Gene: ABCC6

368
ABC34|ARA|EST349056|GACI2|MLP1|MOAT-E|MOATE|MRP6|PXE|PXE1|URG7
ATP binding cassette subfamily C member 6
protein-coding
16p13.11
Ensembl:ENSG00000091262 MIM:603234 Vega:OTTHUMG00000129967 UniprotKB:O95255
NG_007558.2
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.096e-1 (AD)  1.746e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TMEM710.694
ATP8B30.663
CLEC2D0.662
POU5F1B0.66
FAM111A0.651
LOXL30.649
TLR80.649
ZMYND150.642
CARD80.64
CD720.64

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GABRA5-0.366
SVOP-0.361
TENM3-0.36
PTPRR-0.359
GABRG3-0.356
SLC1A6-0.345
FSTL5-0.341
EPHA5-0.338
KCNB2-0.338
MYADML2-0.334

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00328IndomethacinSmall Molecule53-86-1Approved|InvestigationalTransporter
DB00444TeniposideSmall Molecule29767-20-2ApprovedTransporter
DB00515CisplatinSmall Molecule15663-27-1ApprovedTransporter
DB00570VinblastineSmall Molecule865-21-4ApprovedTransporter
DB00694DaunorubicinSmall Molecule20830-81-3ApprovedTransporter
DB00773EtoposideSmall Molecule33419-42-0ApprovedTransporter
DB00970DactinomycinSmall Molecule50-76-0Approved|InvestigationalTransporter
DB00997DoxorubicinSmall Molecule23214-92-8Approved|InvestigationalTransporter
DB01032ProbenecidSmall Molecule57-66-9Approved|InvestigationalTransporter
DB01138SulfinpyrazoneSmall Molecule57-96-5ApprovedTransporter
DB00171ATPSmall Molecule56-65-5Investigational|NutraceuticalTarget
ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of ABCC6 mRNA"27818994
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"[1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased activity of NR1I3 protein] which results in increased expression of ABCC6 mRNA"15833929
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of ABCC6 mRNA"15833929
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of ABCC6 protein"27818994
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of ABCC6 mRNA"19114083
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of ABCC6 mRNA"28433925
C0230353,4,5,3',4'-pentachlorobiphenyl"[3,4,5,3',4'-pentachlorobiphenyl binds to AHR protein] which results in increased expression of ABCC6 mRNA"15833929
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of ABCC6 mRNA"15833929
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of ABCC6 mRNA"18648102
C0170408-azidoadenosine 5'-triphosphateberyllium fluoride promotes the reaction [8-azidoadenosine 5'-triphosphate binds to ABCC6 protein]12069597
C0170408-azidoadenosine 5'-triphosphateCobalt promotes the reaction [8-azidoadenosine 5'-triphosphate binds to ABCC6 protein]12069597
C0170408-azidoadenosine 5'-triphosphateCobalt promotes the reaction [beryllium fluoride promotes the reaction [8-azidoadenosine 5'-triphosphate binds to ABCC6 protein]]12069597
C0170408-azidoadenosine 5'-triphosphateMagnesium Chloride promotes the reaction [8-azidoadenosine 5'-triphosphate binds to ABCC6 protein]12069597
C0170408-azidoadenosine 5'-triphosphateMagnesium Chloride promotes the reaction [beryllium fluoride promotes the reaction [8-azidoadenosine 5'-triphosphate binds to ABCC6 protein]]12069597
C0170408-azidoadenosine 5'-triphosphateManganese promotes the reaction [8-azidoadenosine 5'-triphosphate binds to ABCC6 protein]12069597
C0170408-azidoadenosine 5'-triphosphateManganese promotes the reaction [beryllium fluoride promotes the reaction [8-azidoadenosine 5'-triphosphate binds to ABCC6 protein]]12069597
C0170408-azidoadenosine 5'-triphosphateNickel promotes the reaction [8-azidoadenosine 5'-triphosphate binds to ABCC6 protein]12069597
C0170408-azidoadenosine 5'-triphosphateNickel promotes the reaction [beryllium fluoride promotes the reaction [8-azidoadenosine 5'-triphosphate binds to ABCC6 protein]]12069597
D000082AcetaminophenAcetaminophen results in decreased expression of ABCC6 mRNA21420995|2906747
D000082AcetaminophenAcetaminophen affects the expression of ABCC6 mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of ABCC6 mRNA28959563
D000255Adenosine TriphosphateAdenosine Triphosphate binds to ABCC6 protein11880368
D016604Aflatoxin B1Aflatoxin B1 affects the expression of ABCC6 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ABCC6 mRNA22100608
C103303alitretinoinalitretinoin results in increased expression of ABCC6 mRNA17045963
C103303alitretinoinRARA protein promotes the reaction [alitretinoin results in increased expression of ABCC6 mRNA]17045963
C006463allyl alcoholallyl alcohol results in decreased expression of ABCC6 mRNA19371622
D000638AmiodaroneAmiodarone affects the expression of ABCC6 mRNA19483382
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ABCC6 mRNA16483693
C547126AZM551248AZM551248 results in decreased expression of ABCC6 mRNA22323515
C487081belinostatbelinostat results in decreased expression of ABCC6 mRNA27188386
D001553BenzbromaroneBenzbromarone inhibits the reaction [ABCC6 protein affects the transport of N-ethylmaleimide-S-glutathione]11880368
D001553BenzbromaroneBenzbromarone results in decreased activity of ABCC6 protein14667841
D001553BenzbromaroneBenzbromarone affects the expression of ABCC6 mRNA19483382
D019324beta-Naphthoflavone[beta-Naphthoflavone binds to AHR protein] which results in increased expression of ABCC6 mRNA15833929
D019324beta-Naphthoflavonebeta-Naphthoflavone results in increased expression of ABCC6 mRNA15833929
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ABCC6 mRNA20106945|2163298
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of ABCC6 mRNA"20382639
C035982beryllium fluorideberyllium fluoride promotes the reaction [8-azidoadenosine 5'-triphosphate binds to ABCC6 protein]12069597
C035982beryllium fluorideCobalt promotes the reaction [beryllium fluoride promotes the reaction [8-azidoadenosine 5'-triphosphate binds to ABCC6 protein]]12069597
C035982beryllium fluorideMagnesium Chloride promotes the reaction [beryllium fluoride promotes the reaction [8-azidoadenosine 5'-triphosphate binds to ABCC6 protein]]12069597
C035982beryllium fluorideManganese promotes the reaction [beryllium fluoride promotes the reaction [8-azidoadenosine 5'-triphosphate binds to ABCC6 protein]]12069597
C035982beryllium fluorideNickel promotes the reaction [beryllium fluoride promotes the reaction [8-azidoadenosine 5'-triphosphate binds to ABCC6 protein]]12069597
D004958EstradiolEstradiol results in decreased expression of ABCC6 mRNA20106945
C006780bisphenol A"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of ABCC6 mRNA"28433925
C006780bisphenol A[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of ABCC6 promoter23359474
C006780bisphenol Abisphenol A results in decreased expression of ABCC6 mRNA25181051
D002083Butylated Hydroxyanisole[Butylated Hydroxyanisole results in increased activity of NFE2L2 protein] which results in increased expression of ABCC6 mRNA15833929
D002083Butylated HydroxyanisoleButylated Hydroxyanisole results in increased expression of ABCC6 mRNA15833929
C018475butyraldehydebutyraldehyde results in decreased expression of ABCC6 mRNA26079696
C085925calcein AMGlutathione promotes the reaction [ABCC6 protein affects the transport of calcein AM]15210835
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of ABCC6 mRNA27339419
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of ABCC6 mRNA12734012
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of ABCC6 protein17544377
D002994ClofibrateClofibrate affects the expression of ABCC6 mRNA19483382
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of ABCC6 mRNA17602206
D003035CobaltCobalt promotes the reaction [8-azidoadenosine 5'-triphosphate binds to ABCC6 protein]12069597
D003035CobaltCobalt promotes the reaction [beryllium fluoride promotes the reaction [8-azidoadenosine 5'-triphosphate binds to ABCC6 protein]]12069597
D019327Copper SulfateCopper Sulfate results in decreased expression of ABCC6 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of ABCC6 mRNA20106945|2556210
D003907DexamethasoneDexamethasone affects the expression of ABCC6 mRNA15102944
D003907DexamethasoneDexamethasone results in decreased expression of ABCC6 mRNA16260000
C028009diallyl disulfidediallyl disulfide results in decreased expression of ABCC6 mRNA22397993
C028009diallyl disulfidediallyl disulfide results in increased expression of ABCC6 mRNA22397993
C042577diallyl trisulfidediallyl trisulfide results in increased expression of ABCC6 mRNA22397993
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ABCC6 mRNA21266533
D003993Dibutyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of ABCC6 promoter23359474
D004041Dietary FatsDietary Fats results in decreased expression of ABCC6 mRNA17640958
D004051Diethylhexyl Phthalate"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of ABCC6 mRNA"28433925
D004051Diethylhexyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of ABCC6 promoter23359474
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with kojic acid] results in increased expression of ABCC6 mRNA17917374
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of ABCC6 mRNA17602206
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with kojic acid] results in decreased expression of ABCC6 mRNA18544905
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of ABCC6 mRNA28943392
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of ABCC6 mRNA19638242
D0151279,10-Dimethyl-1,2-benzanthracene"ABCC6 gene SNP affects the susceptibility to 9,10-Dimethyl-1,2-benzanthracene"25622337
C067311docetaxelABCC6 gene SNP affects the susceptibility to docetaxel23758476
C067311docetaxel[docetaxel results in decreased susceptibility to docetaxel] which affects the expression of ABCC6 mRNA19944135
D004642EmodinEmodin results in increased expression of ABCC6 mRNA19549930
D004785Environmental PollutantsEnvironmental Pollutants affects the expression of ABCC6 mRNA19118595
D005001EthionineEthionine affects the expression of ABCC6 mRNA19483382
D005015Ethoxyquin[Ethoxyquin results in increased activity of NFE2L2 protein] which results in increased expression of ABCC6 mRNA15833929
D005015EthoxyquinEthoxyquin results in increased expression of ABCC6 mRNA15833929
C007740fluorexonABCC6 affects the transport of fluorexon14667841
D005472FluorouracilABCC6 protein affects the susceptibility to Fluorouracil15352031
D005472FluorouracilFluorouracil results in increased expression of ABCC6 protein15352031
D005485FlutamideFlutamide results in decreased expression of ABCC6 mRNA24136188
C039281furanfuran results in decreased expression of ABCC6 mRNA25539665
D005978GlutathioneGlutathione promotes the reaction [ABCC6 protein affects the transport of calcein AM]15210835
C412815GW 4064GW 4064 results in increased expression of ABCC6 mRNA26655953
C010178heliotrineheliotrine results in decreased expression of ABCC6 mRNA26100227
D006533HeptachlorHeptachlor results in decreased expression of ABCC6 mRNA23153324
D007213IndomethacinIndomethacin inhibits the reaction [ABCC6 protein affects the transport of N-ethylmaleimide-S-glutathione]11880368
D007213IndomethacinIndomethacin results in decreased activity of ABCC6 protein14667841
D007538IsoniazidIsoniazid results in decreased expression of ABCC6 mRNA16260000
C011890kojic acid[Diethylnitrosamine co-treated with kojic acid] results in increased expression of ABCC6 mRNA17917374
C011890kojic acid[Diethylnitrosamine co-treated with kojic acid] results in decreased expression of ABCC6 mRNA18544905
C099406L 742694L 742694 affects the expression of ABCC6 mRNA15102944
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of ABCC6 mRNA15205389
D008095Lithocholic AcidLithocholic Acid results in decreased expression of ABCC6 protein18032408
D017997Leukotriene C4ABCC6 protein affects the transport of Leukotriene C411880368
D008274Magnesium[Magnesium deficiency co-treated with Phosphates] promotes the reaction [ABCC6 gene mutant form results in increased susceptibility to Warfarin]23415960
D015636Magnesium ChlorideMagnesium Chloride promotes the reaction [8-azidoadenosine 5'-triphosphate binds to ABCC6 protein]12069597
D015636Magnesium ChlorideMagnesium Chloride promotes the reaction [beryllium fluoride promotes the reaction [8-azidoadenosine 5'-triphosphate binds to ABCC6 protein]]12069597
D008345ManganeseManganese promotes the reaction [8-azidoadenosine 5'-triphosphate binds to ABCC6 protein]12069597
D008345ManganeseManganese promotes the reaction [beryllium fluoride promotes the reaction [8-azidoadenosine 5'-triphosphate binds to ABCC6 protein]]12069597
D008694MethamphetamineMethamphetamine results in decreased expression of ABCC6 mRNA25290377
D008694Methamphetamine[Methamphetamine co-treated with SCH 23390] results in decreased expression of ABCC6 mRNA19564919
D008694MethamphetamineMethamphetamine results in decreased expression of ABCC6 mRNA19564919
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ABCC6 mRNA28001369
D008917MirexMirex results in decreased expression of ABCC6 mRNA23153324
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased expression of ABCC6 mRNA22401849
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ABCC6 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of ABCC6 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ABCC6 mRNA"25620056
C051752nefazodonenefazodone results in decreased expression of ABCC6 mRNA24136188
C054449N-ethylmaleimide-S-glutathioneABCC6 protein affects the transport of N-ethylmaleimide-S-glutathione11880368
C054449N-ethylmaleimide-S-glutathioneBenzbromarone inhibits the reaction [ABCC6 protein affects the transport of N-ethylmaleimide-S-glutathione]11880368
C054449N-ethylmaleimide-S-glutathioneIndomethacin inhibits the reaction [ABCC6 protein affects the transport of N-ethylmaleimide-S-glutathione]11880368
C054449N-ethylmaleimide-S-glutathioneProbenecid inhibits the reaction [ABCC6 protein affects the transport of N-ethylmaleimide-S-glutathione]11880368
D009532NickelNickel results in decreased expression of ABCC6 mRNA25583101
D009532NickelNickel promotes the reaction [8-azidoadenosine 5'-triphosphate binds to ABCC6 protein]12069597
D009532NickelNickel promotes the reaction [beryllium fluoride promotes the reaction [8-azidoadenosine 5'-triphosphate binds to ABCC6 protein]]12069597
C026209oltipraz[oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of ABCC6 mRNA15833929
C026209oltiprazoltipraz results in increased expression of ABCC6 mRNA15833929
D009853OmeprazoleOmeprazole affects the expression of ABCC6 mRNA19483382
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of ABCC6 mRNA19162173
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of ABCC6 mRNA16221955
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of ABCC6 mRNA19162173
D010634PhenobarbitalPhenobarbital results in decreased expression of ABCC6 mRNA16837569
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of ABCC6 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in decreased expression of ABCC6 mRNA19482888
D010634PhenobarbitalPhenobarbital results in decreased expression of ABCC6 mRNA16260000
D010710Phosphates[Magnesium deficiency co-treated with Phosphates] promotes the reaction [ABCC6 gene mutant form results in increased susceptibility to Warfarin]23415960
C006253pirinixic acidpirinixic acid results in decreased expression of ABCC6 mRNA20059764|2381119
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in decreased expression of ABCC6 mRNA]20059764
C006253pirinixic acidpirinixic acid affects the expression of ABCC6 mRNA19483382
C006253pirinixic acidpirinixic acid results in decreased expression of ABCC6 mRNA19162173|2248451
D011339ProbenecidProbenecid inhibits the reaction [ABCC6 protein affects the transport of N-ethylmaleimide-S-glutathione]11880368
D011374ProgesteroneProgesterone results in decreased expression of ABCC6 mRNA18070364
C045950propiconazolepropiconazole results in decreased expression of ABCC6 mRNA21278054
C005556propionaldehydepropionaldehyde results in decreased expression of ABCC6 mRNA26079696
D011441PropylthiouracilPropylthiouracil affects the expression of ABCC6 mRNA19483382
D011441PropylthiouracilPropylthiouracil results in increased expression of ABCC6 mRNA24780913
D054328Proton Pump InhibitorsProton Pump Inhibitors results in decreased expression of ABCC6 mRNA25626140
D011763Pyrrolizidine AlkaloidsPyrrolizidine Alkaloids results in decreased expression of ABCC6 mRNA26100227
D011794QuercetinQuercetin results in increased expression of ABCC6 mRNA21632981
D012293RifampinRifampin results in increased expression of ABCC6 mRNA27199754
C089730rosiglitazonerosiglitazone results in decreased expression of ABCC6 mRNA25572481
C534628SCH 23390[Methamphetamine co-treated with SCH 23390] results in decreased expression of ABCC6 mRNA19564919
C009237senecioninesenecionine results in decreased expression of ABCC6 mRNA26100227
C009238senkirkinesenkirkine results in decreased expression of ABCC6 mRNA26100227
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of ABCC6 mRNA25895662
C016104sodium bichromatesodium bichromate affects the expression of ABCC6 mRNA22110744
C016104sodium bichromatesodium bichromate results in decreased expression of ABCC6 mRNA25993096
D013024Soybean OilSoybean Oil affects the expression of ABCC6 mRNA15770074
D013311StreptozocinStreptozocin results in decreased expression of ABCC6 protein22531820
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of ABCC6 mRNA15833929
D013749Tetrachlorodibenzodioxin"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of ABCC6 mRNA"28433925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ABCC6 mRNA15833929
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ABCC6 mRNA21215274
D013750TetrachloroethyleneTetrachloroethylene results in decreased expression of ABCC6 mRNA28973375
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of ABCC6 mRNA28943392
D013853ThioacetamideThioacetamide affects the expression of ABCC6 mRNA19483382
D013853ThioacetamideThioacetamide results in decreased expression of ABCC6 mRNA23411599
D014212TretinoinTretinoin results in increased expression of ABCC6 mRNA17045963
C012589trichostatin Atrichostatin A results in decreased expression of ABCC6 mRNA24935251
C057693troglitazonetroglitazone results in decreased expression of ABCC6 mRNA25572481
D014520UrethaneUrethane results in decreased expression of ABCC6 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased expression of ABCC6 mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of ABCC6 mRNA24935251
D014635Valproic AcidValproic Acid affects the expression of ABCC6 mRNA17963808
D014700VerapamilVerapamil results in decreased activity of ABCC6 protein14667841
D014750Vincristine[Vincristine results in decreased susceptibility to Vincristine] which results in decreased expression of ABCC6 mRNA19944135
D014859WarfarinABCC6 gene mutant form results in increased susceptibility to Warfarin23415960
D014859Warfarin[Magnesium deficiency co-treated with Phosphates] promotes the reaction [ABCC6 gene mutant form results in increased susceptibility to Warfarin]23415960
D015215ZidovudineZidovudine results in increased expression of ABCC6 mRNA24292225

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005215transporter activity-TAS8912525  
GO:0005524ATP binding-IEA-  
GO:0042626ATPase activity, coupled to transmembrane movement of substances-IBA21873635  
GO:0042626ATPase activity, coupled to transmembrane movement of substances-TAS8912525  
GO:0043225ATPase-coupled anion transmembrane transporter activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007601visual perception-IEA-  
GO:0042493response to drug-TAS8912525  
GO:0055085transmembrane transport-IBA21873635  
GO:0055085transmembrane transport-TAS-  
GO:0099133ATP hydrolysis coupled anion transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA-  
GO:0005774vacuolar membrane-IBA21873635  
GO:0005789endoplasmic reticulum membrane-IEA-  
GO:0005886plasma membrane-IDA-  
GO:0005886plasma membrane-TAS-  
GO:0016020membrane-IBA21873635  
GO:0016021integral component of membrane-IEA-  
GO:0016323basolateral plasma membrane-IBA21873635  
GO:0016323basolateral plasma membrane-IEA-  
GO:0016324apical plasma membrane-IEA-  
GO:0016328lateral plasma membrane-IEA-  
KEGG ID KEGG Term
hsa02010ABC transporters
Reactome ID Reactome Term Evidence
R-HSA-1643685DiseaseTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-382556ABC-family proteins mediated transportTAS
R-HSA-5619084ABC transporter disordersTAS
R-HSA-5619115Disorders of transmembrane transportersTAS
R-HSA-5690338Defective ABCC6 causes pseudoxanthoma elasticum (PXE)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25383264PSEUDOXANTHOMA ELASTICUM: DIAGNOSTIC FEATURES, CLASSIFICATION, AND TREATMENT OPTIONS. (2014 Jun 1)Uitto JExpert Opin Orphan Drugs