Gene: ARAF

369
A-RAF|ARAF1|PKS2|RAFA1
A-Raf proto-oncogene, serine/threonine kinase
protein-coding
Xp11.3
Ensembl:ENSG00000078061 MIM:311010 Vega:OTTHUMG00000021446 UniprotKB:P10398
NG_016339.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PTTG1IP0.891
KHNYN0.887
ASCC20.885
HDAC10.884
SORBS30.881
TMEM179B0.88
WASF20.879
SCAMP20.878
CAPN20.877
ECE10.876

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.607
OR4F29-0.593
ABCC12-0.333
ADRA1D-0.328
PPEF1-0.323
FBLN7-0.319
CALHM1-0.308
FREM3-0.306
CRH-0.302
NMU-0.302

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00171ATPSmall Molecule56-65-5Investigational|NutraceuticalTarget
ID Drug Name Action PubMed
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in increased expression of ARAF mRNA"20453058
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of ARAF mRNA"19114083
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran affects the expression of ARAF mRNA"20702594
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of ARAF mRNA"18648102
C0126064-vinyl-1-cyclohexene dioxide4-vinyl-1-cyclohexene dioxide affects the expression of ARAF mRNA20829426
D000082AcetaminophenAcetaminophen results in increased expression of ARAF mRNA25704631
D000082AcetaminophenAcetaminophen affects the expression of ARAF mRNA17562736
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ARAF mRNA16483693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ARAF mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ARAF mRNA23735875
D004958EstradiolEstradiol results in increased activity of ARAF protein12432273
D004958EstradiolEstradiol results in increased expression of ARAF mRNA23094148
D004958EstradiolIGF1R mutant form inhibits the reaction [Estradiol results in increased expression of ARAF mRNA]23094148
C006780bisphenol Abisphenol A affects the expression of ARAF mRNA21786754
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ARAF mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of ARAF mRNA25181051
C584509C646 compoundC646 compound results in increased expression of ARAF mRNA26191083
D002220CarbamazepineCarbamazepine affects the expression of ARAF mRNA24752500
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of ARAF mRNA17805973
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ARAF mRNA17805973
D003471CuprizoneCuprizone results in increased expression of ARAF mRNA26577399
D016572CyclosporineCyclosporine results in increased expression of ARAF mRNA25562108
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of ARAF mRNA24317228
D013759DronabinolDronabinol results in decreased expression of ARAF mRNA12237329
D003907DexamethasoneDexamethasone inhibits the reaction [EGF protein promotes the reaction [EGFR protein binds to ARAF protein]]10807665
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ARAF mRNA28628672
D003907DexamethasoneMifepristone inhibits the reaction [Dexamethasone inhibits the reaction [EGF protein promotes the reaction [EGFR protein binds to ARAF protein]]]10807665
D003976DiazinonDiazinon results in increased methylation of ARAF gene22964155
D003976DiazinonDiazinon affects the expression of ARAF mRNA22546817
D004008DiclofenacDiclofenac affects the expression of ARAF mRNA24752500
C000944dicrotophosdicrotophos results in increased expression of ARAF mRNA28302478
D004026DieldrinDieldrin results in increased expression of ARAF mRNA23041725
D004026DieldrinDieldrin affects the expression of ARAF mRNA22546817
D004785Environmental PollutantsEnvironmental Pollutants affects the expression of ARAF mRNA19118595
D004785Environmental PollutantsEnvironmental Pollutants results in decreased expression of ARAF mRNA12655031
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ARAF mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ARAF mRNA17942748
D005485FlutamideFlutamide results in decreased expression of ARAF mRNA24136188
C039281furanfuran results in increased methylation of ARAF gene22079235
D006843Hydrocarbons, Chlorinated"Hydrocarbons, Chlorinated results in decreased expression of ARAF mRNA"18077114
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ARAF mRNA28628672
C051890irinotecanirinotecan metabolite results in increased expression of ARAF mRNA15956246
C051890irinotecanirinotecan results in increased expression of ARAF mRNA15956246
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ARAF mRNA28628672
C098607JP8 aviation fuelJP8 aviation fuel results in decreased expression of ARAF protein17337753
D007657Ketone BodiesKetone Bodies results in decreased expression of ARAF mRNA16807920
D007854LeadLead results in decreased expression of ARAF mRNA19921347
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of ARAF mRNA18077114
D008769MethylnitronitrosoguanidineMethylnitronitrosoguanidine results in increased expression of ARAF mRNA12634122
D015735MifepristoneMifepristone inhibits the reaction [Dexamethasone inhibits the reaction [EGF protein promotes the reaction [EGFR protein binds to ARAF protein]]]10807665
C517284monomethyl phthalatemonomethyl phthalate affects the expression of ARAF mRNA26924002
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ARAF mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ARAF mRNA"25554681
C022838nickel chloridenickel chloride affects the expression of ARAF mRNA22546817
D052638Particulate MatterParticulate Matter results in increased expression of ARAF mRNA10850371
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls results in decreased expression of ARAF mRNA18077114
D011374ProgesteroneProgesterone results in decreased expression of ARAF mRNA23018184
D011374ProgesteroneProgesterone affects the expression of ARAF mRNA17251523
D011441PropylthiouracilPropylthiouracil results in decreased expression of ARAF mRNA18077114
D011794QuercetinQuercetin results in increased expression of ARAF mRNA27514524
C059514resveratrolARAF protein affects the reaction [resveratrol results in increased expression of and results in increased activity of EGR1 protein]25645941
C059514resveratrolresveratrol results in increased expression of ARAF protein18089832
D012643Selenium[Selenium co-treated with Vitamin E] results in increased expression of ARAF mRNA19244175
D012643SeleniumSelenium results in increased expression of ARAF mRNA19244175
C017947sodium arsenitesodium arsenite affects the expression of ARAF protein17384772
D012999SomanSoman results in increased expression of ARAF mRNA19281266
D010042OuabainOuabain results in decreased expression of ARAF mRNA16412265
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ARAF mRNA20702594|2157046
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ARAF mRNA17942748
C057693troglitazone[troglitazone co-treated with TNF protein] results in decreased expression of ARAF mRNA12732648
D014635Valproic AcidValproic Acid results in increased expression of ARAF mRNA23179753
D014635Valproic AcidValproic Acid results in increased methylation of ARAF gene29154799
D001335Vehicle EmissionsVehicle Emissions results in increased expression of ARAF mRNA10850371
D014810Vitamin E[Selenium co-treated with Vitamin E] results in increased expression of ARAF mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004672protein kinase activity-TAS3029685  
GO:0004674protein serine/threonine kinase activity-IBA21873635  
GO:0004674protein serine/threonine kinase activity-IDA19667065  
GO:0005515protein binding-IPI10967104  11909642  12620389  15324660  15778465  17353931  
17979178  19933840  20052757  20130576  20936779  21903422  
21988832  22939624  24441586  24746704  25036637  25241761  
25852190  
GO:0005524ATP binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000165MAPK cascade-IBA21873635  
GO:0000165MAPK cascade-TAS-  
GO:0000186activation of MAPKK activity-IEA-  
GO:0006464cellular protein modification process-TAS3029685  
GO:0032006regulation of TOR signaling-IMP22609986  
GO:0032434regulation of proteasomal ubiquitin-dependent protein catabolic process-IMP22609986  
GO:0033138positive regulation of peptidyl-serine phosphorylation-IDA19667065  
GO:0043066negative regulation of apoptotic process-IDA19667065  
GO ID GO Term Qualifier Evidence PubMed
GO:0005575cellular_component-ND-  
GO:0005739mitochondrion-IBA21873635  
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa04012ErbB signaling pathway
hsa04270Vascular smooth muscle contraction
hsa04650Natural killer cell mediated cytotoxicity
hsa04720Long-term potentiation
hsa04730Long-term depression
hsa04810Regulation of actin cytoskeleton
hsa04910Insulin signaling pathway
hsa04914Progesterone-mediated oocyte maturation
hsa05160Hepatitis C
hsa05200Pathways in cancer
hsa05210Colorectal cancer
hsa05211Renal cell carcinoma
hsa05212Pancreatic cancer
hsa05213Endometrial cancer
hsa05214Glioma
hsa05215Prostate cancer
hsa05218Melanoma
hsa05219Bladder cancer
hsa05220Chronic myeloid leukemia
hsa05221Acute myeloid leukemia
hsa05223Non-small cell lung cancer
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-1643685DiseaseTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-5673000RAF activationTAS
R-HSA-5673001RAF/MAP kinase cascadeTAS
R-HSA-5674135MAP2K and MAPK activationTAS
R-HSA-5675221Negative regulation of MAPK pathwayTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5684996MAPK1/MAPK3 signalingTAS
R-HSA-6802946Signaling by moderate kinase activity BRAF mutantsTAS
R-HSA-6802948Signaling by high-kinase activity BRAF mutantsTAS
R-HSA-6802949Signaling by RAS mutantsTAS
R-HSA-6802952Signaling by BRAF and RAF fusionsTAS
R-HSA-6802955Paradoxical activation of RAF signaling by kinase inactive BRAFTAS
R-HSA-6802957Oncogenic MAPK signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24204162Epigenomic analysis of lung adenocarcinoma reveals novel DNA methylation patterns associated with smoking. (2013)Tan QOnco Targets Ther