Gene: ITGB6

3694
AI1H
integrin subunit beta 6
protein-coding
2q24.2
Ensembl:ENSG00000115221 MIM:147558 Vega:OTTHUMG00000132026 UniprotKB:P18564
NG_042041.1
PubMed
0   ANCO-SNPs
CD|ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.702e-1 (AD)  5.181e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C9orf1350.567
ZNF1140.553
AGTR10.53
PIRT0.526
LGALS120.526
C7orf310.521
HAS20.52
RPL22L10.519
FABP50.514
STON10.512

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KIF21B-0.444
KCNT1-0.415
SCRT1-0.414
ELFN2-0.413
KCNQ4-0.411
EXTL1-0.405
MPPED1-0.405
ADAMTSL2-0.404
NEUROD2-0.404
WNK2-0.402

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of ITGB6 mRNA"19114083
C0909424-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [TGFB1 protein results in increased expression of ITGB6 mRNA]21303922
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITGB6 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITGB6 mRNA"27188386
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of ITGB6 mRNA12419474
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITGB6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITGB6 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of ITGB6 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of ITGB6 mRNA23630614
D000639AmitriptylineAmitriptyline results in decreased expression of ITGB6 mRNA22341215
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ITGB6 mRNA18164116
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of ITGB6 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ITGB6 mRNA22178795
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ITGB6 mRNA21569818|2222880
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ITGB6 mRNA21839799
D004958EstradiolEGF protein inhibits the reaction [Estradiol results in decreased expression of ITGB6 mRNA]24758408
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of ITGB6 mRNA20660070
D004958EstradiolEstradiol results in decreased expression of ITGB6 mRNA23019147|2475840
D004958Estradiol[Progesterone co-treated with Estradiol] results in decreased expression of ITGB6 mRNA17404688
C095105bexarotenebexarotene results in increased expression of ITGB6 mRNA17178900
C006780bisphenol Abisphenol A results in increased expression of ITGB6 mRNA26063408
C006780bisphenol Abisphenol A results in decreased expression of ITGB6 mRNA25181051
D000069286BortezomibBortezomib results in increased expression of ITGB6 mRNA20977926
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of ITGB6 mRNA12419474
D002101Cacodylic AcidCacodylic Acid results in decreased expression of ITGB6 mRNA17720352
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of ITGB6 mRNA23741332
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of ITGB6 mRNA25827057
D002737ChloropreneChloroprene results in decreased expression of ITGB6 mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ITGB6 mRNA20938992
C018021cobaltous chloridecobaltous chloride results in decreased expression of ITGB6 mRNA24386269
D003042CocaineCocaine results in increased expression of ITGB6 mRNA18000554
D003300Copper[Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of ITGB6 mRNA22276220
D003471CuprizoneCuprizone results in increased expression of ITGB6 mRNA26577399
D003513CycloheximideCycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of ITGB6 mRNA]11007951
D003513CycloheximideCycloheximide inhibits the reaction [TGFB1 protein results in increased expression of ITGB6 mRNA]21303922
D016572CyclosporineCyclosporine results in decreased expression of ITGB6 mRNA27989131
C017160cypermethrincypermethrin results in increased expression of ITGB6 mRNA22528246
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of ITGB6 mRNA]27941970
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ITGB6 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of ITGB6 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of ITGB6 mRNA27392435
D004041Dietary FatsDietary Fats results in decreased expression of ITGB6 mRNA25016146
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ITGB6 mRNA18164116
D002117CalcitriolCalcitriol results in increased expression of ITGB6 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of ITGB6 mRNA21592394
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of ITGB6 mRNA"19480007
C529593EMD 527040EMD 527040 binds to and results in decreased activity of [ITGA5 protein binds to ITGB6 protein]18221819
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of ITGB6 mRNA26865667
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ITGB6 mRNA17557909
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ITGB6 mRNA20938992
C039281furanfuran results in increased expression of ITGB6 mRNA27387713
C039281furanfuran results in increased methylation of ITGB6 gene22079235
C056507gemcitabine[ITGB6 co-treated with ITGAV] affects the susceptibility to gemcitabine20150628
D019833GenisteinGenistein affects the expression of ITGB6 mRNA26865667
D019833GenisteinGenistein results in decreased expression of ITGB6 mRNA23019147
C071834glycidamideglycidamide results in decreased expression of ITGB6 mRNA17822822
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of ITGB6 mRNA12419474
C041508indeno(1,2,3-cd)pyrene"indeno(1,2,3-cd)pyrene results in decreased expression of ITGB6 mRNA"26377693
C016517indole-3-carbinolindole-3-carbinol affects the expression of ITGB6 mRNA21396975
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of ITGB6 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ITGB6 mRNA24796395
C000589733leukadherin-1FGG protein affects the reaction [leukadherin-1 inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of ITGB6 mRNA]]26921287
C000589733leukadherin-1leukadherin-1 inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of ITGB6 mRNA]26921287
C025340manganese chloridemanganese chloride results in decreased methylation of ITGB6 gene27913844
C042720mercuric bromidemercuric bromide results in increased expression of ITGB6 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITGB6 mRNA"27188386
D008713MethimazoleMethimazole results in increased expression of ITGB6 mRNA22504374
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ITGB6 mRNA20938992
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of ITGB6 mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased methylation of ITGB6 promoter"26251327
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of ITGB6 mRNA23876855
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of ITGB6 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ITGB6 mRNA"25554681
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of [ITGB6 protein co-treated with ITGA5 protein]21037076
D0150581-Naphthylisothiocyanate[1-Naphthylisothiocyanate results in increased expression of [ITGB6 protein co-treated with ITGA5 protein]] which results in increased activity of TGFB1 protein21037076
D0150581-NaphthylisothiocyanateF2R protein promotes the reaction [1-Naphthylisothiocyanate results in increased expression of [ITGB6 protein co-treated with ITGA5 protein]]21037076
D0150581-NaphthylisothiocyanateF3 protein promotes the reaction [1-Naphthylisothiocyanate results in increased expression of [ITGB6 protein co-treated with ITGA5 protein]]21037076
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of ITGB6 mRNA21037076|2463342
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of ITGB6 protein22094456
D0150581-NaphthylisothiocyanateEGR1 protein affects the reaction [1-Naphthylisothiocyanate results in increased expression of ITGB6 protein]22094456
D0150581-NaphthylisothiocyanateF2R protein promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ITGB6 mRNA]21037076
D0150581-NaphthylisothiocyanateF3 protein promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ITGB6 mRNA]21037076
D0150581-NaphthylisothiocyanateFGG protein affects the reaction [1-Naphthylisothiocyanate results in increased expression of ITGB6 mRNA]26921287
D0150581-NaphthylisothiocyanateFGG protein affects the reaction [leukadherin-1 inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of ITGB6 mRNA]]26921287
D0150581-NaphthylisothiocyanateIFNG protein affects the reaction [1-Naphthylisothiocyanate results in increased expression of ITGB6 mRNA]26921287
D0150581-Naphthylisothiocyanate[ITGA5 protein co-treated with ITGB6 protein] promotes the reaction [1-Naphthylisothiocyanate results in increased phosphorylation of SMAD2 protein]21037076
D0150581-Naphthylisothiocyanateleukadherin-1 inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of ITGB6 mRNA]26921287
D0150581-NaphthylisothiocyanateRAG1 gene mutant form inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of ITGB6 mRNA]28049044
D0150581-NaphthylisothiocyanateTGFB1 protein promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ITGB6 mRNA]21037076
D009532NickelNickel results in increased expression of ITGB6 mRNA25583101
D017239PaclitaxelPaclitaxel results in decreased expression of ITGB6 mRNA19682730
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in increased expression of ITGB6 mRNA23602845
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITGB6 mRNA"27188386
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ITGB6 mRNA19710929
D017035PravastatinPravastatin affects the expression of ITGB6 mRNA27225895
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of ITGB6 mRNA20660070
D011374Progesterone[Progesterone co-treated with Estradiol] results in decreased expression of ITGB6 mRNA17404688
D011441PropylthiouracilPropylthiouracil results in increased expression of ITGB6 mRNA22504374
C093642SB 203580SB 203580 inhibits the reaction [TGFB1 protein results in increased expression of ITGB6 mRNA]21303922
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of ITGB6 mRNA25895662
C009277sodium arsenatesodium arsenate results in decreased expression of ITGB6 mRNA12727804
C017947sodium arsenitesodium arsenite results in decreased expression of ITGB6 mRNA12727804|2387685
D053260SootSoot results in increased expression of ITGB6 mRNA22461453|2655175
C075117squalestatin 1squalestatin 1 affects the expression of ITGB6 mRNA27225895
C075117squalestatin 1squalestatin 1 results in decreased expression of ITGB6 mRNA27225895
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of ITGB6 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of ITGB6 mRNA21592394
D013749TetrachlorodibenzodioxinCycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of ITGB6 mRNA]11007951
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ITGB6 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ITGB6 mRNA23152189
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ITGB6 mRNA11007951
D013755Tetradecanoylphorbol Acetate[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of ITGB6 mRNA16979875
C020809tetrathiomolybdate[Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of ITGB6 mRNA22276220
D013853ThioacetamideThioacetamide results in increased expression of ITGB6 mRNA18221819
C009495titanium dioxidetitanium dioxide results in increased expression of ITGB6 mRNA19695317
C009495titanium dioxidetitanium dioxide results in increased expression of ITGB6 mRNA23557971
D014118Toxins, Biological"Toxins, Biological affects the expression of ITGB6 mRNA"19682533
C012589trichostatin Atrichostatin A results in increased expression of ITGB6 mRNA24935251
D017974Uranium CompoundsUranium Compounds results in increased expression of ITGB6 mRNA19654044
D014635Valproic AcidValproic Acid results in increased expression of ITGB6 mRNA24383497
D014635Valproic AcidValproic Acid results in increased methylation of ITGB6 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of ITGB6 gene25560391
C025643vinclozolinvinclozolin affects the expression of ITGB6 mRNA19015723
D015032Zinc[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of ITGB6 mRNA16979875
D015032ZincZinc results in decreased expression of ITGB6 mRNA19071009
D015032ZincZinc results in increased expression of ITGB6 mRNA16870260
C016837zinc chloridezinc chloride results in increased expression of ITGB6 mRNA16870260

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001618virus receptor activity-IEA-  
GO:0005178integrin binding-IBA21873635  
GO:0005178integrin binding-IEA-  
GO:0005515protein binding-IPI17158881  21677751  25383667  
GO:0038023signaling receptor activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006954inflammatory response-IEA-  
GO:0007155cell adhesion-TAS2365683  
GO:0007160cell-matrix adhesion-IBA21873635  
GO:0007160cell-matrix adhesion-IEA-  
GO:0007229integrin-mediated signaling pathway-IBA21873635  
GO:0007229integrin-mediated signaling pathway-IEA-  
GO:0016477cell migration-IBA21873635  
GO:0030198extracellular matrix organization-TAS-  
GO:0033627cell adhesion mediated by integrin-IBA21873635  
GO:0033627cell adhesion mediated by integrin-IDA17158881  
GO:0038044transforming growth factor-beta secretion-IEA-  
GO:0046718viral entry into host cell-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005813centrosome-IDA-  
GO:0005886plasma membrane-TAS-  
GO:0005925focal adhesion-IBA21873635  
GO:0005925focal adhesion-IDA17158881  
GO:0008305integrin complex-IBA21873635  
GO:0008305integrin complex-TAS2365683  
GO:0009897external side of plasma membrane-IEA-  
GO:0009986cell surface-IBA21873635  
GO:0030054cell junction-IDA-  
GO:0034685integrin alphav-beta6 complex-IBA21873635  
GO:0034685integrin alphav-beta6 complex-IEA-  
GO:0043235receptor complex-IDA23382219  
KEGG ID KEGG Term
hsa04510Focal adhesion
hsa04512ECM-receptor interaction
hsa04810Regulation of actin cytoskeleton
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
hsa05414Dilated cardiomyopathy
Reactome ID Reactome Term Evidence
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-1566948Elastic fibre formationTAS
R-HSA-2129379Molecules associated with elastic fibresTAS
R-HSA-216083Integrin cell surface interactionsTAS
R-HSA-3000178ECM proteoglycansTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18000554Gene expression in human hippocampus from cocaine abusers identifies genes which regulate extracellular matrix remodeling. (2007 Nov 14)Mash DCPLoS One
24043489Functional characterization of a porcine emphysema model. (2013 Dec)Bruun CSLung