Gene: ITGAD

3681
ADB2|CD11D
integrin subunit alpha D
protein-coding
16p11.2
Ensembl:ENSG00000156886 MIM:602453 Vega:OTTHUMG00000176614 UniprotKB:Q13349
NG_050624.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.295e-3 (AD)  9.969e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2454908chr16:31399864 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLCO2A10.522
ATP4A0.516
COL5A10.513
MPL0.5
PDE4C0.488
LTK0.478
SPATA31C10.457
SH3RF20.456
DGKA0.432
C16orf470.431

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BCAS1-0.284
MOBP-0.269
SOX3-0.266
LHPP-0.264
MBP-0.261
TGFB3-0.256
PDE11A-0.252
LPAR1-0.25
PAIP2B-0.243
ZAR1L-0.241

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ITGAD mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ITGAD mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ITGAD mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ITGAD mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ITGAD mRNA"25510870
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ITGAD mRNA16483693
C006780bisphenol Abisphenol A results in decreased expression of ITGAD mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of ITGAD gene28505145
C018475butyraldehydebutyraldehyde results in increased expression of ITGAD mRNA26079696
D004390Chlorpyrifos[nickel chloride co-treated with Chlorpyrifos] affects the expression of ITGAD mRNA21496282
C039281furanfuran results in increased methylation of ITGAD gene22079235
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ITGAD mRNA25613284
C022838nickel chloridenickel chloride affects the expression of ITGAD mRNA21496282
C022838nickel chloride[nickel chloride co-treated with Chlorpyrifos] affects the expression of ITGAD mRNA21496282
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ITGAD mRNA"25510870
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ITGAD mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of ITGAD mRNA23409001

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0046872metal ion binding-IEA-  
GO:0046982protein heterodimerization activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006955immune response-NAS9841932  
GO:0007229integrin-mediated signaling pathway-IEA-  
GO:0030198extracellular matrix organization-TAS-  
GO:0034113heterotypic cell-cell adhesion-IMP20563599  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0008305integrin complex-TAS20187620  
GO:0009986cell surface-IC20563599  
KEGG ID KEGG Term
hsa04810Regulation of actin cytoskeleton
Reactome ID Reactome Term Evidence
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-216083Integrin cell surface interactionsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal