Gene: ITGA5

3678
CD49e|FNRA|VLA-5|VLA5A
integrin subunit alpha 5
protein-coding
12q13.13
Ensembl:ENSG00000161638 MIM:135620 Vega:OTTHUMG00000169841 UniprotKB:P08648
NC_000012.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.414e-2 (AD)  9.542e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CLIC10.874
ANXA20.873
ITPRIP0.868
CD930.857
TNFRSF10A0.854
B4GALT10.851
VASP0.85
IL1R10.85
TUBB60.849
COL4A10.845

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC7A4-0.518
NEUROD6-0.512
MARCH4-0.511
SMIM18-0.499
ZSCAN1-0.496
TMEM179-0.487
MYADML2-0.481
ABCC12-0.475
SPRN-0.472
CALHM1-0.469

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB02709ResveratrolSmall Molecule501-36-0Approved|Experimental|InvestigationalTarget
ID Drug Name Action PubMed
C0131862,3-pentanedione"2,3-pentanedione results in increased expression of ITGA5 mRNA"25710175
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of ITGA5 mRNA"21346803
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased expression of and affects the localization of [ITGA5 protein binds to ITGB3 protein]]16465378
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of ITGA5 mRNA"21346803
C5779422-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide"2-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide inhibits the reaction [TGFB1 protein results in increased expression of ITGA5 mRNA]"26644586
C5779422-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide"2-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide results in decreased expression of ITGA5 mRNA"26644586
C4267033-(3-(3-(4,5-dihydroimidazol-2-ylamino)propyloxylisoxazol-5-yl)carbonylamino)-2-(phenylsulfonylamino)propionic acid"3-(3-(3-(4,5-dihydroimidazol-2-ylamino)propyloxylisoxazol-5-yl)carbonylamino)-2-(phenylsulfonylamino)propionic acid binds to and results in decreased activity of [ITGA5 protein binds to ITGB3 protein]"16384862
C4786263-(6-methoxypyridin-3-yl)-3-(2-oxo-3-(3-(5,6,7,8-tetrahydro(1,8)naphthyridin-2-yl)propyl)imidazolidin-1-yl)propionic acid"3-(6-methoxypyridin-3-yl)-3-(2-oxo-3-(3-(5,6,7,8-tetrahydro(1,8)naphthyridin-2-yl)propyl)imidazolidin-1-yl)propionic acid binds to [ITGA5 protein binds to ITGB3 protein]"14561098
C4786263-(6-methoxypyridin-3-yl)-3-(2-oxo-3-(3-(5,6,7,8-tetrahydro(1,8)naphthyridin-2-yl)propyl)imidazolidin-1-yl)propionic acid"3-(6-methoxypyridin-3-yl)-3-(2-oxo-3-(3-(5,6,7,8-tetrahydro(1,8)naphthyridin-2-yl)propyl)imidazolidin-1-yl)propionic acid results in decreased activity of [ITGA5 protein binds to ITGB3 protein]"14561098
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of ITGA5 mRNA12419474
C0126064-vinyl-1-cyclohexene dioxide4-vinyl-1-cyclohexene dioxide affects the expression of ITGA5 mRNA20829426
D000096AcetoneAcetone results in increased expression of ITGA5 mRNA12720008
C549106AL-10 compoundAL-10 compound results in decreased metabolism of ITGA5 protein20112294
D000537Aluminum Oxide[Aluminum Oxide co-treated with Magnesium] results in increased expression of ITGA5 protein12209937
C047981arginyl-glycyl-aspartic acidarginyl-glycyl-aspartic acid inhibits the reaction [resveratrol binds to [ITGA5 protein binds to ITGB3 protein]]16790523
D001241AspirinAspirin results in decreased expression of ITGA5 mRNA15928584
D001280AtrazineAtrazine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGA5 mRNA]24211529
C547126AZM551248AZM551248 results in increased expression of ITGA5 mRNA22323515
D001542BenomylBenomyl results in decreased expression of ITGA5 mRNA25530041
D001554BenzeneBenzene results in increased expression of ITGA5 mRNA19162166
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ITGA5 mRNA22228805
D004958Estradiol[Progesterone co-treated with Estradiol] results in increased expression of ITGA5 mRNA20226447
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of ITGA5 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of ITGA5 mRNA21786754
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ITGA5 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of ITGA5 mRNA25594700
C006780bisphenol Abisphenol A results in increased methylation of ITGA5 promoter27312807
C006780bisphenol Abisphenol A results in increased expression of ITGA5 mRNA25181051
C025703bleomycetinbleomycetin results in increased expression of ITGA5 mRNA21040473
D001973BromodeoxyuridineBromodeoxyuridine results in increased expression of ITGA5 mRNA7519154
D001973BromodeoxyuridineBromodeoxyuridine results in increased expression of ITGA5 protein7519154
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of ITGA5 mRNA12419474
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of ITGA5 mRNA22659508
C584509C646 compoundC646 compound results in increased expression of ITGA5 mRNA26191083
D002104CadmiumCadmium results in decreased expression of ITGA5 mRNA20570719
D002104CadmiumCadmium results in increased expression of ITGA5 mRNA20570719
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of ITGA5 mRNA26472689
D019256Cadmium ChlorideCadmium Chloride results in increased expression of ITGA5 protein28527916
D002211CapsaicinCapsaicin results in increased expression of ITGA5 mRNA16278290
C006698carbendazimcarbendazim results in decreased expression of ITGA5 mRNA25530041
C422910CilengitideCilengitide results in decreased activity of [ITGA5 protein binds to ITGB3 protein]16729916
C422910CilengitideCilengitide results in decreased activity of [ITGA5 protein binds to ITGB5 protein]16729916
D007464ClioquinolITGA5 protein promotes the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of EGFR protein]18346929
C018021cobaltous chloridecobaltous chloride results in increased expression of ITGA5 protein16798617
D003300CopperITGA5 protein promotes the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of EGFR protein]18346929
D019327Copper SulfateCopper Sulfate results in increased expression of ITGA5 mRNA21595052
D003634DDTDDT results in increased expression of ITGA5 mRNA22902829
C014347decitabinedecitabine affects the expression of ITGA5 mRNA23300844
C014347decitabinedecitabine results in increased expression of ITGA5 mRNA27915011
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of ITGA5 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ITGA5 mRNA28628672
D003907DexamethasoneDexamethasone results in increased expression of ITGA5 mRNA22733784
D003975DiazepamDiazepam results in increased expression of ITGA5 mRNA19114084
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ITGA5 mRNA15829613|2126653
D002945CisplatinCisplatin affects the expression of ITGA5 mRNA23300844
D004041Dietary FatsDietary Fats results in increased expression of ITGA5 mRNA25016146
D004221DisulfiramDisulfiram results in decreased expression of ITGA5 mRNA20530235
C529593EMD 527040EMD 527040 binds to and results in decreased activity of [ITGA5 protein binds to ITGB6 protein]18221819
D004726EndosulfanEndosulfan results in increased expression of ITGA5 mRNA22902829
D000431EthanolEthanol results in increased expression of ITGA5 mRNA12720008
C540355fenamidonefenamidone results in increased expression of ITGA5 mRNA27029645
D005492Folic AcidFolic Acid affects the expression of ITGA5 mRNA16361273
D005665FurosemideFurosemide results in decreased expression of ITGA5 mRNA16526316
C568713GSK1210151AGSK1210151A inhibits the reaction [TGFB1 protein results in increased expression of ITGA5 mRNA]26644586
C568713GSK1210151AGSK1210151A results in decreased expression of ITGA5 mRNA26644586
D006533HeptachlorHeptachlor results in increased expression of ITGA5 mRNA22902829
D006854HydrocortisoneHydrocortisone results in increased expression of ITGA5 mRNA21267416
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of ITGA5 mRNA12419474
C492448ICG 001ICG 001 results in increased expression of ITGA5 mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of ITGA5 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ITGA5 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of ITGA5 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ITGA5 mRNA28628672
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [TGFB1 protein results in increased expression of ITGA5 mRNA]26644586
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ITGA5 mRNA26644586
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of ITGA5 mRNA]25890327
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ITGA5 mRNA26644586
D016729LeuprolideLeuprolide inhibits the reaction [IGF1 protein results in increased expression of and affects the localization of [ITGA5 protein binds to ITGB3 protein]]17143537
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of ITGA5 mRNA"24972896
D008070Lipopolysaccharides(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of ITGA5 mRNA]25890327
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of ITGA5 mRNA25890327
D008274Magnesium[Aluminum Oxide co-treated with Magnesium] results in increased expression of ITGA5 protein12209937
D008627Mercuric ChlorideMercuric Chloride affects the expression of ITGA5 mRNA20353558
D008727MethotrexateMethotrexate results in increased expression of ITGA5 mRNA17400583
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of ITGA5 mRNA26011545
D009151Mustard GasMustard Gas results in increased expression of ITGA5 mRNA15674843
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of ITGA5 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ITGA5 mRNA"25554681
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of [ITGB6 protein co-treated with ITGA5 protein]21037076
D0150581-Naphthylisothiocyanate[1-Naphthylisothiocyanate results in increased expression of [ITGB6 protein co-treated with ITGA5 protein]] which results in increased activity of TGFB1 protein21037076
D0150581-NaphthylisothiocyanateF2R protein promotes the reaction [1-Naphthylisothiocyanate results in increased expression of [ITGB6 protein co-treated with ITGA5 protein]]21037076
D0150581-NaphthylisothiocyanateF3 protein promotes the reaction [1-Naphthylisothiocyanate results in increased expression of [ITGB6 protein co-treated with ITGA5 protein]]21037076
D0150581-Naphthylisothiocyanate[ITGA5 protein co-treated with ITGB6 protein] promotes the reaction [1-Naphthylisothiocyanate results in increased phosphorylation of SMAD2 protein]21037076
C007350nitrofennitrofen results in increased expression of ITGA5 protein15119844
D010100OxygenOxygen deficiency results in increased expression of ITGA5 protein26476374
D010100OxygenQuercetin inhibits the reaction [Oxygen deficiency results in increased expression of ITGA5 protein]26476374
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of ITGA5 mRNA23948077
D010426Pentosan Sulfuric PolyesterPentosan Sulfuric Polyester results in increased expression of ITGA5 mRNA28973697
D010862PilocarpinePilocarpine results in increased expression of ITGA5 protein12851778
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of ITGA5 mRNA22714537
D011374Progesterone[Progesterone co-treated with Estradiol] results in increased expression of ITGA5 mRNA20226447
D011374ProgesteroneProgesterone results in increased expression of ITGA5 mRNA20226447|2179573
D011374ProgesteroneProgesterone affects the expression of ITGA5 mRNA17962213
D011374ProgesteroneProgesterone affects the expression of ITGA5 protein17962213
C513428pyrachlostrobinpyrachlostrobin results in increased expression of ITGA5 mRNA27029645
C014175pyrazolo(3,4-d)pyrimidine"pyrazolo(3,4-d)pyrimidine analog affects the expression of ITGA5 mRNA"21152443
D011794QuercetinQuercetin inhibits the reaction [Oxygen deficiency results in increased expression of ITGA5 protein]26476374
C037219quinolinequinoline analog binds to and results in decreased activity of [ITGA5 protein binds to ITGB3 protein]16984141
C059514resveratrolarginyl-glycyl-aspartic acid inhibits the reaction [resveratrol binds to [ITGA5 protein binds to ITGB3 protein]]16790523
C059514resveratrol[ITGA5 protein binds to ITGB3 protein] promotes the reaction [resveratrol results in increased phosphorylation of MAPK1 protein]16790523
C059514resveratrol[ITGA5 protein binds to ITGB3 protein] promotes the reaction [resveratrol results in increased phosphorylation of MAPK3 protein]16790523
C059514resveratrol[ITGA5 protein binds to ITGB3 protein] promotes the reaction [resveratrol results in increased phosphorylation of TP53 protein]16790523
C059514resveratrolresveratrol binds to [ITGA5 protein binds to ITGB3 protein]16790523
C059514resveratrolresveratrol results in decreased expression of ITGA5 protein18089832
C089730rosiglitazonerosiglitazone results in increased expression of ITGA5 protein19467017
C089730rosiglitazoneTretinoin promotes the reaction [rosiglitazone results in increased expression of ITGA5 protein]19467017
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of ITGA5 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of ITGA5 mRNA19073995
C009277sodium arsenatesodium arsenate results in decreased expression of ITGA5 mRNA21795629
C017947sodium arsenitesodium arsenite affects the methylation of ITGA5 gene28589171
D012969Sodium FluorideSodium Fluoride results in decreased expression of ITGA5 mRNA27862939
D018038Sodium SeleniteSodium Selenite results in increased expression of ITGA5 mRNA18175754
D012999SomanSoman results in increased expression of ITGA5 mRNA19281266
D014284TriiodothyronineTriiodothyronine binds to [ITGA5 protein binds to ITGB3 protein]16384862
D013629TamoxifenTamoxifen results in decreased expression of ITGA5 mRNA25123088
C561921technetium 99m (HYNIC-3PRGD(2))(tricine)(TPPTS)technetium 99m (HYNIC-3PRGD(2))(tricine)(TPPTS) binds to [ITGA5 protein binds to ITGB3 protein]20694579
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ITGA5 mRNA16051281|2290282
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of ITGA5 mRNA16214954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ITGA5 mRNA28922406
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ITGA5 mRNA21215274
D013752TetracyclineTetracycline results in increased expression of ITGA5 mRNA28882639
D013755Tetradecanoylphorbol AcetateAtrazine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGA5 mRNA]24211529
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of ITGA5 mRNA24211529
C011126tetraiodothyroacetic acidtetraiodothyroacetic acid binds to [ITGA5 protein binds to ITGB3 protein]16384862
D013893ThiramThiram results in decreased expression of ITGA5 mRNA20530235
D013974ThyroxineThyroxine binds to [ITGA5 protein binds to ITGB3 protein]16384862
C009495titanium dioxide[Vitallium analog binds to titanium dioxide] which results in increased expression of ITGA5 mRNA23825117
C009495titanium dioxidetitanium dioxide results in increased expression of ITGA5 mRNA27760801
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of ITGA5 mRNA27865774
D019772TopotecanITGA5 protein affects the susceptibility to Topotecan16217747
D014212TretinoinTretinoin promotes the reaction [rosiglitazone results in increased expression of ITGA5 protein]19467017
D014241TrichloroethyleneTrichloroethylene results in decreased expression of ITGA5 mRNA28973375
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of ITGA5 mRNA29024780
C057693troglitazonetroglitazone results in increased expression of ITGA5 mRNA19140230
D014520UrethaneUrethane results in increased expression of ITGA5 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased expression of ITGA5 mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of ITGA5 mRNA24896083
D014638VanadatesVanadates results in increased expression of ITGA5 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of ITGA5 gene25560391
C029297vinylidene chloridevinylidene chloride results in increased expression of ITGA5 mRNA26682919
D014800Vitallium[Vitallium analog binds to titanium dioxide] which results in increased expression of ITGA5 mRNA23825117

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001618virus receptor activity-IEA-  
GO:0005154epidermal growth factor receptor binding-IEA-  
GO:0005161platelet-derived growth factor receptor binding-TAS19267251  
GO:0005178integrin binding-IEA-  
GO:0005515protein binding-IPI12695522  12724312  12807887  14970227  16051604  16099422  
17158881  19175293  21947080  22178926  22940691  24011356  
GO:0043184vascular endothelial growth factor receptor 2 binding-TAS19267251  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001525angiogenesis-TAS19267251  
GO:0007044cell-substrate junction assembly-IEA-  
GO:0007155cell adhesion-TAS2454952  
GO:0007157heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules-IEA-  
GO:0007159leukocyte cell-cell adhesion-IEA-  
GO:0007229integrin-mediated signaling pathway-IEA-  
GO:0007613memory-IEA-  
GO:0010811positive regulation of cell-substrate adhesion-IEA-  
GO:0030198extracellular matrix organization-TAS-  
GO:0030335positive regulation of cell migration-IEA-  
GO:0030949positive regulation of vascular endothelial growth factor receptor signaling pathway-TAS19267251  
GO:0031589cell-substrate adhesion-IMP19933311  
GO:0033627cell adhesion mediated by integrin-IDA12807887  17158881  
GO:0033631cell-cell adhesion mediated by integrin-IEA-  
GO:0034113heterotypic cell-cell adhesion-IMP20563599  
GO:0035313wound healing, spreading of epidermal cells-IEP14970227  
GO:0035987endodermal cell differentiation-IMP23154389  
GO:0046718viral entry into host cell-IEA-  
GO:0050731positive regulation of peptidyl-tyrosine phosphorylation-IMP10022831  
GO:0050900leukocyte migration-TAS-  
GO:1903672positive regulation of sprouting angiogenesis-IMP19460962  
GO:2000811negative regulation of anoikis-IMP15006356  
GO ID GO Term Qualifier Evidence PubMed
GO:0001726ruffle-TAS11919189  
GO:0005783endoplasmic reticulum-IEA-  
GO:0005794Golgi apparatus-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0005911cell-cell junctioncolocalizes_withIDA14970227  
GO:0005925focal adhesion-HDA21423176  
GO:0005925focal adhesion-IDA17158881  
GO:0005925focal adhesioncolocalizes_withIDA14970227  
GO:0008305integrin complex-IEA-  
GO:0009897external side of plasma membrane-IEA-  
GO:0009986cell surface-HDA19581412  23658023  
GO:0009986cell surface-IDA17158881  20563599  23154389  
GO:0031410cytoplasmic vesicle-IEA-  
GO:0032587ruffle membranecolocalizes_withIDA14970227  
GO:0045202synapse-IEA-  
GO:0071062alphav-beta3 integrin-vitronectin complex-TAS19267251  
KEGG ID KEGG Term
hsa04145Phagosome
hsa04510Focal adhesion
hsa04512ECM-receptor interaction
hsa04640Hematopoietic cell lineage
hsa04810Regulation of actin cytoskeleton
hsa05100Bacterial invasion of epithelial cells
hsa05131Shigellosis
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
hsa05414Dilated cardiomyopathy
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-1266738Developmental BiologyTAS
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-1474244Extracellular matrix organizationIEA
R-HSA-1566948Elastic fibre formationTAS
R-HSA-1566977Fibronectin matrix formationTAS
R-HSA-202733Cell surface interactions at the vascular wallTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-216083Integrin cell surface interactionsTAS
R-HSA-216083Integrin cell surface interactionsIEA
R-HSA-373760L1CAM interactionsTAS
R-HSA-422475Axon guidanceTAS
R-HSA-445144Signal transduction by L1TAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8878166Transcriptional regulation by RUNX2TAS
R-HSA-8941332RUNX2 regulates genes involved in cell migrationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27143927Integrin and gene network analysis reveals that ITGA5 and ITGB1 are prognostic in non-small-cell lung cancer. (2016)Zheng WOnco Targets Ther