Gene info: ID 3709

Gene: ITPR2

GENE ID: 3709

Synonyms: ANHD|CFAP48|INSP3R2|IP3R2

Description: inositol 1,4,5-trisphosphate receptor type 2

Gene type: protein-coding

Location: 12p11.23

dbXrefs: Ensembl:ENSG00000123104 MIM:600144 Vega:OTTHUMG00000169181 UniprotKB:Q14571

RefSeq: NG_042142.1

Retrived from: PubMed|SNP Mapped

SNPs: 1 ANCO-SNPs

Phenotype: ND|AD

# Publications: 3

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 4.005e-1 (AD) 2.307e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs11614384	chr12:26383828 (GRCh38.p7)	T>C	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
YAP1	0.874
CD302	0.873
NOTCH2	0.866
MAML2	0.855
FERMT2	0.855
TGFBR3	0.855
TGFB2	0.85
TLR4	0.849
PTAR1	0.842
FGD4	0.839

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
GALNT14	-0.461
ADTRP	-0.432
MYCNOS	-0.42
RHO	-0.418
ABCC12	-0.414
HAS1	-0.399
SMIM18	-0.395
DLK2	-0.393
TMEFF2	-0.389
DRD5	-0.387

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of ITPR2 mRNA"	21346803
C109986	2-aminoethoxydiphenyl borate	2-aminoethoxydiphenyl borate inhibits the reaction [[adenophostin A results in increased activity of ITPR2 protein] which results in increased transport of Calcium]	15201137
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITPR2 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITPR2 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITPR2 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITPR2 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITPR2 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITPR2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITPR2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITPR2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITPR2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITPR2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITPR2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITPR2 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in decreased expression of ITPR2 mRNA	21420995
D000082	Acetaminophen	Acetaminophen affects the expression of ITPR2 mRNA	17562736
D000086	Acetazolamide	Acetazolamide results in increased expression of ITPR2 mRNA	19274763
C085029	adenophostin A	2-aminoethoxydiphenyl borate inhibits the reaction [[adenophostin A results in increased activity of ITPR2 protein] which results in increased transport of Calcium]	15201137
C085029	adenophostin A	adenophostin A results in increased activity of ITPR2 protein	15201137
C085029	adenophostin A	[adenophostin A results in increased activity of ITPR2 protein] which results in increased transport of Calcium	15201137
C085029	adenophostin A	xestospongin C inhibits the reaction [[adenophostin A results in increased activity of ITPR2 protein] which results in increased transport of Calcium]	15201137
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of ITPR2 mRNA	22100608
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of ITPR2 gene	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of ITPR2 mRNA	19770486
D000393	Air Pollutants	Air Pollutants analog results in decreased expression of ITPR2 mRNA	21757418
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of ITPR2 mRNA	24449571
D001151	Arsenic	Arsenic affects the methylation of ITPR2 gene	25304211
D001280	Atrazine	Atrazine results in increased expression of ITPR2 mRNA	25929836
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of ITPR2 mRNA	20064835\|2010694
D001564	Benzo(a)pyrene	Benzo(a)pyrene promotes the reaction [AHR protein binds to ITPR2 promoter]	19654925
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of ITPR2 mRNA	19770486\|2171566
C006780	bisphenol A	bisphenol A results in increased expression of ITPR2 mRNA	29027980
C018475	butyraldehyde	butyraldehyde results in decreased expression of ITPR2 mRNA	26079696
C055494	caffeic acid phenethyl ester	[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of ITPR2 mRNA	28223344
C055494	caffeic acid phenethyl ester	NR1H4 protein affects the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of ITPR2 mRNA]	28223344
D002118	Calcium	2-aminoethoxydiphenyl borate inhibits the reaction [[adenophostin A results in increased activity of ITPR2 protein] which results in increased transport of Calcium]	15201137
D002118	Calcium	[adenophostin A results in increased activity of ITPR2 protein] which results in increased transport of Calcium	15201137
D002118	Calcium	xestospongin C inhibits the reaction [[adenophostin A results in increased activity of ITPR2 protein] which results in increased transport of Calcium]	15201137
D002220	Carbamazepine	Carbamazepine affects the expression of ITPR2 mRNA	25979313
C031180	chrysene	chrysene results in increased expression of ITPR2 mRNA	26377693
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of ITPR2 mRNA	19320972
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of ITPR2 mRNA	19549813
D003471	Cuprizone	Cuprizone results in increased expression of ITPR2 mRNA	27523638
D016572	Cyclosporine	Cyclosporine results in decreased expression of ITPR2 mRNA	20106945\|2556210
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of ITPR2 mRNA	24317228
D003976	Diazinon	Diazinon results in increased methylation of ITPR2 gene	22964155
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in decreased expression of ITPR2 mRNA	27392435
D002945	Cisplatin	Cisplatin results in decreased expression of ITPR2 mRNA	27392435\|2759478
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate affects the expression of ITPR2 mRNA	26924002
D004041	Dietary Fats	[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of ITPR2 mRNA	28223344
D004041	Dietary Fats	Dietary Fats results in increased expression of ITPR2 mRNA	19030233
D004041	Dietary Fats	[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ITPR2 mRNA	28223344
D004041	Dietary Fats	NR1H4 protein affects the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of ITPR2 mRNA]	28223344
D004041	Dietary Fats	rimonabant inhibits the reaction [Dietary Fats results in increased expression of ITPR2 mRNA]	19030233
D004041	Dietary Fats	tauroursodeoxycholic acid inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ITPR2 mRNA]	28223344
C024629	dimethyl phthalate	dimethyl phthalate results in increased expression of ITPR2 mRNA	26924002
C045651	epigallocatechin gallate	epigallocatechin gallate results in increased expression of ITPR2 mRNA	22079256
C045651	epigallocatechin gallate	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ITPR2 mRNA	22079256
D005557	Formaldehyde	Formaldehyde results in decreased expression of ITPR2 mRNA	23649840
D017313	Fenretinide	Fenretinide results in increased expression of ITPR2 mRNA	28973697
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ITPR2 mRNA	25613284
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in decreased expression of ITPR2 mRNA	27392435
C544151	jinfukang	jinfukang results in decreased expression of ITPR2 mRNA	27392435
D007854	Lead	Lead results in increased expression of ITPR2 mRNA	25921245
D007854	Lead	Lead results in increased expression of ITPR2 protein	25921245
D058185	Magnetite Nanoparticles	[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of ITPR2 mRNA	26378955
C042720	mercuric bromide	mercuric bromide results in increased expression of ITPR2 mRNA	26272509
C042720	mercuric bromide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITPR2 mRNA"	27188386
D008694	Methamphetamine	Methamphetamine results in increased expression of ITPR2 mRNA	26307267
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of ITPR2 mRNA	23649840
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of ITPR2 mRNA	26924002
D009151	Mustard Gas	Mustard Gas results in decreased expression of ITPR2 mRNA	15674843
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of ITPR2 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of ITPR2 mRNA"	25554681
C017096	n-butoxyethanol	n-butoxyethanol results in decreased expression of ITPR2 mRNA	19812364
C097760	N-palmitoylsphingosine	[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ITPR2 mRNA	28223344
C097760	N-palmitoylsphingosine	N-palmitoylsphingosine results in increased expression of ITPR2 mRNA	28223344
C097760	N-palmitoylsphingosine	tauroursodeoxycholic acid inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ITPR2 mRNA]	28223344
C097760	N-palmitoylsphingosine	tauroursodeoxycholic acid inhibits the reaction [N-palmitoylsphingosine results in increased expression of ITPR2 mRNA]	28223344
D010126	Ozone	Ozone results in decreased expression of ITPR2 mRNA	12763052
C496932	panobinostat	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITPR2 mRNA"	27188386
C496932	panobinostat	panobinostat results in increased expression of ITPR2 mRNA	26272509
D052638	Particulate Matter	ITPR2 gene SNP affects the susceptibility to Particulate Matter	19590686
C046012	pentanal	pentanal results in decreased expression of ITPR2 mRNA	26079696
C027579	periodate-oxidized adenosine	periodate-oxidized adenosine affects the expression of ITPR2 mRNA	17097637
D010656	Phenylephrine	Phenylephrine results in increased activity of ITPR2 protein	15201137
D010656	Phenylephrine	[Phenylephrine results in increased activity of ITPR2 protein] which results in increased expression of ACTA1 mRNA	15201137
D010656	Phenylephrine	[Phenylephrine results in increased activity of ITPR2 protein] which results in increased expression of NPPA mRNA	15201137
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITPR2 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of ITPR2 mRNA	26272509
D010936	Plant Extracts	Plant Extracts results in increased expression of ITPR2 mRNA	23557933
C027373	potassium chromate(VI)	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ITPR2 mRNA	22079256
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of ITPR2 mRNA	22079256\|2271453
D011374	Progesterone	Progesterone results in increased expression of ITPR2 mRNA	23012394
C045950	propiconazole	propiconazole results in decreased expression of ITPR2 mRNA	19423681
D011441	Propylthiouracil	Propylthiouracil results in increased expression of ITPR2 mRNA	24780913
C513428	pyrachlostrobin	pyrachlostrobin results in increased expression of ITPR2 mRNA	27029645
D011794	Quercetin	Quercetin results in decreased expression of ITPR2 mRNA	21632981
C089032	rimonabant	rimonabant inhibits the reaction [Dietary Fats results in increased expression of ITPR2 mRNA]	19030233
C016104	sodium bichromate	sodium bichromate results in decreased expression of ITPR2 mRNA	17685462
C016104	sodium bichromate	sodium bichromate results in decreased expression of ITPR2 mRNA	25993096
D012969	Sodium Fluoride	Sodium Fluoride results in increased expression of ITPR2 protein	28918527
D004113	Succimer	[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of ITPR2 mRNA	26378955
C061133	tamibarotene	tamibarotene affects the expression of ITPR2 mRNA	15498508
C031655	tauroursodeoxycholic acid	tauroursodeoxycholic acid inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ITPR2 mRNA]	28223344
C031655	tauroursodeoxycholic acid	tauroursodeoxycholic acid inhibits the reaction [N-palmitoylsphingosine results in increased expression of ITPR2 mRNA]	28223344
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of ITPR2 mRNA	20106945\|2163298
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of ITPR2 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ITPR2 gene]	20819909
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of ITPR2 mRNA	26290441
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of ITPR2 mRNA	17035482\|2081990
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ITPR2 mRNA	25613284
D019284	Thapsigargin	Thapsigargin results in increased expression of ITPR2 mRNA	28223344
D013853	Thioacetamide	Thioacetamide results in decreased expression of ITPR2 mRNA	23411599
C483909	torcetrapib	torcetrapib results in increased expression of ITPR2 mRNA	23228038
D014212	Tretinoin	Tretinoin affects the expression of ITPR2 mRNA	15498508
D014212	Tretinoin	Tretinoin results in increased expression of ITPR2 mRNA	15894607
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITPR2 mRNA"	27188386
C012589	trichostatin A	trichostatin A results in increased expression of ITPR2 mRNA	24935251\|2627250
D014302	Trinitrobenzenesulfonic Acid	Trinitrobenzenesulfonic Acid results in increased expression of ITPR2 mRNA	23537331
C005460	uranyl acetate	uranyl acetate results in increased expression of ITPR2 mRNA	19460415
C005460	uranyl acetate	uranyl acetate results in increased expression of ITPR2 protein	19460415
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITPR2 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid results in decreased expression of ITPR2 mRNA	29154799
D014635	Valproic Acid	Valproic Acid results in decreased methylation of ITPR2 gene	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of ITPR2 mRNA	23179753\|2438349
D014640	Vancomycin	Vancomycin results in increased expression of ITPR2 mRNA	18930951
C029297	vinylidene chloride	vinylidene chloride results in decreased expression of ITPR2 mRNA	26682919
C111237	vorinostat	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITPR2 mRNA"	27188386
C511704	xestospongin C	xestospongin C inhibits the reaction [[adenophostin A results in increased activity of ITPR2 protein] which results in increased transport of Calcium]	15201137

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	-	IBA	21873635
GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	-	ISS	-
GO:0005509	calcium ion binding	-	IBA	21873635
GO:0005515	protein binding	-	IPI	11163362
GO:0015085	calcium ion transmembrane transporter activity	-	TAS	8081734
GO:0035091	phosphatidylinositol binding	-	IBA	21873635
GO:0035091	phosphatidylinositol binding	-	IEA	-
GO:0070679	inositol 1,4,5 trisphosphate binding	-	IBA	21873635
GO:0070679	inositol 1,4,5 trisphosphate binding	-	IEA	-
GO:0097110	scaffold protein binding	-	IPI	11782428

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001666	response to hypoxia	-	IDA	19120137
GO:0007165	signal transduction	-	TAS	8081734
GO:0030168	platelet activation	-	TAS	-
GO:0048016	inositol phosphate-mediated signaling	-	IEA	-
GO:0050796	regulation of insulin secretion	-	TAS	-
GO:0051209	release of sequestered calcium ion into cytosol	-	IBA	21873635
GO:0051209	release of sequestered calcium ion into cytosol	-	ISS	-
GO:0071320	cellular response to cAMP	-	IEA	-
GO:0071361	cellular response to ethanol	-	IEA	-
GO:1903779	regulation of cardiac conduction	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IDA	-
GO:0005783	endoplasmic reticulum	-	IDA	-
GO:0005789	endoplasmic reticulum membrane	-	IBA	21873635
GO:0005789	endoplasmic reticulum membrane	-	TAS	-
GO:0005886	plasma membrane	-	IBA	21873635
GO:0005886	plasma membrane	-	IDA	10828023
GO:0005938	cell cortex	-	IEA	-
GO:0016020	membrane	-	HDA	19946888
GO:0016021	integral component of membrane	-	IEA	-
GO:0016529	sarcoplasmic reticulum	-	IBA	21873635
GO:0030659	cytoplasmic vesicle membrane	-	IBA	21873635
GO:0030667	secretory granule membrane	-	IBA	21873635
GO:0031095	platelet dense tubular network membrane	-	TAS	-
GO:0033017	sarcoplasmic reticulum membrane	-	IMP	10828023
GO:0043235	receptor complex	-	IDA	23382219

KEGG ID	KEGG Term
hsa04020	Calcium signaling pathway
hsa04070	Phosphatidylinositol signaling system
hsa04114	Oocyte meiosis
hsa04270	Vascular smooth muscle contraction
hsa04540	Gap junction
hsa04720	Long-term potentiation
hsa04730	Long-term depression
hsa04912	GnRH signaling pathway
hsa04970	Salivary secretion
hsa04971	Gastric acid secretion
hsa04972	Pancreatic secretion
hsa05010	Alzheimer's disease

Reactome ID	Reactome Term	Evidence
R-HSA-109582	Hemostasis	TAS
R-HSA-111885	Opioid Signalling	IEA
R-HSA-112040	G-protein mediated events	IEA
R-HSA-112043	PLC beta mediated events	IEA
R-HSA-114508	Effects of PIP2 hydrolysis	TAS
R-HSA-1280218	Adaptive Immune System	IEA
R-HSA-1280218	Adaptive Immune System	TAS
R-HSA-139853	Elevation of cytosolic Ca2+ levels	TAS
R-HSA-1430728	Metabolism	IEA
R-HSA-1430728	Metabolism	TAS
R-HSA-1489509	DAG and IP3 signaling	IEA
R-HSA-162582	Signal Transduction	IEA
R-HSA-162582	Signal Transduction	TAS
R-HSA-163685	Integration of energy metabolism	IEA
R-HSA-163685	Integration of energy metabolism	TAS
R-HSA-168249	Innate Immune System	IEA
R-HSA-168256	Immune System	IEA
R-HSA-168256	Immune System	TAS
R-HSA-194138	Signaling by VEGF	IEA
R-HSA-195721	Signaling by WNT	IEA
R-HSA-2029480	Fcgamma receptor (FCGR) dependent phagocytosis	IEA
R-HSA-2029485	Role of phospholipids in phagocytosis	IEA
R-HSA-2454202	Fc epsilon receptor (FCERI) signaling	IEA
R-HSA-2871809	FCERI mediated Ca+2 mobilization	IEA
R-HSA-372790	Signaling by GPCR	IEA
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-381676	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	TAS
R-HSA-3858494	Beta-catenin independent WNT signaling	IEA
R-HSA-388396	GPCR downstream signalling	IEA
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-397014	Muscle contraction	IEA
R-HSA-397014	Muscle contraction	TAS
R-HSA-4086398	Ca2+ pathway	IEA
R-HSA-416476	G alpha (q) signalling events	TAS
R-HSA-418346	Platelet homeostasis	TAS
R-HSA-418360	Platelet calcium homeostasis	TAS
R-HSA-418594	G alpha (i) signalling events	IEA
R-HSA-422356	Regulation of insulin secretion	IEA
R-HSA-422356	Regulation of insulin secretion	TAS
R-HSA-4420097	VEGFA-VEGFR2 Pathway	IEA
R-HSA-5218921	VEGFR2 mediated cell proliferation	IEA
R-HSA-5576891	Cardiac conduction	IEA
R-HSA-5576891	Cardiac conduction	TAS
R-HSA-5578775	Ion homeostasis	IEA
R-HSA-5578775	Ion homeostasis	TAS
R-HSA-5607763	CLEC7A (Dectin-1) induces NFAT activation	IEA
R-HSA-5607764	CLEC7A (Dectin-1) signaling	IEA
R-HSA-5621481	C-type lectin receptors (CLRs)	IEA
R-HSA-76002	Platelet activation, signaling and aggregation	TAS
R-HSA-9006925	Intracellular signaling by second messengers	IEA
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	IEA
R-HSA-983695	Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	IEA
R-HSA-983695	Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	TAS
R-HSA-983705	Signaling by the B Cell Receptor (BCR)	IEA
R-HSA-983705	Signaling by the B Cell Receptor (BCR)	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
23978819	Generalization of adiposity genetic loci to US Hispanic women. (2013 Aug 26)	Graff M	Nutr Diabetes
25053674	Joint association of genome-wide association study-identified susceptibility loci and dietary patterns in risk of renal cell carcinoma among non-Hispanic whites. (2014 Sep 1)	Melkonian SC	Am J Epidemiol
23911636	Germline genetic variations at 11q13 and 12p11 locus modulate age at onset for renal cell carcinoma. (2014 Feb)	Audenet F	J Urol