Gene info: ID 3688

Gene: ITGB1

GENE ID: 3688

Description: integrin subunit beta 1

Gene type: protein-coding

Location: 10p11.22

dbXrefs: Ensembl:ENSG00000150093 MIM:135630 Vega:OTTHUMG00000017928 UniprotKB:P05556

RefSeq: NG_029012.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 6.839e-1 (AD) 4.935e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CLIC4	0.89
TANC1	0.87
ELF1	0.868
ROCK1	0.868
CALD1	0.862
YES1	0.86
WWTR1	0.858
REST	0.854
BNIP2	0.85
SEPT10	0.845

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ABCC12	-0.563
KCNB2	-0.563
MARCH4	-0.559
DLK2	-0.552
HAS1	-0.544
SLC7A4	-0.537
LRTM2	-0.537
ADRA1D	-0.534
LRRC73	-0.53
CDH22	-0.53

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00098	Antithymocyte immunoglobulin (rabbit)	BiotechDrug		Approved	Target

ID	Drug Name	Action	PubMed
C552530	1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane	"1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in decreased expression of ITGB1 mRNA"	26929200
C552530	1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane	"1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in decreased expression of ITGB1 protein"	26929200
C552530	1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane	"ITGB1 protein results in increased susceptibility to 1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane"	26929200
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in decreased expression of ITGB1 mRNA"	19162173
C576882	1-(2-trifluoromethoxyphenyl)-2-nitroethanone	1-(2-trifluoromethoxyphenyl)-2-nitroethanone results in decreased expression of ITGB1 mRNA	25596134
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of ITGB1 mRNA"	28903501
C001079	2-(2,6-dioxopiperidin-3-yl)phthalimidine	"2-(2,6-dioxopiperidin-3-yl)phthalimidine results in decreased expression of ITGB1 protein"	8538367
C404910	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane	"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the expression of ITGB1 mRNA"	19414516
C404910	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane	"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of ITGB1 mRNA]"	19414516
C404910	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane	"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [FSHB protein affects the expression of ITGB1 mRNA]"	19414516
C013186	2,3-pentanedione	"2,3-pentanedione results in increased expression of ITGB1 mRNA"	25710175
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of ITGB1 mRNA"	21346803
C044563	24-hydroxycholesterol	"[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of ITGB1 mRNA"	24802026
C044563	24-hydroxycholesterol	24-hydroxycholesterol results in increased expression of ITGB1 mRNA	24802026
C044563	24-hydroxycholesterol	"Quercetin analog inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of ITGB1 mRNA]"	24802026
C044563	24-hydroxycholesterol	Quercetin analog inhibits the reaction [24-hydroxycholesterol results in increased expression of ITGB1 mRNA]	24802026
C044563	24-hydroxycholesterol	"Quercetin inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of ITGB1 mRNA]"	24802026
C044563	24-hydroxycholesterol	Quercetin inhibits the reaction [24-hydroxycholesterol results in increased expression of ITGB1 mRNA]	24802026
C011269	2,5-hexanedione	"2,5-hexanedione results in decreased expression of ITGB1 mRNA"	16141653
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of ITGB1 mRNA"	21346803
C076996	27-hydroxycholesterol	"[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of ITGB1 mRNA"	24802026
C076996	27-hydroxycholesterol	27-hydroxycholesterol results in increased expression of ITGB1 mRNA	24802026
C076996	27-hydroxycholesterol	"Quercetin analog inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of ITGB1 mRNA]"	24802026
C076996	27-hydroxycholesterol	Quercetin analog inhibits the reaction [27-hydroxycholesterol results in increased expression of ITGB1 mRNA]	24802026
C076996	27-hydroxycholesterol	"Quercetin inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of ITGB1 mRNA]"	24802026
C577942	2-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide	"2-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide results in decreased expression of ITGB1 mRNA"	26644586
C029955	2-nitrotoluene	2-nitrotoluene results in decreased expression of ITGB1 mRNA	16460773
C017906	3-dinitrobenzene	3-dinitrobenzene results in increased expression of ITGB1 mRNA	21983209\|2414075
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of ITGB1 mRNA"	25380136
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ITGB1 protein"	25670856
D000082	Acetaminophen	Acetaminophen affects the expression of ITGB1 mRNA	17562736
D000082	Acetaminophen	Acetaminophen affects the expression of ITGB1 mRNA	16701773
D000082	Acetaminophen	Acetaminophen results in increased expression of ITGB1 mRNA	22112502
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [DDT results in increased expression of ITGB1 mRNA]	24820114
D000242	Cyclic AMP	"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of ITGB1 mRNA]"	19414516
C549106	AL-10 compound	AL-10 compound results in decreased metabolism of ITGB1 protein	20112294
D013196	Dihydrotestosterone	Dihydrotestosterone results in decreased expression of ITGB1 mRNA	17023530
D000537	Aluminum Oxide	[Aluminum Oxide co-treated with Magnesium] results in increased expression of ITGB1 protein	12209937
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of ITGB1 mRNA	16483693
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of ITGB1 mRNA	25339124
D018501	Antirheumatic Agents	Antirheumatic Agents results in increased expression of ITGB1 mRNA	24449571
D001151	Arsenic	Arsenic results in decreased expression of ITGB1 protein	16420308
C058317	arsenic disulfide	arsenic disulfide affects the expression of ITGB1 mRNA	12776498
C058317	arsenic disulfide	arsenic disulfide results in decreased expression of ITGB1 mRNA	12890387
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of ITGB1 mRNA	12852829\|2623859
C039726	artesunate	ITGB1 mRNA results in increased susceptibility to artesunate	20144594
D017638	Asbestos, Crocidolite	"ITGB1 protein affects the reaction [Asbestos, Crocidolite results in increased phosphorylation of AKT1 protein]"	14627993
D017638	Asbestos, Crocidolite	"ITGB1 protein affects the reaction [Asbestos, Crocidolite results in increased phosphorylation of MAPK1 protein]"	14627993
D017638	Asbestos, Crocidolite	"ITGB1 protein affects the reaction [Asbestos, Crocidolite results in increased phosphorylation of MAPK3 protein]"	14627993
D001280	Atrazine	Atrazine results in increased expression of ITGB1 mRNA	18585445
D001374	Azacitidine	Azacitidine results in decreased expression of ITGB1 mRNA	20823114
D001542	Benomyl	Benomyl results in decreased expression of ITGB1 mRNA	25530041
C030935	benz(a)anthracene	benz(a)anthracene results in decreased expression of ITGB1 mRNA	26377693
D001564	Benzo(a)pyrene	AHR protein inhibits the reaction [Benzo(a)pyrene results in decreased expression of ITGB1 mRNA]	15034205
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of ITGB1 mRNA	15034205
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of ITGB1 mRNA	22228805
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of ITGB1 mRNA	22300585
D019207	beta Carotene	beta Carotene results in decreased expression of ITGB1 mRNA	17034753
D004958	Estradiol	[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of ITGB1 mRNA	20823114
D004958	Estradiol	Estradiol results in increased expression of ITGB1 protein	16912569
C006780	bisphenol A	bisphenol A results in increased expression of ITGB1 mRNA	25534675
C006780	bisphenol A	bisphenol A results in increased expression of ITGB1 protein	25534675
C006780	bisphenol A	fulvestrant inhibits the reaction [bisphenol A results in increased expression of ITGB1 protein]	25534675
C006780	bisphenol A	bisphenol A affects the expression of ITGB1 mRNA	25181051
C006780	bisphenol A	bisphenol A results in decreased expression of ITGB1 mRNA	27697584
C006780	bisphenol A	bisphenol A results in decreased expression of ITGB1 protein	19497385
C472645	blebbistatin	blebbistatin results in decreased activity of ITGB1 protein	16723733
C099813	bromochloroacetic acid	bromochloroacetic acid results in decreased expression of ITGB1 mRNA	16460773
D002087	Butyrates	Butyrates results in decreased expression of ITGB1 mRNA	14674679
D002101	Cacodylic Acid	Cacodylic Acid results in decreased expression of ITGB1 mRNA	17720352
D002101	Cacodylic Acid	Cacodylic Acid results in increased expression of ITGB1 mRNA	16122865
D002104	Cadmium	Cadmium results in increased expression of ITGB1 mRNA	20570719\|2256248
D019256	Cadmium Chloride	Cadmium Chloride affects the expression of ITGB1 mRNA	25596134
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of ITGB1 protein	28527916
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of ITGB1 mRNA	18974090
D002220	Carbamazepine	Carbamazepine affects the expression of ITGB1 mRNA	24752500
C006698	carbendazim	carbendazim results in decreased expression of ITGB1 mRNA	25530041
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of ITGB1 mRNA	17484886
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of ITGB1 mRNA	22112502
D002330	Carmustine	Carmustine results in decreased expression of ITGB1 protein	18443378
D002712	Chlorides	ITGB1 protein results in increased transport of Chlorides	20164377
D002713	Chlorine	[Ozone co-treated with Chlorine] results in decreased expression of ITGB1 mRNA	18636392
C004656	chloroacetaldehyde	chloroacetaldehyde results in decreased expression of ITGB1 mRNA	25596134
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of ITGB1 mRNA	23650126
C100187	chloropicrin	chloropicrin results in decreased expression of ITGB1 mRNA	28476498
C100187	chloropicrin	chloropicrin results in increased expression of ITGB1 mRNA	26352163
C011724	cholest-5-en-3 beta,7 alpha-diol	"[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of ITGB1 mRNA"	24802026
C011724	cholest-5-en-3 beta,7 alpha-diol	"cholest-5-en-3 beta,7 alpha-diol results in increased expression of ITGB1 mRNA"	24802026
C011724	cholest-5-en-3 beta,7 alpha-diol	"Quercetin analog inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of ITGB1 mRNA]"	24802026
C011724	cholest-5-en-3 beta,7 alpha-diol	"Quercetin analog inhibits the reaction [cholest-5-en-3 beta,7 alpha-diol results in increased expression of ITGB1 mRNA]"	24802026
C011724	cholest-5-en-3 beta,7 alpha-diol	"Quercetin inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of ITGB1 mRNA]"	24802026
C031180	chrysene	chrysene results in decreased expression of ITGB1 mRNA	26377693
C059262	cidofovir	cidofovir affects the expression of ITGB1 mRNA	25596134
D007464	Clioquinol	[Clioquinol binds to Copper] which results in increased expression of ITGB1 protein	18346929
D003042	Cocaine	Cocaine affects the expression of ITGB1 protein	19073234
D005576	Colforsin	ITGB1 protein affects the susceptibility to Colforsin	15836982
D003300	Copper	[Clioquinol binds to Copper] which results in increased expression of ITGB1 protein	18346929
D003300	Copper	[Disulfiram binds to Copper] which results in increased expression of ITGB1 mRNA	24690739
D019327	Copper Sulfate	Copper Sulfate results in increased expression of ITGB1 mRNA	19549813
D003474	Curcumin	Curcumin inhibits the reaction [IL1B protein results in decreased expression of ITGB1 protein]	17291458
D003474	Curcumin	Curcumin results in increased expression of ITGB1 protein	17291458
D016572	Cyclosporine	Cyclosporine results in decreased expression of ITGB1 mRNA	25596134
D003634	DDT	Acetylcysteine inhibits the reaction [DDT results in increased expression of ITGB1 mRNA]	24820114
D003634	DDT	DDT results in increased expression of ITGB1 mRNA	24820114
D003634	DDT	INCB018424 inhibits the reaction [DDT results in increased expression of ITGB1 mRNA]	24820114
D003634	DDT	WP1066 inhibits the reaction [DDT results in increased expression of ITGB1 mRNA]	24820114
D003847	Deoxyglucose	Deoxyglucose analog results in decreased expression of ITGB1 protein	27931795
D003907	Dexamethasone	ITGB1 protein promotes the reaction [ST6GAL1 protein inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of CEBPB mRNA]]	28031460
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of ITGB1 mRNA	21266533
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of ITGB1 mRNA	21266533
D003994	Bucladesine	[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of ITGB1 mRNA	20823114
D002945	Cisplatin	Cisplatin results in increased expression of ITGB1 mRNA	25596134\|2759478
D002945	Cisplatin	ITGB1 protein affects the susceptibility to Cisplatin	21720550
D002945	Cisplatin	[ITGB1 protein results in increased activity of EGFR protein] which results in decreased susceptibility to Cisplatin	21478906
D004008	Diclofenac	Diclofenac affects the expression of ITGB1 mRNA	24752500
C000944	dicrotophos	dicrotophos results in decreased expression of ITGB1 mRNA	28302478
D004041	Dietary Fats	Dietary Fats results in increased expression of ITGB1 mRNA	19030233
D004041	Dietary Fats	rimonabant inhibits the reaction [Dietary Fats results in increased expression of ITGB1 mRNA]	19030233
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased expression of ITGB1 mRNA	20920545
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased expression of ITGB1 protein	20920545
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of ITGB1 mRNA	25374375
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Phenobarbital] results in increased methylation of ITGB1 promoter	25374375
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of ITGB1 mRNA	25380136
D004221	Disulfiram	[Disulfiram binds to Copper] which results in increased expression of ITGB1 mRNA	24690739
D004237	Diuron	Diuron results in decreased expression of ITGB1 mRNA	21551480
D004280	Dobutamine	ITGB1 protein affects the susceptibility to Dobutamine	11884376
D004837	Epinephrine	ITGB1 results in increased susceptibility to Epinephrine	14984413
D000069347	Erlotinib Hydrochloride	Erlotinib Hydrochloride results in decreased expression of ITGB1 mRNA	24768708
C032773	ethyl caffeate	ethyl caffeate affects the expression of [ITGA3 protein binds to ITGB1 protein]	24892518
D017308	Etodolac	Etodolac results in decreased expression of [ITGA4 protein binds to ITGB1 protein]	16046235
D005054	Eugenol	Eugenol results in increased expression of ITGB1 mRNA	17936526
C540355	fenamidone	fenamidone results in increased expression of ITGB1 mRNA	27029645
D011345	Fenofibrate	Fenofibrate results in decreased expression of ITGB1 mRNA	25596134
D005492	Folic Acid	Folic Acid affects the expression of ITGB1 mRNA	16361273
C070081	fulvestrant	fulvestrant inhibits the reaction [bisphenol A results in increased expression of ITGB1 protein]	25534675
C070081	fulvestrant	fulvestrant results in increased expression of ITGB1 mRNA	12154049
C039281	furan	furan results in increased expression of ITGB1 mRNA	15120968\|2056205
C419708	gefitinib	[ITGB1 protein results in increased activity of EGFR protein] which results in decreased susceptibility to gefitinib	21478906
D019833	Genistein	Genistein results in increased expression of ITGB1 mRNA	26865667
D019833	Genistein	Genistein results in decreased expression of ITGB1 mRNA	21048042
C112772	ginsenoside M1	ginsenoside M1 inhibits the reaction [TNF protein results in increased expression of [ITGA4 protein binds to ITGB1 protein]]	21875580
C425564	ginsenoside Rh1	ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of [ITGA4 protein binds to ITGB1 protein]]	21875580
D005947	Glucose	Glucose results in decreased expression of ITGB1 mRNA	25503068
D005947	Glucose	Glucose results in decreased expression of ITGB1 protein	25503068
D005947	Glucose	notoginsenoside R1 inhibits the reaction [Glucose results in decreased expression of ITGB1 mRNA]	25503068
D005947	Glucose	notoginsenoside R1 inhibits the reaction [Glucose results in decreased expression of ITGB1 protein]	25503068
D005947	Glucose	Glucose results in increased expression of ITGB1 mRNA	17441352
D005947	Glucose	Glucose results in increased expression of ITGB1 protein	17441352
D005947	Glucose	rosiglitazone inhibits the reaction [Glucose results in increased expression of ITGB1 mRNA]	17441352
D005947	Glucose	rosiglitazone inhibits the reaction [Glucose results in increased expression of ITGB1 protein]	17441352
C568713	GSK1210151A	GSK1210151A results in decreased expression of ITGB1 mRNA	26644586
C401858	GW 7604	GW 7604 results in increased expression of ITGB1 mRNA	12154049
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of ITGB1 mRNA	20044591
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of ITGB1 mRNA	12419474
C031927	hydroquinone	hydroquinone results in decreased expression of ITGB1 mRNA	19148301
C031927	hydroquinone	hydroquinone results in decreased activity of ITGB1 protein	17464197
C031927	hydroquinone	hydroquinone results in decreased expression of ITGB1 protein	17464197
D007069	Ifosfamide	Ifosfamide affects the expression of ITGB1 mRNA	25596134
C540383	INCB018424	INCB018424 inhibits the reaction [DDT results in increased expression of ITGB1 mRNA]	24820114
C027185	indirubin	indirubin results in decreased expression of ITGB1 mRNA	15056799
C053476	invasin, Yersinia	"[ITGA7 protein binds to ITGB1 protein] which binds to invasin, Yersinia"	21584882
C053476	invasin, Yersinia	"Magnesium promotes the reaction [[ITGA7 protein binds to ITGB1 protein] which binds to invasin, Yersinia]"	21584882
C053476	invasin, Yersinia	"Magnesium promotes the reaction [Manganese promotes the reaction [[ITGA7 protein binds to ITGB1 protein] which binds to invasin, Yersinia]]"	21584882
C053476	invasin, Yersinia	"Manganese promotes the reaction [[ITGA7 protein binds to ITGB1 protein] which binds to invasin, Yersinia]"	21584882
C053476	invasin, Yersinia	"Manganese promotes the reaction [Magnesium promotes the reaction [[ITGA7 protein binds to ITGB1 protein] which binds to invasin, Yersinia]]"	21584882
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ITGB1 mRNA	25613284
D015056	1-Methyl-3-isobutylxanthine	ITGB1 protein promotes the reaction [ST6GAL1 protein inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of CEBPB mRNA]]	28031460
D007545	Isoproterenol	DMD gene mutant form promotes the reaction [ITGB1 gene affects the susceptibility to Isoproterenol]	18340010
D007545	Isoproterenol	Isoproterenol results in decreased expression of ITGB1	18808529
C561695	(+)-JQ1 compound	(+)-JQ1 compound inhibits the reaction [TGFB1 protein results in increased expression of ITGB1 mRNA]	26644586
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of ITGB1 mRNA	25961927\|2664458
C037067	latrunculin A	latrunculin A results in decreased activity of ITGB1 protein	16723733
C008261	lead acetate	lead acetate results in increased expression of ITGB1 mRNA	22609695
D008095	Lithocholic Acid	Lithocholic Acid results in decreased metabolism of ITGB1 protein	21224350
D008274	Magnesium	[Aluminum Oxide co-treated with Magnesium] results in increased expression of ITGB1 protein	12209937
D008274	Magnesium	Magnesium inhibits the reaction [Ofloxacin inhibits the reaction [ITGB1 protein binds to PTK2 protein]]	23274517
D008274	Magnesium	Magnesium inhibits the reaction [Ofloxacin inhibits the reaction [ITGB1 protein binds to PXN protein]]	23274517
D008274	Magnesium	Magnesium inhibits the reaction [Ofloxacin inhibits the reaction [ITGB1 protein binds to VCL protein]]	23274517
D008274	Magnesium	"Magnesium promotes the reaction [[ITGA7 protein binds to ITGB1 protein] which binds to invasin, Yersinia]"	21584882
D008274	Magnesium	"Magnesium promotes the reaction [Manganese promotes the reaction [[ITGA7 protein binds to ITGB1 protein] which binds to invasin, Yersinia]]"	21584882
D008274	Magnesium	"Manganese promotes the reaction [Magnesium promotes the reaction [[ITGA7 protein binds to ITGB1 protein] which binds to invasin, Yersinia]]"	21584882
D008345	Manganese	Manganese results in increased activity of ITGB1 protein	10820171\|1660636
D008345	Manganese	"Magnesium promotes the reaction [Manganese promotes the reaction [[ITGA7 protein binds to ITGB1 protein] which binds to invasin, Yersinia]]"	21584882
D008345	Manganese	"Manganese promotes the reaction [[ITGA7 protein binds to ITGB1 protein] which binds to invasin, Yersinia]"	21584882
D008345	Manganese	"Manganese promotes the reaction [Magnesium promotes the reaction [[ITGA7 protein binds to ITGB1 protein] which binds to invasin, Yersinia]]"	21584882
D017258	Medroxyprogesterone Acetate	[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of ITGB1 mRNA	20823114
D008628	Mercury	Mercury results in increased activity of ITGB1 protein	10820171
D008687	Metformin	Metformin results in increased expression of ITGB1 mRNA	25596134
D008727	Methotrexate	Methotrexate results in decreased expression of ITGB1 mRNA	25339124
D008727	Methotrexate	Methotrexate results in increased expression of ITGB1 mRNA	21678067\|2444957
C587228	methyl 3-hydroxyimino-11-oxoolean-12-en-28-oate	methyl 3-hydroxyimino-11-oxoolean-12-en-28-oate results in decreased expression of ITGB1 mRNA	28322779
C587228	methyl 3-hydroxyimino-11-oxoolean-12-en-28-oate	methyl 3-hydroxyimino-11-oxoolean-12-en-28-oate results in decreased expression of ITGB1 protein	28322779
C005219	methyl cellosolve	methyl cellosolve results in increased expression of ITGB1 mRNA	21061450
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of ITGB1 mRNA	23649840
C008493	methylselenic acid	methylselenic acid results in decreased expression of ITGB1 mRNA	11172735
D015741	Metribolone	Metribolone results in decreased expression of [ITGA2 protein binds to ITGB1 protein]	17541959
C070571	ML 7	ML 7 affects the localization of [ITGA3 protein binds to ITGB1 protein]	14691950
C070571	ML 7	ML 7 results in decreased activity of ITGB1 protein	16723733
C056218	ML 9	ML 9 results in decreased activity of ITGB1 protein	16723733
D016686	Monocrotaline	Monocrotaline results in increased expression of ITGB1 mRNA	28818515
C057451	morusin	morusin results in decreased expression of ITGB1 protein	25476160
D009151	Mustard Gas	Mustard Gas results in increased expression of ITGB1 mRNA	15674843\|1895507
C451426	N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide	"[systhane co-treated with N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide] results in decreased expression of ITGB1 mRNA"	25461557
D037742	Nanotubes, Carbon	"Nanotubes, Carbon affects the expression of ITGB1 protein"	21135415
C000621033	napabucasin	napabucasin results in decreased expression of ITGB1 mRNA	25605917
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of ITGB1 mRNA	25380136
D009538	Nicotine	Nicotine results in decreased expression of ITGB1 protein	11338295
D009607	Nitrosourea Compounds	Nitrosourea Compounds results in decreased expression of ITGB1 protein	18443378
C072936	notoginsenoside R1	notoginsenoside R1 inhibits the reaction [Glucose results in decreased expression of ITGB1 mRNA]	25503068
C072936	notoginsenoside R1	notoginsenoside R1 inhibits the reaction [Glucose results in decreased expression of ITGB1 protein]	25503068
C072936	notoginsenoside R1	notoginsenoside R1 inhibits the reaction [Streptozocin results in decreased expression of ITGB1 mRNA]	25503068
C072936	notoginsenoside R1	notoginsenoside R1 inhibits the reaction [Streptozocin results in decreased expression of ITGB1 protein]	25503068
D015242	Ofloxacin	CYBB mutant form inhibits the reaction [Ofloxacin results in decreased expression of ITGB1 protein]	23274517
D015242	Ofloxacin	Magnesium inhibits the reaction [Ofloxacin inhibits the reaction [ITGB1 protein binds to PTK2 protein]]	23274517
D015242	Ofloxacin	Magnesium inhibits the reaction [Ofloxacin inhibits the reaction [ITGB1 protein binds to PXN protein]]	23274517
D015242	Ofloxacin	Magnesium inhibits the reaction [Ofloxacin inhibits the reaction [ITGB1 protein binds to VCL protein]]	23274517
D015242	Ofloxacin	Ofloxacin inhibits the reaction [ITGB1 protein binds to PTK2 protein]	23274517
D015242	Ofloxacin	Ofloxacin inhibits the reaction [ITGB1 protein binds to PXN protein]	23274517
D015242	Ofloxacin	Ofloxacin inhibits the reaction [ITGB1 protein binds to VCL protein]	23274517
D015242	Ofloxacin	Ofloxacin results in decreased expression of ITGB1 protein	23274517
D010100	Oxygen	ITGB1 affects the reaction [Oxygen deficiency affects the expression of BIRC5 mRNA]	16628086
D010100	Oxygen	ITGB1 affects the reaction [Oxygen deficiency affects the expression of BIRC5 protein]	16628086
D010100	Oxygen	Oxygen deficiency results in increased expression of ITGB1 mRNA	25596134
D010100	Oxygen	Oxygen deficiency results in increased expression of ITGB1 protein	26476374
D010100	Oxygen	Quercetin inhibits the reaction [Oxygen deficiency results in increased expression of ITGB1 protein]	26476374
D010126	Ozone	Ozone affects the localization of ITGB1 protein	9730863
D010126	Ozone	[Ozone co-treated with Chlorine] results in decreased expression of ITGB1 mRNA	18636392
D017239	Paclitaxel	ITGB1 results in increased susceptibility to Paclitaxel	14984413
D052638	Particulate Matter	Particulate Matter results in increased expression of ITGB1 mRNA	28846189
C000610380	p-carboxymethylphenyl 1,1-bis(3'-indolyl)-1-(p-carboxymethylphenyl)methane	"ITGB1 protein results in increased susceptibility to p-carboxymethylphenyl 1,1-bis(3'-indolyl)-1-(p-carboxymethylphenyl)methane"	26929200
C000610380	p-carboxymethylphenyl 1,1-bis(3'-indolyl)-1-(p-carboxymethylphenyl)methane	"p-carboxymethylphenyl 1,1-bis(3'-indolyl)-1-(p-carboxymethylphenyl)methane results in decreased expression of ITGB1 mRNA"	26929200
C000610380	p-carboxymethylphenyl 1,1-bis(3'-indolyl)-1-(p-carboxymethylphenyl)methane	"p-carboxymethylphenyl 1,1-bis(3'-indolyl)-1-(p-carboxymethylphenyl)methane results in decreased expression of ITGB1 protein"	26929200
D015232	Dinoprostone	ITGB1 results in increased susceptibility to Dinoprostone	14984413
D010634	Phenobarbital	[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of ITGB1 mRNA	25374375
D010634	Phenobarbital	[Diethylnitrosamine co-treated with Phenobarbital] results in increased methylation of ITGB1 promoter	25374375
D010672	Phenytoin	Phenytoin results in decreased expression of ITGB1 protein	15948689
D010795	Phthalic Acids	Phthalic Acids results in increased expression of ITGB1 mRNA	21061450
D010862	Pilocarpine	Pilocarpine results in decreased expression of ITGB1 protein	19631748
D010862	Pilocarpine	Pilocarpine results in increased expression of ITGB1 protein	12851778
C006253	pirinixic acid	pirinixic acid results in increased expression of ITGB1 mRNA	16221962
D028321	Plant Preparations	Plant Preparations results in increased expression of ITGB1 mRNA	24973489
D011092	Polyethylene Glycols	Polyethylene Glycols results in decreased expression of ITGB1 mRNA	22558349
D011374	Progesterone	Progesterone affects the expression of ITGB1 mRNA	17962213
D011374	Progesterone	Progesterone affects the expression of ITGB1 protein	17962213
D011374	Progesterone	Progesterone results in increased expression of ITGB1 mRNA	21770760
C066229	prolinedithiocarbamate	prolinedithiocarbamate affects the expression of ITGB1 protein	25476160
D011480	Protease Inhibitors	Protease Inhibitors inhibits the reaction [MMP9 protein results in increased degradation of ITGB1 protein]	19631748
D011692	Puromycin Aminonucleoside	Puromycin Aminonucleoside results in decreased expression of ITGB1 mRNA	11274237
D011692	Puromycin Aminonucleoside	Puromycin Aminonucleoside results in decreased expression of ITGB1 protein	11274237
D011692	Puromycin Aminonucleoside	Puromycin Aminonucleoside results in increased expression of ITGB1 protein	12065681\|1455971
C513428	pyrachlostrobin	pyrachlostrobin results in increased expression of ITGB1 mRNA	27029645
D011794	Quercetin	"Quercetin analog inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of ITGB1 mRNA]"	24802026
D011794	Quercetin	Quercetin analog inhibits the reaction [24-hydroxycholesterol results in increased expression of ITGB1 mRNA]	24802026
D011794	Quercetin	Quercetin analog inhibits the reaction [27-hydroxycholesterol results in increased expression of ITGB1 mRNA]	24802026
D011794	Quercetin	"Quercetin analog inhibits the reaction [cholest-5-en-3 beta,7 alpha-diol results in increased expression of ITGB1 mRNA]"	24802026
D011794	Quercetin	"Quercetin inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of ITGB1 mRNA]"	24802026
D011794	Quercetin	Quercetin inhibits the reaction [24-hydroxycholesterol results in increased expression of ITGB1 mRNA]	24802026
D011794	Quercetin	Quercetin inhibits the reaction [Oxygen deficiency results in increased expression of ITGB1 protein]	26476374
C012526	quercitrin	quercitrin affects the expression of ITGB1 mRNA	25193878
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride results in increased expression of ITGB1 mRNA	12154049\|1942943
C059514	resveratrol	resveratrol inhibits the reaction [IL1B protein results in decreased expression of ITGB1 protein]	17404069
C059514	resveratrol	resveratrol results in decreased expression of ITGB1 mRNA	22610192
C089032	rimonabant	rimonabant inhibits the reaction [Dietary Fats results in increased expression of ITGB1 mRNA]	19030233
C089730	rosiglitazone	rosiglitazone inhibits the reaction [Glucose results in increased expression of ITGB1 mRNA]	17441352
C089730	rosiglitazone	rosiglitazone inhibits the reaction [Glucose results in increased expression of ITGB1 protein]	17441352
C089730	rosiglitazone	rosiglitazone results in decreased expression of ITGB1 mRNA	25596134
C410733	scriptaid	scriptaid affects the expression of ITGB1 mRNA	18813790
C016101	shikonin	shikonin results in decreased expression of ITGB1 mRNA	23562787
C016101	shikonin	shikonin results in decreased expression of ITGB1 protein	23562787
D012795	Sialoglycoproteins	[ST6GAL1 protein results in increased abundance of Sialoglycoproteins] which results in increased glycosylation of and results in increased activity of ITGB1 protein	28031460
D012795	Sialoglycoproteins	[[ST6GAL1 protein results in increased abundance of Sialoglycoproteins] which results in increased glycosylation of and results in increased activity of ITGB1 protein] which results in increased phosphorylation of PTK2 protein	28031460
D012834	Silver	Silver results in decreased expression of ITGB1 mRNA	27131904
D019821	Simvastatin	Simvastatin results in decreased expression of ITGB1 mRNA	17428261
D019821	Simvastatin	Simvastatin results in decreased expression of ITGB1 protein	17428261\|2187422
C118258	SN50 peptide	SN50 peptide inhibits the reaction [TNF protein results in increased expression of [ITGA4 protein binds to ITGB1 protein]]	21875580
C009277	sodium arsenate	sodium arsenate results in increased expression of ITGB1 mRNA	21795629
C017947	sodium arsenite	sodium arsenite results in decreased expression of ITGB1 mRNA	24431212
C017947	sodium arsenite	sodium arsenite results in increased stability of and results in increased expression of ITGB1 protein	16054901
D012999	Soman	Soman results in increased expression of ITGB1 mRNA	19281266
D013311	Streptozocin	notoginsenoside R1 inhibits the reaction [Streptozocin results in decreased expression of ITGB1 mRNA]	25503068
D013311	Streptozocin	notoginsenoside R1 inhibits the reaction [Streptozocin results in decreased expression of ITGB1 protein]	25503068
D013311	Streptozocin	Streptozocin results in decreased expression of ITGB1 mRNA	25503068
D013311	Streptozocin	Streptozocin results in decreased expression of ITGB1 protein	25503068
D013481	Superoxides	[DDIT3 protein results in increased abundance of Superoxides] which results in decreased expression of ITGB1 protein	16400006
C446685	systhane	"[systhane co-treated with N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide] results in decreased expression of ITGB1 mRNA"	25461557
D013629	Tamoxifen	Tamoxifen results in increased expression of ITGB1 mRNA	19429434
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of ITGB1 mRNA	15056799
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of ITGB1 mRNA	19684285
D013749	Tetrachlorodibenzodioxin	AHR protein promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of ITGB1 mRNA]	15034205
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of ITGB1 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of ITGB1 mRNA	15034205
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of ITGB1 mRNA	15328365\|1661135
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ITGB1 mRNA	25613284
D013853	Thioacetamide	Thioacetamide results in increased expression of ITGB1 mRNA	23411599
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of ITGB1 mRNA	27480279
D014212	Tretinoin	Tretinoin results in increased cleavage of [ITGAV protein binds to ITGB1 protein]	11369141
D014212	Tretinoin	Tretinoin results in increased expression of [ITGAV protein binds to ITGB1 protein]	11718225
D014212	Tretinoin	Tretinoin results in increased expression of ITGB1 mRNA	23724009
D014212	Tretinoin	Tretinoin inhibits the reaction [RARG gene mutant form results in increased expression of ITGB1 mRNA]	10748128
D014212	Tretinoin	Tretinoin promotes the reaction [RARA gene mutant form results in decreased expression of ITGB1 mRNA]	10748128
D014212	Tretinoin	Tretinoin results in decreased expression of ITGB1 mRNA	10748128
C015559	trimellitic anhydride	trimellitic anhydride results in increased expression of ITGB1 mRNA	19042947
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of ITGB1 mRNA"	26179874
D014415	Tunicamycin	Tunicamycin results in decreased expression of ITGB1 mRNA	17127020
D017974	Uranium Compounds	Uranium Compounds results in decreased expression of ITGB1 mRNA	19654044
D014635	Valproic Acid	Valproic Acid results in decreased methylation of ITGB1 gene	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of ITGB1 mRNA	23179753\|2800136
D014640	Vancomycin	Vancomycin results in decreased expression of ITGB1 mRNA	18930951
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of ITGB1 gene	25560391
C025643	vinclozolin	vinclozolin affects the expression of ITGB1 mRNA	19015723
D014801	Vitamin A	Vitamin A affects the localization of ITGB1 protein	17241391
D014801	Vitamin A	Vitamin A results in increased expression of ITGB1 protein	17241391
D002762	Cholecalciferol	Cholecalciferol results in increased expression of ITGB1 mRNA	17170073
C111237	vorinostat	vorinostat results in increased expression of ITGB1 mRNA	19911379
C111237	vorinostat	vorinostat results in increased expression of ITGB1 protein	19911379
C519885	WP1066	WP1066 inhibits the reaction [DDT results in increased expression of ITGB1 mRNA]	24820114
C108830	Y 27632	Y 27632 affects the localization of [ITGA3 protein binds to ITGB1 protein]	14691950
C521292	YSNSG cyclopeptide	YSNSG cyclopeptide affects the localization of ITGB1 protein	19551865
D015032	Zinc	Zinc deficiency results in increased expression of ITGB1 mRNA	18356318
C028541	zirconium oxide	zirconium oxide results in increased expression of ITGB1 mRNA	17197017

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001618	virus receptor activity	-	IEA	-
GO:0001968	fibronectin binding	-	IBA	21873635
GO:0001968	fibronectin binding	-	IPI	11792823
GO:0002020	protease binding	-	IPI	10455171
GO:0003779	actin binding	-	IDA	16803572
GO:0005178	integrin binding	-	IBA	21873635
GO:0005178	integrin binding	-	IEA	-
GO:0005515	protein binding	-	IPI	1542691 9281591 9360996 9722563 10676904 10906324 11279249 11807099 12473654 12592401 12695522 12724312 12807887 14681217 14970227 15225631 15703214 16076904 16099422 16754661 16754960 16803572 17158881 17690686 17704059 17925226 18177638 19168626 19268462 19738201 20159608 20183869 20802515 20802519 21134644 21397862 21806020 21947080 22178926 22623428 22940691 24789099 25661773
GO:0015026	coreceptor activity	-	TAS	23125415
GO:0019960	C-X3-C chemokine binding	CONTRIBUTES_TO	IBA	21873635
GO:0019960	C-X3-C chemokine binding	contributes_to	IDA	23125415
GO:0043236	laminin binding	CONTRIBUTES_TO	IBA	21873635
GO:0043236	laminin binding	-	IEA	-
GO:0044877	protein-containing complex binding	-	IPI	25336636
GO:0045296	cadherin binding	-	HDA	25468996
GO:0046872	metal ion binding	-	IEA	-
GO:0046982	protein heterodimerization activity	-	IDA	10455171
GO:0046982	protein heterodimerization activity	-	NAS	9552005
GO:0050839	cell adhesion molecule binding	-	IPI	12869515
GO:0098639	collagen binding involved in cell-matrix adhesion	-	IBA	21873635
GO:0098639	collagen binding involved in cell-matrix adhesion	-	IMP	24823363

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000082	G1/S transition of mitotic cell cycle	-	IEA	-
GO:0001701	in utero embryonic development	-	IEA	-
GO:0001708	cell fate specification	-	IEA	-
GO:0002042	cell migration involved in sprouting angiogenesis	-	IEA	-
GO:0006968	cellular defense response	-	TAS	10201960
GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	-	TAS	10201960
GO:0007159	leukocyte cell-cell adhesion	-	IDA	1715889
GO:0007160	cell-matrix adhesion	-	IBA	21873635
GO:0007160	cell-matrix adhesion	-	IMP	18156211 18308860 24823363
GO:0007161	calcium-independent cell-matrix adhesion	-	IGI	19651211
GO:0007179	transforming growth factor beta receptor signaling pathway	NOT	IMP	24036928
GO:0007229	integrin-mediated signaling pathway	-	IBA	21873635
GO:0007229	integrin-mediated signaling pathway	-	IMP	24823363
GO:0008284	positive regulation of cell proliferation	-	IEA	-
GO:0008354	germ cell migration	-	IEA	-
GO:0008542	visual learning	-	IEA	-
GO:0010710	regulation of collagen catabolic process	-	IDA	10455171
GO:0016477	cell migration	-	IBA	21873635
GO:0016477	cell migration	-	TAS	11919189
GO:0019221	cytokine-mediated signaling pathway	-	TAS	-
GO:0021943	formation of radial glial scaffolds	-	IEA	-
GO:0030183	B cell differentiation	-	IC	1715889
GO:0030198	extracellular matrix organization	-	TAS	-
GO:0031589	cell-substrate adhesion	-	IMP	19933311
GO:0031623	receptor internalization	-	ISS	-
GO:0033627	cell adhesion mediated by integrin	-	IBA	21873635
GO:0033627	cell adhesion mediated by integrin	-	IDA	12807887 17158881
GO:0033631	cell-cell adhesion mediated by integrin	-	IEP	17704059
GO:0034113	heterotypic cell-cell adhesion	-	IMP	20563599
GO:0035024	negative regulation of Rho protein signal transduction	-	IEA	-
GO:0043065	positive regulation of apoptotic process	-	IGI	19364818
GO:0043149	stress fiber assembly	NOT	IMP	24036928
GO:0043547	positive regulation of GTPase activity	-	IMP	25911094
GO:0045214	sarcomere organization	-	IEA	-
GO:0045596	negative regulation of cell differentiation	-	IEA	-
GO:0045766	positive regulation of angiogenesis	-	IMP	24044949
GO:0046718	viral entry into host cell	-	IEA	-
GO:0048333	mesodermal cell differentiation	-	IEP	23154389
GO:0048675	axon extension	-	IEA	-
GO:0048813	dendrite morphogenesis	-	IEA	-
GO:0050776	regulation of immune response	-	TAS	-
GO:0050900	leukocyte migration	-	TAS	-
GO:0050901	leukocyte tethering or rolling	-	IMP	18308860
GO:0051726	regulation of cell cycle	-	IEA	-
GO:0051897	positive regulation of protein kinase B signaling	-	IDA	24044949
GO:0055007	cardiac muscle cell differentiation	-	IEA	-
GO:0071404	cellular response to low-density lipoprotein particle stimulus	-	ISS	-
GO:0071711	basement membrane organization	-	IEA	-
GO:1903078	positive regulation of protein localization to plasma membrane	-	IDA	10455171
GO:2000273	positive regulation of signaling receptor activity	-	IDA	24044949
GO:2000811	negative regulation of anoikis	-	IMP	15006356

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001726	ruffle	-	TAS	11919189
GO:0005737	cytoplasm	-	IDA	16803572
GO:0005886	plasma membrane	-	IDA	12869515 16803572 21310825
GO:0005886	plasma membrane	-	NAS	10455171
GO:0005886	plasma membrane	-	TAS	-
GO:0005925	focal adhesion	-	HDA	21423176
GO:0005925	focal adhesion	-	IBA	21873635
GO:0005925	focal adhesion	-	IDA	12417594 17158881 23023225
GO:0005925	focal adhesion	colocalizes_with	IDA	14970227
GO:0008305	integrin complex	-	IBA	21873635
GO:0008305	integrin complex	-	NAS	9552005
GO:0009897	external side of plasma membrane	-	IEA	-
GO:0009986	cell surface	-	HDA	19581412 23382103 23658023 23981064
GO:0009986	cell surface	-	IBA	21873635
GO:0009986	cell surface	-	IDA	1715889 17158881 19234460 19933311 20563599 21310825 23023225 23154389 23620790 24036928 25063885
GO:0014704	intercalated disc	-	IEA	-
GO:0016020	membrane	-	HDA	19946888
GO:0030027	lamellipodium	-	IEA	-
GO:0030175	filopodium	-	IDA	16803572
GO:0031594	neuromuscular junction	-	IDA	9415431
GO:0032154	cleavage furrow	-	IEA	-
GO:0032587	ruffle membrane	colocalizes_with	IDA	14970227
GO:0032587	ruffle membrane	-	NAS	10455171
GO:0034665	integrin alpha1-beta1 complex	-	IDA	24823363
GO:0034666	integrin alpha2-beta1 complex	-	IDA	24823363
GO:0034667	integrin alpha3-beta1 complex	-	IDA	24220332 25063885
GO:0034677	integrin alpha7-beta1 complex	-	IEA	-
GO:0034678	integrin alpha8-beta1 complex	-	TAS	21335239
GO:0034680	integrin alpha10-beta1 complex	-	IDA	24823363
GO:0034681	integrin alpha11-beta1 complex	-	IDA	24823363
GO:0035748	myelin sheath abaxonal region	-	IEA	-
GO:0042383	sarcolemma	-	IDA	9415431
GO:0042470	melanosome	-	IEA	-
GO:0043197	dendritic spine	-	IEA	-
GO:0043235	receptor complex	-	IDA	23382219
GO:0045121	membrane raft	-	IDA	14559243
GO:0048471	perinuclear region of cytoplasm	colocalizes_with	IDA	20183869
GO:0055037	recycling endosome	-	IEA	-
GO:0070062	extracellular exosome	-	HDA	19056867 23533145
GO:0071438	invadopodium membrane	-	IDA	10455171
GO:0097060	synaptic membrane	-	IEA	-

KEGG ID	KEGG Term
hsa04145	Phagosome
hsa04360	Axon guidance
hsa04510	Focal adhesion
hsa04512	ECM-receptor interaction
hsa04514	Cell adhesion molecules (CAMs)
hsa04670	Leukocyte transendothelial migration
hsa04810	Regulation of actin cytoskeleton
hsa05100	Bacterial invasion of epithelial cells
hsa05130	Pathogenic Escherichia coli infection
hsa05131	Shigellosis
hsa05140	Leishmaniasis
hsa05145	Toxoplasmosis
hsa05200	Pathways in cancer
hsa05222	Small cell lung cancer
hsa05410	Hypertrophic cardiomyopathy (HCM)
hsa05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)
hsa05414	Dilated cardiomyopathy

Reactome ID	Reactome Term	Evidence
R-HSA-109582	Hemostasis	IEA
R-HSA-109582	Hemostasis	TAS
R-HSA-1266738	Developmental Biology	IEA
R-HSA-1266738	Developmental Biology	TAS
R-HSA-1280215	Cytokine Signaling in Immune system	TAS
R-HSA-1280218	Adaptive Immune System	TAS
R-HSA-1474244	Extracellular matrix organization	IEA
R-HSA-1474244	Extracellular matrix organization	TAS
R-HSA-1500931	Cell-Cell communication	TAS
R-HSA-1566948	Elastic fibre formation	TAS
R-HSA-1566977	Fibronectin matrix formation	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-168256	Immune System	TAS
R-HSA-194315	Signaling by Rho GTPases	TAS
R-HSA-195258	RHO GTPase Effectors	TAS
R-HSA-198933	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	TAS
R-HSA-202733	Cell surface interactions at the vascular wall	TAS
R-HSA-210991	Basigin interactions	TAS
R-HSA-2129379	Molecules associated with elastic fibres	TAS
R-HSA-216083	Integrin cell surface interactions	IEA
R-HSA-216083	Integrin cell surface interactions	TAS
R-HSA-3000157	Laminin interactions	IEA
R-HSA-3000157	Laminin interactions	TAS
R-HSA-3000170	Syndecan interactions	TAS
R-HSA-3000171	Non-integrin membrane-ECM interactions	TAS
R-HSA-3000178	ECM proteoglycans	TAS
R-HSA-373755	Semaphorin interactions	IEA
R-HSA-373760	L1CAM interactions	IEA
R-HSA-373760	L1CAM interactions	TAS
R-HSA-416700	Other semaphorin interactions	IEA
R-HSA-422475	Axon guidance	IEA
R-HSA-422475	Axon guidance	TAS
R-HSA-445144	Signal transduction by L1	TAS
R-HSA-446343	Localization of the PINCH-ILK-PARVIN complex to focal adhesions	TAS
R-HSA-446353	Cell-extracellular matrix interactions	TAS
R-HSA-446728	Cell junction organization	TAS
R-HSA-447041	CHL1 interactions	IEA
R-HSA-449147	Signaling by Interleukins	TAS
R-HSA-5663220	RHO GTPases Activate Formins	TAS
R-HSA-6785807	Interleukin-4 and 13 signaling	TAS
R-HSA-6806834	Signaling by MET	TAS
R-HSA-75892	Platelet Adhesion to exposed collagen	IEA
R-HSA-8874081	MET activates PTK2 signaling	TAS
R-HSA-8875513	MET interacts with TNS proteins	TAS
R-HSA-8875878	MET promotes cell motility	TAS
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
17634906	Polymorphisms in 33 inflammatory genes and risk of myocardial infarction--a system genetics approach. (2007 Nov)	Barbaux S	J Mol Med (Berl)
27143927	Integrin and gene network analysis reveals that ITGA5 and ITGB1 are prognostic in non-small-cell lung cancer. (2016)	Zheng W	Onco Targets Ther