Gene: ITPR1

3708
ACV|CLA4|INSP3R1|IP3R|IP3R1|PPP1R94|SCA15|SCA16|SCA29
inositol 1,4,5-trisphosphate receptor type 1
protein-coding
3p26.1
Ensembl:ENSG00000150995 MIM:147265 Vega:OTTHUMG00000154996 UniprotKB:Q14643
NG_016144.1
PubMed
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.476e-1 (AD)  5.399e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg03836615chr3:4856096ITPR16.200e-10Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DLGAP10.971
MYT1L0.968
KIAA1549L0.967
RIMS30.967
THRB0.966
INPP4A0.964
GABRB20.963
PRKCB0.961
CREG20.961
SLC4A100.959

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.553
MYL3-0.543
SNHG18-0.539
TFPI2-0.526
HEY2-0.524
RAB13-0.518
RAI14-0.514
CMTM3-0.505
WWTR1-0.504
FLT3LG-0.502

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB11590ThimerosalSmall Molecule54-64-8ApprovedTransporter
ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of ITPR1 mRNA"19162173
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of ITPR1 mRNA"21354444
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in increased expression of ITPR1 mRNA"20453058
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ITPR1 mRNA"25510870
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in increased expression of ITPR1 protein"21673325
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of ITPR1 mRNA"19167446
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ITPR1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ITPR1 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ITPR1 mRNA"25510870
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of ITPR1 mRNA"21346803
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of ITPR1 protein16278292
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ITPR1 mRNA"25510870
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in decreased expression of ITPR1 mRNA"20406850
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of ITPR1 mRNA"21346803
C1099862-aminoethoxydiphenyl borate[2-aminoethoxydiphenyl borate results in decreased activity of ITPR1 protein] which affects the susceptibility to Diamide21148766
C1099862-aminoethoxydiphenyl borate2-aminoethoxydiphenyl borate results in decreased activity of ITPR1 protein15326217
C5387582-aminoethyl diphenylborinate2-aminoethyl diphenylborinate inhibits the reaction [arsenic trioxide results in increased expression of ITPR1 protein modified form]27638049
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in decreased expression of ITPR1 mRNA"20206263
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of ITPR1 mRNA"20959002
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITPR1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITPR1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITPR1 mRNA"27188386
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of ITPR1 mRNA"21346803
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITPR1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITPR1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITPR1 mRNA"27188386
C0060148-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate"8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate results in decreased activity of ITPR1 protein"15326217
C0207389,10-dihydro-9,10-dihydroxybenzo(a)pyrene"9,10-dihydro-9,10-dihydroxybenzo(a)pyrene results in increased expression of ITPR1 mRNA"26238291
D000079AcetaldehydeAcetaldehyde results in increased expression of and affects the localization of ITPR1 protein17241155
D000079AcetaldehydeITPR1 protein promotes the reaction [Acetaldehyde metabolite results in increased abundance of Calcium]17241155
D000082AcetaminophenAcetaminophen results in increased expression of ITPR1 mRNA22230336|2906747
D000082AcetaminophenAcetaminophen affects the expression of ITPR1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 affects the expression of ITPR1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ITPR1 mRNA21632981|2164198
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ITPR1 mRNA19770486
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ITPR1 mRNA16483693
D001151ArsenicArsenic affects the methylation of ITPR1 gene25304211
C006632arsenic trioxidearsenic trioxide results in increased expression of ITPR1 mRNA27829220
C006632arsenic trioxide2-aminoethyl diphenylborinate inhibits the reaction [arsenic trioxide results in increased expression of ITPR1 protein modified form]27638049
C006632arsenic trioxide"4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [arsenic trioxide results in increased expression of ITPR1 protein modified form]"27638049
C006632arsenic trioxidearsenic trioxide results in decreased expression of ITPR1 mRNA24831965
C006632arsenic trioxidearsenic trioxide results in increased expression of ITPR1 protein modified form27638049
C006632arsenic trioxidearsenic trioxide results in increased phosphorylation of ITPR1 protein27461142
C006632arsenic trioxideATF4 protein promotes the reaction [arsenic trioxide results in increased expression of ITPR1 protein modified form]27638049
C015001arsenitearsenite results in increased methylation of ITPR1 promoter23974009
D001280AtrazineAtrazine results in increased expression of ITPR1 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of ITPR1 mRNA21714911
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ITPR1 mRNA20064835|2010694
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ITPR1 mRNA22316170|2623829
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ITPR1 mRNA20127859|2222880
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ITPR1 mRNA"19150397|2001819
D004958EstradiolEGF protein inhibits the reaction [Estradiol results in decreased expression of ITPR1 mRNA]24758408
D004958EstradiolESR2 protein promotes the reaction [Estradiol results in decreased expression of ITPR1 mRNA]19426747
D004958EstradiolEstradiol affects the expression of ITPR1 mRNA22574217
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of ITPR1 mRNA20660070
D004958EstradiolEstradiol results in decreased expression of ITPR1 mRNA19167446|1942674
D004958EstradiolTamoxifen inhibits the reaction [Estradiol results in decreased expression of ITPR1 mRNA]19426747
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of ITPR1 mRNA26496021
C095105bexarotenebexarotene results in increased expression of ITPR1 mRNA17178900
C006780bisphenol Abisphenol A results in increased expression of ITPR1 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of ITPR1 mRNA21932408|2268799
C006780bisphenol Abisphenol A affects the expression of ITPR1 mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of ITPR1 mRNA26496021
C006780bisphenol Abisphenol A results in increased methylation of ITPR1 gene28505145
C025703bleomycetinbleomycetin results in increased expression of ITPR1 mRNA21040473
C515564bromovaninbromovanin results in decreased expression of ITPR1 protein21419150
D002104CadmiumCadmium results in increased expression of ITPR1 protein10970901
C055494caffeic acid phenethyl ester[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of ITPR1 mRNA28223344
C055494caffeic acid phenethyl esterGW 4064 inhibits the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of ITPR1 mRNA]28223344
C055494caffeic acid phenethyl esterNR1H4 protein affects the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of ITPR1 mRNA]28223344
D002110CaffeineCaffeine results in decreased expression of ITPR1 mRNA18444173
D002118CalciumITPR1 protein promotes the reaction [Acetaldehyde metabolite results in increased abundance of Calcium]17241155
D002118CalciumITPR1 protein promotes the reaction [Ethanol metabolite results in increased abundance of Calcium]17241155
D002994ClofibrateClofibrate results in decreased expression of ITPR1 mRNA17585979
C018021cobaltous chloridecobaltous chloride results in increased expression of ITPR1 mRNA22941251
C018021cobaltous chloridecobaltous chloride results in decreased expression of ITPR1 mRNA24386269
D003042Cocaine[Cocaine co-treated with FOS protein mutant form] results in decreased expression of ITPR1 mRNA18355967
D003042CocaineCocaine results in increased expression of ITPR1 protein25100957
D009243NAD[ITPR1 protein binds to GAPDH protein] which results in increased abundance of NAD15677321
D019327Copper SulfateCopper Sulfate results in decreased expression of ITPR1 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of ITPR1 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in decreased expression of ITPR1 mRNA19167446
D003375CoumestrolCoumestrol results in decreased expression of ITPR1 mRNA19167446
D003471CuprizoneCuprizone results in decreased expression of ITPR1 mRNA26577399
D003474CurcuminCurcumin results in decreased expression of ITPR118462866
D003513CycloheximideCycloheximide inhibits the reaction [Ethanol results in increased expression of ITPR1 mRNA]17241155
D003513CycloheximideCycloheximide inhibits the reaction [linsidomine results in increased expression of ITPR1 mRNA]17241155
D003513CycloheximideCycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of ITPR1 mRNA]11007951
C017160cypermethrincypermethrin results in increased activity of ITPR1 protein16278292
C017160cypermethrincypermethrin results in decreased expression of ITPR1 mRNA22528246
D003609DactinomycinDactinomycin inhibits the reaction [Ethanol results in increased expression of ITPR1 mRNA]17241155
D003609DactinomycinDactinomycin inhibits the reaction [linsidomine results in increased expression of ITPR1 mRNA]17241155
D000069439DasatinibDasatinib results in increased expression of ITPR1 mRNA20579391
D003703DemecolcineDemecolcine results in increased expression of ITPR1 mRNA23649840
D003907DexamethasoneDexamethasone results in increased expression of ITPR1 mRNA23137833
D003958Diamide[2-aminoethoxydiphenyl borate results in decreased activity of ITPR1 protein] which affects the susceptibility to Diamide21148766
D003958DiamideDiamide results in increased glutathionylation of ITPR1 protein21148766
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ITPR1 mRNA21266533
C000944dicrotophosdicrotophos results in increased expression of ITPR1 mRNA28302478
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of ITPR1 mRNA26924002
D004041Dietary Fats[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of ITPR1 mRNA28223344
D004041Dietary FatsGW 4064 inhibits the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of ITPR1 mRNA]28223344
D004041Dietary Fats[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ITPR1 mRNA28223344
D004041Dietary FatsNR1H4 protein affects the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of ITPR1 mRNA]28223344
D004041Dietary Fatstauroursodeoxycholic acid inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ITPR1 mRNA]28223344
D002117CalcitriolCalcitriol results in increased expression of ITPR1 mRNA21592394|2648566
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of ITPR1 mRNA21592394
D002117CalcitriolTestosterone promotes the reaction [Calcitriol results in increased expression of ITPR1 mRNA]21592394
D0178784,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid"4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [arsenic trioxide results in increased expression of ITPR1 protein modified form]"27638049
C024629dimethyl phthalatedimethyl phthalate results in decreased expression of ITPR1 mRNA26924002
D004237DiuronDiuron results in decreased expression of ITPR1 mRNA21551480
D004642EmodinEmodin results in decreased expression of ITPR1 mRNA16045814
C118739entinostatentinostat results in increased expression of ITPR1 mRNA26272509|2718838
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITPR1 mRNA"27188386
D000431EthanolCycloheximide inhibits the reaction [Ethanol results in increased expression of ITPR1 mRNA]17241155
D000431EthanolDactinomycin inhibits the reaction [Ethanol results in increased expression of ITPR1 mRNA]17241155
D000431EthanolEthanol results in increased expression of and affects the localization of ITPR1 protein17241155
D000431EthanolEthanol results in increased expression of ITPR1 mRNA17241155
D000431Ethanolfomepizole inhibits the reaction [Ethanol results in increased expression of and affects the localization of ITPR1 protein]17241155
D000431EthanolITPR1 protein promotes the reaction [Ethanol metabolite results in increased abundance of Calcium]17241155
D000431EthanolUric Acid inhibits the reaction [Ethanol results in increased expression of and affects the localization of ITPR1 protein]17241155
D000431Ethanolxestospongin C inhibits the reaction [Ethanol results in increased expression of and affects the localization of ITPR1 protein]17241155
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of ITPR1 mRNA17555576
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ITPR1 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of ITPR1 mRNA17557909
D005047EtoposideITPR1 protein affects the susceptibility to Etoposide16217747
C017690fenvaleratefenvalerate results in increased expression of ITPR1 mRNA19428952
D005419FlavonoidsFlavonoids results in increased expression of ITPR1 mRNA18035473
D005472FluorouracilTP53 protein affects the reaction [Fluorouracil results in decreased expression of ITPR1 mRNA]15016801
C010238fomepizolefomepizole inhibits the reaction [Ethanol results in increased expression of and affects the localization of ITPR1 protein]17241155
D005557FormaldehydeFormaldehyde results in increased expression of ITPR1 mRNA23649840
D019833GenisteinGenistein results in increased expression of ITPR1 mRNA18444173|1884745
C010974glyphosateglyphosate results in decreased expression of ITPR1 protein alternative form24073338
C412815GW 4064GW 4064 inhibits the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of ITPR1 mRNA]28223344
D017313FenretinideFenretinide results in increased expression of ITPR1 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of ITPR1 mRNA18951874
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ITPR1 mRNA25613284
C098607JP8 aviation fuelJP8 aviation fuel results in decreased expression of ITPR1 mRNA15618438
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ITPR1 mRNA26752646
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of ITPR1 mRNA23430699|2479639
D007854LeadLead results in decreased expression of ITPR1 mRNA24960059
D007854LeadLead results in decreased expression of ITPR1 protein24960059
D007854LeadLead results in increased expression of ITPR1 mRNA25921245
D007854LeadLead results in increased expression of ITPR1 protein25921245
C008261lead acetatelead acetate results in increased expression of ITPR1 mRNA21829687
C002385linsidomineCycloheximide inhibits the reaction [linsidomine results in increased expression of ITPR1 mRNA]17241155
C002385linsidomineDactinomycin inhibits the reaction [linsidomine results in increased expression of ITPR1 mRNA]17241155
C002385linsidominelinsidomine results in increased expression of ITPR1 mRNA17241155
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of ITPR1 mRNA26378955
D008344Maneb[Maneb co-treated with Paraquat] results in decreased expression of ITPR1 mRNA23963992
D008344ManebMelatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ITPR1 mRNA]23963992
D008550MelatoninMelatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ITPR1 mRNA]23963992
D008727MethotrexateITPR1 protein affects the susceptibility to Methotrexate16217747
D008727MethotrexateMethotrexate results in increased expression of ITPR1 mRNA21678067
D008748MethylcholanthreneMethylcholanthrene promotes the reaction [AHR protein binds to ITPR1 promoter]20348232
D008748MethylcholanthreneMethylcholanthrene results in increased expression of ITPR1 mRNA20348232
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of ITPR1 mRNA28001369
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of ITPR1 mRNA"26251327
C008493methylselenic acidmethylselenic acid results in increased expression of ITPR1 mRNA18548127
C517284monomethyl phthalatemonomethyl phthalate affects the expression of ITPR1 mRNA26924002
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ITPR1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ITPR1 mRNA"25554681
D019829NevirapineNevirapine results in increased expression of ITPR1 mRNA23947594
D009532NickelNickel results in decreased expression of ITPR1 mRNA25583101
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in decreased expression of ITPR1 mRNA17616710
C097760N-palmitoylsphingosine[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ITPR1 mRNA28223344
C097760N-palmitoylsphingosineN-palmitoylsphingosine results in increased expression of ITPR1 mRNA28223344
C097760N-palmitoylsphingosinetauroursodeoxycholic acid inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ITPR1 mRNA]28223344
C097760N-palmitoylsphingosinetauroursodeoxycholic acid inhibits the reaction [N-palmitoylsphingosine results in increased expression of ITPR1 mRNA]28223344
C558013NSC 689534NSC 689534 results in increased expression of ITPR1 mRNA20971185
D019319Okadaic AcidOkadaic Acid results in increased activity of ITPR1 protein16278292
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of ITPR1 mRNA25729387
D010098OxycodoneOxycodone results in increased expression of ITPR1 mRNA23439660
D010269Paraquat[Maneb co-treated with Paraquat] results in decreased expression of ITPR1 mRNA23963992
D010269ParaquatMelatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ITPR1 mRNA]23963992
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ITPR1 mRNA"25510870
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid inhibits the reaction [ITPR1 protein binds to HSPA9 protein binds to VDAC1 protein]28288859
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid promotes the reaction [ITPR1 protein binds to AKT1 protein]28288859
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of ITPR1 mRNA20136073
D010634PhenobarbitalPhenobarbital affects the expression of ITPR1 mRNA19084549
C006253pirinixic acidpirinixic acid results in decreased expression of ITPR1 mRNA17426115
C006253pirinixic acidpirinixic acid results in increased expression of ITPR1 mRNA12832660
D010936Plant ExtractsPlant Extracts results in increased expression of ITPR1 mRNA23557933
D011189Potassium ChloridePotassium Chloride results in increased expression of ITPR1 mRNA16412482
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of ITPR1 mRNA20660070
C045950propiconazolepropiconazole results in increased expression of ITPR1 mRNA19363144|2127805
C005556propionaldehydepropionaldehyde results in increased expression of ITPR1 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in decreased expression of ITPR1 mRNA24780913
D011794QuercetinQuercetin results in decreased expression of ITPR1 mRNA21632981
C059514resveratrol[Coumestrol co-treated with resveratrol] results in decreased expression of ITPR1 mRNA19167446
C059514resveratrolresveratrol results in increased expression of ITPR1 mRNA23137833
D012524SarinSarin results in decreased expression of ITPR1 mRNA19522546
D012601Scopolamine HydrobromideScopolamine Hydrobromide results in increased expression of ITPR1 mRNA12818353
D012822Silicon DioxideSilicon Dioxide results in increased expression of ITPR1 mRNA25351596
D020123SirolimusSirolimus analog results in decreased activity of ITPR1 protein16278292
D020123SirolimusSirolimus inhibits the reaction [FKBP1A protein binds to ITPR1 protein]16278292
D020123SirolimusSirolimus results in decreased activity of ITPR1 protein16278292
C017947sodium arsenitesodium arsenite results in decreased expression of and affects the splicing of ITPR1 mRNA25879800
C016104sodium bichromatesodium bichromate results in decreased expression of ITPR1 mRNA22561333
C016104sodium bichromatesodium bichromate affects the expression of ITPR1 mRNA22110744
C016104sodium bichromatesodium bichromate results in increased expression of ITPR1 mRNA22561333
D012999SomanSoman results in decreased expression of ITPR1 mRNA19281266
D019311StaurosporineITPR1 results in increased susceptibility to Staurosporine15284241
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of ITPR1 mRNA26378955
C025462sulindac sulfidesulindac sulfide results in decreased expression of ITPR1 mRNA15767558
D014284TriiodothyronineTriiodothyronine results in increased expression of ITPR1 mRNA15953391
D016559TacrolimusTacrolimus inhibits the reaction [FKBP1A protein binds to ITPR1 protein]16278292
D016559TacrolimusTacrolimus results in increased activity of ITPR1 protein16278292
D013629TamoxifenTamoxifen inhibits the reaction [Estradiol results in decreased expression of ITPR1 mRNA]19426747
D013629TamoxifenTamoxifen results in increased expression of ITPR1 mRNA19426747
D013629TamoxifenTamoxifen affects the expression of ITPR1 mRNA17555576
C031655tauroursodeoxycholic acidtauroursodeoxycholic acid inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ITPR1 mRNA]28223344
C031655tauroursodeoxycholic acidtauroursodeoxycholic acid inhibits the reaction [N-palmitoylsphingosine results in increased expression of ITPR1 mRNA]28223344
D013739TestosteroneTestosterone affects the expression of ITPR1 mRNA21592394
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of ITPR1 mRNA21592394
D013739TestosteroneTestosterone promotes the reaction [Calcitriol results in increased expression of ITPR1 mRNA]21592394
D013739TestosteroneTestosterone results in decreased expression of ITPR1 mRNA21592394
D013749TetrachlorodibenzodioxinAHR protein promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to ITPR1 gene]]19574409
D013749TetrachlorodibenzodioxinCycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of ITPR1 mRNA]11007951
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ITPR1 gene]19574409
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ITPR1 mRNA11007951|1957440
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ITPR1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ITPR1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ITPR1 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ITPR1 mRNA20959002|2121527
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in decreased expression of ITPR1 protein alternative form24073338
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ITPR1 mRNA25613284
D019284ThapsigarginThapsigargin results in increased expression of ITPR1 mRNA28223344
D013853ThioacetamideThioacetamide results in decreased expression of ITPR1 mRNA23411599
D013974ThyroxineThyroxine results in increased expression of ITPR1 mRNA17403546
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of ITPR1 mRNA28065790
D014050TolueneToluene affects the expression of ITPR1 mRNA21827849
C052342topiramatetopiramate results in increased expression of ITPR1 mRNA16979414
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of ITPR1 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of ITPR1 mRNA23724009
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITPR1 mRNA"27188386
C012589trichostatin Atrichostatin A affects the expression of ITPR1 mRNA28542535
C012589trichostatin Atrichostatin A results in increased expression of ITPR1 mRNA24935251|2627250
C012589trichostatin Atrichostatin A results in increased expression of ITPR1 mRNA15901671
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of ITPR1 mRNA"26179874
C005460uranyl acetateuranyl acetate results in increased expression of ITPR1 mRNA19460415
C005460uranyl acetateuranyl acetate results in increased expression of ITPR1 protein19460415
D014520UrethaneUrethane results in increased expression of ITPR1 mRNA28818685
D014527Uric AcidUric Acid inhibits the reaction [Ethanol results in increased expression of and affects the localization of ITPR1 protein]17241155
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITPR1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of ITPR1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of ITPR1 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased methylation of ITPR1 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of ITPR1 mRNA15901671
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of ITPR1 gene25560391
C025643vinclozolinvinclozolin results in increased expression of ITPR1 mRNA15686871
D014750VincristineVincristine results in increased expression of ITPR1 mRNA23649840
C111237vorinostatvorinostat results in increased expression of ITPR1 mRNA27188386
C078549xestospongin BBCL2 mutant form promotes the reaction [xestospongin B inhibits the reaction [ITPR1 protein binds to BECN1 protein]]19325567
C078549xestospongin BBCL2 protein inhibits the reaction [xestospongin B inhibits the reaction [ITPR1 protein binds to BECN1 protein]]19325567
C078549xestospongin Bxestospongin B inhibits the reaction [ITPR1 protein binds to BECN1 protein]19325567
C511704xestospongin Cxestospongin C inhibits the reaction [Ethanol results in increased expression of and affects the localization of ITPR1 protein]17241155

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005220inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity-IBA21873635  
GO:0005220inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity-ISS-  
GO:0005220inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity-TAS8648241  
GO:0005509calcium ion binding-IBA21873635  
GO:0005515protein binding-IPI16793548  18250332  19220705  20010695  22045699  23884412  
24947355  
GO:0015085calcium ion transmembrane transporter activity-TAS7500840  
GO:0015278calcium-release channel activity-ISS-  
GO:0019855calcium channel inhibitor activity-IDA16793548  
GO:0035091phosphatidylinositol binding-IBA21873635  
GO:0035091phosphatidylinositol binding-ISS-  
GO:0070679inositol 1,4,5 trisphosphate binding-IBA21873635  
GO:0070679inositol 1,4,5 trisphosphate binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001666response to hypoxia-IDA19120137  
GO:0006816calcium ion transport-NAS7852357  
GO:0007165signal transduction-NAS8648241  
GO:0009791post-embryonic development-IEA-  
GO:0010506regulation of autophagy-TAS22770472  
GO:0030168platelet activation-TAS-  
GO:0032469endoplasmic reticulum calcium ion homeostasis-IEA-  
GO:0042045epithelial fluid transport-IEA-  
GO:0048016inositol phosphate-mediated signaling-IEA-  
GO:0050796regulation of insulin secretion-TAS-  
GO:0050849negative regulation of calcium-mediated signaling-IDA16793548  
GO:0050882voluntary musculoskeletal movement-IEA-  
GO:0051209release of sequestered calcium ion into cytosol-IBA21873635  
GO:0051209release of sequestered calcium ion into cytosol-ISS-  
GO:0070059intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress-ISS-  
GO:1903779regulation of cardiac conduction-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005637nuclear inner membrane-IEA-  
GO:0005730nucleolus-IEA-  
GO:0005783endoplasmic reticulum-ISS-  
GO:0005783endoplasmic reticulum-NAS8648241  
GO:0005789endoplasmic reticulum membrane-IBA21873635  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0005886plasma membrane-IBA21873635  
GO:0005955calcineurin complex-IEA-  
GO:0014069postsynaptic density-IEA-  
GO:0016020membrane-HDA19946888  
GO:0016021integral component of membrane-IEA-  
GO:0016529sarcoplasmic reticulum-IBA21873635  
GO:0016529sarcoplasmic reticulum-IEA-  
GO:0030658transport vesicle membrane-IEA-  
GO:0030659cytoplasmic vesicle membrane-IBA21873635  
GO:0030667secretory granule membrane-IBA21873635  
GO:0031088platelet dense granule membrane-IDA10828023  
GO:0031094platelet dense tubular network-IDA10828023  
GO:0031095platelet dense tubular network membrane-TAS-  
GO:0048471perinuclear region of cytoplasm-IEA-  
KEGG ID KEGG Term
hsa04020Calcium signaling pathway
hsa04070Phosphatidylinositol signaling system
hsa04114Oocyte meiosis
hsa04270Vascular smooth muscle contraction
hsa04540Gap junction
hsa04720Long-term potentiation
hsa04730Long-term depression
hsa04912GnRH signaling pathway
hsa04970Salivary secretion
hsa04971Gastric acid secretion
hsa04972Pancreatic secretion
hsa05010Alzheimer's disease
hsa05016Huntington's disease
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-111885Opioid SignallingIEA
R-HSA-112040G-protein mediated eventsIEA
R-HSA-112043PLC beta mediated eventsIEA
R-HSA-114508Effects of PIP2 hydrolysisTAS
R-HSA-1280218Adaptive Immune SystemIEA
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-139853Elevation of cytosolic Ca2+ levelsTAS
R-HSA-1430728MetabolismIEA
R-HSA-1430728MetabolismTAS
R-HSA-1489509DAG and IP3 signalingIEA
R-HSA-162582Signal TransductionIEA
R-HSA-162582Signal TransductionTAS
R-HSA-163685Integration of energy metabolismIEA
R-HSA-163685Integration of energy metabolismTAS
R-HSA-168249Innate Immune SystemIEA
R-HSA-168256Immune SystemIEA
R-HSA-168256Immune SystemTAS
R-HSA-194138Signaling by VEGFIEA
R-HSA-195721Signaling by WNTIEA
R-HSA-2029480Fcgamma receptor (FCGR) dependent phagocytosisIEA
R-HSA-2029485Role of phospholipids in phagocytosisIEA
R-HSA-2454202Fc epsilon receptor (FCERI) signalingIEA
R-HSA-2871809FCERI mediated Ca+2 mobilizationIEA
R-HSA-372790Signaling by GPCRIEA
R-HSA-372790Signaling by GPCRTAS
R-HSA-381676Glucagon-like Peptide-1 (GLP1) regulates insulin secretionTAS
R-HSA-3858494Beta-catenin independent WNT signalingIEA
R-HSA-388396GPCR downstream signallingIEA
R-HSA-388396GPCR downstream signallingTAS
R-HSA-392154Nitric oxide stimulates guanylate cyclaseTAS
R-HSA-397014Muscle contractionIEA
R-HSA-397014Muscle contractionTAS
R-HSA-4086398Ca2+ pathwayIEA
R-HSA-416476G alpha (q) signalling eventsTAS
R-HSA-418346Platelet homeostasisTAS
R-HSA-418360Platelet calcium homeostasisTAS
R-HSA-418457cGMP effectsTAS
R-HSA-418594G alpha (i) signalling eventsIEA
R-HSA-422356Regulation of insulin secretionIEA
R-HSA-422356Regulation of insulin secretionTAS
R-HSA-4420097VEGFA-VEGFR2 PathwayIEA
R-HSA-5218921VEGFR2 mediated cell proliferationIEA
R-HSA-5576891Cardiac conductionIEA
R-HSA-5576891Cardiac conductionTAS
R-HSA-5578775Ion homeostasisIEA
R-HSA-5578775Ion homeostasisTAS
R-HSA-5607763CLEC7A (Dectin-1) induces NFAT activationIEA
R-HSA-5607764CLEC7A (Dectin-1) signalingIEA
R-HSA-5621481C-type lectin receptors (CLRs)IEA
R-HSA-76002Platelet activation, signaling and aggregationTAS
R-HSA-9006925Intracellular signaling by second messengersIEA
R-HSA-9006934Signaling by Receptor Tyrosine KinasesIEA
R-HSA-983695Antigen activates B Cell Receptor (BCR) leading to generation of second messengersIEA
R-HSA-983695Antigen activates B Cell Receptor (BCR) leading to generation of second messengersTAS
R-HSA-983705Signaling by the B Cell Receptor (BCR)IEA
R-HSA-983705Signaling by the B Cell Receptor (BCR)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26455281Novel candidate genes for alcoholism--transcriptomic analysis of prefrontal medial cortex, hippocampus and nucleus accumbens of Warsaw alcohol-preferring and non-preferring rats. (2015 Dec)Stankiewicz AMPharmacol Biochem Behav