Gene: ITGB2

3689
CD18|LAD|LCAMB|LFA-1|MAC-1|MF17|MFI7
integrin subunit beta 2
protein-coding
21q22.3
Ensembl:ENSG00000160255 MIM:600065 Vega:OTTHUMG00000090257 UniprotKB:P05107
NG_007270.2
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.246e-1 (AD)  2.987e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg18663307chr21:46341389ITGB22.500e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LAPTM50.96
SASH30.952
LAT20.95
C1QC0.943
HCK0.942
ABI30.941
ALOX5AP0.94
FCGR3A0.94
PARVG0.94
SPI10.939

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNIP3-0.431
ATP2C2-0.427
ZSCAN1-0.421
ST6GAL2-0.419
MARCH4-0.415
WNT7A-0.412
HES5-0.409
CPLX3-0.406
NEUROD6-0.399
KREMEN2-0.398

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00641SimvastatinSmall Molecule79902-63-9ApprovedTarget
ID Drug Name Action PubMed
C0703791,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [ITGB2 protein results in increased activity of RAP1A protein]"16963453
C0703791,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGB2 protein]"16393473
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of ITGB2 mRNA"27291303
C0010792-(2,6-dioxopiperidin-3-yl)phthalimidine"2-(2,6-dioxopiperidin-3-yl)phthalimidine results in decreased expression of ITGB2 protein"8538367
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ITGB2 protein results in increased activity of RAP1A protein]16963453
C0299552-nitrotoluene2-nitrotoluene results in increased expression of ITGB2 mRNA16460773
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of ITGB2 mRNA"28973690
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of ITGB2 mRNA"25380136
C1081234-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine"4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [ITGB2 protein results in increased activity of RAP1A protein]"16963453
D000082AcetaminophenAcetaminophen affects the expression of ITGB2 mRNA17562736
D000171AcroleinAcrolein results in increased expression of ITGB2 mRNA18515264
C058956acteosideacteoside inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGB2 protein]16393473
C058956acteosideacteoside inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGB2 protein]16393473
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ITGB2 mRNA22100608
C430898AGN 194204AGN 194204 results in increased expression of ITGB2 mRNA16339527
C103303alitretinoinDimethyl Sulfoxide promotes the reaction [alitretinoin results in increased expression of ITGB2 protein]15964820
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of ITGB2 mRNA28522335
C453459AMD 6221AMD 6221 results in decreased expression of ITGB2 protein12658210
D000636Aminosalicylic AcidsAminosalicylic Acids inhibits the reaction [TNF protein results in increased expression of ITGB2 protein]8094364
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of ITGB2 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in increased expression of ITGB2 mRNA20458559
D001194AsbestosAsbestos results in decreased expression of ITGB2 mRNA22398240
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of ITGB2 mRNA"23634900
D001241AspirinAspirin results in decreased expression of [ITGA2B protein binds to ITGB2 protein]15140583
D000069059Atorvastatin CalciumAtorvastatin Calcium inhibits the reaction [TNF results in increased expression of ITGB2]12615677
D001374AzacitidineAzacitidine results in decreased expression of ITGB2 mRNA19194470
C547126AZM551248AZM551248 results in increased expression of ITGB2 mRNA22323515
D001554BenzeneBenzene results in decreased expression of ITGB2 mRNA16188091|2003664
D001564Benzo(a)pyreneBenzo(a)pyrene metabolite results in increased expression of ITGB2 mRNA26314263
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ITGB2 mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ITGB2 mRNA22228805
D004958Estradiol[Progesterone co-treated with Estradiol] results in increased expression of ITGB2 mRNA20226447
C070515bisindolylmaleimide Ibisindolylmaleimide I inhibits the reaction [ITGB2 protein results in increased activity of RAP1A protein]16963453
C006780bisphenol Abisphenol A results in increased expression of ITGB2 mRNA14555285
C006780bisphenol Abisphenol A results in increased expression of ITGB2 protein14555285
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ITGB2 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of ITGB2 mRNA25594700
C006780bisphenol Abisphenol A results in decreased expression of ITGB2 mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of ITGB2 mRNA26314263
D001966BromineBromine results in increased expression of ITGB2 mRNA21391292
C099813bromochloroacetic acidbromochloroacetic acid results in increased expression of ITGB2 mRNA16460773
D002065BuspironeBuspirone results in decreased expression of ITGB2 mRNA24136188
C018475butyraldehydebutyraldehyde results in decreased expression of ITGB2 mRNA26079696
C584509C646 compoundC646 compound results in increased expression of ITGB2 mRNA26191083
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of ITGB2 promoter22457795
D000001CalcimycinCalcimycin results in increased expression of ITGB2 protein8094364
D000074262Canola OilCanola Oil metabolite results in decreased expression of ITGB2 mRNA27363782
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ITGB2 mRNA15056808|2733941
D002392CatechinCatechin inhibits the reaction [S100B protein results in increased expression of ITGB2 mRNA]17103373
C086276cerivastatincerivastatin inhibits the reaction [TNF results in increased expression of ITGB2]12615677
D002706ChlordanChlordan results in decreased expression of ITGB2 mRNA23153324
D002726Chlorogenic Acid"Chlorogenic Acid inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of ITGB2 protein]"21414398
D002726Chlorogenic AcidChlorogenic Acid results in decreased expression of ITGB2 protein21414398
D002793Cholic Acids[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of ITGB2 mRNA27344345
D002793Cholic Acids[Ethinyl Estradiol co-treated with Cholic Acids] affects the expression of ITGB2 mRNA27344345
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ITGB2 mRNA20938992
C018021cobaltous chloridecobaltous chloride results in increased expression of ITGB2 mRNA26314263
C060728cobalt oxidecobalt oxide analog results in increased expression of ITGB2 mRNA24821434
C083069crenatosidecrenatoside inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGB2 protein]16393473
C083069crenatosidecrenatoside inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGB2 protein]16393473
D003471CuprizoneCuprizone results in increased expression of ITGB2 mRNA27523638
C038459curdlancurdlan affects the expression of ITGB2 mRNA19904525
D016572CyclosporineCyclosporine results in decreased expression of ITGB2 mRNA25562108
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of ITGB2 mRNA23640034
C007262deoxynivalenoldeoxynivalenol results in increased expression of ITGB2 mRNA22968694
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ITGB2 mRNA28628672
D003976DiazinonDiazinon results in increased methylation of ITGB2 gene22964155
D002945CisplatinCisplatin results in decreased expression of ITGB2 mRNA22023808
D004008DiclofenacDiclofenac results in increased expression of ITGB2 mRNA26934552
C036042dicyclohexyl phthalatedicyclohexyl phthalate results in decreased expression of ITGB2 mRNA26924002
D004041Dietary FatsDietary Fats affects the expression of ITGB2 mRNA19680557
D004041Dietary FatsDietary Fats results in decreased expression of ITGB2 mRNA18042831
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of ITGB2 mRNA25380136
C024629dimethyl phthalatedimethyl phthalate results in decreased expression of ITGB2 mRNA26924002
D004121Dimethyl SulfoxideDimethyl Sulfoxide promotes the reaction [alitretinoin results in increased expression of ITGB2 protein]15964820
D004785Environmental PollutantsEnvironmental Pollutants results in increased expression of ITGB2 mRNA24534155
C007630estradiol 17 beta-cypionateestradiol 17 beta-cypionate results in increased expression of ITGB2 mRNA22497863
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with Cholic Acids] affects the expression of ITGB2 mRNA27344345
D005472FluorouracilFluorouracil results in decreased expression of ITGB215485462
D005485FlutamideFlutamide results in decreased expression of ITGB2 mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ITGB2 mRNA20938992
D005557FormaldehydeFormaldehyde results in decreased expression of ITGB2 mRNA23649840
C042932formylmethionyl-leucyl-phenylalanine methyl esterformylmethionyl-leucyl-phenylalanine methyl ester results in increased expression of ITGB2 protein9605577
C042932formylmethionyl-leucyl-phenylalanine methyl esterresveratrol analog inhibits the reaction [formylmethionyl-leucyl-phenylalanine methyl ester results in increased expression of ITGB2 protein]9605577
D009240N-Formylmethionine Leucyl-Phenylalanine"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGB2 protein]"16393473
D009240N-Formylmethionine Leucyl-Phenylalanineacteoside inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGB2 protein]16393473
D009240N-Formylmethionine Leucyl-Phenylalaninecrenatoside inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGB2 protein]16393473
D009240N-Formylmethionine Leucyl-PhenylalanineN-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGB2 protein10215738|1639347
D009240N-Formylmethionine Leucyl-Phenylalanineplaunotol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGB2 protein]10215738
D009240N-Formylmethionine Leucyl-PhenylalanineN-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGB2 protein21664406
C038958gadolinium chloridegadolinium chloride promotes the reaction [[ICAM1 protein binds to ICAM1 protein] which binds to ITGB2 protein]18317931
C038958gadolinium chlorideLovastatin inhibits the reaction [gadolinium chloride promotes the reaction [[ICAM1 protein binds to ICAM1 protein] which binds to ITGB2 protein]]18317931
D005839GentamicinsGentamicins results in increased expression of ITGB2 mRNA22061828
C112772ginsenoside M1ginsenoside M1 inhibits the reaction [TNF protein results in increased expression of [ITGAL protein binds to ITGB2 protein]]21875580
C442759ginsenoside Rb1ginsenoside Rb1 inhibits the reaction [Lipopolysaccharides results in increased expression of ITGB2 protein]17655881
C425564ginsenoside Rh1ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of [ITGAL protein binds to ITGB2 protein]]21875580
D006118GriseofulvinGriseofulvin affects the expression of ITGB2 mRNA12735108
D007975Leukotriene B4Leukotriene B4 results in increased expression of [ITGAM protein binds to ITGB2 protein]7473568
D007975Leukotriene B4LY 255283 analog inhibits the reaction [Leukotriene B4 results in increased expression of [ITGAM protein binds to ITGB2 protein]]7473568
D007975Leukotriene B4LY 255283 inhibits the reaction [Leukotriene B4 results in increased expression of [ITGAM protein binds to ITGB2 protein]]7473568
D007975Leukotriene B4LY 293111 inhibits the reaction [Leukotriene B4 results in increased expression of [ITGAM protein binds to ITGB2 protein]]7473568
D007975Leukotriene B4Leukotriene B4 results in increased expression of ITGB2 protein14716214
C031927hydroquinonehydroquinone results in decreased expression of ITGB2 mRNA19148301
C031927hydroquinonehydroquinone results in decreased expression of ITGB2 protein17464197
C031927hydroquinonehydroquinone results in increased expression of ITGB2 protein21664406
C492448ICG 001ICG 001 results in increased expression of ITGB2 mRNA26191083
C027185indirubinindirubin results in increased expression of ITGB2 protein16115123
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ITGB2 mRNA28628672
D007213IndomethacinIndomethacin results in increased expression of [ITGAM protein binds to ITGB2 protein]10761979
D007213IndomethacinITGB2 protein affects the susceptibility to Indomethacin10486359
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ITGB2 mRNA25613284
D007501IronIron deficiency results in increased expression of ITGB2 mRNA20368581
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ITGB2 mRNA28628672
D007529IsoflavonesIsoflavones affects the expression of ITGB2 mRNA16365062
D015570JosamycinJosamycin results in decreased expression of ITGB2 protein8096833
D015570JosamycinRibomunyl inhibits the reaction [Josamycin results in decreased expression of ITGB2 protein]8096833
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ITGB2 mRNA23086925
C410337K 7174K 7174 results in decreased expression of ITGB2 mRNA24086573
D008012LidocaineLidocaine inhibits the reaction [TNF protein results in increased expression of [ITGAM protein binds to ITGB2 protein]]9336308
C433788lipopolysaccharide, E. coli O26-B6"Chlorogenic Acid inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of ITGB2 protein]"21414398
C433788lipopolysaccharide, E. coli O26-B6"lipopolysaccharide, E. coli O26-B6 results in increased expression of ITGB2 protein"21414398
D008070LipopolysaccharidesITGB2 protein affects the reaction [Lipopolysaccharides results in increased expression of TNF protein]12538815
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of ITGB2 mRNA10975854|2733941
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of ITGB2 mRNA25613284
D008070Lipopolysaccharidesginsenoside Rb1 inhibits the reaction [Lipopolysaccharides results in increased expression of ITGB2 protein]17655881
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of ITGB2 protein17655881
D008070Lipopolysaccharidesnotoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of ITGB2 protein]17655881
D008148LovastatinLovastatin inhibits the reaction [gadolinium chloride promotes the reaction [[ICAM1 protein binds to ICAM1 protein] which binds to ITGB2 protein]]18317931
C063823LY 255283LY 255283 analog inhibits the reaction [Leukotriene B4 results in increased expression of [ITGAM protein binds to ITGB2 protein]]7473568
C063823LY 255283LY 255283 inhibits the reaction [Leukotriene B4 results in increased expression of [ITGAM protein binds to ITGB2 protein]]7473568
C094099LY 293111LY 293111 inhibits the reaction [Leukotriene B4 results in increased expression of [ITGAM protein binds to ITGB2 protein]]7473568
D015636Magnesium ChlorideMagnesium Chloride promotes the reaction [[ICAM1 protein binds to ICAM1 protein] which binds to ITGB2 protein]18317931
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ITGB2 mRNA20938992
D008727MethotrexateMethotrexate results in increased expression of ITGB2 mRNA21678067
C030957methylmercury IImethylmercury II results in increased expression of ITGB2 mRNA26314263
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of ITGB2 mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of ITGB2 mRNA23649840
C517284monomethyl phthalatemonomethyl phthalate results in decreased expression of ITGB2 mRNA26924002
D009151Mustard GasMustard Gas results in increased expression of ITGB2 mRNA18955075
D009151Mustard GasMustard Gas results in increased expression of ITGB2 mRNA18988085
D009183MycotoxinsMycotoxins results in increased expression of ITGB2 mRNA19818335
C104820N-(3-(aminomethyl)benzyl)acetamidineN-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [ITGB2 protein results in increased activity of RAP1A protein]16963453
C104820N-(3-(aminomethyl)benzyl)acetamidineN-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [ITGB2 protein results in increased activity of RAP2A protein]16963453
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of ITGB2 mRNA"23845593
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of ITGB2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ITGB2 mRNA"25554681
D0150581-Naphthylisothiocyanate[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of ITGB2 mRNA27344345
D0150581-NaphthylisothiocyanateITGB2 protein results in increased susceptibility to 1-Naphthylisothiocyanate16614373|2107079
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of ITGB2 mRNA25380136
C490266neoechinulin Aneoechinulin A results in increased expression of ITGB2 mRNA19818335
D009532NickelNickel results in increased expression of ITGB2 mRNA25583101
D009569Nitric OxideNitric Oxide promotes the reaction [ITGB2 protein results in increased activity of RAP1A protein]16963453
D009569Nitric OxideNitric Oxide promotes the reaction [ITGB2 protein results in increased activity of RAP2A protein]16963453
D009569Nitric OxideCSF2 protein promotes the reaction [ITGB2 protein results in increased abundance of Nitric Oxide]8600936
D009569Nitric Oxide[CSF2 protein results in increased expression of ITGB2 protein] which results in increased abundance of Nitric Oxide8600936
D009569Nitric OxideITGB2 protein results in increased abundance of Nitric Oxide8600936
D009569Nitric Oxide[ITGB2 protein results in increased susceptibility to Ozone] which results in increased abundance of Nitric Oxide8600936
D009569Nitric OxideOzone promotes the reaction [[CSF2 protein results in increased expression of ITGB2 protein] which results in increased abundance of Nitric Oxide]8600936
C072936notoginsenoside R1notoginsenoside R1 results in decreased expression of ITGB2 protein18176958
C072936notoginsenoside R1notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of ITGB2 protein]17655881
C025589ochratoxin Aochratoxin A metabolite results in increased expression of ITGB2 mRNA26314263
C025589ochratoxin Aochratoxin A results in increased expression of ITGB2 mRNA26314263
D010098OxycodoneOxycodone results in decreased expression of ITGB2 mRNA23439660
D010126OzoneITGB2 protein results in increased susceptibility to Ozone8600936
D010126Ozone[ITGB2 protein results in increased susceptibility to Ozone] which results in increased abundance of Nitric Oxide8600936
D010126OzoneOzone promotes the reaction [[CSF2 protein results in increased expression of ITGB2 protein] which results in increased abundance of Nitric Oxide]8600936
D000073878Palm OilPalm Oil results in decreased expression of ITGB2 mRNA18042831
C046012pentanalpentanal results in decreased expression of ITGB2 mRNA26079696
D010431PentoxifyllinePentoxifylline affects the expression of ITGB21976392
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ITGB2 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of ITGB2 mRNA17426115
C047686plaunotolplaunotol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGB2 protein]10215738
D011341ProbucolProbucol promotes the reaction [APOE gene mutant form results in increased expression of ITGB2 mRNA]19394937
D011374Progesterone[Progesterone co-treated with Estradiol] results in increased expression of ITGB2 mRNA20226447
D011374ProgesteroneProgesterone results in increased expression of ITGB2 mRNA21540246
D011374ProgesteroneProgesterone affects the expression of ITGB2 mRNA17251523
C513428pyrachlostrobinpyrachlostrobin results in increased expression of ITGB2 mRNA27029645
D011794QuercetinQuercetin inhibits the reaction [S100B protein results in increased expression of ITGB2 mRNA]17103373
C059514resveratrolresveratrol analog inhibits the reaction [formylmethionyl-leucyl-phenylalanine methyl ester results in increased expression of ITGB2 protein]9605577
C059514resveratrolresveratrol results in increased expression of ITGB2 mRNA25888808
C059514resveratrol[resveratrol co-treated with Streptozocin] results in increased expression of ITGB2 mRNA25905778
D015474IsotretinoinIsotretinoin results in increased expression of ITGB2 mRNA20436886
C034206RibomunylRibomunyl inhibits the reaction [Josamycin results in decreased expression of ITGB2 protein]8096833
C034206RibomunylRibomunyl results in increased expression of ITGB2 protein8096833
C037663ropivacaineropivacaine inhibits the reaction [TNF protein results in increased expression of [ITGAM protein binds to ITGB2 protein]]9336308
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of ITGB2 mRNA25895662
D019821SimvastatinSimvastatin binds to [ITGAL protein binds to ITGB2 protein]15041742
D019821SimvastatinSimvastatin inhibits the reaction [TNF results in increased expression of ITGB2]12615677
D019821SimvastatinSimvastatin results in decreased expression of ITGB2 mRNA12615677
D019821SimvastatinSimvastatin results in decreased expression of [ITGAM protein binds to ITGB2 protein]21330348
C017947sodium arsenitesodium arsenite results in decreased expression of ITGB2 mRNA14691202
D012999SomanSoman results in increased expression of ITGB2 mRNA19281266
D019311StaurosporineStaurosporine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGB2 protein]16393473
D013311StreptozocinKLK1 protein inhibits the reaction [Streptozocin results in increased expression of ITGB2 protein]16129698
D013311Streptozocin[resveratrol co-treated with Streptozocin] results in increased expression of ITGB2 mRNA25905778
D013311StreptozocinStreptozocin results in increased expression of ITGB2 protein16129698
C416927SU 6656SU 6656 inhibits the reaction [ITGB2 protein results in increased activity of RAP1A protein]16963453
D012460SulfasalazineSulfasalazine inhibits the reaction [TNF protein results in increased expression of ITGB2 protein]8094364
C016766sulforafansulforafan results in increased expression of ITGB2 mRNA26833863
C013698tallowtallow affects the expression of ITGB2 mRNA19680557
C061133tamibaroteneCSF3 protein inhibits the reaction [tamibarotene results in decreased expression of ITGB2 mRNA]27737899
C061133tamibarotenetamibarotene inhibits the reaction [CSF3 protein results in increased expression of ITGB2 mRNA]27737899
C061133tamibarotenetamibarotene results in decreased expression of ITGB2 mRNA27737899
C061133tamibarotenetamibarotene results in increased expression of ITGB2 mRNA15498508
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ITGB2 mRNA16962184
D013755Tetradecanoylphorbol Acetateacteoside inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGB2 protein]16393473
D013755Tetradecanoylphorbol Acetatecrenatoside inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGB2 protein]16393473
D013755Tetradecanoylphorbol AcetateStaurosporine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGB2 protein]16393473
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of ITGB2 protein16393473
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ITGB2 mRNA25613284
D013806TheophyllineTheophylline results in increased expression of ITGB2 mRNA16083514
C402696TMC 120ATMC 120A results in increased expression of ITGB2 mRNA19818335
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of ITGB2 mRNA22363418|2806579
C024746tobacco tartobacco tar results in decreased expression of ITGB2 mRNA19559774
D014212TretinoinCSF3 protein promotes the reaction [Tretinoin results in increased expression of ITGB2 protein]18055984
D014212TretinoinEP300 protein promotes the reaction [Tretinoin results in increased expression of ITGB2 mRNA]16581781
D014212Tretinoin[GABPA protein binds to EP300 protein] promotes the reaction [Tretinoin results in increased expression of ITGB2 mRNA]16581781
D014212TretinoinTretinoin results in increased expression of ITGB2 mRNA15498508|1632206
D014212TretinoinTretinoin results in increased expression of ITGB2 protein18055984
C011559tributyltintributyltin results in increased expression of ITGB2 mRNA26314263
D014241TrichloroethyleneTrichloroethylene results in increased methylation of ITGB2 gene27618143
C030665triphenyltintriphenyltin results in increased expression of ITGB2 mRNA12788061
C030665triphenyltintriphenyltin results in increased expression of ITGB2 protein12788061
D014635Valproic AcidValproic Acid results in increased expression of ITGB2 mRNA23527032
D014635Valproic AcidValproic Acid results in increased methylation of ITGB2 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of ITGB2 gene25560391
C025643vinclozolinvinclozolin affects the expression of ITGB2 mRNA19015723
C029297vinylidene chloridevinylidene chloride results in increased expression of ITGB2 mRNA26682919
D014807Vitamin DVitamin D results in increased expression of ITGB2 mRNA20368581
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in increased expression of ITGB2 mRNA"23246600
C009687wortmanninwortmannin inhibits the reaction [ITGB2 protein results in increased activity of RAP1A protein]16963453
C063449zileutonzileuton results in decreased expression of ITGB2 protein9738763
D015032ZincZinc results in decreased expression of ITGB2 mRNA19071009
C088658zoledronic acidzoledronic acid results in increased expression of ITGB2 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001540amyloid-beta binding-IBA21873635  
GO:0001540amyloid-beta binding-ISS-  
GO:0001851complement component C3b binding-ISS-  
GO:0005178integrin binding-IBA21873635  
GO:0005515protein binding-IPI10766246  14722085  16831868  17321526  19234221  19828450  
20033057  20183869  20679211  21193407  25416956  25910212  
28807980  
GO:0019901protein kinase binding-IPI12885943  
GO:0030369ICAM-3 receptor activity-IMP19029120  
GO:0031072heat shock protein binding-IPI12496435  
GO:0044877protein-containing complex binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO:0046982protein heterodimerization activity-NAS20199584  
GO:0050839cell adhesion molecule binding-IMP19029120  
GO ID GO Term Qualifier Evidence PubMed
GO:0001774microglial cell activation-NAS18981141  
GO:0002523leukocyte migration involved in inflammatory response-IEA-  
GO:0006911phagocytosis, engulfment-ISS-  
GO:0006915apoptotic process-NAS12885943  
GO:0006954inflammatory response-NAS12885943  
GO:0007155cell adhesion-TAS1694220  
GO:0007159leukocyte cell-cell adhesion-IDA12885943  
GO:0007160cell-matrix adhesion-IBA21873635  
GO:0007160cell-matrix adhesion-IMP19029120  
GO:0007229integrin-mediated signaling pathway-IBA21873635  
GO:0007229integrin-mediated signaling pathway-IMP28807980  
GO:0007229integrin-mediated signaling pathway-NAS12885943  
GO:0007267cell-cell signaling-NAS12885943  
GO:0007568aging-IEA-  
GO:0008360regulation of cell shape-NAS12885943  
GO:0016477cell migration-IBA21873635  
GO:0019221cytokine-mediated signaling pathway-TAS-  
GO:0030101natural killer cell activation-IEA-  
GO:0030198extracellular matrix organization-TAS-  
GO:0030593neutrophil chemotaxis-IDA12885943  
GO:0031623receptor internalization-ISS-  
GO:0032930positive regulation of superoxide anion generation-IGI21193407  
GO:0032930positive regulation of superoxide anion generation-NAS18981141  
GO:0033627cell adhesion mediated by integrin-IBA21873635  
GO:0034113heterotypic cell-cell adhesion-IMP20563599  
GO:0034142toll-like receptor 4 signaling pathway-TAS-  
GO:0035987endodermal cell differentiation-IEP23154389  
GO:0043113receptor clustering-IMP19029120  
GO:0043312neutrophil degranulation-TAS-  
GO:0043315positive regulation of neutrophil degranulation-IGI21193407  
GO:0043542endothelial cell migration-IEA-  
GO:0045123cellular extravasation-IEA-  
GO:0045429positive regulation of nitric oxide biosynthetic process-IEA-  
GO:0045766positive regulation of angiogenesis-IEA-  
GO:0045963negative regulation of dopamine metabolic process-NAS18981141  
GO:0050730regulation of peptidyl-tyrosine phosphorylation-IDA12885943  
GO:0050776regulation of immune response-TAS-  
GO:0050900leukocyte migration-TAS-  
GO:0051092positive regulation of NF-kappaB transcription factor activity-IEA-  
GO:0071404cellular response to low-density lipoprotein particle stimulus-ISS-  
GO:0090314positive regulation of protein targeting to membrane-NAS18981141  
GO:0097242amyloid-beta clearance-ISS-  
GO:0098742cell-cell adhesion via plasma-membrane adhesion molecules-NAS20199584  
GO:1901216positive regulation of neuron death-NAS18981141  
GO:1903980positive regulation of microglial cell activation-NAS18981141  
GO:1990266neutrophil migration-IMP28807980  
GO:2000363positive regulation of prostaglandin-E synthase activity-NAS18981141  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005925focal adhesion-IBA21873635  
GO:0008305integrin complex-IBA21873635  
GO:0008305integrin complex-NAS12885943  
GO:0009897external side of plasma membrane-NAS20199584  
GO:0009986cell surface-HDA23981064  
GO:0009986cell surface-IBA21873635  
GO:0009986cell surface-IDA19029120  19234460  20563599  23620790  
GO:0016020membrane-HDA19946888  
GO:0034687integrin alphaL-beta2 complex-IDA19029120  
GO:0034688integrin alphaM-beta2 complex-NAS20199584  
GO:0035579specific granule membrane-TAS-  
GO:0043235receptor complex-IDA23382219  
GO:0044853plasma membrane raft-IDA21193407  
GO:0070062extracellular exosome-HDA20458337  
GO:0070821tertiary granule membrane-TAS-  
GO:0099568cytoplasmic regioncolocalizes_withIPI20183869  
GO:0101003ficolin-1-rich granule membrane-TAS-  
GO:1903561extracellular vesicle-HDA24769233  
KEGG ID KEGG Term
hsa04145Phagosome
hsa04514Cell adhesion molecules (CAMs)
hsa04650Natural killer cell mediated cytotoxicity
hsa04670Leukocyte transendothelial migration
hsa04810Regulation of actin cytoskeleton
hsa05140Leishmaniasis
hsa05144Malaria
hsa05146Amoebiasis
hsa05150Staphylococcus aureus infection
hsa05323Rheumatoid arthritis
hsa05416Viral myocarditis
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-166016Toll Like Receptor 4 (TLR4) CascadeTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-168898Toll-Like Receptors CascadesTAS
R-HSA-198933Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellTAS
R-HSA-202733Cell surface interactions at the vascular wallTAS
R-HSA-216083Integrin cell surface interactionsTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-6785807Interleukin-4 and 13 signalingTAS
R-HSA-6798695Neutrophil degranulationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21605946Development of a multicomponent prediction model for acute esophagitis in lung cancer patients receiving chemoradiotherapy. (2011 Oct 1)De Ruyck KInt J Radiat Oncol Biol Phys
23803696Innate immunity gene polymorphisms and the risk of colorectal neoplasia. (2013 Nov)Chang CMCarcinogenesis