Gene: ITGAE

3682
CD103|HUMINAE
integrin subunit alpha E
protein-coding
17p13.2
Ensembl:ENSG00000083457 MIM:604682 Vega:OTTHUMG00000177634 UniprotKB:P38570
NC_000017.11
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.094e-1 (AD)  2.156e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs9916609chr17:3769220 (GRCh38.p7)C>Anicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GTF2F20.83
IMMP1L0.829
LSM30.822
PMF10.822
COMMD60.806
MORN20.806
COX160.805
GTF2A20.801
MRPL400.8
SWI50.794

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.549
OR4F29-0.532
MTRNR2L6-0.243
RNF223-0.23
SDIM1-0.223
SFTPA1-0.22
SFTPB-0.216
HSD3B1-0.212
MXRA5-0.205
EPPIN-0.202

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in decreased expression of ITGAE mRNA"20453058
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of ITGAE mRNA"19167446
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of ITGAE mRNA"21346803
D020106AcrylamideAcrylamide results in decreased expression of ITGAE mRNA28959563
C068073Am 580Am 580 results in increased expression of ITGAE mRNA16982809
D001151ArsenicArsenic affects the methylation of ITGAE gene25304211
C015001arsenitearsenite results in increased methylation of ITGAE promoter23974009
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of ITGAE mRNA]22228805
D004958EstradiolEstradiol results in increased expression of ITGAE mRNA17010207
C006780bisphenol Abisphenol A results in decreased expression of ITGAE mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased expression of ITGAE mRNA12160620
C100187chloropicrinchloropicrin results in decreased expression of ITGAE mRNA26352163
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of ITGAE mRNA28472532
D019327Copper SulfateCopper Sulfate results in decreased expression of ITGAE mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of ITGAE mRNA"19167446
D003375CoumestrolCoumestrol results in increased expression of ITGAE mRNA19167446
D016572CyclosporineCyclosporine results in decreased expression of ITGAE mRNA25562108
C017160cypermethrincypermethrin results in decreased expression of ITGAE mRNA22528246
D003907DexamethasoneDexamethasone results in increased expression of ITGAE mRNA21041162
D002945CisplatinITGAE protein results in increased susceptibility to Cisplatin16734730
C000944dicrotophosdicrotophos results in decreased expression of ITGAE mRNA28302478
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of ITGAE mRNA17010207
D004986EtherEther results in increased expression of ITGAE mRNA28717108
C010974glyphosateglyphosate results in increased expression of ITGAE mRNA17984146
D007213IndomethacinIndomethacin results in increased expression of ITGAE mRNA16771604
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ITGAE mRNA25613284
C051890irinotecanITGAE protein results in increased susceptibility to irinotecan16734730
D007530IsofluraneIsoflurane results in increased expression of ITGAE mRNA28717108
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of ITGAE mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of ITGAE mRNA"25554681
C474055octylphenoloctylphenol results in increased expression of ITGAE mRNA17010207
D010424PentobarbitalPentobarbital results in increased expression of ITGAE mRNA28717108
C006253pirinixic acidpirinixic acid results in decreased expression of ITGAE mRNA17426115
C006253pirinixic acidpirinixic acid results in increased expression of ITGAE mRNA20813756
D011192Potassium DichromatePotassium Dichromate results in decreased expression of ITGAE mRNA23608068
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of ITGAE mRNA22698814
C089730rosiglitazonerosiglitazone results in increased expression of ITGAE mRNA16982809
D012643SeleniumSelenium results in decreased expression of ITGAE mRNA19244175
D012834SilverSilver results in increased expression of ITGAE mRNA27131904
C017947sodium arsenitesodium arsenite affects the methylation of ITGAE gene28589171
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ITGAE mRNA21570461|2637764
D013752TetracyclineTetracycline results in increased expression of ITGAE mRNA16917069
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ITGAE mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of ITGAE mRNA21259345
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of ITGAE mRNA20133372
D014051Toluene 2,4-Diisocyanate"Toluene 2,4-Diisocyanate results in increased expression of ITGAE protein"27103660
D014635Valproic AcidValproic Acid results in increased methylation of ITGAE gene29154799
D014635Valproic AcidValproic Acid affects the expression of ITGAE mRNA17963808

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007155cell adhesion-IEA-  
GO:0007229integrin-mediated signaling pathway-IEA-  
GO:0030198extracellular matrix organization-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0008305integrin complex-IEA-  
GO:0009897external side of plasma membrane-IEA-  
KEGG ID KEGG Term
hsa04810Regulation of actin cytoskeleton
Reactome ID Reactome Term Evidence
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-216083Integrin cell surface interactionsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal