Gene: ITPA

3704
C20orf37|HLC14-06-P|ITPase|My049|NTPase|dJ794I6.3
inosine triphosphatase
protein-coding
20p13
Ensembl:ENSG00000125877 MIM:147520 Vega:OTTHUMG00000031738 UniprotKB:Q9BY32
NG_012093.2
PubMed
0   ANCO-SNPs
ND
2   
4.137e-1 (AD)  3.434e-1 (ND)   (Frontal_Cortex)
4.507e-1 (AD)  8.666e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EIF60.917
MRPL550.916
C12orf100.911
FIBP0.909
MRTO40.909
MRPL280.908
UROD0.905
PDCD60.904
EIF3K0.903
ARF50.903

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.682
OR4F29-0.627
MTRNR2L6-0.36
MTRNR2L9-0.353
MAGEA12-0.328
FCGR3B-0.327
VNN1-0.326
ARHGAP42-0.325
EBF1-0.322
CXCR2-0.305

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB04272Citric AcidSmall Molecule77-92-9Approved|NutraceuticalTarget
ID Drug Name Action PubMed
C0067181,12-benzoperylene"1,12-benzoperylene results in decreased expression of ITPA mRNA"26377693
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of ITPA mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of ITPA mRNA"21346803
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in decreased expression of ITPA mRNA]28655636
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in decreased expression of ITPA mRNA]28655636
D000082AcetaminophenAcetaminophen results in decreased expression of ITPA mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of ITPA mRNA17562736
D020106AcrylamideAcrylamide results in increased expression of ITPA mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of ITPA mRNA19770486
D001280AtrazineAtrazine results in decreased expression of ITPA mRNA22378314
D001379AzathioprineITPA gene polymorphism affects the susceptibility to Azathioprine15167706|1557126
D001379AzathioprineITPA protein affects the susceptibility to Azathioprine21544018
C006780bisphenol Abisphenol A results in increased expression of ITPA mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of ITPA mRNA21297351
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ITPA mRNA25270620|2733941
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of ITPA mRNA24763279
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of ITPA mRNA28472532
C018021cobaltous chloridecobaltous chloride results in decreased expression of ITPA protein16622835
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of ITPA mRNA17361019|2126653
D002945CisplatinITPA protein affects the susceptibility to Cisplatin16217747
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of ITPA mRNA26924002
C024629dimethyl phthalatedimethyl phthalate affects the expression of ITPA mRNA26924002
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of ITPA protein23301498
C007738fluoranthene[fluoranthene co-treated with Permethrin] results in decreased expression of ITPA mRNA22406618
D005485FlutamideFlutamide results in decreased expression of ITPA mRNA24793618
D005485FlutamideFlutamide results in increased expression of ITPA mRNA24136188
D019833GenisteinGenistein results in decreased expression of ITPA mRNA22228119
D005897GlafenineGlafenine results in increased expression of ITPA mRNA24136188
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of ITPA mRNA24763279
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ITPA mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ITPA mRNA23086925
D048628KetolidesKetolides analog results in increased expression of ITPA mRNA24967691
D008727MethotrexateITPA gene polymorphism affects the susceptibility to Methotrexate16947783|1753070
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of ITPA protein26558463
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of ITPA mRNA26011545
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of ITPA protein26558463
C517284monomethyl phthalatemonomethyl phthalate affects the expression of ITPA mRNA26924002
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of ITPA mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ITPA mRNA"25554681
C029938nickel sulfatenickel sulfate results in decreased expression of ITPA mRNA22714537
D052638Particulate Matter2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in decreased expression of ITPA mRNA]28655636
D052638Particulate MatterParticulate Matter results in decreased expression of ITPA mRNA28412507|2865563
C522391perfluorododecanoic acidperfluorododecanoic acid results in increased expression of ITPA protein26168851
D026023Permethrin[fluoranthene co-treated with Permethrin] results in decreased expression of ITPA mRNA22406618
D026023PermethrinPermethrin results in decreased expression of ITPA mRNA22406618
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ITPA mRNA19710929
D010936Plant ExtractsPlant Extracts results in increased expression of ITPA mRNA23557933
D012254RibavirinITPA 5' UTR SNP results in increased susceptibility to Ribavirin20637204
C017947sodium arsenitesodium arsenite results in decreased expression of ITPA mRNA22714537
D018038Sodium SeleniteSodium Selenite results in increased expression of ITPA mRNA18175754
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ITPA mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ITPA mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of ITPA mRNA27760801
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of ITPA mRNA19042947
D014520UrethaneUrethane results in decreased expression of ITPA mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of ITPA mRNA25979313
D014635Valproic AcidValproic Acid affects the expression of ITPA mRNA17292431|1796380
D001335Vehicle Emissions2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in decreased expression of ITPA mRNA]28655636
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of ITPA mRNA28655636

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000166nucleotide binding-IEA-  
GO:0035529NADH pyrophosphatase activity-IEA-  
GO:0035870dITP diphosphatase activity-EXP11278832  
GO:0036220ITP diphosphatase activity-EXP11278832  
GO:0036222XTP diphosphatase activity-EXP11278832  
GO:0042802identical protein binding-IPI25416956  
GO:0046872metal ion binding-IEA-  
GO:0047429nucleoside-triphosphate diphosphatase activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006193ITP catabolic process-IEA-  
GO:0006195purine nucleotide catabolic process-TAS-  
GO:0009143nucleoside triphosphate catabolic process-IBA21873635  
GO:0051276chromosome organization-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa00230Purine metabolism
hsa00240Pyrimidine metabolism
hsa00983Drug metabolism - other enzymes
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-15869Metabolism of nucleotidesTAS
R-HSA-74259Purine catabolismTAS
R-HSA-8956319Nucleobase catabolismTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17530705A clinical pharmacogenetic model to predict the efficacy of methotrexate monotherapy in recent-onset rheumatoid arthritis. (2007 Jun)Wessels JAArthritis Rheum
25611567Prevalence of abnormal glycometabolism in treatment-naive patients with hepatitis C virus infection in a Chinese Han population. (2015 Jun)Rao HJ Gastroenterol Hepatol