Gene: ITIH3

3699
H3P|ITI-HC3|SHAP
inter-alpha-trypsin inhibitor heavy chain 3
protein-coding
3p21.1
Ensembl:ENSG00000162267 MIM:146650 Vega:OTTHUMG00000158956 UniprotKB:Q06033
NC_000003.12
SNP Mapped
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.253e-1 (AD)  1.287e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs115714636chr3:52796511 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC13A40.86
PLN0.855
AOC30.853
MYOCD0.845
OGN0.835
COL8A10.828
KCNMB10.824
TRABD2B0.819
ACTA20.818
TBX180.807

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ASPDH-0.3
HES6-0.29
NANOS3-0.286
HAGHL-0.283
CLDND2-0.28
HHATL-0.261
SLC25A48-0.258
DOK7-0.252
TMEM74-0.242
NXPH3-0.239

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01593ZincSmall Molecule7440-66-6Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene affects the expression of ITIH3 mRNA"18281256
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of ITIH3 mRNA"28903501
C0364231-aminomethylphosphonic acid[Herbicides co-treated with 1-aminomethylphosphonic acid] results in decreased expression of ITIH3 mRNA20566314
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of ITIH3 mRNA"23962555
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of ITIH3 mRNA"19114083
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran affects the expression of ITIH3 mRNA"18343893
C0630022,3-dimethoxy-1,4-naphthoquinone"2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of ITIH3 mRNA"17547211
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of ITIH3 mRNA"21346803
D000082AcetaminophenAcetaminophen affects the expression of ITIH3 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ITIH3 mRNA27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ITIH3 mRNA16483693
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of ITIH3 mRNA"22863853
D000965AntimonyAntimony results in decreased expression of ITIH3 mRNA17547211
D000966Antimony Potassium TartrateAntimony Potassium Tartrate results in decreased expression of ITIH3 mRNA17547211
C547126AZM551248AZM551248 results in decreased expression of ITIH3 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ITIH3 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ITIH3 mRNA22300585
C095105bexarotenebexarotene results in decreased expression of ITIH3 mRNA16648578
C006780bisphenol Abisphenol A results in increased expression of ITIH3 mRNA27104808
C006780bisphenol Abisphenol A affects the expression of ITIH3 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of ITIH3 mRNA18804290
D002101Cacodylic AcidCacodylic Acid results in increased expression of ITIH3 mRNA17481689
D019256Cadmium ChlorideCadmium Chloride results in increased expression of ITIH3 mRNA18804290
D019256Cadmium ChlorideCadmium Chloride affects the expression of ITIH3 mRNA22110744
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of ITIH3 promoter22457795
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of ITIH3 mRNA12734012
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of ITIH3 mRNA18804290
D002857ChromiumChromium results in decreased expression of ITIH3 mRNA17547211
C039671ciglitazone[ciglitazone binds to PPARG protein alternative form] which results in increased expression of ITIH3 mRNA16197558
D002994ClofibrateClofibrate results in decreased expression of ITIH3 mRNA22300585
C018021cobaltous chloridecobaltous chloride results in decreased expression of ITIH3 mRNA24386269
D003471CuprizoneCuprizone results in increased expression of ITIH3 mRNA27523638
D016572CyclosporineCyclosporine results in decreased expression of ITIH3 mRNA25562108
D016572CyclosporineCyclosporine results in increased expression of ITIH3 mRNA20106945|2163298
C093628cyproconazolecyproconazole results in decreased expression of ITIH3 mRNA22334560
C016366dibenzothiophenedibenzothiophene results in decreased expression of ITIH3 mRNA23656968
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of ITIH3 mRNA28962523
D004008DiclofenacDiclofenac results in increased expression of ITIH3 mRNA26934552
D004041Dietary FatsDietary Fats results in decreased expression of ITIH3 mRNA25016146
C014476diethyl maleatediethyl maleate results in decreased expression of ITIH3 mRNA25270620
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of ITIH3 mRNA28943392
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of ITIH3 mRNA20360939
C109476epoxiconazoleepoxiconazole results in decreased expression of ITIH3 mRNA22334560
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of ITIH3 mRNA17555576
C024565ethylene dichlorideethylene dichloride results in increased expression of ITIH3 mRNA28189721
D005632FructoseFructose results in decreased expression of ITIH3 protein26930160
C039281furanfuran results in decreased expression of ITIH3 mRNA25539665
D005839GentamicinsGentamicins results in decreased expression of ITIH3 mRNA22061828
C508665gold (III) porphyrin 1agold (III) porphyrin 1a results in decreased expression of ITIH3 mRNA16206274
C412815GW 4064GW 4064 results in increased expression of ITIH3 mRNA26655953
D006540Herbicides[Herbicides co-treated with 1-aminomethylphosphonic acid] results in decreased expression of ITIH3 mRNA20566314
D007545IsoproterenolIsoproterenol results in increased expression of ITIH3 mRNA20003209
D007649KetamineKetamine results in increased expression of ITIH3 mRNA20080153
D007657Ketone BodiesKetone Bodies results in increased expression of ITIH3 mRNA16807920
C017461lead nitrate[nickel chloride co-treated with lead nitrate] results in increased expression of ITIH3 mRNA19187980
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of ITIH3 mRNA27339419
D008627Mercuric ChlorideMercuric Chloride affects the expression of ITIH3 mRNA20353558
D008628MercuryMercury results in decreased expression of ITIH3 mRNA17547211
D008748MethylcholanthreneMethylcholanthrene results in increased expression of ITIH3 mRNA18804290
C020300monomethylarsonic acidmonomethylarsonic acid results in increased expression of ITIH3 mRNA17481689
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of ITIH3 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ITIH3 mRNA"25554681|2562005
D009532NickelITIH3 protein binds to Nickel23896426
C022838nickel chloride[nickel chloride co-treated with lead nitrate] results in increased expression of ITIH3 mRNA19187980
C022838nickel chloridenickel chloride results in increased expression of ITIH3 mRNA19187980
C016030pantogabpantogab results in increased expression of ITIH3 mRNA17379144
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in decreased expression of ITIH3 mRNA23602845
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of ITIH3 protein26879310
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of ITIH3 mRNA18804290
C027579periodate-oxidized adenosineperiodate-oxidized adenosine affects the expression of ITIH3 mRNA17097637
D010578PetroleumPetroleum affects the expression of ITIH3 mRNA25208076
C014153pirimiphos methylpirimiphos methyl results in increased expression of ITIH3 mRNA27845199
C006253pirinixic acidpirinixic acid results in increased expression of ITIH3 mRNA18445702
D010936Plant ExtractsPlant Extracts results in decreased expression of ITIH3 mRNA23557933
D011192Potassium DichromatePotassium Dichromate results in decreased expression of ITIH3 mRNA17547211
D011192Potassium DichromatePotassium Dichromate results in decreased expression of ITIH3 mRNA23608068
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of ITIH3 mRNA28903501
C045950propiconazolepropiconazole results in decreased expression of ITIH3 mRNA19363144|2233456
D011441PropylthiouracilPropylthiouracil results in decreased expression of ITIH3 mRNA24780913
D011794QuercetinQuercetin affects the expression of ITIH3 mRNA21632981
C059514resveratrolresveratrol results in increased expression of ITIH3 mRNA23419489
C009277sodium arsenatesodium arsenate results in increased expression of ITIH3 mRNA23922661
C017947sodium arsenitesodium arsenite results in increased expression of ITIH3 mRNA16014739
D012999SomanSoman results in decreased expression of ITIH3 mRNA19281266
D013629TamoxifenTamoxifen affects the expression of ITIH3 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ITIH3 mRNA18343893|2892240
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ITIH3 mRNA16267337
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of ITIH3 mRNA28943392
C032910triadimefontriadimefon results in decreased expression of ITIH3 mRNA26705709
C052920trimethylarsine oxidetrimethylarsine oxide results in increased expression of ITIH3 mRNA17481689
D014635Valproic AcidValproic Acid results in decreased expression of ITIH3 mRNA29154799
C029297vinylidene chloridevinylidene chloride results in increased expression of ITIH3 mRNA26682919
D014874Water Pollutants, Chemical"Water Pollutants, Chemical affects the expression of ITIH3 mRNA"25208076
D015032ZincITIH3 protein binds to Zinc23896426
C088658zoledronic acidzoledronic acid results in increased expression of ITIH3 protein28871336

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004866endopeptidase inhibitor activity-TAS2465147  
GO:0004867serine-type endopeptidase inhibitor activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002576platelet degranulation-TAS-  
GO:0010951negative regulation of endopeptidase activity-IEA-  
GO:0030212hyaluronan metabolic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-NAS14718574  
GO:0005576extracellular region-TAS-  
GO:0031089platelet dense granule lumen-TAS-  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-114608Platelet degranulation TAS
R-HSA-76002Platelet activation, signaling and aggregationTAS
R-HSA-76005Response to elevated platelet cytosolic Ca2+TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal