Gene info: ID 3695

Gene: ITGB7

GENE ID: 3695

Synonyms: -

Description: integrin subunit beta 7

Gene type: protein-coding

Location: 12q13.13

dbXrefs: Ensembl:ENSG00000139626 MIM:147559 Vega:OTTHUMG00000169775 UniprotKB:P26010

RefSeq: NC_000012.12

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 6.475e-2 (AD) 1.577e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg08699196	chr12:53591398	ITGB7		4.000e-9	Maternal smoking in pregnancy	27040690
cg08699196	chr12:53591398	ITGB7		1.220e-8	Maternal smoking in pregnancy	27040690

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SLC15A3	0.745
BTN3A1	0.731
SP110	0.714
TLR3	0.711
TRIM21	0.708
ADAP2	0.704
CXCL16	0.702
TGIF2	0.699
TRIM5	0.698
EHD4	0.697

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
KCNB2	-0.429
MYADML2	-0.409
ISLR2	-0.39
CHRNB2	-0.385
SV2B	-0.38
MUM1L1	-0.378
AMER3	-0.376
CLEC2L	-0.375
AGBL4	-0.375
HCN1	-0.375

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB05122	R1295	Small Molecule	-	Investigational	Target
DB09033	Vedolizumab	BiotechDrug	943609-66-3	Approved	Target

ID	Drug Name	Action	PubMed
D000082	Acetaminophen	Acetaminophen affects the expression of ITGB7 mRNA	17562736
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of ITGB7 gene	27153756
C430898	AGN 194204	AGN 194204 results in increased expression of ITGB7 mRNA	16339527
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of ITGB7 mRNA	16483693
D000968	Antimycin A	Antimycin A results in increased expression of ITGB7 mRNA	19304788
C006632	arsenic trioxide	arsenic trioxide results in increased expression of ITGB7 mRNA	15761015
C022921	benzo(k)fluoranthene	benzo(k)fluoranthene results in increased expression of ITGB7 mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of ITGB7 mRNA	20064835
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of ITGB7 mRNA	21569818
C006780	bisphenol A	bisphenol A results in decreased expression of ITGB7 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of ITGB7 gene	28505145
D002737	Chloroprene	Chloroprene results in decreased expression of ITGB7 mRNA	23125180
C074702	chromium hexavalent ion	chromium hexavalent ion affects the expression of ITGB7 mRNA	28472532
D002994	Clofibrate	Clofibrate results in increased expression of ITGB7 mRNA	17585979
D003042	Cocaine	Cocaine results in decreased expression of ITGB7 mRNA	17898221
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of ITGB7 mRNA	24317228
D003907	Dexamethasone	Dexamethasone results in increased expression of ITGB7 mRNA	21041162
D002945	Cisplatin	Cisplatin results in increased expression of ITGB7 mRNA	27594783
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate affects the expression of ITGB7 mRNA	26924002
D004026	Dieldrin	Dieldrin results in increased expression of ITGB7 mRNA	28385952
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of ITGB7 mRNA	15766595
C024629	dimethyl phthalate	dimethyl phthalate affects the expression of ITGB7 mRNA	26924002
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of ITGB7 mRNA	17555576
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of ITGB7 mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ITGB7 mRNA	17942748
D005419	Flavonoids	Flavonoids results in decreased expression of ITGB7 mRNA	18035473
D005557	Formaldehyde	Formaldehyde results in decreased expression of ITGB7 mRNA	23649840
C039281	furan	furan results in increased expression of ITGB7 mRNA	27387713
D005839	Gentamicins	Gentamicins results in increased expression of ITGB7 mRNA	22061828
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ITGB7 mRNA	25613284
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of ITGB7 mRNA	23086925
C072105	KN 93	KN 93 inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of ITGB7 mRNA]	18089838
D058185	Magnetite Nanoparticles	[Succimer binds to Magnetite Nanoparticles] which results in increased expression of ITGB7 mRNA	21641980
D020366	Methylmethacrylate	Methylmethacrylate results in increased expression of ITGB7 mRNA	16916219
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of ITGB7 mRNA	23649840
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of ITGB7 mRNA	26924002
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of ITGB7 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of ITGB7 mRNA"	25554681
C017096	n-butoxyethanol	n-butoxyethanol results in decreased expression of ITGB7 mRNA	19812364
D009532	Nickel	Nickel results in increased expression of ITGB7 mRNA	24768652\|2558310
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ITGB7 mRNA	19710929
D011441	Propylthiouracil	Propylthiouracil affects the expression of ITGB7 mRNA	24780913
D012402	Rotenone	Rotenone results in increased expression of ITGB7 mRNA	19304788
D017632	Asbestos, Serpentine	"Asbestos, Serpentine results in decreased expression of ITGB7 mRNA"	21148743
C458525	STO 609	STO 609 results in increased expression of ITGB7 mRNA	18755850
D004113	Succimer	[Succimer binds to Magnetite Nanoparticles] which results in increased expression of ITGB7 mRNA	21641980
C016766	sulforafan	sulforafan results in increased expression of ITGB7 mRNA	26833863
C061133	tamibarotene	tamibarotene results in increased expression of ITGB7 mRNA	15498508\|1722964
D013629	Tamoxifen	Tamoxifen affects the expression of ITGB7 mRNA	17555576
D013739	Testosterone	Testosterone results in increased expression of ITGB7 mRNA	22138414
D013749	Tetrachlorodibenzodioxin	KN 93 inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of ITGB7 mRNA]	18089838
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of ITGB7 mRNA	18089838\|1875585
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of ITGB7 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ITGB7 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of ITGB7 mRNA	20159946
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of ITGB7 mRNA	17337447\|2323856
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of ITGB7 mRNA	23238561
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ITGB7 mRNA	25613284
C009495	titanium dioxide	titanium dioxide results in decreased expression of ITGB7 mRNA	27760801
C009495	titanium dioxide	titanium dioxide results in increased expression of ITGB7 mRNA	23557971
D014118	Toxins, Biological	"Toxins, Biological affects the expression of ITGB7 mRNA"	19682533
D014212	Tretinoin	Tretinoin results in increased expression of ITGB7 mRNA	15498508\|1721838
D014241	Trichloroethylene	PPARA protein inhibits the reaction [Trichloroethylene results in increased expression of ITGB7 protein]	15363585
D014241	Trichloroethylene	Trichloroethylene results in increased expression of ITGB7 mRNA	15363585
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of ITGB7 mRNA"	26179874
D014639	Vanadium	Vanadium results in increased expression of ITGB7 mRNA	19000753
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of ITGB7 gene	25560391
D014750	Vincristine	Vincristine results in decreased expression of ITGB7 mRNA	23649840

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001618	virus receptor activity	-	IEA	-
GO:0005178	integrin binding	-	IBA	21873635
GO:0005515	protein binding	-	IPI	1542691 12606711 14681217 15225631 17690686 19828450 21524097 22232704
GO:0038023	signaling receptor activity	-	IEA	-
GO:0046872	metal ion binding	-	IEA	-
GO:0050839	cell adhesion molecule binding	-	IMP	23986478

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003366	cell-matrix adhesion involved in ameboidal cell migration	-	IMP	23986478
GO:0007155	cell adhesion	-	TAS	2040616
GO:0007160	cell-matrix adhesion	-	IBA	21873635
GO:0007160	cell-matrix adhesion	-	IMP	18308860 23986478
GO:0007229	integrin-mediated signaling pathway	-	IBA	21873635
GO:0007229	integrin-mediated signaling pathway	-	IMP	23986478
GO:0016477	cell migration	-	IBA	21873635
GO:0030198	extracellular matrix organization	-	TAS	-
GO:0033627	cell adhesion mediated by integrin	-	IBA	21873635
GO:0034113	heterotypic cell-cell adhesion	-	IMP	18308860
GO:0034446	substrate adhesion-dependent cell spreading	-	IMP	23986478
GO:0043113	receptor clustering	-	IMP	23986478
GO:0046718	viral entry into host cell	-	IEA	-
GO:0050776	regulation of immune response	-	TAS	-
GO:0050901	leukocyte tethering or rolling	-	IMP	18308860
GO:0072678	T cell migration	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005886	plasma membrane	-	TAS	-
GO:0005925	focal adhesion	-	IBA	21873635
GO:0008305	integrin complex	-	IBA	21873635
GO:0008305	integrin complex	-	TAS	2040616
GO:0009986	cell surface	-	IBA	21873635
GO:0009986	cell surface	-	IDA	18308860 23986478
GO:0016020	membrane	-	HDA	19946888
GO:0034669	integrin alpha4-beta7 complex	-	IDA	18308860 23986478
GO:0043235	receptor complex	-	IDA	23382219
GO:0070062	extracellular exosome	-	HDA	20458337

KEGG ID	KEGG Term
hsa04510	Focal adhesion
hsa04512	ECM-receptor interaction
hsa04514	Cell adhesion molecules (CAMs)
hsa04672	Intestinal immune network for IgA production
hsa04810	Regulation of actin cytoskeleton
hsa05410	Hypertrophic cardiomyopathy (HCM)
hsa05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)
hsa05414	Dilated cardiomyopathy

Reactome ID	Reactome Term	Evidence
R-HSA-1280218	Adaptive Immune System	TAS
R-HSA-1474244	Extracellular matrix organization	TAS
R-HSA-168256	Immune System	TAS
R-HSA-198933	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	TAS
R-HSA-216083	Integrin cell surface interactions	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
29695247	Impact on birth weight of maternal smoking throughout pregnancy mediated by DNA methylation. (2018 Apr 25)	Witt SH	BMC Genomics