Gene: ITGA4

3676
CD49D|IA4
integrin subunit alpha 4
protein-coding
2q31.3
Ensembl:ENSG00000115232 MIM:192975 Vega:OTTHUMG00000154212 UniprotKB:P13612
NG_050623.1
PubMed
ND
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.575e-1 (AD)  6.155e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CERKL0.747
THSD7A0.68
NHSL20.664
MYO1B0.661
PRKG20.628
PDGFD0.622
ALG110.606
GPC60.603
EPHA60.602
NPR30.599

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NRN1L-0.437
KIF19-0.382
HPN-0.346
FAM178B-0.34
CCL27-0.339
ANKRD23-0.334
TMEM31-0.329
FEZF2-0.325
CRYBB2-0.323
CLDND2-0.322

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00108NatalizumabBiotechDrug189261-10-7Approved|InvestigationalTarget
DB04997ATL1102Small Molecule-InvestigationalTarget
DB05092CDP323Small Molecule-InvestigationalTarget
DB05122R1295Small Molecule-InvestigationalTarget
DB05468R411Small Molecule-InvestigationalTarget
DB06822TinzaparinSmall Molecule9041-08-1ApprovedTarget
DB09033VedolizumabBiotechDrug943609-66-3ApprovedTarget
ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ITGA4 mRNA"25510870
C0010792-(2,6-dioxopiperidin-3-yl)phthalimidine"2-(2,6-dioxopiperidin-3-yl)phthalimidine results in decreased expression of ITGA4 protein"8538367
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ITGA4 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ITGA4 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ITGA4 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ITGA4 mRNA"25510870
C5779422-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide"2-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide inhibits the reaction [TGFB1 protein results in increased expression of ITGA4 mRNA]"26644586
C5779422-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide"2-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide results in decreased expression of ITGA4 mRNA"26644586
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of ITGA4 mRNA]"19467301
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ITGA4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ITGA4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ITGA4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITGA4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITGA4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITGA4 mRNA"27188386
C0022024-oxoretinoic acid4-oxoretinoic acid results in increased expression of ITGA4 mRNA15982314
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ITGA4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ITGA4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ITGA4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITGA4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITGA4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITGA4 mRNA"27188386
C496492abrineabrine results in increased expression of ITGA4 mRNA22595364
D000082AcetaminophenAcetaminophen results in increased expression of ITGA4 mRNA26690555
D000082AcetaminophenAcetaminophen results in increased expression of ITGA4 mRNA17585979
D000393Air PollutantsAir Pollutants results in increased expression of ITGA4 mRNA23649983
D000447AldehydesAldehydes results in increased expression of ITGA4 mRNA25014914
C103303alitretinoinalitretinoin results in increased expression of ITGA4 mRNA15982314
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of ITGA4 mRNA28522335
D000499AllylamineAllylamine results in decreased expression of ITGA4 mRNA15698866
D000499AllylamineAllylamine results in decreased expression of ITGA4 protein15698866
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of ITGA4 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in decreased expression of ITGA4 mRNA26238599
C015001arsenitearsenite results in increased methylation of ITGA4 promoter23974009
D001194AsbestosAsbestos affects the expression of ITGA4 mRNA17297452
D017636Asbestos, Amphibole"Asbestos, Amphibole results in decreased expression of ITGA4 protein"23746315
C547126AZM551248AZM551248 results in increased expression of ITGA4 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene metabolite results in increased expression of ITGA4 mRNA26314263
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ITGA4 mRNA21569818
C006780bisphenol Abisphenol A results in decreased expression of ITGA4 mRNA22576693
C006780bisphenol Abisphenol A results in increased methylation of ITGA4 gene22576693
C006780bisphenol Abisphenol A results in decreased expression of ITGA4 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of ITGA4 mRNA29097150
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of ITGA4 mRNA26314263
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of ITGA4 mRNA15336504
C018475butyraldehydebutyraldehyde results in increased expression of ITGA4 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of ITGA4 mRNA26238599
D000074262Canola OilCanola Oil metabolite results in decreased expression of ITGA4 mRNA27363782
D000074262Canola OilStarch analog inhibits the reaction [Canola Oil metabolite results in decreased expression of ITGA4 mRNA]27363782
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ITGA4 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of ITGA4 mRNA26272509
D002737ChloropreneChloroprene results in decreased expression of ITGA4 mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ITGA4 mRNA20938992
D002927CimetidineCimetidine results in decreased expression of ITGA4 protein11556524
C018021cobaltous chloridecobaltous chloride results in increased expression of ITGA4 mRNA26314263
D003703DemecolcineDemecolcine results in decreased expression of ITGA4 mRNA23649840
D003907DexamethasoneDexamethasone results in decreased expression of ITGA4 mRNA12782123
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of ITGA4 mRNA28962523
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of ITGA4 mRNA]"19467301
D004041Dietary FatsDietary Fats results in decreased expression of ITGA4 mRNA18042831
D004041Dietary FatsDietary Fats results in increased expression of ITGA4 mRNA19467301
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ITGA4 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ITGA4 mRNA29097150
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of ITGA4 mRNA23649840
D017308EtodolacEtodolac results in decreased expression of [ITGA4 protein binds to ITGB1 protein]16046235
D005492Folic AcidFolic Acid affects the expression of ITGA4 mRNA17320366
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ITGA4 mRNA20938992
D005557FormaldehydeFormaldehyde results in decreased expression of ITGA4 mRNA23649840
C112772ginsenoside M1ginsenoside M1 inhibits the reaction [TNF protein results in increased expression of [ITGA4 protein binds to ITGB1 protein]]21875580
C425564ginsenoside Rh1ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of [ITGA4 protein binds to ITGB1 protein]]21875580
C568713GSK1210151AGSK1210151A inhibits the reaction [TGFB1 protein results in increased expression of ITGA4 mRNA]26644586
C568713GSK1210151AGSK1210151A results in decreased expression of ITGA4 mRNA26644586
D017313FenretinideFenretinide results in decreased expression of ITGA4 mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ITGA4 mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [TGFB1 protein results in increased expression of ITGA4 mRNA]26644586
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ITGA4 mRNA22802445|2308692
C045463leflunomideleflunomide results in decreased expression of ITGA4 mRNA19751817
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of ITGA4 mRNA"24972896
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of ITGA4 mRNA18192897
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of ITGA4 mRNA21641980
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of ITGA4 mRNA26378955
D008294MalathionMalathion results in decreased expression of ITGA4 mRNA26494550
C042720mercuric bromidemercuric bromide results in decreased expression of ITGA4 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ITGA4 mRNA"27188386
D008627Mercuric ChlorideMercuric Chloride results in increased expression of ITGA4 protein17250768
D008627Mercuric ChlorideTretinoin inhibits the reaction [Mercuric Chloride results in increased expression of ITGA4 mRNA]17250768
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ITGA4 mRNA20938992
D008727MethotrexateMethotrexate affects the expression of ITGA4 mRNA18502557
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ITGA4 mRNA28001369
C030957methylmercury IImethylmercury II results in increased expression of ITGA4 mRNA26314263
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of ITGA4 mRNA23649840
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of ITGA4 mRNA24810058
C451426N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide"N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of ITGA4 mRNA"25461557
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ITGA4 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ITGA4 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ITGA4 mRNA"22293422
C000621033napabucasinnapabucasin results in decreased expression of ITGA4 mRNA25605917
D009532NickelNickel results in increased expression of ITGA4 mRNA25583101
C025589ochratoxin Aochratoxin A metabolite results in increased expression of ITGA4 mRNA26314263
C025589ochratoxin Aochratoxin A results in increased expression of ITGA4 mRNA26314263
D010100OxygenOxygen deficiency affects the expression of ITGA4 mRNA17193925
D000073878Palm OilPalm Oil results in decreased expression of ITGA4 mRNA18042831
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ITGA4 mRNA"25510870
C046012pentanalpentanal results in increased expression of ITGA4 mRNA26079696
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ITGA4 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of ITGA4 mRNA26272509
D010862PilocarpinePilocarpine results in increased expression of ITGA4 protein12851778
D010936Plant ExtractsPlant Extracts results in increased expression of ITGA4 mRNA23557933
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ITGA4 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of ITGA4 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of ITGA4 mRNA22714537
D011374ProgesteroneProgesterone results in decreased expression of ITGA4 mRNA21795739
C005556propionaldehydepropionaldehyde results in increased expression of ITGA4 mRNA26079696
D015474IsotretinoinIsotretinoin results in increased expression of ITGA4 mRNA15982314
C013672riddelliineriddelliine results in increased expression of ITGA4 mRNA18047727
C118258SN50 peptideSN50 peptide inhibits the reaction [TNF protein results in increased expression of [ITGA4 protein binds to ITGB1 protein]]21875580
C017947sodium arsenitesodium arsenite results in increased expression of ITGA4 mRNA12760830|2271453
D013213StarchStarch analog inhibits the reaction [Canola Oil metabolite results in decreased expression of ITGA4 mRNA]27363782
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of ITGA4 mRNA21641980
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of ITGA4 mRNA26378955
C061133tamibarotenetamibarotene affects the expression of ITGA4 mRNA15498508
C043062tesmilifenetesmilifene results in decreased expression of ITGA4 protein11556524
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ITGA4 mRNA26377647
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of ITGA4 mRNA28973375
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ITGA4 mRNA25613284
C009495titanium dioxidetitanium dioxide results in decreased expression of ITGA4 mRNA27760801
D014118Toxins, Biological"Toxins, Biological affects the expression of ITGA4 mRNA"19682533
D014212TretinoinTretinoin metabolite results in increased expression of ITGA4 mRNA15982314
D014212TretinoinTretinoin results in decreased expression of ITGA4 mRNA15498508
D014212TretinoinTretinoin results in increased expression of ITGA4 mRNA15982314|2193413
D014212TretinoinTretinoin inhibits the reaction [Mercuric Chloride results in increased expression of ITGA4 mRNA]17250768
C032910triadimefontriadimefon analog results in decreased expression of ITGA4 mRNA26238599
C011559tributyltintributyltin results in increased expression of ITGA4 mRNA26314263
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITGA4 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of ITGA4 mRNA24935251|2627250
D014311TriprolidineTriprolidine results in decreased expression of ITGA4 protein11556524
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITGA4 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of ITGA4 mRNA26272509|2800136
D014638VanadatesVanadates results in decreased expression of ITGA4 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of ITGA4 gene25560391
D014750VincristineVincristine results in decreased expression of ITGA4 mRNA23649840
D024483Vitamin K 3Vitamin K 3 affects the expression of ITGA4 mRNA20829426
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITGA4 mRNA"27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001968fibronectin binding-IEA-  
GO:0005515protein binding-IPI1542691  9079671  10604475  14681217  20159608  21173240  
22232704  26779610  
GO:0015026coreceptor activity-TAS23125415  
GO:0019960C-X3-C chemokine bindingcontributes_toIDA23125415  
GO:0046872metal ion binding-IEA-  
GO:0050839cell adhesion molecule binding-IMP23986478  
GO:0050839cell adhesion molecule binding-IPI12869515  
GO:1990405protein antigen binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0003366cell-matrix adhesion involved in ameboidal cell migration-IMP23986478  
GO:0007159leukocyte cell-cell adhesion-IDA1715889  
GO:0007160cell-matrix adhesion-IMP18308860  23986478  
GO:0007229integrin-mediated signaling pathway-IEA-  
GO:0030183B cell differentiation-IC1715889  
GO:0030198extracellular matrix organization-TAS-  
GO:0034113heterotypic cell-cell adhesion-IMP18308860  
GO:0034446substrate adhesion-dependent cell spreading-IMP23986478  
GO:0035987endodermal cell differentiation-IEP23154389  
GO:0043113receptor clustering-IMP23986478  
GO:0050776regulation of immune response-TAS-  
GO:0050900leukocyte migration-TAS-  
GO:0050901leukocyte tethering or rolling-IMP18308860  
GO:0050904diapedesis-IEA-  
GO:0071345cellular response to cytokine stimulus-IEA-  
GO:0090074negative regulation of protein homodimerization activity-IDA12869515  
GO:1903238positive regulation of leukocyte tethering or rolling-IEA-  
GO:1905564positive regulation of vascular endothelial cell proliferation-IMP27464494  
GO:1990771clathrin-dependent extracellular exosome endocytosis-IEA-  
GO:2000353positive regulation of endothelial cell apoptotic process-IMP27464494  
GO:2000406positive regulation of T cell migration-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IDA12869515  
GO:0005886plasma membrane-TAS-  
GO:0005925focal adhesion-HDA21423176  
GO:0009986cell surface-IDA1715889  18308860  20563599  23986478  
GO:0016020membrane-HDA19946888  
GO:0034669integrin alpha4-beta7 complex-IDA18308860  23986478  
GO:0070062extracellular exosome-HDA12519789  20458337  
KEGG ID KEGG Term
hsa04510Focal adhesion
hsa04512ECM-receptor interaction
hsa04514Cell adhesion molecules (CAMs)
hsa04640Hematopoietic cell lineage
hsa04670Leukocyte transendothelial migration
hsa04672Intestinal immune network for IgA production
hsa04810Regulation of actin cytoskeleton
hsa05140Leishmaniasis
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
hsa05414Dilated cardiomyopathy
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-1474244Extracellular matrix organizationIEA
R-HSA-168256Immune SystemTAS
R-HSA-198933Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellTAS
R-HSA-202733Cell surface interactions at the vascular wallTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-216083Integrin cell surface interactionsTAS
R-HSA-216083Integrin cell surface interactionsIEA
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8878159Transcriptional regulation by RUNX3TAS
R-HSA-8949275RUNX3 Regulates Immune Response and Cell MigrationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28814981CpG location and methylation level are crucial factors for the early detection of oral squamous cell carcinoma in brushing samples using bisulfite sequencing of a 13-gene panel. (2017)Morandi LClin Epigenetics
28823962Frequent promoter hypermethylation associated with human papillomavirus infection in pharyngeal cancer. (2017 Oct 28)Nakagawa TCancer Lett
28193307Heritability and GWAS Studies for Monocyte-Lymphocyte Ratio. (2017 Apr)Lin BDTwin Res Hum Genet
17634906Polymorphisms in 33 inflammatory genes and risk of myocardial infarction--a system genetics approach. (2007 Nov)Barbaux SJ Mol Med (Berl)