Gene: ITGA2B

3674
BDPLT16|BDPLT2|CD41|CD41B|GP2B|GPIIb|GT|GTA|HPA3|PPP1R93
integrin subunit alpha 2b
protein-coding
17q21.31
Ensembl:ENSG00000005961 MIM:607759 Vega:OTTHUMG00000177935 UniprotKB:P08514
NG_008331.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.563e-1 (AD)  9.037e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg25809905chr17:42467728ITGA2B4.500e-22Smoking27651444
cg20810975chr17:42467199ITGA2B1.700e-18Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYO15A0.867
SFI10.861
RTEL10.827
CORO60.826
CCDC570.826
ABCA70.814
STRC0.812
PKD10.812
ZFR20.809
IFT1720.806

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LRAT-0.418
YES1-0.412
GNG12-0.41
TSPAN12-0.41
SLC40A1-0.396
MTRNR2L8-0.395
ZNF114-0.388
MDFI-0.386
MTRNR2L2-0.386
PDLIM3-0.382

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00054AbciximabBiotechDrug143653-53-6ApprovedTarget
DB00775TirofibanSmall Molecule144494-65-5ApprovedTarget
DB04863LefradafibanSmall Molecule149503-79-7InvestigationalTarget
DB06472FradafibanSmall Molecule148396-36-5InvestigationalTarget
ID Drug Name Action PubMed
C55310010-(4'-(N-diethylamino)butyl)-2-chlorophenoxazine10-(4'-(N-diethylamino)butyl)-2-chlorophenoxazine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGA2B protein]20523355
C55310010-(4'-(N-diethylamino)butyl)-2-chlorophenoxazine10-(4'-(N-diethylamino)butyl)-2-chlorophenoxazine inhibits the reaction [THPO protein results in increased expression of ITGA2B protein]20523355
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of ITGA2B mRNA"20959002
C5054173-hydrogenkwadaphnin3-hydrogenkwadaphnin results in increased expression of ITGA2B protein21396949
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of ITGA2B mRNA"25380136
C0106436-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGA2B protein]"20523355
C0106436-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [THPO protein results in increased expression of ITGA2B protein]"20523355
D000082AcetaminophenAcetaminophen affects the expression of ITGA2B mRNA17562736
C056165acetovanilloneacetovanillone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGA2B protein]20523355
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGA2B protein]20523355
D000111AcetylcysteineAcetylcysteine inhibits the reaction [THPO protein results in increased expression of ITGA2B protein]20523355
D000244Adenosine Diphosphatecangrelor inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]]18404433
D000244Adenosine Diphosphate"N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]]"18404433
D000244Adenosine Diphosphate"N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate promotes the reaction [cangrelor inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]]]"18404433
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of ITGA2B gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of ITGA2B mRNA19770486
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGA2B protein]"20523355
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [THPO protein results in increased expression of ITGA2B protein]"20523355
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of ITGA2B mRNA21298039
C021139anagrelideanagrelide inhibits the reaction [THPO protein results in increased expression of ITGA2B mRNA]20586925
D016718Arachidonic AcidArachidonic Acid results in increased expression of ITGA2B protein18413191
D016718Arachidonic AcidAspirin inhibits the reaction [Arachidonic Acid results in increased expression of ITGA2B protein]18413191
D016718Arachidonic AcidGlucose inhibits the reaction [Aspirin inhibits the reaction [Arachidonic Acid results in increased expression of ITGA2B protein]]18413191
C006632arsenic trioxidearsenic trioxide results in increased expression of ITGA2B mRNA15761015
D001241AspirinAspirin inhibits the reaction [Arachidonic Acid results in increased expression of ITGA2B protein]18413191
D001241AspirinAspirin results in decreased expression of ITGA2B protein15381054
D001241AspirinAspirin results in decreased expression of [ITGA2B protein binds to ITGB2 protein]15140583
D001241AspirinAspirin results in decreased expression of [ITGA2B protein binds to ITGB3 protein]15381054
D001241AspirinGlucose inhibits the reaction [Aspirin inhibits the reaction [Arachidonic Acid results in increased expression of ITGA2B protein]]18413191
D000068342Aspirin, Dipyridamole Drug Combination"Aspirin, Dipyridamole Drug Combination results in decreased expression of ITGA2B protein"15381054
D000068342Aspirin, Dipyridamole Drug Combination"Aspirin, Dipyridamole Drug Combination results in decreased expression of [ITGA2B protein binds to ITGB3 protein]"15381054
D001280AtrazineAtrazine results in increased expression of ITGA2B mRNA22378314
D001554BenzeneBenzene results in decreased expression of ITGA2B mRNA19162166
D004958EstradiolEstradiol results in increased expression of ITGA2B mRNA19484750
C117446cangrelorcangrelor inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]]18404433
C117446cangrelor"N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate promotes the reaction [cangrelor inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]]]"18404433
D003471CuprizoneCuprizone results in increased expression of ITGA2B mRNA26577399
D003474CurcuminCurcumin inhibits the reaction [F2 protein results in increased expression of ITGA2B protein]18565277
D003609DactinomycinDactinomycin results in increased expression of ITGA2B mRNA21527772
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of ITGA2B mRNA27392435
D002945CisplatinCisplatin results in increased expression of ITGA2B mRNA27392435
C036042dicyclohexyl phthalatedicyclohexyl phthalate results in decreased expression of ITGA2B mRNA26924002
D004026DieldrinDieldrin results in increased expression of ITGA2B mRNA23041725
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of ITGA2B mRNA25380136
C024629dimethyl phthalatedimethyl phthalate results in decreased expression of ITGA2B mRNA26924002
C007517diphenyleneiodoniumdiphenyleneiodonium inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGA2B protein]20523355
D004391DustDust results in decreased expression of ITGA2B mRNA17805423
C086648eptifibatideeptifibatide results in decreased activity of [ITGA2B protein binds to ITGB3 protein]14744276
D005047EtoposideEtoposide results in increased expression of ITGA2B mRNA21527772
D005419FlavonoidsFlavonoids results in increased expression of ITGA2B mRNA15465739
D005485FlutamideFlutamide results in decreased expression of ITGA2B mRNA24136188
D009240N-Formylmethionine Leucyl-PhenylalanineITGA2B protein promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of SELP protein]11116075
D005947GlucoseGlucose inhibits the reaction [Aspirin inhibits the reaction [Arachidonic Acid results in increased expression of ITGA2B protein]]18413191
D017313FenretinideFenretinide results in increased expression of ITGA2B mRNA28973697
C013038hydroxyhydroquinonehydroxyhydroquinone results in increased expression of ITGA2B mRNA17572062
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ITGA2B mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of ITGA2B mRNA27392435
C544151jinfukangjinfukang results in increased expression of ITGA2B mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ITGA2B mRNA23086925|2675264
C025340manganese chloridemanganese chloride inhibits the reaction [TLN1 protein mutant form results in decreased activity of [ITGB3 protein binds to ITGA2B protein]]20971947
C025340manganese chloridemanganese chloride results in increased activity of [ITGB3 protein binds to ITGA2B protein]20971947
C054634methyllycaconitine[methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] which results in decreased expression of ITGA2B mRNA21385097
C054634methyllycaconitine[methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] which results in decreased expression of ITGA2B protein21385097
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of ITGA2B mRNA24810058
C517284monomethyl phthalatemonomethyl phthalate results in decreased expression of ITGA2B mRNA26924002
C111914N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate"N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]]"18404433
C111914N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate"N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate promotes the reaction [cangrelor inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]]]"18404433
C031721naphthalenenaphthalene results in increased expression of ITGA2B mRNA18978301
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of ITGA2B mRNA25380136
D009538NicotineNicotine results in decreased expression of ITGA2B mRNA21385097
D009538NicotineNicotine results in decreased expression of ITGA2B protein21385097
D010936Plant ExtractsPlant Extracts results in increased expression of ITGA2B mRNA15465739
D059808PolyphenolsPolyphenols results in increased expression of ITGA2B mRNA15465739
C432165pyrazolanthronepyrazolanthrone promotes the reaction [THPO protein results in increased expression of ITGA2B protein]20523355
D011794QuercetinQuercetin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGA2B protein]20523355
C059514resveratrolresveratrol inhibits the reaction [ITGA2B protein binds to ITGB3 protein]26482867
C059514resveratrolresveratrol results in decreased expression of ITGA2B23617069
C089730rosiglitazonerosiglitazone affects the expression of ITGA2B protein19556978
C071275SK&F 106760SK&F 106760 binds to and results in decreased activity of [ITGA2B protein binds to ITGB3 protein]1605806
C106774SR 121566SR 121566 binds to and results in decreased activity of ITGA2B protein11116075
D013749TetrachlorodibenzodioxinAHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of ITGA2B mRNA]21215274
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ITGA2B mRNA21215274
D013755Tetradecanoylphorbol Acetate10-(4'-(N-diethylamino)butyl)-2-chlorophenoxazine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGA2B protein]20523355
D013755Tetradecanoylphorbol Acetate"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGA2B protein]"20523355
D013755Tetradecanoylphorbol Acetateacetovanillone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGA2B protein]20523355
D013755Tetradecanoylphorbol AcetateAcetylcysteine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGA2B protein]20523355
D013755Tetradecanoylphorbol Acetate"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGA2B protein]"20523355
D013755Tetradecanoylphorbol AcetateCYBA protein promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGA2B protein]20523355
D013755Tetradecanoylphorbol Acetatediphenyleneiodonium inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGA2B protein]20523355
D013755Tetradecanoylphorbol AcetateQuercetin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGA2B protein]20523355
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of ITGA2B protein10428506|2052335
D013755Tetradecanoylphorbol AcetateU 0126 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGA2B protein]20523355
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ITGA2B mRNA25613284
C009495titanium dioxidetitanium dioxide results in decreased expression of ITGA2B mRNA23409001
C113580U 0126U 0126 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGA2B protein]20523355
C113580U 0126U 0126 inhibits the reaction [THPO protein results in increased expression of ITGA2B protein]20523355
D014520UrethaneUrethane results in increased expression of ITGA2B mRNA28818685

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI14681217  15379538  19279667  22779914  
GO:0042802identical protein binding-IPI11606749  14681217  15067009  
GO:0046872metal ion binding-IEA-  
GO:0050840extracellular matrix binding-IEA-  
GO:0070051fibrinogen binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002576platelet degranulation-TAS-  
GO:0002687positive regulation of leukocyte migration-IEA-  
GO:0007160cell-matrix adhesion-IEA-  
GO:0007229integrin-mediated signaling pathway-HDA23382103  
GO:0030198extracellular matrix organization-TAS-  
GO:0045652regulation of megakaryocyte differentiation-TAS-  
GO:0070527platelet aggregation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005925focal adhesion-IEA-  
GO:0008305integrin complex-IEA-  
GO:0009897external side of plasma membrane-IEA-  
GO:0009986cell surface-HDA23382103  
GO:0031092platelet alpha granule membrane-TAS-  
GO:0070062extracellular exosome-IDA15908444  
GO:0072562blood microparticle-HDA22516433  
KEGG ID KEGG Term
hsa04510Focal adhesion
hsa04512ECM-receptor interaction
hsa04640Hematopoietic cell lineage
hsa04810Regulation of actin cytoskeleton
hsa05200Pathways in cancer
hsa05222Small cell lung cancer
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
hsa05414Dilated cardiomyopathy
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-114608Platelet degranulation TAS
R-HSA-1266738Developmental BiologyTAS
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-162582Signal TransductionTAS
R-HSA-1643685DiseaseTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-216083Integrin cell surface interactionsTAS
R-HSA-3000178ECM proteoglycansTAS
R-HSA-354192Integrin alphaIIb beta3 signalingTAS
R-HSA-354194GRB2:SOS provides linkage to MAPK signaling for Integrins TAS
R-HSA-372708p130Cas linkage to MAPK signaling for integrinsTAS
R-HSA-373760L1CAM interactionsTAS
R-HSA-422475Axon guidanceTAS
R-HSA-445144Signal transduction by L1TAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-5673001RAF/MAP kinase cascadeTAS
R-HSA-5674135MAP2K and MAPK activationTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5684996MAPK1/MAPK3 signalingTAS
R-HSA-6802946Signaling by moderate kinase activity BRAF mutantsTAS
R-HSA-6802948Signaling by high-kinase activity BRAF mutantsTAS
R-HSA-6802949Signaling by RAS mutantsTAS
R-HSA-6802952Signaling by BRAF and RAF fusionsTAS
R-HSA-6802955Paradoxical activation of RAF signaling by kinase inactive BRAFTAS
R-HSA-6802957Oncogenic MAPK signalingTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-76002Platelet activation, signaling and aggregationTAS
R-HSA-76005Response to elevated platelet cytosolic Ca2+TAS
R-HSA-76009Platelet Aggregation (Plug Formation)TAS
R-HSA-8878171Transcriptional regulation by RUNX1TAS
R-HSA-8936459RUNX1 regulates genes involved in megakaryocyte differentiation and platelet functionTAS
R-HSA-9006921Integrin signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29329538Peripheral blood gene expression signatures which reflect smoking and aspirin exposure are associated with cardiovascular events. (2018 Jan 12)Wingrove JABMC Med Genomics