Gene: ITGB8

3696
-
integrin subunit beta 8
protein-coding
7p21.1
Ensembl:ENSG00000105855 MIM:604160 Vega:OTTHUMG00000023594 UniprotKB:P26012
NC_000007.14
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.992e-2 (AD)  3.479e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RHOBTB30.885
LIFR0.883
KAT2B0.86
SASH10.859
QKI0.851
CPNE30.844
ITGAV0.839
MEGF100.836
PTPN130.835
BAZ2B0.832

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PNOC-0.498
ADRA1D-0.495
ABCC12-0.477
FBLN7-0.475
MCHR1-0.466
KRT5-0.461
RTP1-0.453
GRIP2-0.435
MYOZ3-0.434
PHOSPHO1-0.432

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of ITGB8 mRNA28329830
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl affects the expression of ITGB8 mRNA"20638727
C0127962-butenal[2-butenal co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of ITGB8 mRNA24849683
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl affects the expression of ITGB8 mRNA"20638727
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITGB8 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITGB8 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of ITGB8 gene27153756
D000393Air PollutantsAir Pollutants analog results in increased expression of ITGB8 mRNA21757418
C011512alpha-naphthoflavonealpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in decreased expression of ITGB8 mRNA]29094188
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of ITGB8 mRNA24449571
C547126AZM551248AZM551248 results in decreased expression of ITGB8 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ITGB8 mRNA20064835
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ITGB8 mRNA"19150397
D004958EstradiolEstradiol affects the expression of ITGB8 mRNA22574217
D004958EstradiolEstradiol results in decreased expression of ITGB8 mRNA19484750|2521013
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of ITGB8 mRNA26496021
C006780bisphenol Abisphenol A affects the expression of ITGB8 mRNA23557687
C006780bisphenol Abisphenol A results in decreased expression of ITGB8 mRNA20678512
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of ITGB8 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of ITGB8 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of ITGB8 mRNA29097150
C018475butyraldehydebutyraldehyde results in decreased expression of ITGB8 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in increased expression of ITGB8 mRNA12160620
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ITGB8 mRNA25827057
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ITGB8 mRNA20938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of ITGB8 gene20938992
D003035Cobalt[tungsten carbide co-treated with Cobalt] results in decreased expression of ITGB8 mRNA18078969
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of ITGB8 mRNA20971185
D003471CuprizoneCuprizone results in decreased expression of ITGB8 mRNA26577399|2752363
D003703DemecolcineDemecolcine results in increased expression of ITGB8 mRNA23649840
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ITGB8 mRNA17361019
D004041Dietary FatsDietary Fats results in decreased expression of ITGB8 mRNA25016146
D004041Dietary FatsDietary Fats results in increased expression of ITGB8 mRNA18042831
D002117CalcitriolCalcitriol results in increased expression of ITGB8 mRNA26485663
C521792DMU-212DMU-212 affects the expression of ITGB8 mRNA26428916
C118739entinostatentinostat results in decreased expression of ITGB8 mRNA27188386
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ITGB8 mRNA29097150
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of ITGB8 mRNA23649840
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of ITGB8 mRNA28329830
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ITGB8 mRNA20938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of ITGB8 gene20938992
D005557FormaldehydeFormaldehyde results in increased expression of ITGB8 mRNA23649840
D005557FormaldehydeFormaldehyde results in increased expression of ITGB8 mRNA23322811
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ITGB8 mRNA26752646
D018021Lithium ChlorideLithium Chloride results in increased expression of ITGB8 mRNA15711924
D008344Maneb[Paraquat co-treated with Maneb] affects the expression of ITGB8 mRNA22563483
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ITGB8 mRNA20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of ITGB8 gene20938992
D008727MethotrexateMethotrexate results in increased expression of ITGB8 mRNA21678067
D008748Methylcholanthrenealpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in decreased expression of ITGB8 mRNA]29094188
D008748MethylcholanthreneMethylcholanthrene results in decreased expression of ITGB8 mRNA29094188
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of ITGB8 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of ITGB8 mRNA23649840
C022838nickel chloridenickel chloride results in increased expression of ITGB8 mRNA17312168
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of ITGB8 mRNA20971185
C030110oxaliplatinoxaliplatin results in decreased expression of ITGB8 mRNA16510598
D000073878Palm OilPalm Oil results in increased expression of ITGB8 mRNA18042831
D010269Paraquat[Paraquat co-treated with Maneb] affects the expression of ITGB8 mRNA22563483
D010269ParaquatParaquat results in increased expression of ITGB8 mRNA22563483
D052638Particulate MatterParticulate Matter results in decreased expression of ITGB8 mRNA23085030
D010656PhenylephrinePhenylephrine results in increased expression of ITGB8 mRNA18158353
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITGB8 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of ITGB8 mRNA26272509
D010936Plant ExtractsPlant Extracts results in increased expression of ITGB8 mRNA21297082
D011192Potassium DichromatePotassium Dichromate results in increased expression of ITGB8 mRNA23608068
D011441PropylthiouracilPropylthiouracil results in decreased expression of ITGB8 mRNA24780913
C107773pterostilbenepterostilbene results in decreased expression of ITGB8 mRNA22450950
C107773pterostilbenepterostilbene results in increased expression of ITGB8 mRNA22450950
C428725pyridabenpyridaben results in increased expression of ITGB8 mRNA22563483
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of ITGB8 mRNA"24160326
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ITGB8 mRNA21354282
D013755Tetradecanoylphorbol Acetate[2-butenal co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of ITGB8 mRNA24849683
C009495titanium dioxidetitanium dioxide results in decreased expression of ITGB8 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of ITGB8 mRNA28065790
C012589trichostatin Atrichostatin A results in decreased expression of ITGB8 mRNA24935251
C012589trichostatin Atrichostatin A results in increased expression of ITGB8 mRNA24935251
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of ITGB8 mRNA19042947
C002802tungsten carbide[tungsten carbide co-treated with Cobalt] results in decreased expression of ITGB8 mRNA18078969
D014635Valproic AcidValproic Acid affects the expression of ITGB8 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of ITGB8 mRNA23179753|2493525
D014635Valproic AcidValproic Acid results in increased expression of ITGB8 mRNA27188386|2800136
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of ITGB8 gene25560391
D014750VincristineVincristine results in increased expression of ITGB8 mRNA23649840
C029297vinylidene chloridevinylidene chloride results in decreased expression of ITGB8 mRNA26682919
D015032ZincZinc results in increased expression of ITGB8 mRNA18316168

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005102signaling receptor binding-IEA-  
GO:0005178integrin binding-IBA21873635  
GO:0038023signaling receptor activity-IEA-  
GO:1990430extracellular matrix protein binding-IDA7525578  
GO ID GO Term Qualifier Evidence PubMed
GO:0001573ganglioside metabolic process-IEA-  
GO:0007155cell adhesion-TAS1918072  
GO:0007160cell-matrix adhesion-IBA21873635  
GO:0007160cell-matrix adhesionNOTIMP7525578  
GO:0007229integrin-mediated signaling pathway-IBA21873635  
GO:0007229integrin-mediated signaling pathway-IEA-  
GO:0010628positive regulation of gene expression-IMP24312400  
GO:0010629negative regulation of gene expression-IMP24312400  
GO:0016477cell migration-IBA21873635  
GO:0030198extracellular matrix organization-TAS-  
GO:0033627cell adhesion mediated by integrin-IBA21873635  
GO:0045766positive regulation of angiogenesis-IMP25801897  
GO:0051216cartilage development-IMP24312400  
GO:0060674placenta blood vessel development-TAS19267251  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005925focal adhesion-IBA21873635  
GO:0008305integrin complex-IBA21873635  
GO:0008305integrin complex-TAS1918072  
GO:0009986cell surface-IBA21873635  
GO:0009986cell surface-IDA1918072  7525578  
GO:0034686integrin alphav-beta8 complex-IDA1918072  7525578  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
hsa04510Focal adhesion
hsa04512ECM-receptor interaction
hsa04514Cell adhesion molecules (CAMs)
hsa04810Regulation of actin cytoskeleton
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
hsa05414Dilated cardiomyopathy
Reactome ID Reactome Term Evidence
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-1566948Elastic fibre formationTAS
R-HSA-2129379Molecules associated with elastic fibresTAS
R-HSA-216083Integrin cell surface interactionsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18549475Genome wide SNP comparative analysis between EGFR and KRAS mutated NSCLC and characterization of two models of oncogenic cooperation in non-small cell lung carcinoma. (2008 Jun 12)Blons HBMC Med Genomics