Gene info: ID 3690

Gene: ITGB3

GENE ID: 3690

Synonyms: BDPLT16|BDPLT2|CD61|GP3A|GPIIIa|GT

Description: integrin subunit beta 3

Gene type: protein-coding

Location: 17q21.32

dbXrefs: Ensembl:ENSG00000259207 MIM:173470 Vega:OTTHUMG00000171956 UniprotKB:P05106

RefSeq: NG_008332.2

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 6

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 9.369e-1 (AD) 9.993e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg10753610	chr17:45335202	ITGB3	Gene body	1.429e-4	Alcohol use disorders	26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
COL4A1	0.908
CD93	0.88
COL4A2	0.865
CASP4	0.858
ADAMTS9	0.849
PPP1R3B	0.84
ITGA5	0.835
IL1R1	0.831
ANXA2	0.826
SLC1A5	0.825

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
TMEM179	-0.504
KCNIP3	-0.496
BCL11A	-0.468
KCNK4	-0.463
FBLL1	-0.454
MYADML2	-0.449
DLK2	-0.446
NEUROD6	-0.445
CHRM1	-0.443
EXTL1	-0.44

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00054	Abciximab	BiotechDrug	143653-53-6	Approved	Target
DB00063	Eptifibatide	BiotechDrug	188627-80-7	Approved\|Investigational	Target
DB00098	Antithymocyte immunoglobulin (rabbit)	BiotechDrug		Approved	Target
DB00775	Tirofiban	Small Molecule	144494-65-5	Approved	Target
DB02709	Resveratrol	Small Molecule	501-36-0	Approved\|Experimental\|Investigational	Target
DB04863	Lefradafiban	Small Molecule	149503-79-7	Investigational	Target
DB05787	LM-609	BiotechDrug	-	Investigational	Target
DB06472	Fradafiban	Small Molecule	148396-36-5	Investigational	Target

ID	Drug Name	Action	PubMed
C553100	10-(4'-(N-diethylamino)butyl)-2-chlorophenoxazine	10-(4'-(N-diethylamino)butyl)-2-chlorophenoxazine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGB3 protein]	20523355
C553100	10-(4'-(N-diethylamino)butyl)-2-chlorophenoxazine	10-(4'-(N-diethylamino)butyl)-2-chlorophenoxazine inhibits the reaction [THPO protein results in increased expression of ITGB3 protein]	20523355
C552530	1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane	"1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in decreased expression of ITGB3 mRNA"	26929200
C001079	2-(2,6-dioxopiperidin-3-yl)phthalimidine	"2-(2,6-dioxopiperidin-3-yl)phthalimidine results in decreased expression of ITGB3 protein"	8538367
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ITGB3 protein results in increased susceptibility to Carmustine]	21332719
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Thyroxine promotes the reaction [SRC protein binds to ITGB3 protein]]	22227104
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Triiodothyronine promotes the reaction [SRC protein binds to ITGB3 protein]]	22227104
C013186	2,3-pentanedione	"2,3-pentanedione results in increased expression of ITGB3 mRNA"	25710175
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased expression of and affects the localization of [ITGA5 protein binds to ITGB3 protein]]	16465378
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [manganese chloride affects the localization of and affects the activity of [ITGB3 protein binds to ITGAV protein]]	15213856
C457499	2-chloro-5-nitrobenzanilide	2-chloro-5-nitrobenzanilide promotes the reaction [Particulate Matter results in increased expression of ITGB3 protein]	24192212
C457499	2-chloro-5-nitrobenzanilide	2-chloro-5-nitrobenzanilide promotes the reaction [Vehicle Emissions results in increased expression of ITGB3 protein]	24192212
C457499	2-chloro-5-nitrobenzanilide	hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Particulate Matter results in increased expression of ITGB3 protein]]	24192212
C457499	2-chloro-5-nitrobenzanilide	hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Vehicle Emissions results in increased expression of ITGB3 protein]]	24192212
C426703	3-(3-(3-(4,5-dihydroimidazol-2-ylamino)propyloxylisoxazol-5-yl)carbonylamino)-2-(phenylsulfonylamino)propionic acid	"3-(3-(3-(4,5-dihydroimidazol-2-ylamino)propyloxylisoxazol-5-yl)carbonylamino)-2-(phenylsulfonylamino)propionic acid binds to and results in decreased activity of [ITGA5 protein binds to ITGB3 protein]"	16384862
C478626	3-(6-methoxypyridin-3-yl)-3-(2-oxo-3-(3-(5,6,7,8-tetrahydro(1,8)naphthyridin-2-yl)propyl)imidazolidin-1-yl)propionic acid	"3-(6-methoxypyridin-3-yl)-3-(2-oxo-3-(3-(5,6,7,8-tetrahydro(1,8)naphthyridin-2-yl)propyl)imidazolidin-1-yl)propionic acid binds to [ITGA5 protein binds to ITGB3 protein]"	14561098
C478626	3-(6-methoxypyridin-3-yl)-3-(2-oxo-3-(3-(5,6,7,8-tetrahydro(1,8)naphthyridin-2-yl)propyl)imidazolidin-1-yl)propionic acid	"3-(6-methoxypyridin-3-yl)-3-(2-oxo-3-(3-(5,6,7,8-tetrahydro(1,8)naphthyridin-2-yl)propyl)imidazolidin-1-yl)propionic acid results in decreased activity of [ITGA5 protein binds to ITGB3 protein]"	14561098
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of ITGB3 mRNA"	25380136
C010643	6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid	"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGB3 protein]"	20523355
C010643	6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid	"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [THPO protein results in increased expression of ITGB3 protein]"	20523355
D000082	Acetaminophen	Acetaminophen results in increased expression of ITGB3 mRNA	29067470
D000082	Acetaminophen	Acetaminophen affects the expression of ITGB3 mRNA	17562736
C056165	acetovanillone	acetovanillone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGB3 protein]	20523355
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGB3 protein]	20523355
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [THPO protein results in increased expression of ITGB3 protein]	20523355
D000171	Acrolein	Acrolein results in decreased expression of ITGB3 protein	24812010
D000171	Acrolein	Acrolein results in increased expression of ITGB3 mRNA	18515264
D000244	Adenosine Diphosphate	cangrelor inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]]	18404433
D000244	Adenosine Diphosphate	"N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]]"	18404433
D000244	Adenosine Diphosphate	"N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate promotes the reaction [cangrelor inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]]]"	18404433
C412373	AG 1879	[AG 1879 results in decreased activity of SRC protein] promotes the reaction [manganese chloride affects the localization of and affects the activity of [ITGB3 protein binds to ITGAV protein]]	15213856
C412373	AG 1879	AG 1879 inhibits the reaction [Thyroxine promotes the reaction [SRC protein binds to ITGB3 protein]]	22227104
C412373	AG 1879	AG 1879 inhibits the reaction [Triiodothyronine promotes the reaction [SRC protein binds to ITGB3 protein]]	22227104
C095512	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGB3 protein]"	20523355
C095512	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [THPO protein results in increased expression of ITGB3 protein]"	20523355
D016718	Arachidonic Acid	Arachidonic Acid results in increased expression of ITGB3 protein	18413191\|2324918
D016718	Arachidonic Acid	Aspirin inhibits the reaction [Arachidonic Acid results in increased expression of ITGB3 protein]	18413191
D016718	Arachidonic Acid	Glucose inhibits the reaction [Aspirin inhibits the reaction [Arachidonic Acid results in increased expression of ITGB3 protein]]	18413191
D016718	Arachidonic Acid	Quercetin inhibits the reaction [Arachidonic Acid results in increased expression of ITGB3 protein]	23249183
C047981	arginyl-glycyl-aspartic acid	arginyl-glycyl-aspartic acid inhibits the reaction [manganese chloride affects the localization of and affects the activity of [ITGB3 protein binds to ITGAV protein]]	15213856
C047981	arginyl-glycyl-aspartic acid	arginyl-glycyl-aspartic acid inhibits the reaction [resveratrol binds to [ITGA5 protein binds to ITGB3 protein]]	16790523
C006632	arsenic trioxide	arsenic trioxide results in increased expression of ITGB3 protein	16360329
D001241	Aspirin	Aspirin inhibits the reaction [Arachidonic Acid results in increased expression of ITGB3 protein]	18413191
D001241	Aspirin	Aspirin results in decreased expression of [ITGA2B protein binds to ITGB3 protein]	15381054
D001241	Aspirin	Glucose inhibits the reaction [Aspirin inhibits the reaction [Arachidonic Acid results in increased expression of ITGB3 protein]]	18413191
D001241	Aspirin	ITGB3 gene polymorphism affects the susceptibility to Aspirin	17184645
D001241	Aspirin	ITGB3 gene polymorphism results in decreased susceptibility to Aspirin	13678940
D001241	Aspirin	ITGB3 polymorphism affects the reaction [Aspirin affects the cleavage of F2 protein]	16675000
D001241	Aspirin	ITGB3 polymorphism results in decreased susceptibility to Aspirin	16153930
D001241	Aspirin	ITGB3 results in decreased susceptibility to Aspirin	15840736
D001241	Aspirin	Aspirin results in increased expression of ITGB3 mRNA	21035850
D001241	Aspirin	Aspirin results in increased expression of ITGB3 protein	21035850
D000068342	Aspirin, Dipyridamole Drug Combination	"Aspirin, Dipyridamole Drug Combination results in decreased expression of [ITGA2B protein binds to ITGB3 protein]"	15381054
D001280	Atrazine	Atrazine results in increased expression of ITGB3 mRNA	22378314
D001564	Benzo(a)pyrene	Benzo(a)pyrene inhibits the reaction [FGF2 protein results in increased expression of [ITGAV protein binds to ITGB3 protein]]	20876236
D001564	Benzo(a)pyrene	Benzo(a)pyrene inhibits the reaction [FGF2 protein results in increased expression of ITGB3 protein]	20876236
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of ITGB3 mRNA	22300585
C020711	beryllium sulfate	beryllium sulfate results in increased expression of ITGB3 mRNA	16314022
D004958	Estradiol	[Estradiol co-treated with Progesterone] results in decreased expression of ITGB3 mRNA	20660070
D004958	Estradiol	[Progesterone co-treated with Estradiol] results in decreased expression of ITGB3 mRNA	17404688
D004958	Estradiol	[Progesterone co-treated with Estradiol] results in increased expression of ITGB3 mRNA	20226447
C006780	bisphenol A	bisphenol A results in decreased expression of ITGB3 mRNA	29275510
C006780	bisphenol A	bisphenol A results in increased expression of ITGB3 mRNA	27685785
C006780	bisphenol A	ITGB3 inhibits the reaction [bisphenol A inhibits the reaction [Thyroxine inhibits the reaction [NCOR1 protein binds to and results in decreased activity of THRB protein]]]	22227104
C006780	bisphenol A	ITGB3 inhibits the reaction [bisphenol A inhibits the reaction [Thyroxine inhibits the reaction [NCOR2 protein binds to and results in decreased activity of THRB protein]]]	22227104
C006780	bisphenol A	ITGB3 inhibits the reaction [bisphenol A inhibits the reaction [Triiodothyronine inhibits the reaction [NCOR1 protein binds to and results in decreased activity of THRB protein]]]	22227104
C006780	bisphenol A	ITGB3 inhibits the reaction [bisphenol A inhibits the reaction [Triiodothyronine inhibits the reaction [NCOR2 protein binds to and results in decreased activity of THRB protein]]]	22227104
C006780	bisphenol A	bisphenol A results in decreased expression of ITGB3 protein	26884915
C006780	bisphenol A	[bisphenol A co-treated with Genistein] results in increased methylation of ITGB3 gene	28505145
C006780	bisphenol A	bisphenol A results in decreased expression of ITGB3 mRNA	21285323\|2518105
C006780	bisphenol A	bisphenol A results in increased methylation of ITGB3 gene	28505145
C006780	bisphenol A	bisphenol A inhibits the reaction [Thyroxine promotes the reaction [SRC protein binds to ITGB3 protein]]	22227104
C006780	bisphenol A	bisphenol A inhibits the reaction [Triiodothyronine promotes the reaction [SRC protein binds to ITGB3 protein]]	22227104
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of ITGB3 mRNA	22659508
C117446	cangrelor	cangrelor inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]]	18404433
C117446	cangrelor	"N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate promotes the reaction [cangrelor inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]]]"	18404433
D002246	Carbon Disulfide	Carbon Disulfide results in decreased expression of ITGB3 mRNA	24025711
D002246	Carbon Disulfide	Carbon Disulfide results in decreased expression of ITGB3 protein	24025711
D002330	Carmustine	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ITGB3 protein results in increased susceptibility to Carmustine]	21332719
D002330	Carmustine	ITGB3 protein results in increased susceptibility to Carmustine	21332719
D002330	Carmustine	ITGB3 protein results in increased susceptibility to Carmustine	21332719
C119957	CGP 77675	[CGP 77675 results in decreased activity of SRC protein] promotes the reaction [manganese chloride affects the localization of and affects the activity of [ITGB3 protein binds to ITGAV protein]]	15213856
C422910	Cilengitide	Cilengitide results in decreased activity of [ITGA5 protein binds to ITGB3 protein]	16729916
D002996	Clomiphene	Clomiphene results in decreased expression of ITGB3 protein	15749485
C055162	clopidogrel	ITGB3 gene SNP affects the susceptibility to clopidogrel	15166949
C055162	clopidogrel	ITGB3 gene SNP results in decreased susceptibility to clopidogrel	19530321
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of ITGB3 mRNA	19320972
D003042	Cocaine	Cocaine affects the expression of ITGB3 protein	19073234
D003474	Curcumin	Curcumin inhibits the reaction [F2 protein results in increased expression of ITGB3 protein]	18565277
D003513	Cycloheximide	Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of ITGB3 mRNA]	11007951
C017160	cypermethrin	cypermethrin results in increased expression of ITGB3 mRNA	22528246
D002945	Cisplatin	Cisplatin results in decreased expression of ITGB3 mRNA	27392435
D004008	Diclofenac	Diclofenac inhibits the reaction [TNF protein results in increased expression of ITGB3 protein]	19691487
D004041	Dietary Fats	Dietary Fats results in increased expression of ITGB3 mRNA	21852083
D004054	Diethylstilbestrol	Diethylstilbestrol results in decreased expression of ITGB3 mRNA	21285323
C472511	dimethylarsinous acid	dimethylarsinous acid results in decreased expression of ITGB3 mRNA	16507463
C472511	dimethylarsinous acid	dimethylarsinous acid results in increased expression of ITGB3 mRNA	23876855
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of ITGB3 mRNA	25380136
C007517	diphenyleneiodonium	diphenyleneiodonium inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGB3 protein]	20523355
C086648	eptifibatide	eptifibatide results in decreased activity of [ITGA2B protein binds to ITGB3 protein]	14744276
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of ITGB3 mRNA	26865667
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of ITGB3 mRNA	17555576
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of ITGB3 mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ITGB3 mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of ITGB3 mRNA	23550701
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in decreased expression of ITGB3 mRNA	23649840
D005047	Etoposide	ITGB3 protein results in increased susceptibility to Etoposide	21332719
D011345	Fenofibrate	Fenofibrate affects the expression of ITGB3 mRNA	20801182
D009240	N-Formylmethionine Leucyl-Phenylalanine	N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGB3 protein	21664406
C069837	fullerene C60	fullerene C60 results in decreased expression of ITGB3 mRNA	19167457
C001277	geldanamycin	geldanamycin results in increased expression of ITGB3 mRNA	26705709
D019833	Genistein	Genistein affects the expression of ITGB3 mRNA	26865667
D019833	Genistein	Genistein results in decreased expression of ITGB3 mRNA	23019147
D019833	Genistein	[bisphenol A co-treated with Genistein] results in increased methylation of ITGB3 gene	28505145
D005947	Glucose	Glucose inhibits the reaction [Aspirin inhibits the reaction [Arachidonic Acid results in increased expression of ITGB3 protein]]	18413191
D017313	Fenretinide	Fenretinide results in decreased expression of ITGB3 mRNA	28973697
D012701	Serotonin	ITGB3 gene polymorphism affects the abundance of Serotonin	16724005\|1720330
C031927	hydroquinone	hydroquinone results in increased expression of ITGB3 protein	21664406
C013038	hydroxyhydroquinone	hydroxyhydroquinone results in increased expression of ITGB3 mRNA	17572062
C085278	hydroxysafflor yellow A	hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Particulate Matter results in increased expression of ITGB3 protein]]	24192212
C085278	hydroxysafflor yellow A	hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Vehicle Emissions results in increased expression of ITGB3 protein]]	24192212
C085278	hydroxysafflor yellow A	hydroxysafflor yellow A inhibits the reaction [Particulate Matter results in increased expression of ITGB3 protein]	24192212
C085278	hydroxysafflor yellow A	hydroxysafflor yellow A inhibits the reaction [Vehicle Emissions results in increased expression of ITGB3 protein]	24192212
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of ITGB3 mRNA	25613284
C544151	jinfukang	jinfukang results in increased expression of ITGB3 mRNA	27392435
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of ITGB3 mRNA	23086925
C073601	KT 5823	KT 5823 inhibits the reaction [NOC 18 results in increased expression of [ITGAV protein binds to ITGB3 protein]]	21307347
D007854	Lead	Lead results in decreased expression of ITGB3 mRNA	19921347
D016729	Leuprolide	Leuprolide inhibits the reaction [IGF1 protein results in increased expression of and affects the localization of [ITGA5 protein binds to ITGB3 protein]]	17143537
C025340	manganese chloride	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [manganese chloride affects the localization of and affects the activity of [ITGB3 protein binds to ITGAV protein]]	15213856
C025340	manganese chloride	[AG 1879 results in decreased activity of SRC protein] promotes the reaction [manganese chloride affects the localization of and affects the activity of [ITGB3 protein binds to ITGAV protein]]	15213856
C025340	manganese chloride	arginyl-glycyl-aspartic acid inhibits the reaction [manganese chloride affects the localization of and affects the activity of [ITGB3 protein binds to ITGAV protein]]	15213856
C025340	manganese chloride	[CGP 77675 results in decreased activity of SRC protein] promotes the reaction [manganese chloride affects the localization of and affects the activity of [ITGB3 protein binds to ITGAV protein]]	15213856
C025340	manganese chloride	manganese chloride affects the localization of and affects the activity of [ITGB3 protein binds to ITGAV protein]	15213856
C025340	manganese chloride	wortmannin inhibits the reaction [manganese chloride affects the localization of and affects the activity of [ITGB3 protein binds to ITGAV protein]]	15213856
C025340	manganese chloride	manganese chloride inhibits the reaction [TLN1 protein mutant form results in decreased activity of [ITGB3 protein binds to ITGA2B protein]]	20971947
C025340	manganese chloride	manganese chloride results in increased activity of [ITGB3 protein binds to ITGA2B protein]	20971947
C054634	methyllycaconitine	[methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] which results in decreased expression of ITGB3 mRNA	21385097
C054634	methyllycaconitine	[methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] which results in decreased expression of ITGB3 protein	21385097
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of ITGB3 mRNA	23649840
C059539	midostaurin	midostaurin results in increased expression of and results in increased localization of ITGB3 protein	19573588
C016599	mono-(2-ethylhexyl)phthalate	mono-(2-ethylhexyl)phthalate results in decreased expression of ITGB3 mRNA	22401849
C406082	monomethylarsonous acid	monomethylarsonous acid results in decreased expression of ITGB3 mRNA	16507463
C406082	monomethylarsonous acid	monomethylarsonous acid results in increased expression of ITGB3 protein	24625837
C583365	N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide	"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of ITGB3 mRNA"	29244179
C111914	N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate	"N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]]"	18404433
C111914	N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate	"N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate promotes the reaction [cangrelor inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]]]"	18404433
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of ITGB3 mRNA"	25554681\|2562005
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of ITGB3 mRNA"	25554681\|2562005
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of ITGB3 mRNA	25380136
D009532	Nickel	Nickel results in increased expression of ITGB3 mRNA	24768652\|2558310
C029938	nickel sulfate	nickel sulfate results in increased expression of ITGB3 mRNA	16780908
D009534	Niclosamide	Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of ITGB3 mRNA]	26792726
D009538	Nicotine	Nicotine results in decreased expression of ITGB3 mRNA	21385097
D009538	Nicotine	Nicotine results in decreased expression of ITGB3 protein	21385097
D009569	Nitric Oxide	Nitric Oxide results in increased expression of ITGB3 protein	21332719
D009599	Nitroprusside	[Nitroprusside results in increased expression of ITGB3 protein] which results in increased phosphorylation of and results in increased activity of AKT1 protein	21332719
D009599	Nitroprusside	[Nitroprusside results in increased expression of ITGB3 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein	21332719
D009599	Nitroprusside	[Nitroprusside results in increased expression of ITGB3 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein	21332719
C093285	NOC 18	[ITGAV protein binds to ITGB3 protein] which results in increased susceptibility to NOC 18	21307347
C093285	NOC 18	KT 5823 inhibits the reaction [NOC 18 results in increased expression of [ITGAV protein binds to ITGB3 protein]]	21307347
C093285	NOC 18	NOC 18 results in increased expression of [ITGAV protein binds to ITGB3 protein]	21307347
D009711	Nucleotides	ITGB3 protein affects the reaction [Nucleotides results in increased phosphorylation of MAPK1 protein]	17620283
D009711	Nucleotides	ITGB3 protein affects the reaction [Nucleotides results in increased phosphorylation of MAPK3 protein]	17620283
D009966	Orphenadrine	Orphenadrine affects the expression of ITGB3 mRNA	23665939
D052638	Particulate Matter	Particulate Matter results in increased expression of ITGB3 mRNA	28846189
D052638	Particulate Matter	2-chloro-5-nitrobenzanilide promotes the reaction [Particulate Matter results in increased expression of ITGB3 protein]	24192212
D052638	Particulate Matter	hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Particulate Matter results in increased expression of ITGB3 protein]]	24192212
D052638	Particulate Matter	hydroxysafflor yellow A inhibits the reaction [Particulate Matter results in increased expression of ITGB3 protein]	24192212
D052638	Particulate Matter	Particulate Matter results in increased expression of ITGB3 protein	24192212
C000610380	p-carboxymethylphenyl 1,1-bis(3'-indolyl)-1-(p-carboxymethylphenyl)methane	"p-carboxymethylphenyl 1,1-bis(3'-indolyl)-1-(p-carboxymethylphenyl)methane results in decreased expression of ITGB3 mRNA"	26929200
D010862	Pilocarpine	Pilocarpine results in increased expression of ITGB3 protein	12851778
C006253	pirinixic acid	NCF1 protein promotes the reaction [pirinixic acid results in decreased expression of ITGB3 mRNA]	17950772
C006253	pirinixic acid	pirinixic acid results in decreased expression of ITGB3 mRNA	17950772\|2381119
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of ITGB3 mRNA	22714537
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of ITGB3 mRNA	28903501
D011374	Progesterone	[Estradiol co-treated with Progesterone] results in decreased expression of ITGB3 mRNA	20660070
D011374	Progesterone	[Progesterone co-treated with Estradiol] results in decreased expression of ITGB3 mRNA	17404688
D011374	Progesterone	[Progesterone co-treated with Estradiol] results in increased expression of ITGB3 mRNA	20226447
D011374	Progesterone	Progesterone results in decreased expression of ITGB3 mRNA	17404688
D011374	Progesterone	Progesterone results in increased expression of ITGB3 mRNA	16403803\|2022644
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGB3 protein]	20523355
C432165	pyrazolanthrone	pyrazolanthrone promotes the reaction [THPO protein results in increased expression of ITGB3 protein]	20523355
D011794	Quercetin	Quercetin inhibits the reaction [Arachidonic Acid results in increased expression of ITGB3 protein]	23249183
D011794	Quercetin	Quercetin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGB3 protein]	20523355
D011794	Quercetin	Quercetin results in decreased expression of ITGB3 mRNA	28431985
D011794	Quercetin	Quercetin results in decreased expression of [ITGB3 protein binds to ITGAV protein]	28431985
C037219	quinoline	quinoline analog binds to and results in decreased activity of [ITGA5 protein binds to ITGB3 protein]	16984141
C059514	resveratrol	arginyl-glycyl-aspartic acid inhibits the reaction [resveratrol binds to [ITGA5 protein binds to ITGB3 protein]]	16790523
C059514	resveratrol	[ITGA5 protein binds to ITGB3 protein] promotes the reaction [resveratrol results in increased phosphorylation of MAPK1 protein]	16790523
C059514	resveratrol	[ITGA5 protein binds to ITGB3 protein] promotes the reaction [resveratrol results in increased phosphorylation of MAPK3 protein]	16790523
C059514	resveratrol	[ITGA5 protein binds to ITGB3 protein] promotes the reaction [resveratrol results in increased phosphorylation of TP53 protein]	16790523
C059514	resveratrol	resveratrol affects the localization of ITGB3 protein	21467134
C059514	resveratrol	resveratrol binds to [ITGA5 protein binds to ITGB3 protein]	16790523
C059514	resveratrol	resveratrol binds to ITGB3 protein	16790523
C059514	resveratrol	resveratrol inhibits the reaction [ITGA2B protein binds to ITGB3 protein]	26482867
C059514	resveratrol	resveratrol promotes the reaction [[ITGAV protein binds to ITGB3 protein] which affects the localization of FYN protein]	21467134
C059514	resveratrol	resveratrol promotes the reaction [[ITGAV protein binds to ITGB3 protein] which affects the localization of GRB2 protein]	21467134
C059514	resveratrol	resveratrol promotes the reaction [[ITGAV protein binds to ITGB3 protein] which affects the localization of PTK2 protein]	21467134
C059514	resveratrol	resveratrol promotes the reaction [[ITGAV protein binds to ITGB3 protein] which affects the localization of SOS1 protein]	21467134
C089730	rosiglitazone	rosiglitazone affects the expression of ITGB3 protein	19556978
C420822	SB 273005	SB 273005 binds to and results in decreased activity of [ITGAV protein binds to ITGB3 protein]	22964516
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of ITGB3 mRNA	25895662
C071275	SK&F 106760	SK&F 106760 binds to and results in decreased activity of [ITGA2B protein binds to ITGB3 protein]	1605806
C017947	sodium arsenite	sodium arsenite results in decreased expression of ITGB3 mRNA	16507463
C017947	sodium arsenite	sodium arsenite results in increased expression of ITGB3 protein	19072884
C120642	sophoricoside	sophoricoside results in decreased expression of ITGB3	24877640
D013467	Sulindac	Sulindac inhibits the reaction [CDKN1A protein results in increased expression of ITGB3 mRNA]	15190207
D014284	Triiodothyronine	ITGB3 inhibits the reaction [bisphenol A inhibits the reaction [Triiodothyronine inhibits the reaction [NCOR1 protein binds to and results in decreased activity of THRB protein]]]	22227104
D014284	Triiodothyronine	ITGB3 inhibits the reaction [bisphenol A inhibits the reaction [Triiodothyronine inhibits the reaction [NCOR2 protein binds to and results in decreased activity of THRB protein]]]	22227104
D014284	Triiodothyronine	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Triiodothyronine promotes the reaction [SRC protein binds to ITGB3 protein]]	22227104
D014284	Triiodothyronine	AG 1879 inhibits the reaction [Triiodothyronine promotes the reaction [SRC protein binds to ITGB3 protein]]	22227104
D014284	Triiodothyronine	bisphenol A inhibits the reaction [Triiodothyronine promotes the reaction [SRC protein binds to ITGB3 protein]]	22227104
D014284	Triiodothyronine	tetraiodothyroacetic acid inhibits the reaction [Triiodothyronine promotes the reaction [SRC protein binds to ITGB3 protein]]	22227104
D014284	Triiodothyronine	Triiodothyronine binds to [ITGA5 protein binds to ITGB3 protein]	16384862
D014284	Triiodothyronine	Triiodothyronine promotes the reaction [SRC protein binds to ITGB3 protein]	22227104
D013629	Tamoxifen	Tamoxifen affects the expression of ITGB3 mRNA	17555576
C561921	technetium 99m (HYNIC-3PRGD(2))(tricine)(TPPTS)	technetium 99m (HYNIC-3PRGD(2))(tricine)(TPPTS) binds to [ITGA5 protein binds to ITGB3 protein]	20694579
C087926	tellimagrandin I	tellimagrandin I inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGB3 protein]	14757314
D013749	Tetrachlorodibenzodioxin	Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of ITGB3 mRNA]	11007951
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of ITGB3 mRNA	11007951\|2791314
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ITGB3 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of ITGB3 mRNA	22666406
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of ITGB3 mRNA	27913140
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of ITGB3 mRNA	27913140
D013755	Tetradecanoylphorbol Acetate	10-(4'-(N-diethylamino)butyl)-2-chlorophenoxazine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGB3 protein]	20523355
D013755	Tetradecanoylphorbol Acetate	"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGB3 protein]"	20523355
D013755	Tetradecanoylphorbol Acetate	acetovanillone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGB3 protein]	20523355
D013755	Tetradecanoylphorbol Acetate	Acetylcysteine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGB3 protein]	20523355
D013755	Tetradecanoylphorbol Acetate	"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGB3 protein]"	20523355
D013755	Tetradecanoylphorbol Acetate	CYBA protein promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGB3 protein]	20523355
D013755	Tetradecanoylphorbol Acetate	diphenyleneiodonium inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGB3 protein]	20523355
D013755	Tetradecanoylphorbol Acetate	pyrazolanthrone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGB3 protein]	20523355
D013755	Tetradecanoylphorbol Acetate	Quercetin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGB3 protein]	20523355
D013755	Tetradecanoylphorbol Acetate	tellimagrandin I inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGB3 protein]	14757314
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of ITGB3 protein	10910098\|1475731
D013755	Tetradecanoylphorbol Acetate	U 0126 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGB3 protein]	20523355
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of ITGB3 mRNA	25613284
C011126	tetraiodothyroacetic acid	tetraiodothyroacetic acid binds to [ITGA5 protein binds to ITGB3 protein]	16384862
C011126	tetraiodothyroacetic acid	tetraiodothyroacetic acid inhibits the reaction [Thyroxine promotes the reaction [SRC protein binds to ITGB3 protein]]	22227104
C011126	tetraiodothyroacetic acid	tetraiodothyroacetic acid inhibits the reaction [Triiodothyronine promotes the reaction [SRC protein binds to ITGB3 protein]]	22227104
D013974	Thyroxine	ITGB3 inhibits the reaction [bisphenol A inhibits the reaction [Thyroxine inhibits the reaction [NCOR1 protein binds to and results in decreased activity of THRB protein]]]	22227104
D013974	Thyroxine	ITGB3 inhibits the reaction [bisphenol A inhibits the reaction [Thyroxine inhibits the reaction [NCOR2 protein binds to and results in decreased activity of THRB protein]]]	22227104
D013974	Thyroxine	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Thyroxine promotes the reaction [SRC protein binds to ITGB3 protein]]	22227104
D013974	Thyroxine	AG 1879 inhibits the reaction [Thyroxine promotes the reaction [SRC protein binds to ITGB3 protein]]	22227104
D013974	Thyroxine	bisphenol A inhibits the reaction [Thyroxine promotes the reaction [SRC protein binds to ITGB3 protein]]	22227104
D013974	Thyroxine	tetraiodothyroacetic acid inhibits the reaction [Thyroxine promotes the reaction [SRC protein binds to ITGB3 protein]]	22227104
D013974	Thyroxine	Thyroxine binds to [ITGA5 protein binds to ITGB3 protein]	16384862
D013974	Thyroxine	Thyroxine promotes the reaction [SRC protein binds to ITGB3 protein]	22227104
D014118	Toxins, Biological	"Toxins, Biological affects the expression of ITGB3 mRNA"	19682533
C032910	triadimefon	triadimefon analog results in decreased expression of ITGB3 mRNA	26238599
C012589	trichostatin A	trichostatin A results in increased expression of ITGB3 mRNA	26238599
C012589	trichostatin A	trichostatin A results in increased expression of ITGB3 mRNA	23463510
C113580	U 0126	U 0126 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGB3 protein]	20523355
C113580	U 0126	U 0126 inhibits the reaction [THPO protein results in increased expression of ITGB3 protein]	20523355
D014635	Valproic Acid	Valproic Acid results in increased expression of ITGB3 mRNA	26238599
D014638	Vanadates	Vanadates results in increased expression of ITGB3 mRNA	22714537
D001335	Vehicle Emissions	Vehicle Emissions affects the methylation of ITGB3 gene	25560391
D001335	Vehicle Emissions	2-chloro-5-nitrobenzanilide promotes the reaction [Vehicle Emissions results in increased expression of ITGB3 protein]	24192212
D001335	Vehicle Emissions	hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Vehicle Emissions results in increased expression of ITGB3 protein]]	24192212
D001335	Vehicle Emissions	hydroxysafflor yellow A inhibits the reaction [Vehicle Emissions results in increased expression of ITGB3 protein]	24192212
D001335	Vehicle Emissions	Vehicle Emissions results in increased expression of ITGB3 protein	24192212
C025643	vinclozolin	vinclozolin results in decreased expression of ITGB3 mRNA	18042343
C029297	vinylidene chloride	vinylidene chloride results in increased expression of ITGB3 mRNA	26682919
C111237	vorinostat	vorinostat results in increased expression of ITGB3 mRNA	26238599
C009687	wortmannin	wortmannin inhibits the reaction [manganese chloride affects the localization of and affects the activity of [ITGB3 protein binds to ITGAV protein]]	15213856

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001618	virus receptor activity	-	IEA	-
GO:0001968	fibronectin binding	-	IBA	21873635
GO:0001968	fibronectin binding	-	IMP	24658351
GO:0002020	protease binding	-	IDA	22505472
GO:0003756	protein disulfide isomerase activity	-	IDA	12204115 15466936
GO:0005161	platelet-derived growth factor receptor binding	-	TAS	19267251
GO:0005178	integrin binding	-	IBA	21873635
GO:0005178	integrin binding	-	IPI	20826760
GO:0005515	protein binding	-	IPI	1694173 2116421 10822899 11470407 11546839 11884718 11940607 12535520 12606711 12682293 12695522 12807887 14593208 14681217 15062093 15299032 15379538 15466936 16051604 16099422 16115959 16275649 16546176 17218263 17485491 18045938 19279667 19805198 20639902 21134644 22178926 22210111 23125415 24658351 24789099 25398877 25849143
GO:0015026	coreceptor activity	-	TAS	23125415
GO:0017134	fibroblast growth factor binding	contributes_to	IDA	18441324
GO:0019899	enzyme binding	-	IPI	21670307
GO:0019960	C-X3-C chemokine binding	contributes_to	IDA	23125415
GO:0031994	insulin-like growth factor I binding	contributes_to	IDA	19578119
GO:0038132	neuregulin binding	contributes_to	IDA	20682778
GO:0042802	identical protein binding	-	IPI	11606749 14681217 22178926
GO:0043184	vascular endothelial growth factor receptor 2 binding	-	IPI	10022831
GO:0043184	vascular endothelial growth factor receptor 2 binding	-	TAS	19267251
GO:0050839	cell adhesion molecule binding	-	IPI	8837777
GO:0050840	extracellular matrix binding	-	IDA	22505472
GO:0070051	fibrinogen binding	CONTRIBUTES_TO	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001934	positive regulation of protein phosphorylation	-	TAS	19267251
GO:0001938	positive regulation of endothelial cell proliferation	-	IMP	10022831
GO:0002576	platelet degranulation	-	TAS	-
GO:0007155	cell adhesion	-	TAS	2452834 10429193
GO:0007160	cell-matrix adhesion	-	IBA	21873635
GO:0007160	cell-matrix adhesion	-	IMP	7525578 24658351
GO:0007229	integrin-mediated signaling pathway	-	HDA	23382103
GO:0007229	integrin-mediated signaling pathway	-	IBA	21873635
GO:0007229	integrin-mediated signaling pathway	-	TAS	21488147
GO:0007596	blood coagulation	-	TAS	1438206
GO:0010595	positive regulation of endothelial cell migration	-	IMP	10022831
GO:0010745	negative regulation of macrophage derived foam cell differentiation	-	IMP	15215180
GO:0010888	negative regulation of lipid storage	-	IMP	15215180
GO:0014909	smooth muscle cell migration	-	IMP	8837777
GO:0016477	cell migration	-	IBA	21873635
GO:0030168	platelet activation	-	IMP	15466936
GO:0030198	extracellular matrix organization	-	TAS	-
GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway	-	TAS	19267251
GO:0031589	cell-substrate adhesion	-	IMP	19933311
GO:0032147	activation of protein kinase activity	-	IMP	10022831
GO:0032369	negative regulation of lipid transport	-	IMP	15215180
GO:0033627	cell adhesion mediated by integrin	-	IBA	21873635
GO:0033627	cell adhesion mediated by integrin	-	IDA	12807887
GO:0034113	heterotypic cell-cell adhesion	-	IMP	20563599
GO:0034446	substrate adhesion-dependent cell spreading	-	IDA	24658351
GO:0035295	tube development	-	TAS	19267251
GO:0038027	apolipoprotein A-I-mediated signaling pathway	-	IMP	23726972
GO:0042060	wound healing	-	IC	8837777
GO:0043277	apoptotic cell clearance	-	IGI	20826760
GO:0045124	regulation of bone resorption	-	TAS	19267251
GO:0045715	negative regulation of low-density lipoprotein particle receptor biosynthetic process	-	IMP	15215180
GO:0046718	viral entry into host cell	-	IMP	25063885
GO:0048010	vascular endothelial growth factor receptor signaling pathway	-	TAS	-
GO:0048333	mesodermal cell differentiation	-	IEP	23154389
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	-	IMP	10022831
GO:0050748	negative regulation of lipoprotein metabolic process	-	IMP	15215180
GO:0050900	leukocyte migration	-	TAS	-
GO:0050919	negative chemotaxis	-	IMP	23726972
GO:0060055	angiogenesis involved in wound healing	-	TAS	19267251
GO:0070527	platelet aggregation	-	IMP	15466936

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IDA	22027834
GO:0005886	plasma membrane	-	IDA	15466936
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	TAS	2452834
GO:0005925	focal adhesion	-	HDA	21423176
GO:0005925	focal adhesion	-	IBA	21873635
GO:0005925	focal adhesion	-	IDA	23023225 25063885
GO:0008305	integrin complex	-	IBA	21873635
GO:0008305	integrin complex	-	IDA	15215180
GO:0009986	cell surface	-	HDA	23382103 23658023
GO:0009986	cell surface	-	IBA	21873635
GO:0009986	cell surface	-	IDA	7525578 19234460 19933311 20563599 22505472 23023225 25063885
GO:0031092	platelet alpha granule membrane	-	TAS	-
GO:0031258	lamellipodium membrane	-	IDA	25063885
GO:0031527	filopodium membrane	-	IDA	25063885
GO:0031528	microvillus membrane	-	IDA	25063885
GO:0032587	ruffle membrane	-	IDA	25063885
GO:0034683	integrin alphav-beta3 complex	-	IDA	20826760 22505472 23726972 24658351 25063885
GO:0035866	alphav-beta3 integrin-PKCalpha complex	-	IDA	16014375
GO:0035867	alphav-beta3 integrin-IGF-1-IGF1R complex	-	IDA	19578119
GO:0035868	alphav-beta3 integrin-HMGB1 complex	-	IDA	20826760
GO:0042470	melanosome	-	IDA	15466936
GO:0043235	receptor complex	-	IDA	23382219
GO:0070062	extracellular exosome	-	HDA	20458337
GO:0071062	alphav-beta3 integrin-vitronectin complex	-	TAS	19267251

KEGG ID	KEGG Term
hsa04145	Phagosome
hsa04380	Osteoclast differentiation
hsa04510	Focal adhesion
hsa04512	ECM-receptor interaction
hsa04640	Hematopoietic cell lineage
hsa04810	Regulation of actin cytoskeleton
hsa05410	Hypertrophic cardiomyopathy (HCM)
hsa05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)
hsa05414	Dilated cardiomyopathy

Reactome ID	Reactome Term	Evidence
R-HSA-109582	Hemostasis	TAS
R-HSA-114608	Platelet degranulation	TAS
R-HSA-1266738	Developmental Biology	TAS
R-HSA-1474244	Extracellular matrix organization	TAS
R-HSA-1474244	Extracellular matrix organization	IEA
R-HSA-1566948	Elastic fibre formation	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-1643685	Disease	TAS
R-HSA-194138	Signaling by VEGF	TAS
R-HSA-202733	Cell surface interactions at the vascular wall	TAS
R-HSA-210990	PECAM1 interactions	TAS
R-HSA-2129379	Molecules associated with elastic fibres	TAS
R-HSA-216083	Integrin cell surface interactions	TAS
R-HSA-216083	Integrin cell surface interactions	IEA
R-HSA-3000170	Syndecan interactions	IEA
R-HSA-3000170	Syndecan interactions	TAS
R-HSA-3000171	Non-integrin membrane-ECM interactions	IEA
R-HSA-3000171	Non-integrin membrane-ECM interactions	TAS
R-HSA-3000178	ECM proteoglycans	TAS
R-HSA-354192	Integrin alphaIIb beta3 signaling	TAS
R-HSA-354194	GRB2:SOS provides linkage to MAPK signaling for Integrins	TAS
R-HSA-372708	p130Cas linkage to MAPK signaling for integrins	TAS
R-HSA-373760	L1CAM interactions	TAS
R-HSA-422475	Axon guidance	TAS
R-HSA-4420097	VEGFA-VEGFR2 Pathway	TAS
R-HSA-445144	Signal transduction by L1	TAS
R-HSA-5663202	Diseases of signal transduction	TAS
R-HSA-5673001	RAF/MAP kinase cascade	TAS
R-HSA-5674135	MAP2K and MAPK activation	TAS
R-HSA-5683057	MAPK family signaling cascades	TAS
R-HSA-5684996	MAPK1/MAPK3 signaling	TAS
R-HSA-6802946	Signaling by moderate kinase activity BRAF mutants	TAS
R-HSA-6802948	Signaling by high-kinase activity BRAF mutants	TAS
R-HSA-6802949	Signaling by RAS mutants	TAS
R-HSA-6802952	Signaling by BRAF and RAF fusions	TAS
R-HSA-6802955	Paradoxical activation of RAF signaling by kinase inactive BRAF	TAS
R-HSA-6802957	Oncogenic MAPK signaling	TAS
R-HSA-76002	Platelet activation, signaling and aggregation	TAS
R-HSA-76005	Response to elevated platelet cytosolic Ca2+	TAS
R-HSA-76009	Platelet Aggregation (Plug Formation)	TAS
R-HSA-9006921	Integrin signaling	TAS
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
16353042	[Associations of hemostasis factors genes with early development of ischemic heart disease and manifestation of myocardial infarction in young age]. (2005)	Dankovtseva EN	Kardiologiia
22535530	Prothrombotic gene polymorphisms and plasma factors in young North Indian survivors of acute myocardial infarction. (2012 Aug)	Dogra RK	J Thromb Thrombolysis
16100725	Risks of human conotruncal heart defects associated with 32 single nucleotide polymorphisms of selected cardiovascular disease-related genes. (2005 Sep 15)	Shaw GM	Am J Med Genet A
26739544	Rs5918ITGB3 Polymorphism, Smoking, and BMI as Risk Factors for Early Onset and Recurrence of DVT in Young Women. (2017 Sep)	Komsa-Penkova R	Clin Appl Thromb Hemost
24289603	Investigation of ICAM-1 and beta3 integrin gene variations in patients with brain tumors. (2013)	Yilmaz U	Asian Pac J Cancer Prev
25155498	Genetic polymorphisms, Biochemical Factors, and Conventional Risk Factors in Young and Elderly North Indian Patients With Acute Myocardial Infarction. (2016 Mar)	Kaur R	Clin Appl Thromb Hemost