Gene info: ID 3702

Gene: ITK

GENE ID: 3702

Synonyms: EMT|LPFS1|LYK|PSCTK2

Description: IL2 inducible T cell kinase

Gene type: protein-coding

Location: 5q33.3

dbXrefs: Ensembl:ENSG00000113263 MIM:186973 Vega:OTTHUMG00000130245 UniprotKB:Q08881

RefSeq: NG_016276.1

Retrived from: SNP Mapped

SNPs: 1 ANCO-SNPs

Phenotype: AD

# Publications: 0

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 4.424e-1 (AD) 6.311e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs13190673	chr5:157244863 (GRCh38.p7)	C>A	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
LRRC15	0.856
CALCA	0.83
DMBX1	0.824
CHRNB4	0.802
TAS2R60	0.771
IL20	0.768
ADM2	0.765
PLEKHS1	0.763
CRYBA4	0.75
RAX	0.75

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OMG	-0.351
ASIC2	-0.288
KHDC1	-0.284
SEC14L5	-0.28
C19orf73	-0.28
B3GALT2	-0.28
CKMT1B	-0.28
AMER3	-0.279
YPEL4	-0.279
GPR150	-0.277

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB02010	Staurosporine	Small Molecule	62996-74-1	Experimental	Target
DB06589	Pazopanib	Small Molecule	444731-52-6	Approved	Target

ID	Drug Name	Action	PubMed
C027309	3,4,5,3',4',5'-hexachlorobiphenyl	"3,4,5,3',4',5'-hexachlorobiphenyl results in increased expression of ITK mRNA"	16050139
D000082	Acetaminophen	Acetaminophen affects the expression of ITK mRNA	17562736
C014949	acetylhydrazine	acetylhydrazine results in decreased expression of ITK mRNA	15282401
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of ITK mRNA	24449571
D001507	Beclomethasone	Beclomethasone results in decreased expression of ITK mRNA	23656298
D001564	Benzo(a)pyrene	Benzo(a)pyrene metabolite results in decreased expression of ITK mRNA	26314263
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of ITK mRNA	22316170
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of ITK mRNA	16050139
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of ITK mRNA	21839799
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of ITK protein	21467743
C006780	bisphenol A	bisphenol A results in increased expression of ITK mRNA	26364221
C006780	bisphenol A	bisphenol A results in decreased expression of ITK mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of ITK gene	28505145
D002737	Chloroprene	Chloroprene results in decreased expression of ITK mRNA	23125180
C018021	cobaltous chloride	cobaltous chloride results in increased expression of ITK mRNA	26314263
D003520	Cyclophosphamide	Cyclophosphamide results in decreased expression of ITK mRNA	21041162
D003907	Dexamethasone	Dexamethasone results in decreased expression of ITK mRNA	21041162
D004054	Diethylstilbestrol	Diethylstilbestrol results in decreased expression of ITK mRNA	21041162
D019813	1,2-Dimethylhydrazine	"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in increased expression of ITK mRNA"	27840820
C039281	furan	furan results in increased expression of ITK mRNA	27387713
C029424	hydrazine	hydrazine results in decreased expression of ITK mRNA	15282401
D007545	Isoproterenol	Isoproterenol results in decreased expression of ITK mRNA	20003209
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of ITK mRNA	26387944
D008701	Methapyrilene	Methapyrilene results in increased methylation of ITK gene	26431795
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of ITK mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of ITK mRNA"	25554681
D009532	Nickel	Nickel results in increased expression of ITK mRNA	25583101
C025589	ochratoxin A	ochratoxin A metabolite results in decreased expression of ITK mRNA	26314263
C025589	ochratoxin A	ochratoxin A results in decreased expression of ITK mRNA	26314263
C006253	pirinixic acid	pirinixic acid results in increased expression of ITK mRNA	23811191
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of ITK mRNA	24780913
D018038	Sodium Selenite	Sodium Selenite results in decreased expression of ITK mRNA	18175754
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of ITK mRNA	26377647
C009495	titanium dioxide	titanium dioxide results in decreased expression of ITK mRNA	23557971
D014118	Toxins, Biological	"Toxins, Biological affects the expression of ITK mRNA"	19682533
D014635	Valproic Acid	Valproic Acid results in decreased methylation of ITK gene	29154799
D019287	Zinc Sulfate	Zinc Sulfate results in increased expression of ITK mRNA	27504894

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004715	non-membrane spanning protein tyrosine kinase activity	-	IBA	21873635
GO:0004715	non-membrane spanning protein tyrosine kinase activity	-	IDA	12186560
GO:0005102	signaling receptor binding	-	IBA	21873635
GO:0005515	protein binding	-	IPI	8892607 10556826 12186560 16273093 17420479 19807924 21725281
GO:0005524	ATP binding	-	IEA	-
GO:0046872	metal ion binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001816	cytokine production	-	ISS	-
GO:0001865	NK T cell differentiation	-	IBA	21873635
GO:0002250	adaptive immune response	-	IBA	21873635
GO:0002250	adaptive immune response	-	ISS	-
GO:0006968	cellular defense response	-	TAS	8364206
GO:0007165	signal transduction	-	TAS	8364206
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	-	IBA	21873635
GO:0007202	activation of phospholipase C activity	-	ISS	-
GO:0030154	cell differentiation	-	IBA	21873635
GO:0032609	interferon-gamma production	-	IEA	-
GO:0032633	interleukin-4 production	-	IEA	-
GO:0035556	intracellular signal transduction	-	IEA	-
GO:0038083	peptidyl-tyrosine autophosphorylation	-	IBA	21873635
GO:0038095	Fc-epsilon receptor signaling pathway	-	TAS	-
GO:0042110	T cell activation	-	TAS	12186560
GO:0042127	regulation of cell proliferation	-	IBA	21873635
GO:0045087	innate immune response	-	IBA	21873635
GO:0050852	T cell receptor signaling pathway	-	IBA	21873635
GO:0050852	T cell receptor signaling pathway	-	ISS	-
GO:0050852	T cell receptor signaling pathway	-	TAS	-
GO:0050853	B cell receptor signaling pathway	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	ISS	-
GO:0005829	cytosol	-	TAS	-
GO:0005911	cell-cell junction	-	IEA	-
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	-	IBA	21873635

KEGG ID	KEGG Term
hsa04062	Chemokine signaling pathway
hsa04660	T cell receptor signaling pathway
hsa04670	Leukocyte transendothelial migration

Reactome ID	Reactome Term	Evidence
R-HSA-1280218	Adaptive Immune System	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168249	Innate Immune System	IEA
R-HSA-168256	Immune System	TAS
R-HSA-168256	Immune System	IEA
R-HSA-202403	TCR signaling	TAS
R-HSA-202433	Generation of second messenger molecules	TAS
R-HSA-2454202	Fc epsilon receptor (FCERI) signaling	TAS
R-HSA-2454202	Fc epsilon receptor (FCERI) signaling	IEA
R-HSA-2871809	FCERI mediated Ca+2 mobilization	TAS
R-HSA-2871809	FCERI mediated Ca+2 mobilization	IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal