Gene: ITGAL

3683
CD11A|LFA-1|LFA1A
integrin subunit alpha L
protein-coding
16p11.2
Ensembl:ENSG00000005844 MIM:153370 Vega:OTTHUMG00000176964 UniprotKB:P20701
NC_000016.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.295e-3 (AD)  8.883e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg06972908chr16:30488321ITGALGene body6.817e-5Alcohol use disorders26763658
cg06235438chr16:30485966ITGAL2.080e-9Maternal smoking in pregnancy27040690
cg09099830chr16:30485485ITGAL6.400e-15Smoking27651444
cg16391678chr16:30485597ITGAL2.400e-14Smoking27651444
cg16519923chr16:30485810ITGAL4.400e-14Smoking27651444
cg06972908chr16:30488321ITGAL4.200e-13Smoking27651444
cg24033122chr16:30485383ITGAL3.500e-10Smoking27651444
cg06235438chr16:30485966ITGAL8.400e-10Smoking27651444
cg04716530chr16:30485684ITGAL6.500e-9Smoking27651444
cg09099830chr16:30485485ITGAL3.670e-11Tobacco smoking28225026
cg06235438chr16:30485966ITGAL4.900e-11Tobacco smoking28225026
cg16391678chr16:30485597ITGAL1.390e-9Tobacco smoking28225026

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LRRC250.91
MYO1F0.896
LILRB10.89
SASH30.886
PIK3AP10.886
SCIN0.884
SLC7A70.883
CCR50.882
CIITA0.878
SNX200.878

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC7A4-0.422
MARCH4-0.415
ANKRD55-0.415
SLC1A6-0.412
HAS1-0.411
TMEM179-0.41
MYADML2-0.409
KCNB2-0.408
C9orf24-0.408
CYP46A1-0.398

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00095EfalizumabBiotechDrug214745-43-4Approved|InvestigationalTarget
DB00098Antithymocyte immunoglobulin (rabbit)BiotechDrugApprovedTarget
DB00227LovastatinSmall Molecule75330-75-5Approved|InvestigationalTarget
DB00641SimvastatinSmall Molecule79902-63-9ApprovedTarget
DB021771-Acetyl-4-(4-{4-[(2-Ethoxyphenyl)Thio]-3-Nitrophenyl}Pyridin-2-Yl)PiperazineSmall MoleculeExperimentalTarget
DB03932LFA703Small MoleculeExperimentalTarget
DB04724(S)-2-((S)-3-ISOBUTYL-2,5-DIOXO-4-QUINOLIN-3-YLMETHYL-[1,4]DIAZEPAN-1YL)-N-METHYL-3-NAPHTALEN-2-YL-PROPIONAMIDESmall MoleculeExperimentalTarget
DB069727A-[(4-cyanophenyl)methyl]-6-(3,5-dichlorophenyl)-5-oxo-2,3,5,7A-tetrahydro-1H-pyrrolo[1,2-A]pyrrole-7-carbonitrileSmall MoleculeExperimentalTarget
DB074863-({4-[(1E)-3-morpholin-4-yl-3-oxoprop-1-en-1-yl]-2,3-bis(trifluoromethyl)phenyl}sulfanyl)anilineSmall MoleculeExperimentalTarget
DB11611LifitegrastSmall Molecule1025967-78-5ApprovedTarget
ID Drug Name Action PubMed
C06289417-hydroxy-4,7,10,13,15,19-docosahexaenoic acid"17-hydroxy-4,7,10,13,15,19-docosahexaenoic acid inhibits the reaction [Dextran Sulfate results in increased expression of ITGAL mRNA]"21724996
C0010792-(2,6-dioxopiperidin-3-yl)phthalimidine"2-(2,6-dioxopiperidin-3-yl)phthalimidine results in decreased expression of ITGAL protein"8538367
C1045642-(4-acetoxyphenyl)-2-chloro-N-methylethylamine2-(4-acetoxyphenyl)-2-chloro-N-methylethylamine results in decreased expression of ITGAL protein19997594
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of ITGAL mRNA"25380136
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of ITGAL mRNA19191707
D000584AmilorideAmiloride inhibits the reaction [TNF protein results in increased expression of ITGAL mRNA]10198263
D000584AmilorideAmiloride inhibits the reaction [TNF protein results in increased expression of ITGAL protein]10198263
D0150812-Naphthylamine2-Naphthylamine results in decreased expression of ITGAL mRNA18247414
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ITGAL mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of ITGAL mRNA24449571
C015001arsenitearsenite results in decreased expression of ITGAL mRNA18191166
D000069059Atorvastatin CalciumAtorvastatin Calcium inhibits the reaction [TNF results in increased expression of ITGAL]12615677
D001280AtrazineAtrazine results in decreased expression of ITGAL mRNA25929836
C547126AZM551248AZM551248 results in increased expression of ITGAL mRNA22323515
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of ITGAL mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene metabolite results in increased expression of ITGAL mRNA26314263
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ITGAL mRNA18247414
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ITGAL mRNA21569818
C006780bisphenol Abisphenol A results in increased expression of ITGAL mRNA26063408
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of ITGAL mRNA26314263
D000069286BortezomibBortezomib results in decreased expression of ITGAL mRNA20977926
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of ITGAL mRNA12419474
D019256Cadmium ChlorideCadmium Chloride results in increased expression of ITGAL mRNA25993096
D002392CatechinCatechin results in increased expression of ITGAL mRNA15465739
C086276cerivastatincerivastatin inhibits the reaction [TNF results in increased expression of ITGAL]12615677
D002737ChloropreneChloroprene results in decreased expression of ITGAL mRNA23125180
C018021cobaltous chloridecobaltous chloride results in increased expression of ITGAL mRNA26314263
D003471CuprizoneCuprizone results in increased expression of ITGAL mRNA27523638
D016264Dextran Sulfate"17-hydroxy-4,7,10,13,15,19-docosahexaenoic acid inhibits the reaction [Dextran Sulfate results in increased expression of ITGAL mRNA]"21724996
D016264Dextran SulfateDextran Sulfate results in increased expression of ITGAL mRNA21724996
D016264Dextran Sulfateresolvin D1 inhibits the reaction [Dextran Sulfate results in increased expression of ITGAL mRNA]21724996
D016264Dextran Sulfateresolvin D2 inhibits the reaction [Dextran Sulfate results in increased expression of ITGAL mRNA]21724996
D002945CisplatinCisplatin results in increased expression of ITGAL mRNA27594783
D004008DiclofenacDiclofenac results in increased expression of ITGAL mRNA26934552
D004041Dietary FatsDietary Fats results in increased expression of ITGAL mRNA25016146
C014476diethyl maleatediethyl maleate results in decreased expression of ITGAL mRNA21161181
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of ITGAL mRNA25380136
D004785Environmental PollutantsEnvironmental Pollutants results in increased expression of ITGAL mRNA19118595
D017308EtodolacEtodolac results in decreased expression of ITGAL protein16046235
D005419FlavonoidsFlavonoids results in increased expression of ITGAL mRNA15465739
D005485FlutamideFlutamide results in decreased expression of ITGAL mRNA24136188
C112772ginsenoside M1ginsenoside M1 inhibits the reaction [TNF protein results in increased expression of [ITGAL protein binds to ITGB2 protein]]21875580
C425564ginsenoside Rh1ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of [ITGAL protein binds to ITGB2 protein]]21875580
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of ITGAL mRNA12419474
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ITGAL mRNA25613284
D007530IsofluraneIsoflurane inhibits the reaction [ITGAL protein binds to ICAM1 protein]28003439
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ITGAL mRNA23086925
C008261lead acetatelead acetate results in decreased expression of ITGAL mRNA22609695
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of ITGAL mRNA10198263
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of ITGAL protein10198263
D008070LipopolysaccharidesStaurosporine inhibits the reaction [Lipopolysaccharides results in increased expression of ITGAL mRNA]10198263
D008070LipopolysaccharidesStaurosporine inhibits the reaction [Lipopolysaccharides results in increased expression of ITGAL protein]10198263
D008727MethotrexateMethotrexate results in increased expression of ITGAL mRNA17400583
C030957methylmercury IImethylmercury II results in increased expression of ITGAL mRNA26314263
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of ITGAL mRNA23649840
D015735MifepristoneMifepristone results in decreased expression of ITGAL mRNA25972201
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ITGAL mRNA"25554681
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of ITGAL mRNA25380136
D009532NickelNickel affects the expression of ITGAL mRNA14575637
D009532NickelNickel results in increased expression of ITGAL mRNA25583101
D009532Nickeltrichostatin A inhibits the reaction [Nickel affects the expression of ITGAL mRNA]14575637
D009538NicotineNicotine results in decreased expression of ITGAL mRNA18247414
C025589ochratoxin Aochratoxin A metabolite results in increased expression of ITGAL mRNA26314263
C025589ochratoxin Aochratoxin A results in increased expression of ITGAL mRNA26314263
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of ITGAL mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of ITGAL mRNA25729387
D017239PaclitaxelPaclitaxel results in decreased expression of ITGAL mRNA12649748
D017239PaclitaxelPaclitaxel results in decreased expression of ITGAL protein12649748
D010654PhenylbutyratesPhenylbutyrates promotes the reaction [Tretinoin results in increased expression of ITGAL protein]18055984
D010936Plant ExtractsPlant Extracts results in increased expression of ITGAL mRNA15465739
D059808PolyphenolsPolyphenols results in increased expression of ITGAL mRNA15465739
C518399resolvin D1resolvin D1 inhibits the reaction [Dextran Sulfate results in increased expression of ITGAL mRNA]21724996
C545423resolvin D2resolvin D2 inhibits the reaction [Dextran Sulfate results in increased expression of ITGAL mRNA]21724996
C059514resveratrolresveratrol inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in decreased expression of ITGAL mRNA]16267019
C059514resveratrol[resveratrol co-treated with Streptozocin] results in increased expression of ITGAL mRNA25905778
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of ITGAL mRNA25895662
D019821SimvastatinSimvastatin binds to [ITGAL protein binds to ITGB2 protein]15041742
D019821SimvastatinSimvastatin inhibits the reaction [ITGAL affects the susceptibility to and affects the activity of CHAT protein]16828882
D019821SimvastatinSimvastatin inhibits the reaction [ITGAL affects the susceptibility to and affects the expression of CHAT mRNA]16828882
D019821SimvastatinSimvastatin inhibits the reaction [ITGAL affects the susceptibility to and affects the expression of CHRM5 mRNA]16828882
D019821SimvastatinSimvastatin inhibits the reaction [TNF results in increased expression of ITGAL]12615677
D019821SimvastatinSimvastatin results in decreased expression of ITGAL mRNA12615677
D019821SimvastatinSimvastatin binds to ITGAL protein16828882
D019311StaurosporineStaurosporine inhibits the reaction [Lipopolysaccharides results in increased expression of ITGAL mRNA]10198263
D019311StaurosporineStaurosporine inhibits the reaction [Lipopolysaccharides results in increased expression of ITGAL protein]10198263
D019311StaurosporineStaurosporine inhibits the reaction [TNF protein results in increased expression of ITGAL mRNA]10198263
D019311StaurosporineStaurosporine inhibits the reaction [TNF protein results in increased expression of ITGAL protein]10198263
D013311StreptozocinKLK1 protein inhibits the reaction [Streptozocin results in increased expression of ITGAL protein]16129698
D013311Streptozocin[resveratrol co-treated with Streptozocin] results in increased expression of ITGAL mRNA25905778
D013311StreptozocinStreptozocin results in increased expression of ITGAL protein16129698
D016559TacrolimusTacrolimus results in decreased expression of ITGAL9794552
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ITGAL mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ITGAL mRNA28922406
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased activity of ITGAL17201180
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ITGAL17201180
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ITGAL protein15310856|2021193
D013752TetracyclineTetracycline results in decreased expression of ITGAL mRNA28882639
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ITGAL mRNA25613284
C009495titanium dioxidetitanium dioxide affects the expression of ITGAL mRNA17656681
C009495titanium dioxidetitanium dioxide results in decreased expression of ITGAL mRNA27760801
C009495titanium dioxidetitanium dioxide results in increased expression of ITGAL mRNA23409001
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of ITGAL mRNA25729387
D019772TopotecanTopotecan results in increased expression of ITGAL mRNA25729387
D014212TretinoinCSF3 protein promotes the reaction [Tretinoin results in increased expression of ITGAL protein]18055984
D014212TretinoinPhenylbutyrates promotes the reaction [Tretinoin results in increased expression of ITGAL protein]18055984
D014212TretinoinTretinoin results in increased expression of ITGAL10025910
D014212TretinoinTretinoin results in increased expression of ITGAL protein18055984
C011559tributyltintributyltin results in increased expression of ITGAL mRNA26314263
C012589trichostatin Atrichostatin A inhibits the reaction [Nickel affects the expression of ITGAL mRNA]14575637
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of ITGAL mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of ITGAL mRNA"26179874
D014520UrethaneUrethane results in decreased expression of ITGAL mRNA28818685
D014635Valproic AcidValproic Acid results in increased methylation of ITGAL gene29154799
D014747VinblastineVinblastine results in decreased expression of ITGAL mRNA12649748
D014747VinblastineVinblastine results in decreased expression of ITGAL protein12649748
C025643vinclozolinvinclozolin affects the expression of ITGAL mRNA19015723

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI11544294  12526797  15946252  16595626  18985028  
GO:0030369ICAM-3 receptor activity-IMP19029120  
GO:0044877protein-containing complex binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO:0046982protein heterodimerization activity-IEA-  
GO:0050839cell adhesion molecule binding-IMP19029120  
GO:0050839cell adhesion molecule binding-IPI1448173  
GO ID GO Term Qualifier Evidence PubMed
GO:0002291T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell-IMP2477710  
GO:0006909phagocytosis-IEA-  
GO:0006954inflammatory response-NAS8103515  
GO:0007155cell adhesion-NAS8103515  
GO:0007157heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules-IMP2477710  
GO:0007159leukocyte cell-cell adhesion-IMP2477710  
GO:0007160cell-matrix adhesion-IMP19029120  
GO:0007165signal transduction-NAS8103515  
GO:0007229integrin-mediated signaling pathway-IEA-  
GO:0030198extracellular matrix organization-TAS-  
GO:0043113receptor clustering-IMP19029120  
GO:0043312neutrophil degranulation-TAS-  
GO:0050776regulation of immune response-TAS-  
GO:0050900leukocyte migration-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0008305integrin complex-NAS8103515  
GO:0009986cell surface-HDA23981064  
GO:0009986cell surface-IDA19029120  19234460  
GO:0016020membrane-HDA19946888  
GO:0034687integrin alphaL-beta2 complex-IDA19029120  
GO:0035579specific granule membrane-TAS-  
GO:0070062extracellular exosome-HDA20458337  
KEGG ID KEGG Term
hsa04514Cell adhesion molecules (CAMs)
hsa04650Natural killer cell mediated cytotoxicity
hsa04670Leukocyte transendothelial migration
hsa04810Regulation of actin cytoskeleton
hsa05144Malaria
hsa05150Staphylococcus aureus infection
hsa05323Rheumatoid arthritis
hsa05416Viral myocarditis
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-198933Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellTAS
R-HSA-202733Cell surface interactions at the vascular wallTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-216083Integrin cell surface interactionsTAS
R-HSA-6798695Neutrophil degranulationTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8878159Transcriptional regulation by RUNX3TAS
R-HSA-8949275RUNX3 Regulates Immune Response and Cell MigrationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22452928Controlled human wood smoke exposure: oxidative stress, inflammation and microvascular function. (2012 Mar 27)Forchhammer LPart Fibre Toxicol