA21852083
D004041Dietary Fatsresveratrol inhibits the reaction [Dietary Fats results in decreased expression of ITGA2 mRNA]21852083
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate affects the expression of ITGA2 mRNA27405655
D002117CalcitriolCalcitriol results in increased expression of ITGA2 mRNA21592394|2648566
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of ITGA2 mRNA21592394
D004656EnalaprilEnalapril results in decreased expression of ITGA2 mRNA25037058
D004837EpinephrineITGA2 gene SNP affects the susceptibility to [Aspirin co-treated with clopidogrel co-treated with Epinephrine]16214444
D000431EthanolEthanol results in increased expression of [ITGA2 protein binds to LYN protein binds to TRPV4 protein]18234883
D000431EthanolITGA2 protein results in increased susceptibility to Ethanol18234883
C005023fulvic acidfulvic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of ITGA2 mRNA]21331654
D019833GenisteinGenistein results in decreased expression of ITGA2 mRNA22228119
D019833GenisteinGenistein results in decreased expression of ITGA2 mRNA16169203
D006632HistamineITGA2 protein results in increased susceptibility to [KNG1 protein modified form co-treated with TAC1 protein modified form co-treated with Serotonin co-treated with Dinoprostone co-treated with Histamine]18234883
D012701SerotoninITGA2 protein promotes the reaction [[Dinoprostone co-treated with Serotonin] results in increased import of Calcium]18234883
D012701SerotoninTRPV4 protein promotes the reaction [ITGA2 protein promotes the reaction [[Dinoprostone co-treated with Serotonin] results in increased import of Calcium]]18234883
D012701SerotoninITGA2 protein results in increased susceptibility to [KNG1 protein modified form co-treated with TAC1 protein modified form co-treated with Serotonin co-treated with Dinoprostone co-treated with Histamine]18234883
D006812Humic SubstancesHumic Substances results in increased expression of ITGA2 protein19686714
C041508indeno(1,2,3-cd)pyrene"Acetylcysteine inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of ITGA2 mRNA]"21635667
C041508indeno(1,2,3-cd)pyrene"indeno(1,2,3-cd)pyrene results in increased expression of ITGA2 mRNA"21635667
C041508indeno(1,2,3-cd)pyrene"SB 203580 inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of ITGA2 mRNA]"21635667
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ITGA2 mRNA25613284
C051890irinotecanirinotecan analog results in increased expression of ITGA2 mRNA18927307
C561695(+)-JQ1 compound[PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of ITGA2 mRNA25119042
C410337K 7174K 7174 results in increased expression of ITGA2 mRNA24086573
C045463leflunomideleflunomide results in increased expression of ITGA2 mRNA28988120
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of ITGA2 mRNA"24972896
D017258Medroxyprogesterone AcetateMedroxyprogesterone Acetate results in decreased expression of ITGA2 mRNA18497975
D015741MetriboloneMetribolone results in decreased expression of [ITGA2 protein binds to ITGB1 protein]17541959
C057451morusinmorusin results in decreased expression of ITGA2 protein25476160
C500085muraglitazarmuraglitazar results in decreased expression of ITGA2 mRNA21515302
D009151Mustard GasMustard Gas results in increased expression of ITGA2 mRNA15674843
C000621033napabucasinnapabucasin results in decreased expression of ITGA2 mRNA25605917
D017239PaclitaxelITGA2 protein results in increased susceptibility to Paclitaxel18234883
C084656paricalcitolparicalcitol results in decreased expression of ITGA2 mRNA25037058
D052638Particulate Matter2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in increased expression of ITGA2 mRNA]28655636
D052638Particulate MatterParticulate Matter results in increased expression of ITGA2 mRNA24769257|2865563
C506614PD 0325901[PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of ITGA2 mRNA25119042
C506614PD 0325901PD 0325901 results in decreased expression of ITGA2 mRNA25119042
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of ITGA2 protein26879310
D010575PesticidesPesticides results in decreased methylation of ITGA2 gene28396702
D015232DinoprostoneITGA2 protein promotes the reaction [[Dinoprostone co-treated with Serotonin] results in increased import of Calcium]18234883
D015232DinoprostoneTRPV4 protein promotes the reaction [ITGA2 protein promotes the reaction [[Dinoprostone co-treated with Serotonin] results in increased import of Calcium]]18234883
D015232DinoprostoneITGA2 protein results in increased susceptibility to [KNG1 protein modified form co-treated with TAC1 protein modified form co-treated with Serotonin co-treated with Dinoprostone co-treated with Histamine]18234883
D010672PhenytoinPhenytoin results in decreased expression of ITGA2 protein15948689
D010862PilocarpinePilocarpine results in increased expression of ITGA2 protein12851778
D011192Potassium DichromatePotassium Dichromate results in decreased expression of ITGA2 mRNA23608068
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of ITGA2 mRNA20660070
C014175pyrazolo(3,4-d)pyrimidine"pyrazolo(3,4-d)pyrimidine analog affects the expression of ITGA2 mRNA"21152443
D011794QuercetinQuercetin results in increased expression of ITGA2 mRNA21632981
C059514resveratrol[Coumestrol co-treated with resveratrol] results in decreased expression of ITGA2 mRNA19167446
C059514resveratrolresveratrol results in increased expression of ITGA2 mRNA18089832
C059514resveratrolresveratrol results in increased expression of ITGA2 protein18089832
C059514resveratrolresveratrol inhibits the reaction [Dietary Fats results in decreased expression of ITGA2 mRNA]21852083
C089730rosiglitazonerosiglitazone results in decreased expression of ITGA2 mRNA21515302
C093642SB 203580SB 203580 inhibits the reaction [benz(a)anthracene results in increased expression of ITGA2 mRNA]21635667
C093642SB 203580SB 203580 inhibits the reaction [benzo(k)fluoranthene results in increased expression of ITGA2 mRNA]21635667
C093642SB 203580"SB 203580 inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of ITGA2 mRNA]"21635667
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of ITGA2 mRNA25895662
D012834SilverSilver results in increased expression of ITGA2 mRNA28959546
D013467SulindacSulindac results in increased expression of ITGA2 mRNA11906190
C436947T 113242T 113242 results in increased expression of ITGA2 mRNA11545736
C501413tesaglitazartesaglitazar results in decreased expression of ITGA2 mRNA21515302
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of ITGA2 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of ITGA2 mRNA21592394
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of ITGA2 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ITGA2 mRNA19619570|2315218
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ITGA2 mRNA16704738|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ITGA2 mRNA21570461|2892240
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ITGA2 mRNA22298810
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of ITGA2 mRNA28973375
D013755Tetradecanoylphorbol Acetatefulvic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of ITGA2 mRNA]21331654
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of ITGA2 mRNA21331654
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of ITGA2 mRNA17669516
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ITGA2 mRNA25613284
C009495titanium dioxidetitanium dioxide results in decreased expression of ITGA2 mRNA23131501
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of ITGA2 mRNA27865774
D014118Toxins, Biological"Toxins, Biological affects the expression of ITGA2 mRNA"19682533
D014212TretinoinTretinoin results in increased expression of ITGA2 mRNA21934132
D014212TretinoinTretinoin inhibits the reaction [RARA gene mutant form results in increased expression of ITGA2 mRNA]10748128
D014212TretinoinTretinoin results in decreased expression of ITGA2 mRNA10748128
C012589trichostatin Atrichostatin A results in increased expression of ITGA2 mRNA24935251
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of ITGA2 mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of ITGA2 mRNA29024780
C057693troglitazonetroglitazone results in increased expression of ITGA2 mRNA19140230
C057693troglitazonetroglitazone results in decreased expression of ITGA2 mRNA21515302
D014520UrethaneUrethane results in increased expression of ITGA2 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITGA2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of ITGA2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of ITGA2 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of ITGA2 mRNA19101580|2317975
D014638VanadatesVanadates results in increased expression of ITGA2 mRNA22714537
D001335Vehicle Emissions2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in increased expression of ITGA2 mRNA]28655636
D001335Vehicle EmissionsVehicle Emissions results in increased expression of ITGA2 mRNA28655636
C111237vorinostatvorinostat results in increased expression of ITGA2 mRNA27188386
D015032ZincZinc results in decreased expression of ITGA2 mRNA19071009

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001540amyloid-beta binding-ISS-  
GO:0001618virus receptor activity-IEA-  
GO:0005178integrin binding-IEA-  
GO:0005515protein binding-IPI7639691  14681217  16754661  16754960  18587047  21596751  
21947080  26779610  
GO:0005518collagen binding-IMP11518510  
GO:0038064collagen receptor activity-IMP11518510  
GO:0043236laminin binding-IEA-  
GO:0043395heparan sulfate proteoglycan binding-TAS21126803  
GO:0044877protein-containing complex binding-IPI25336636  
GO:0046872metal ion binding-IEA-  
GO:0046982protein heterodimerization activity-IEA-  
GO:0098639collagen binding involved in cell-matrix adhesion-IMP24823363  
GO ID GO Term Qualifier Evidence PubMed
GO:0001666response to hypoxia-IEA-  
GO:0002687positive regulation of leukocyte migration-IEA-  
GO:0006929substrate-dependent cell migration-IMP11518510  
GO:0006971hypotonic response-IEA-  
GO:0007155cell adhesion-TAS10201960  10942362  
GO:0007160cell-matrix adhesion-IMP11518510  24823363  
GO:0007229integrin-mediated signaling pathway-IMP24823363  
GO:0007565female pregnancy-IEA-  
GO:0007596blood coagulation-TAS2933589  
GO:0008283cell proliferation-IEA-  
GO:0009887animal organ morphogenesis-TAS9391074  
GO:0010634positive regulation of epithelial cell migration-IEA-  
GO:0010694positive regulation of alkaline phosphatase activity-IEA-  
GO:0014075response to amine-IEA-  
GO:0014850response to muscle activity-IEA-  
GO:0014911positive regulation of smooth muscle cell migration-IEA-  
GO:0030198extracellular matrix organization-TAS-  
GO:0030879mammary gland development-IEA-  
GO:0031346positive regulation of cell projection organization-IEA-  
GO:0031589cell-substrate adhesion-IMP19933311  
GO:0032967positive regulation of collagen biosynthetic process-IEA-  
GO:0033343positive regulation of collagen binding-IEA-  
GO:0033591response to L-ascorbic acid-IEA-  
GO:0033627cell adhesion mediated by integrin-IMP11518510  
GO:0038065collagen-activated signaling pathway-IMP11518510  
GO:0042493response to drug-IEA-  
GO:0043388positive regulation of DNA binding-IEA-  
GO:0043589skin morphogenesis-IEA-  
GO:0045184establishment of protein localization-IEA-  
GO:0045727positive regulation of translation-IEA-  
GO:0045785positive regulation of cell adhesion-IEA-  
GO:0045987positive regulation of smooth muscle contraction-IEA-  
GO:0046718viral entry into host cell-IEA-  
GO:0048041focal adhesion assembly-IEA-  
GO:0048333mesodermal cell differentiation-IEP23154389  
GO:0048661positive regulation of smooth muscle cell proliferation-IEA-  
GO:0050729positive regulation of inflammatory response-IEA-  
GO:0050927positive regulation of positive chemotaxis-IEA-  
GO:0050966detection of mechanical stimulus involved in sensory perception of pain-IEA-  
GO:0051971positive regulation of transmission of nerve impulse-IEA-  
GO:0060100positive regulation of phagocytosis, engulfment-IEA-  
GO:0070365hepatocyte differentiation-IEA-  
GO:0071107response to parathyroid hormone-IEA-  
GO:0071260cellular response to mechanical stimulus-IEA-  
GO:0071392cellular response to estradiol stimulus-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
GO:0005886plasma membrane-IDA21310825  
GO:0005886plasma membrane-TAS-  
GO:0005925focal adhesion-HDA21423176  
GO:0005925focal adhesion-IDA11518510  
GO:0008305integrin complex-TAS2545729  
GO:0009897external side of plasma membrane-IEA-  
GO:0009986cell surface-HDA19581412  23382103  23658023  
GO:0009986cell surface-IDA19933311  20563599  21310825  
GO:0034666integrin alpha2-beta1 complex-IDA24823363  
GO:0043679axon terminus-IEA-  
GO:0045178basal part of cell-IEA-  
GO:0048471perinuclear region of cytoplasm-IEA-  
KEGG ID KEGG Term
hsa04145Phagosome
hsa04510Focal adhesion
hsa04512ECM-receptor interaction
hsa04640Hematopoietic cell lineage
hsa04810Regulation of actin cytoskeleton
hsa05200Pathways in cancer
hsa05222Small cell lung cancer
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
hsa05414Dilated cardiomyopathy
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisIEA
R-HSA-1266738Developmental BiologyIEA
R-HSA-1474244Extracellular matrix organizationIEA
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-162582Signal TransductionTAS
R-HSA-216083Integrin cell surface interactionsIEA
R-HSA-216083Integrin cell surface interactionsTAS
R-HSA-3000157Laminin interactionsIEA
R-HSA-3000157Laminin interactionsTAS
R-HSA-3000170Syndecan interactionsTAS
R-HSA-3000171Non-integrin membrane-ECM interactionsTAS
R-HSA-3000178ECM proteoglycansTAS
R-HSA-373760L1CAM interactionsIEA
R-HSA-422475Axon guidanceIEA
R-HSA-447041CHL1 interactionsIEA
R-HSA-6806834Signaling by METTAS
R-HSA-75892Platelet Adhesion to exposed collagenIEA
R-HSA-8874081MET activates PTK2 signalingTAS
R-HSA-8875878MET promotes cell motilityTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22535530Prothrombotic gene polymorphisms and plasma factors in young North Indian survivors of acute myocardial infarction. (2012 Aug)Dogra RKJ Thromb Thrombolysis
17036337Risks of human limb deficiency anomalies associated with 29 SNPs of genes involved in homocysteine metabolism, coagulation, cell-cell interactions, inflammatory response, and blood pressure regulation. (2006 Nov 15)Carmichael SLAm J Med Genet A
29121049Haplotype CGC from XPD, hOGG1 and ITGA2 polymorphisms increases the risk of nasopharyngeal carcinoma in Malaysia. (2017)Ban EZPLoS One
17070428Assessment of the genetic component of hypertension. (2006 Nov)Yamada YAm J Hypertens
24890784Exon microarray analysis of human dorsolateral prefrontal cortex in alcoholism. (2014 Jun)Manzardo AMAlcohol Clin Exp Res
25155498Genetic polymorphisms, Biochemical Factors, and Conventional Risk Factors in Young and Elderly North Indian Patients With Acute Myocardial Infarction. (2016 Mar)Kaur RClin Appl Thromb Hemost