Gene: ITIH4

3700
GP120|H4P|IHRP|ITI-HC4|ITIHL1|PK-120|PK120
inter-alpha-trypsin inhibitor heavy chain family member 4
protein-coding
3p21.1
Ensembl:ENSG00000055955 MIM:600564 Vega:OTTHUMG00000159023 UniprotKB:Q14624
NG_016006.1
PubMed
0   ANCO-SNPs
ND
1   
4.626e-1 (AD)  4.289e-1 (ND)   (Frontal_Cortex)
3.214e-1 (AD)  7.470e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
IDUA0.768
LENG80.76
MICAL10.754
SPPL2B0.75
ZNF2760.739
EXD30.737
CHTF180.736
PLA2G4B0.732
TTC21A0.731
WDR900.73

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DLEU1-0.324
OR4F5-0.32
OR4F29-0.306
MTRNR2L10-0.274
MTRNR2L9-0.273
MTRNR2L6-0.266
CYP39A1-0.266
KLRC2-0.264
ZNF114-0.263
PHEX-0.262

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01593ZincSmall Molecule7440-66-6Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of ITIH4 mRNA"19162173
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of ITIH4 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of ITIH4 mRNA"21346803
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of ITIH4 mRNA]"19467301
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of ITIH4 mRNA"23196670
C0179063-dinitrobenzene3-dinitrobenzene results in increased expression of ITIH4 mRNA24140754
C0293704-toluidine4-toluidine results in decreased expression of ITIH4 mRNA27638505
D000082AcetaminophenAcetaminophen results in decreased expression of ITIH4 mRNA29067470
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of ITIH4 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of ITIH4 mRNA]17585979
D016604Aflatoxin B1Aflatoxin B1 affects the expression of ITIH4 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ITIH4 mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ITIH4 mRNA19770486
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of ITIH4 mRNA21298039
D000537Aluminum Oxide"[Nanotubes, Carbon co-treated with Aluminum Oxide] results in increased secretion of ITIH4 protein"25598225
D000638AmiodaroneAmiodarone affects the expression of ITIH4 mRNA19483382
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of ITIH4 mRNA26377693
D001553BenzbromaroneBenzbromarone affects the expression of ITIH4 mRNA19483382
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ITIH4 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ITIH4 mRNA22228805
D004958EstradiolEstradiol inhibits the reaction [Lipopolysaccharides results in increased expression of ITIH4 mRNA]16977382
D004958EstradiolEstradiol results in increased expression of ITIH4 mRNA17010207
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of ITIH4 mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of ITIH4 mRNA27104808
C006780bisphenol Abisphenol A results in decreased expression of ITIH4 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of ITIH4 gene28505145
D001966BromineBromine results in increased expression of ITIH4 mRNA21391292
C032036bromobenzenebromobenzene results in decreased expression of ITIH4 mRNA12628495
D002104CadmiumCadmium results in decreased expression of ITIH4 mRNA24376830
D002104CadmiumITIH4 protein binds to Cadmium23896426
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of ITIH4 promoter22457795
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ITIH4 mRNA16239168
D002793Cholic Acids[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of ITIH4 mRNA27344345
D002793Cholic Acids[Cyclosporine co-treated with Cholic Acids] affects the expression of ITIH4 mRNA27344345
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of ITIH4 mRNA17585979
D002994ClofibrateClofibrate results in decreased expression of ITIH4 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of ITIH4 mRNA]17585979
D002994ClofibrateClofibrate affects the expression of ITIH4 mRNA19483382
C018021cobaltous chloridecobaltous chloride results in decreased expression of ITIH4 mRNA24386269
D003300CopperITIH4 protein binds to Copper23896426
C029892cupric chloridecupric chloride results in decreased expression of ITIH4 mRNA24650576
D016572Cyclosporine[Cyclosporine co-treated with Cholic Acids] affects the expression of ITIH4 mRNA27344345
D016572CyclosporineCyclosporine results in decreased expression of ITIH4 mRNA20106945|2798913
D016572CyclosporineCyclosporine results in decreased methylation of ITIH4 promoter27989131
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of ITIH4 mRNA28628672
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of ITIH4 mRNA28962523
D002945CisplatinCisplatin results in decreased expression of ITIH4 mRNA27392435
D004008DiclofenacDiclofenac results in increased expression of ITIH4 mRNA26934552
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of ITIH4 mRNA]"19467301
D004041Dietary FatsDietary Fats results in decreased expression of ITIH4 mRNA25016146
D004041Dietary FatsDietary Fats results in increased expression of ITIH4 mRNA19467301
C014476diethyl maleatediethyl maleate results in decreased expression of ITIH4 mRNA25270620
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of ITIH4 mRNA17010207
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in decreased expression of ITIH4 mRNA27638505
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ITIH4 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ITIH4 mRNA17942748
D005001EthionineEthionine affects the expression of ITIH4 mRNA19483382
C056933fumonisin B1fumonisin B1 results in decreased expression of ITIH4 mRNA16221962
C039281furanfuran results in decreased expression of ITIH4 mRNA15120968|2553966
D017313FenretinideFenretinide results in increased expression of ITIH4 mRNA28973697
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of ITIH4 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of ITIH4 mRNA28628672
D007545IsoproterenolIsoproterenol results in increased expression of ITIH4 mRNA20003209
C544151jinfukangjinfukang results in increased expression of ITIH4 mRNA27392435
D007657Ketone BodiesKetone Bodies results in decreased expression of ITIH4 mRNA16807920
D007854LeadITIH4 protein binds to Lead23896426
C008261lead acetatelead acetate results in increased expression of ITIH4 mRNA22609695
C017461lead nitrate[nickel chloride co-treated with lead nitrate] results in increased expression of ITIH4 mRNA19187980
D008070LipopolysaccharidesEstradiol inhibits the reaction [Lipopolysaccharides results in increased expression of ITIH4 mRNA]16977382
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of ITIH4 mRNA16977382|2733941
D008628MercuryMercury affects the expression of ITIH4 protein22030286
D008727MethotrexateMethotrexate results in increased expression of ITIH4 mRNA15120968
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of ITIH4 protein24055825
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of ITIH4 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of ITIH4 mRNA"25554681|2562005
D037742Nanotubes, Carbon"[Nanotubes, Carbon co-treated with Aluminum Oxide] results in increased secretion of ITIH4 protein"25598225
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ITIH4 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased secretion of ITIH4 protein"25598225
D0150581-Naphthylisothiocyanate[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of ITIH4 mRNA27344345
D009532NickelITIH4 protein binds to Nickel23896426
C022838nickel chloride[nickel chloride co-treated with lead nitrate] results in increased expression of ITIH4 mRNA19187980
C022838nickel chloridenickel chloride results in increased expression of ITIH4 mRNA19187980
C028007nickel monoxidenickel monoxide results in increased expression of ITIH4 mRNA19167457
C474055octylphenoloctylphenol results in increased expression of ITIH4 mRNA17010207
C076029olanzapineolanzapine affects the phosphorylation of ITIH4 protein25821032
D009853OmeprazoleOmeprazole affects the expression of ITIH4 mRNA19483382
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of ITIH4 mRNA19162173
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ITIH4 mRNA19710929
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in decreased expression of ITIH4 mRNA20813756
C006253pirinixic acidpirinixic acid results in decreased expression of ITIH4 mRNA16221962|2005976
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in decreased expression of ITIH4 mRNA]20059764
C006253pirinixic acidpirinixic acid affects the expression of ITIH4 mRNA19483382
C006253pirinixic acidpirinixic acid results in decreased expression of ITIH4 mRNA19162173
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of ITIH4 mRNA28903501
D011441PropylthiouracilPropylthiouracil affects the expression of ITIH4 mRNA19483382
D054328Proton Pump InhibitorsProton Pump Inhibitors results in decreased expression of ITIH4 mRNA25626140
C016104sodium bichromatesodium bichromate affects the expression of ITIH4 mRNA22110744
D012969Sodium FluorideSodium Fluoride results in increased expression of ITIH4 protein28918527
D053260SootSoot results in increased expression of ITIH4 mRNA22461453|2655175
C010792testosterone undecanoatetestosterone undecanoate results in increased expression of ITIH4 mRNA19074003
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ITIH4 mRNA17942748
D013853ThioacetamideThioacetamide affects the expression of ITIH4 mRNA19483382
C009495titanium dioxidetitanium dioxide results in increased expression of ITIH4 mRNA19464567|2355797
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of ITIH4 mRNA20133372
D014635Valproic AcidValproic Acid results in decreased expression of ITIH4 mRNA29154799
D001335Vehicle EmissionsVehicle Emissions affects the methylation of ITIH4 gene25560391
D015215Zidovudine[Zidovudine co-treated with IFNA1 protein] results in increased expression of ITIH4 mRNA20370541
D015032ZincITIH4 protein binds to Zinc23896426

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004866endopeptidase inhibitor activity-TAS9756925  
GO:0004867serine-type endopeptidase inhibitor activity-IEA-  
GO:0005515protein binding-IPI16271702  
GO ID GO Term Qualifier Evidence PubMed
GO:0002576platelet degranulation-TAS-  
GO:0006953acute-phase response-IEP19263524  
GO:0010951negative regulation of endopeptidase activity-IEA-  
GO:0030212hyaluronan metabolic process-IEA-  
GO:0034097response to cytokine-IEP10486281  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-NAS14718574  
GO:0005576extracellular region-TAS-  
GO:0031089platelet dense granule lumen-TAS-  
GO:0070062extracellular exosome-HDA19056867  23533145  
GO:0072562blood microparticle-HDA22516433  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-114608Platelet degranulation TAS
R-HSA-76002Platelet activation, signaling and aggregationTAS
R-HSA-76005Response to elevated platelet cytosolic Ca2+TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26130910Comparative evaluation of risk factors, outcome and biomarker levels in young and old acute ischemic stroke patients. (2015 Apr)Kawle APAnn Neurosci