Gene: ITGB4

3691
CD104|GP150
integrin subunit beta 4
protein-coding
17q25.1
Ensembl:ENSG00000132470 MIM:147557 Vega:OTTHUMG00000179814 UniprotKB:P16144
NG_007372.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.233e-1 (AD)  3.907e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PLCD10.875
TMBIM10.874
ITPKB0.869
MRVI10.862
RFX40.861
FAM189A20.86
LRP100.853
ABHD40.846
ERBB20.846
ALDH1L10.846

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ABCC12-0.542
KCNS3-0.53
ADRA1D-0.506
PPEF1-0.506
ZNF385D-0.502
VWC2-0.496
MCHR1-0.493
HAPLN1-0.493
PNOC-0.492
TYRP1-0.492

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB05122R1295Small Molecule-InvestigationalTarget
ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of ITGB4 mRNA"26377693
C0326681-nitropyrene1-nitropyrene results in decreased expression of ITGB4 mRNA19041380
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl affects the expression of ITGB4 mRNA"20638727
C549106AL-10 compoundAL-10 compound results in decreased metabolism of ITGB4 protein20112294
C004984apocarotenalapocarotenal results in decreased expression of ITGB4 mRNA17034753
D034341Aristolochic AcidsAristolochic Acids results in increased expression of ITGB4 mRNA19717638
C006632arsenic trioxideITGB4 protein results in decreased susceptibility to arsenic trioxide20707922
D001241AspirinAspirin results in decreased expression of ITGB4 mRNA14976132
D001280AtrazineAtrazine results in decreased expression of ITGB4 mRNA25929836
C547126AZM551248AZM551248 results in decreased expression of ITGB4 mRNA22323515
D001507BeclomethasoneBeclomethasone results in increased expression of ITGB4 mRNA23656298
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of ITGB4 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to ITGB4 promoter]19654925
D019207beta Carotenebeta Carotene results in decreased expression of ITGB4 mRNA17034753
D004958Estradiol[Progesterone co-treated with Estradiol] results in decreased expression of ITGB4 mRNA20226447
D004958Estradiol[Progesterone co-treated with Estradiol] results in increased expression of ITGB4 mRNA20226447
C006780bisphenol Abisphenol A results in decreased methylation of ITGB4 promoter27312807
C006780bisphenol Abisphenol A affects the expression of ITGB4 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of ITGB4 mRNA12419474|1533650
D002104CadmiumCadmium results in increased expression of ITGB4 mRNA23358150
D019256Cadmium Chloride[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in increased expression of ITGB4 mRNA12634122
C035196cadmium nitratecadmium nitrate results in decreased expression of ITGB4 protein19061949
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of ITGB4 mRNA12734012
C100187chloropicrinchloropicrin results in decreased expression of ITGB4 mRNA26352163|2847649
D002737ChloropreneChloroprene results in increased expression of ITGB4 mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of ITGB420938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ITGB4 gene20938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ITGB4 mRNA20938992
C023600chromic oxide[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in increased expression of ITGB4 mRNA12634122
C017133chromous chloride[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in increased expression of ITGB4 mRNA12634122
D017291ClarithromycinClarithromycin results in decreased expression of ITGB4 protein14687228
D016572CyclosporineCyclosporine results in increased expression of ITGB4 mRNA22147139
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of ITGB4 mRNA27392435
D002945CisplatinCisplatin results in increased expression of ITGB4 mRNA12066199
D004041Dietary FatsDietary Fats results in increased expression of ITGB4 mRNA18042831
D002117CalcitriolCalcitriol results in increased expression of ITGB4 mRNA26485663
D004317DoxorubicinDoxorubicin results in decreased expression of ITGB4 mRNA15205334
D004317DoxorubicinDoxorubicin results in increased oxidation of ITGB4 protein28818578
C045651epigallocatechin gallate[Sulindac co-treated with epigallocatechin gallate] results in decreased expression of ITGB4 mRNA12628509
C574336excavatolide Bexcavatolide B results in decreased expression of ITGB4 protein26790859
C082360fipronilfipronil results in decreased expression of ITGB4 mRNA23962444
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in increased expression of ITGB4 mRNA17317680
D005472FluorouracilFluorouracil results in decreased expression of ITGB4 mRNA15205334
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of ITGB420938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ITGB4 gene20938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ITGB4 mRNA20938992
C039281furanfuran results in increased expression of ITGB4 mRNA27387713
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of ITGB4 mRNA26846883
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of ITGB4 mRNA12419474
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of ITGB4 mRNA27392435
C544151jinfukangjinfukang results in increased expression of ITGB4 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ITGB4 mRNA26644586
D007854LeadLead affects the expression of ITGB4 mRNA28903495
C008261lead acetate[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in increased expression of ITGB4 mRNA12634122
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of ITGB420938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ITGB4 gene20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ITGB4 mRNA20938992
D008727MethotrexateMethotrexate results in increased expression of ITGB4 mRNA21678067
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of ITGB4 mRNA26011545
D008769MethylnitronitrosoguanidineMethylnitronitrosoguanidine results in decreased expression of ITGB4 mRNA12634122|1277377
C008493methylselenic acidmethylselenic acid results in decreased expression of ITGB4 mRNA12517777
C059539midostaurinmidostaurin results in decreased expression of ITGB4 mRNA20980353
C070571ML 7ML 7 affects the localization of [ITGA6 protein binds to ITGB4 protein]14691950
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of ITGB4 mRNA22401849
C568376MT19c compoundMT19c compound results in decreased expression of ITGB4 mRNA21781307
D009151Mustard GasMustard Gas affects the expression of [ITGA6 protein binds to ITGB4 protein]12880345
D009151Mustard GasMustard Gas results in decreased expression of ITGB4 protein11428621|1288034
D009151Mustard GasMustard Gas affects the expression of ITGB4 protein9285538
D009151Mustard GasMustard Gas inhibits the reaction [ITGA6 protein binds to ITGB4 protein]18300329
D009151Mustard GasMustard Gas results in decreased expression of ITGB418300329
C017557nickel subsulfidenickel subsulfide results in decreased expression of ITGB4 mRNA12760830
C029938nickel sulfatenickel sulfate results in increased expression of ITGB4 mRNA18651567|2271453
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of ITGB4 mRNA17616710
C558013NSC 689534NSC 689534 results in increased expression of ITGB4 mRNA20971185
C025589ochratoxin Aochratoxin A results in increased expression of ITGB4 mRNA19717638
D015242OfloxacinOfloxacin results in decreased expression of ITGB4 protein14687228
D015525Fatty Acids, Omega-3"Fatty Acids, Omega-3 results in increased expression of ITGB4 mRNA"16823509
D043371Fatty Acids, Omega-6"Fatty Acids, Omega-6 results in increased expression of ITGB4 mRNA"16823509
D000073878Palm OilPalm Oil results in increased expression of ITGB4 mRNA18042831
D010862PilocarpinePilocarpine results in increased expression of ITGB4 protein12851778
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of ITGB4 mRNA22714537
D011192Potassium DichromatePotassium Dichromate results in decreased expression of ITGB4 mRNA23608068
D011374Progesterone[Progesterone affects the activity of PGR protein alternative form] which affects the expression of ITGB4 mRNA15866122
D011374Progesterone[Progesterone co-treated with Estradiol] results in decreased expression of ITGB4 mRNA20226447
D011374Progesterone[Progesterone co-treated with Estradiol] results in increased expression of ITGB4 mRNA20226447
D011374ProgesteroneProgesterone results in increased expression of ITGB4 mRNA20226447
C005556propionaldehydepropionaldehyde results in increased expression of ITGB4 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of ITGB4 mRNA24780913
C014175pyrazolo(3,4-d)pyrimidine"pyrazolo(3,4-d)pyrimidine analog affects the expression of ITGB4 mRNA"21152443
D015575RoxithromycinRoxithromycin results in decreased expression of ITGB4 protein14687228
D019821SimvastatinSimvastatin affects the expression of ITGB4 mRNA19110722
D019821SimvastatinSimvastatin affects the expression of ITGB4 protein19110722
D019821SimvastatinSimvastatin results in increased expression of ITGB4 mRNA14630613
D019821SimvastatinSimvastatin results in increased expression of ITGB4 protein14630613
D012906SmokeSmoke results in decreased expression of ITGB4 mRNA21095227
C017947sodium arsenite[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in increased expression of ITGB4 mRNA12634122
C017947sodium arsenitesodium arsenite results in decreased expression of and affects the splicing of ITGB4 mRNA25879800
C017947sodium arsenitesodium arsenite results in decreased expression of ITGB4 mRNA12377979
C016104sodium bichromatesodium bichromate results in decreased expression of ITGB4 mRNA12760830
D013467Sulindac[Sulindac co-treated with epigallocatechin gallate] results in decreased expression of ITGB4 mRNA12628509
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ITGB4 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ITGB4 mRNA22298810
C020809tetrathiomolybdatetetrathiomolybdate analog results in decreased expression of ITGB4 mRNA19323979
D013853ThioacetamideThioacetamide results in increased expression of ITGB4 mRNA23411599
C009495titanium dioxidetitanium dioxide results in decreased expression of ITGB4 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of ITGB4 mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of ITGB4 mRNA27865774
D014212TretinoinTretinoin inhibits the reaction [RARA gene mutant form results in increased expression of ITGB4 mRNA]10748128
D014212TretinoinTretinoin results in decreased expression of ITGB4 mRNA10748128
D014635Valproic AcidValproic Acid results in increased methylation of ITGB4 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of ITGB4 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of ITGB4 mRNA23034163
D014800VitalliumVitallium analog results in increased expression of ITGB4 mRNA23825117
C111237vorinostatvorinostat results in increased expression of ITGB4 mRNA20060208
C108830Y 27632Y 27632 affects the localization of [ITGA6 protein binds to ITGB4 protein]14691950

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001664G-protein coupled receptor binding-IPI24851274  
GO:0005178integrin binding-IBA21873635  
GO:0005515protein binding-IPI2649503  11375975  12482924  19242489  19403692  20603614  
21880726  24007983  24851274  25703379  27178753  
GO:0031994insulin-like growth factor I bindingcontributes_toIDA22351760  
GO:0038132neuregulin bindingcontributes_toIDA20682778  
GO ID GO Term Qualifier Evidence PubMed
GO:0006914autophagy-IMP24007983  
GO:0007155cell adhesion-NAS2311577  
GO:0007160cell-matrix adhesion-IBA21873635  
GO:0007160cell-matrix adhesion-IMP23496044  
GO:0007229integrin-mediated signaling pathway-IBA21873635  
GO:0007229integrin-mediated signaling pathway-IEA-  
GO:0009611response to wounding-IDA19403692  
GO:0016477cell migration-IBA21873635  
GO:0030198extracellular matrix organization-TAS-  
GO:0031581hemidesmosome assembly-IDA12482924  
GO:0031581hemidesmosome assembly-IMP23496044  
GO:0031581hemidesmosome assembly-TAS-  
GO:0033627cell adhesion mediated by integrin-IBA21873635  
GO:0035878nail development-IMP23496044  
GO:0043588skin development-IMP23496044  
GO:0048333mesodermal cell differentiation-IEP23154389  
GO:0048565digestive tract development-IMP23496044  
GO:0048870cell motility-IMP19403692  
GO:0072001renal system development-IMP23496044  
GO:0097186amelogenesis-IMP23496044  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IDA21310825  24851274  
GO:0005886plasma membrane-TAS-  
GO:0005925focal adhesion-IBA21873635  
GO:0008305integrin complex-IBA21873635  
GO:0008305integrin complex-IEA-  
GO:0009986cell surface-IBA21873635  
GO:0009986cell surface-IDA19933311  21310825  
GO:0030054cell junction-IDA-  
GO:0030056hemidesmosome-IDA12482924  
GO:0031252cell leading edge-IDA19403692  
GO:0043235receptor complex-IDA23382219  
GO:0070062extracellular exosome-HDA19199708  
KEGG ID KEGG Term
hsa04510Focal adhesion
hsa04512ECM-receptor interaction
hsa04810Regulation of actin cytoskeleton
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
hsa05414Dilated cardiomyopathy
Reactome ID Reactome Term Evidence
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-1474290Collagen formationTAS
R-HSA-1500931Cell-Cell communicationTAS
R-HSA-2022090Assembly of collagen fibrils and other multimeric structuresTAS
R-HSA-3000157Laminin interactionsTAS
R-HSA-3000170Syndecan interactionsTAS
R-HSA-3000171Non-integrin membrane-ECM interactionsTAS
R-HSA-446107Type I hemidesmosome assemblyTAS
R-HSA-446728Cell junction organizationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27143927Integrin and gene network analysis reveals that ITGA5 and ITGB1 are prognostic in non-small-cell lung cancer. (2016)Zheng WOnco Targets Ther