Gene: ITGB5

3693
-
integrin subunit beta 5
protein-coding
3q21.2
Ensembl:ENSG00000082781 MIM:147561 Vega:OTTHUMG00000159432 UniprotKB:P18084
NC_000003.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.970e-1 (AD)  9.396e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6771896chr3:124826903 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg27252776chr3:124564252ITGB51.100e-10Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PLTP0.885
ARHGEF400.882
FKBP100.88
AXL0.868
RIN20.867
S1PR10.863
ARHGAP310.862
FCGRT0.86
LRP100.859
EZR0.852

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NRG1-0.572
KCNB2-0.541
AGBL4-0.533
TYRP1-0.53
PPEF1-0.528
PCSK1-0.528
ADTRP-0.527
NELL1-0.525
CALHM1-0.524
GABRG3-0.523

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of ITGB5 mRNA"19114083
C5779422-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide"2-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide inhibits the reaction [TGFB1 protein results in increased expression of ITGB5 mRNA]"26644586
C5779422-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide"2-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide results in decreased expression of ITGB5 mRNA"26644586
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of ITGB5 mRNA"23196670
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ITGB5 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ITGB5 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ITGB5 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ITGB5 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ITGB5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ITGB5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ITGB5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ITGB5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ITGB5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ITGB5 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of ITGB5 mRNA21420995
D000638AmiodaroneAmiodarone results in decreased expression of ITGB5 mRNA23397585
D000640AmitroleAmitrole results in decreased expression of ITGB5 mRNA23397585
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of ITGB5 mRNA24449571
D001151ArsenicArsenic affects the methylation of ITGB5 gene25304211
D001280AtrazineAtrazine results in increased expression of ITGB5 mRNA25929836
C547126AZM551248AZM551248 results in increased expression of ITGB5 mRNA22323515
C487081belinostatbelinostat results in decreased expression of ITGB5 mRNA26272509
D001554BenzeneBenzene results in decreased expression of ITGB5 mRNA19162166
D001564Benzo(a)pyreneBenzo(a)pyrene affects the reaction [AHR protein binds to ITGB5 promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ITGB5 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ITGB5 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ITGB5 mRNA"19150397
C044887beta-methylcholinebeta-methylcholine affects the expression of ITGB5 mRNA21179406
C006780bisphenol Abisphenol A affects the expression of ITGB5 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of ITGB5 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of ITGB5 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of ITGB5 gene28505145
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ITGB5 mRNA28628672
C025703bleomycetinbleomycetin results in increased expression of ITGB5 mRNA21040473
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of ITGB5 mRNA12419474
C584509C646 compoundC646 compound results in increased expression of ITGB5 mRNA26191083
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of ITGB5 mRNA23397585
D002220CarbamazepineCarbamazepine affects the expression of ITGB5 mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of ITGB5 mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ITGB5 mRNA25827057
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of ITGB5 mRNA23650126
C039671ciglitazone[ciglitazone binds to PPARG protein] which results in increased expression of ITGB5 mRNA16197558
C422910CilengitideCilengitide results in decreased activity of [ITGA5 protein binds to ITGB5 protein]16729916
D002994ClofibrateClofibrate results in decreased expression of ITGB5 mRNA17585979
C018021cobaltous chloridecobaltous chloride results in decreased expression of ITGB5 mRNA19376846
C018021cobaltous chloridecobaltous chloride results in increased expression of ITGB5 mRNA19376846
C018021cobaltous chloridecobaltous chloride results in decreased expression of ITGB5 mRNA24386269
D003042CocaineCocaine affects the expression of ITGB5 mRNA20187946
D005576ColforsinColforsin results in increased expression of ITGB5 mRNA16751804
D003300Copper[Disulfiram binds to Copper] which results in increased expression of ITGB5 mRNA24690739
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of ITGB5 mRNA15467011
D019327Copper SulfateCopper Sulfate results in increased expression of ITGB5 mRNA19549813
D003471CuprizoneCuprizone results in increased expression of ITGB5 mRNA26577399
D003561CytarabineCytarabine results in decreased expression of ITGB5 mRNA21198554
C561627dabrafenib"dabrafenib inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of [ITGAV protein binds to ITGB5 protein]]"29042256
C014347decitabinedecitabine affects the expression of ITGB5 mRNA23300844
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ITGB5 mRNA28628672
D003907DexamethasoneDexamethasone results in increased expression of ITGB5 mRNA21041162
D002945CisplatinCisplatin affects the expression of ITGB5 mRNA23300844
D002945CisplatinCisplatin results in decreased expression of ITGB5 mRNA21151649
D004112DimercaprolDimercaprol inhibits the reaction [Mustard Gas results in decreased expression of ITGB5 mRNA]16377760
D004221Disulfiram[Disulfiram binds to Copper] which results in increased expression of ITGB5 mRNA24690739
C118739entinostatentinostat results in decreased expression of ITGB5 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ITGB5 mRNA"27188386
C038939enzacameneenzacamene results in decreased expression of ITGB5 mRNA23397585
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of ITGB5 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of ITGB5 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of ITGB5 mRNA17942748
D015025ZearalenoneZearalenone results in increased expression of ITGB5 mRNA25455459
C017690fenvaleratefenvalerate results in decreased expression of ITGB5 mRNA23397585
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of ITGB5 mRNA22634610
C568713GSK1210151AGSK1210151A inhibits the reaction [TGFB1 protein results in increased expression of ITGB5 mRNA]26644586
C568713GSK1210151AGSK1210151A results in decreased expression of ITGB5 mRNA26644586
D017313FenretinideFenretinide results in decreased expression of ITGB5 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of ITGB5 mRNA12419474
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of ITGB5 mRNA18951874
D006997Hypochlorous AcidHypochlorous Acid results in decreased expression of ITGB5 mRNA19376150
C492448ICG 001ICG 001 results in increased expression of ITGB5 mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ITGB5 mRNA28628672
D007213IndomethacinIndomethacin results in increased expression of ITGB5 mRNA28201806
D007480Iopanoic AcidIopanoic Acid results in decreased expression of ITGB5 mRNA23397585
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ITGB5 mRNA28628672
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [TGFB1 protein results in increased expression of ITGB5 mRNA]26644586
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ITGB5 mRNA26644586
C008261lead acetatelead acetate results in increased expression of ITGB5 mRNA22609695
C440499lipopolysaccharide, Escherichia coli O111 B4"dabrafenib inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of [ITGAV protein binds to ITGB5 protein]]"29042256
C440499lipopolysaccharide, Escherichia coli O111 B4"ITGB5 protein affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TGFBI protein]"27287417|2904225
C440499lipopolysaccharide, Escherichia coli O111 B4"lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of [ITGAV protein binds to ITGB5 protein]"27287417|2904225
C440499lipopolysaccharide, Escherichia coli O111 B4"Triterpenes inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of [ITGAV protein binds to ITGB5 protein]]"27287417
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of ITGB5 mRNA26378955
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of ITGB5 mRNA21641980
D008345ManganeseManganese results in increased expression of ITGB5 mRNA17175027
C025340manganese chloridemanganese chloride results in increased expression of ITGB5 mRNA17175027
D017258Medroxyprogesterone AcetateMedroxyprogesterone Acetate results in decreased expression of ITGB5 mRNA18497975
D008713MethimazoleMethimazole results in increased expression of ITGB5 mRNA23397585
D008731MethoxychlorMethoxychlor results in decreased expression of ITGB5 mRNA23397585
D008748MethylcholanthreneMethylcholanthrene results in decreased expression of ITGB5 mRNA23397585
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of ITGB5 mRNA23397585
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of ITGB5 mRNA26011545
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of ITGB5 mRNA"20188158
C008493methylselenic acidmethylselenic acid results in decreased expression of ITGB5 mRNA12517777
D009151Mustard GasDimercaprol inhibits the reaction [Mustard Gas results in decreased expression of ITGB5 mRNA]16377760
D009151Mustard GasMustard Gas results in decreased expression of ITGB5 mRNA16377760
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ITGB5 mRNA"25554681
D009532NickelNickel results in decreased expression of ITGB5 mRNA25583101
D009538NicotineNicotine results in increased expression of ITGB5 mRNA20426880
C118580octylmethoxycinnamateoctylmethoxycinnamate results in decreased expression of ITGB5 mRNA23397585
D017239PaclitaxelITGB5 mRNA results in decreased susceptibility to Paclitaxel16322897
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ITGB5 mRNA"27188386
C496932panobinostatpanobinostat results in decreased expression of ITGB5 mRNA26272509
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ITGB5 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of ITGB5 mRNA26272509
C006253pirinixic acidpirinixic acid results in decreased expression of ITGB5 mRNA17426115
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls results in decreased expression of ITGB5 mRNA23397585
C045950propiconazolepropiconazole results in decreased expression of ITGB5 mRNA21278054
D011441PropylthiouracilPropylthiouracil results in decreased expression of ITGB5 mRNA23397585
D011441PropylthiouracilPropylthiouracil results in decreased expression of ITGB5 mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in increased expression of ITGB5 mRNA27029645
D012822Silicon DioxideSilicon Dioxide results in increased expression of ITGB5 mRNA25351596
C017947sodium arsenitesodium arsenite results in decreased expression of ITGB5 mRNA16014739
C016104sodium bichromatesodium bichromate results in decreased expression of ITGB5 mRNA17685462
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of ITGB5 mRNA26378955
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of ITGB5 mRNA21641980
C446685systhanesysthane results in decreased expression of ITGB5 mRNA25461557
D014284TriiodothyronineTriiodothyronine results in decreased expression of ITGB5 mRNA23397585
D014284TriiodothyronineTriiodothyronine results in increased expression of ITGB5 mRNA23397585
D013629TamoxifenTamoxifen affects the expression of ITGB5 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ITGB5 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the reaction [AHR protein binds to ITGB5 promoter]19654925
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of ITGB5 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ITGB5 mRNA19490992|2791314
D019284ThapsigarginThapsigargin results in decreased expression of ITGB5 protein24648495
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of ITGB5 mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of ITGB5 mRNA27865774
D019772TopotecanTopotecan results in increased expression of ITGB5 mRNA25729387
D014118Toxins, Biological"Toxins, Biological affects the expression of ITGB5 mRNA"19682533
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ITGB5 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of ITGB5 mRNA24935251|2627250
D014315Triterpenes"Triterpenes inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of [ITGAV protein binds to ITGB5 protein]]"27287417
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ITGB5 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of ITGB5 mRNA23179753|2597931
D014635Valproic AcidValproic Acid results in decreased expression of ITGB5 mRNA26272509|2800136
D014638VanadatesVanadates results in increased expression of ITGB5 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions affects the methylation of ITGB5 gene25560391
C088658zoledronic acidzoledronic acid results in decreased expression of ITGB5 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001618virus receptor activity-IEA-  
GO:0005178integrin binding-IBA21873635  
GO:0005515protein binding-IPI1694173  15611078  19910644  21397862  21642953  24997346  
25448675  
GO:0038023signaling receptor activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent-TAS-  
GO:0006936muscle contraction-TAS-  
GO:0007160cell-matrix adhesion-IBA21873635  
GO:0007160cell-matrix adhesion-IMP24036928  
GO:0007179transforming growth factor beta receptor signaling pathway-IMP24036928  
GO:0007229integrin-mediated signaling pathway-IBA21873635  
GO:0007229integrin-mediated signaling pathway-IMP24036928  
GO:0016477cell migration-IBA21873635  
GO:0030198extracellular matrix organization-TAS-  
GO:0033627cell adhesion mediated by integrin-IBA21873635  
GO:0035987endodermal cell differentiation-IEP23154389  
GO:0043149stress fiber assembly-IMP24036928  
GO:0046718viral entry into host cell-IEA-  
GO:0090136epithelial cell-cell adhesion-IMP24036928  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005925focal adhesion-HDA21423176  
GO:0005925focal adhesion-IBA21873635  
GO:0008305integrin complex-IBA21873635  
GO:0009986cell surface-HDA23658023  
GO:0009986cell surface-IBA21873635  
GO:0009986cell surface-IDA7525578  23154389  24036928  25063885  
GO:0034684integrin alphav-beta5 complex-IDA25063885  
GO:0043235receptor complex-IDA23382219  
GO:0045335phagocytic vesicle-TAS-  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
hsa04145Phagosome
hsa04510Focal adhesion
hsa04512ECM-receptor interaction
hsa04810Regulation of actin cytoskeleton
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
hsa05414Dilated cardiomyopathy
Reactome ID Reactome Term Evidence
R-HSA-1236973Cross-presentation of particulate exogenous antigens (phagosomes)TAS
R-HSA-1236975Antigen processing-Cross presentationTAS
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-1474244Extracellular matrix organizationIEA
R-HSA-1566948Elastic fibre formationTAS
R-HSA-168256Immune SystemTAS
R-HSA-2129379Molecules associated with elastic fibresTAS
R-HSA-216083Integrin cell surface interactionsTAS
R-HSA-216083Integrin cell surface interactionsIEA
R-HSA-3000170Syndecan interactionsIEA
R-HSA-3000170Syndecan interactionsTAS
R-HSA-3000171Non-integrin membrane-ECM interactionsIEA
R-HSA-3000171Non-integrin membrane-ECM interactionsTAS
R-HSA-3000178ECM proteoglycansTAS
R-HSA-397014Muscle contractionTAS
R-HSA-445355Smooth Muscle ContractionTAS
R-HSA-983169Class I MHC mediated antigen processing & presentationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal