Gene: ITPKB

3707
IP3-3KB|IP3K|IP3K-B|IP3KB|PIG37
inositol-trisphosphate 3-kinase B
protein-coding
1q42.12
Ensembl:ENSG00000143772 MIM:147522 Vega:OTTHUMG00000037582 UniprotKB:P27987
NC_000001.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.803e-1 (AD)  8.248e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1050492chr1:226632799 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg17933936chr1:226885709ITPKB1.400e-9Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RFX40.909
LRP100.907
MRVI10.905
DDR10.899
ABHD40.899
GNA120.899
RHOBTB30.894
TMBIM10.893
PLCD10.886
PTTG1IP0.886

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ABCC12-0.567
PPEF1-0.563
NMU-0.563
MYOZ3-0.561
NXPH2-0.555
ADRA1D-0.547
CNTN6-0.543
C8orf34-0.538
MCHR1-0.537
ZNF385D-0.536

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITPKB mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITPKB mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITPKB mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITPKB mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of ITPKB mRNA26690555
D000082AcetaminophenAcetaminophen affects the expression of ITPKB mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of ITPKB mRNA28959563
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ITPKB mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of ITPKB mRNA24449571
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of ITPKB mRNA18164116
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ITPKB mRNA18164116
C002791bismuth tripotassium dicitratebismuth tripotassium dicitrate results in decreased expression of ITPKB mRNA15912405
C006780bisphenol Abisphenol A results in increased expression of ITPKB mRNA27685785
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in decreased expression of ITPKB mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of ITPKB mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of ITPKB mRNA29097150
C013418bromfenacoumbromfenacoum results in decreased expression of ITPKB protein28903499
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of ITPKB mRNA22079614
D002509CephaloridineCephaloridine results in increased expression of ITPKB mRNA18500788
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ITPKB gene20938992
D003042CocaineCocaine results in increased expression of ITPKB mRNA16076954
D003300CopperCopper deficiency results in increased expression of ITPKB mRNA26033743
D004041Dietary FatsDietary Fats results in increased expression of ITPKB mRNA18042831
D019422Dietary SucroseDietary Sucrose results in increased expression of ITPKB mRNA26033743
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of ITPKB mRNA17942915
D004052DiethylnitrosamineMET protein inhibits the reaction [Diethylnitrosamine results in decreased expression of ITPKB mRNA]17942915
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of ITPKB mRNA18164116
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ITPKB mRNA18164116
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of ITPKB gene16724327
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ITPKB gene20938992
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of ITPKB mRNA26846883
D007545IsoproterenolIsoproterenol results in decreased expression of ITPKB mRNA20003209
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ITPKB mRNA22802445|2675264
D007854LeadLead affects the expression of ITPKB mRNA28903495
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ITPKB gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of ITPKB mRNA28001369
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of ITPKB mRNA"20188158
D009538NicotineNicotine results in increased expression of ITPKB mRNA11478936
D000073878Palm OilPalm Oil results in increased expression of ITPKB mRNA18042831
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITPKB mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of ITPKB mRNA26272509
D012822Silicon DioxideSilicon Dioxide results in increased expression of ITPKB mRNA25351596
C009277sodium arsenatesodium arsenate results in increased expression of ITPKB mRNA21795629
D013739Testosterone[bisphenol A co-treated with Testosterone] results in decreased expression of ITPKB mRNA26496021
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITPKB mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of ITPKB mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of ITPKB mRNA23179753|2800136
D014750VincristineVincristine results in decreased expression of ITPKB mRNA23649840
D014810Vitamin EVitamin E results in increased expression of ITPKB mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI21516116  23060452  25416956  
GO:0005516calmodulin binding-IEA-  
GO:0005524ATP binding-IEA-  
GO:0008440inositol-1,4,5-trisphosphate 3-kinase activity-IDA1654894  
GO:0008440inositol-1,4,5-trisphosphate 3-kinase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000165MAPK cascade-IEA-  
GO:0001932regulation of protein phosphorylation-IEA-  
GO:0002262myeloid cell homeostasis-IEA-  
GO:0007165signal transduction-TAS1654894  
GO:0007166cell surface receptor signaling pathway-IEA-  
GO:0032957inositol trisphosphate metabolic process-IDA1654894  
GO:0032958inositol phosphate biosynthetic process-IEA-  
GO:0033030negative regulation of neutrophil apoptotic process-IEA-  
GO:0035726common myeloid progenitor cell proliferation-IEA-  
GO:0043647inositol phosphate metabolic process-TAS-  
GO:0045059positive thymic T cell selection-IEA-  
GO:0045638negative regulation of myeloid cell differentiation-IEA-  
GO:0046579positive regulation of Ras protein signal transduction-IEA-  
GO:0046638positive regulation of alpha-beta T cell differentiation-IEA-  
GO:0071277cellular response to calcium ion-IDA1654894  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
GO:0005829cytosol-TAS-  
GO:0016020membrane-IEA-  
KEGG ID KEGG Term
hsa00562Inositol phosphate metabolism
hsa01100Metabolic pathways
hsa04020Calcium signaling pathway
hsa04070Phosphatidylinositol signaling system
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1483249Inositol phosphate metabolismTAS
R-HSA-1855204Synthesis of IP3 and IP4 in the cytosolTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal