Gene info: ID 3710

Gene: ITPR3

GENE ID: 3710

Synonyms: IP3R|IP3R3

Description: inositol 1,4,5-trisphosphate receptor type 3

Gene type: protein-coding

Location: 6p21.31

dbXrefs: Ensembl:ENSG00000096433 MIM:147267 Vega:OTTHUMG00000014532 UniprotKB:Q14573

RefSeq: NG_027729.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 3.450e-2 (AD) 8.632e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg17865955	chr6:33601177	ITPR3		7.000e-10	Alcohol consumption der day	27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PODXL	0.86
MYO1C	0.854
ADCY4	0.849
NBEAL2	0.848
PKN3	0.847
NOS3	0.843
ACVRL1	0.84
MMRN2	0.84
LAMC1	0.835
CDH5	0.83

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CRH	-0.375
C1orf53	-0.331
SMIM18	-0.327
ALG1L	-0.311
ZSCAN1	-0.305
ASPDH	-0.303
CPLX3	-0.297
ARSF	-0.291
MYADML2	-0.288
MYCNOS	-0.287

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C109986	2-aminoethoxydiphenyl borate	2-aminoethoxydiphenyl borate binds to and results in decreased activity of ITPR3 protein	15245872
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of ITPR3 mRNA"	23196670
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITPR3 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITPR3 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITPR3 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITPR3 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in increased expression of ITPR3 mRNA	26690555
D000082	Acetaminophen	Acetaminophen affects the expression of ITPR3 mRNA	17562736
C085029	adenophostin A	adenophostin A analog binds to and results in increased activity of ITPR3 protein	18247493
C085029	adenophostin A	adenophostin A binds to and results in increased activity of ITPR3 protein	18247493
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of ITPR3 mRNA	16483693
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of ITPR3 mRNA	24449571
D001280	Atrazine	Atrazine results in decreased expression of ITPR3 mRNA	25929836
D001280	Atrazine	Atrazine results in increased expression of ITPR3 mRNA	22378314
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of ITPR3 mRNA	22316170
D004958	Estradiol	Estradiol affects the expression of ITPR3 mRNA	23557687
C543008	bis(4-hydroxyphenyl)sulfone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of ITPR3 mRNA	28628672
C551172	bis-N,N-dimethylamino-2-(N-methylpyrrolyl)methyl cyclopentadienyl titanium (IV)	"bis-N,N-dimethylamino-2-(N-methylpyrrolyl)methyl cyclopentadienyl titanium (IV) results in increased expression of ITPR3 mRNA"	20162321
C006780	bisphenol A	bisphenol A affects the expression of ITPR3 mRNA	21786754
C006780	bisphenol A	bisphenol A results in increased expression of ITPR3 mRNA	29027980
C006780	bisphenol A	bisphenol A affects the expression of ITPR3 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased expression of ITPR3 protein	24552547
C000611646	bisphenol F	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ITPR3 mRNA	28628672
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide affects the expression of ITPR3 mRNA	23410634
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of ITPR3 mRNA	24982889
D002118	Calcium	Calcium affects the expression of ITPR3 protein	10963052
D002713	Chlorine	[Ozone co-treated with Chlorine] results in increased expression of ITPR3 mRNA	18636392
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in increased expression of ITPR3 mRNA	25270620
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ITPR3 mRNA	20938992
D002994	Clofibrate	Clofibrate results in increased expression of ITPR3 mRNA	25270620
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of ITPR3 mRNA	19376846
D019327	Copper Sulfate	Copper Sulfate results in increased expression of ITPR3 mRNA	19549813
D016572	Cyclosporine	Cyclosporine results in increased expression of ITPR3 mRNA	20106945\|2163298
C014347	decitabine	decitabine affects the expression of ITPR3 mRNA	23300844
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of ITPR3 mRNA	28628672
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ITPR3 mRNA	28628672
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of ITPR3 mRNA	28628672
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of ITPR3 mRNA	21266533
D002945	Cisplatin	Cisplatin affects the expression of ITPR3 mRNA	23300844
D002945	Cisplatin	Cisplatin results in increased expression of ITPR3 mRNA	21151649
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate affects the expression of ITPR3 mRNA	26924002
D004041	Dietary Fats	Dietary Fats results in increased expression of ITPR3 mRNA	18042831
C118739	entinostat	entinostat results in increased expression of ITPR3 mRNA	26272509\|2718838
C118739	entinostat	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITPR3 mRNA"	27188386
C017690	fenvalerate	fenvalerate results in increased expression of ITPR3 mRNA	19428952
D005419	Flavonoids	Flavonoids results in increased expression of ITPR3 mRNA	18035473
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ITPR3 mRNA	20938992
C069837	fullerene C60	fullerene C60 results in increased expression of ITPR3 mRNA	19167457
D019833	Genistein	[Genistein co-treated with Methoxychlor] results in decreased expression of ITPR3 mRNA	21782745
D006534	Heptachlor Epoxide	Heptachlor Epoxide results in increased expression of ITPR3 mRNA	25270620
D017313	Fenretinide	Fenretinide results in increased expression of ITPR3 mRNA	28973697
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of ITPR3 mRNA	20044591\|2341063
C492448	ICG 001	ICG 001 results in increased expression of ITPR3 mRNA	26191083
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of ITPR3 mRNA	28628672
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ITPR3 mRNA	28628672
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of ITPR3 mRNA	28628672
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ITPR3 mRNA	25613284
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of ITPR3 mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ITPR3 mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of ITPR3 mRNA	28628672
C544151	jinfukang	jinfukang results in increased expression of ITPR3 mRNA	27392435
C098607	JP8 aviation fuel	JP8 aviation fuel results in decreased expression of ITPR3 protein	17337753
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of ITPR3 mRNA	24796395
C045463	leflunomide	leflunomide results in increased expression of ITPR3 mRNA	28988120
C002385	linsidomine	linsidomine results in increased oxidation of ITPR3 protein	28086193
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ITPR3 mRNA	20938992
D008727	Methotrexate	Methotrexate results in increased expression of ITPR3 mRNA	21678067
D008731	Methoxychlor	[Genistein co-treated with Methoxychlor] results in decreased expression of ITPR3 mRNA	21782745
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of ITPR3 mRNA	26924002
C017096	n-butoxyethanol	n-butoxyethanol results in decreased expression of ITPR3 mRNA	19812364
C028007	nickel monoxide	nickel monoxide results in increased expression of ITPR3 mRNA	19167457
C029938	nickel sulfate	nickel sulfate results in increased expression of ITPR3 mRNA	22714537
D010126	Ozone	[Ozone co-treated with Chlorine] results in increased expression of ITPR3 mRNA	18636392
D000073878	Palm Oil	Palm Oil results in increased expression of ITPR3 mRNA	18042831
D052638	Particulate Matter	Particulate Matter results in increased expression of ITPR3 mRNA	28412507
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in increased expression of ITPR3 mRNA	26705709
D010634	Phenobarbital	NR1I3 protein affects the reaction [Phenobarbital results in increased expression of ITPR3 mRNA]	19482888
D010634	Phenobarbital	Phenobarbital results in increased expression of ITPR3 mRNA	19482888
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ITPR3 mRNA	19710929
C006253	pirinixic acid	pirinixic acid results in decreased expression of ITPR3 mRNA	17426115
D011794	Quercetin	Quercetin results in increased expression of ITPR3 mRNA	21632981
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride affects the expression of ITPR3 mRNA	14699072
C059514	resveratrol	resveratrol results in increased phosphorylation of ITPR3 protein	25311616
C017947	sodium arsenite	sodium arsenite results in increased expression of ITPR3 protein	19072884
C061133	tamibarotene	tamibarotene results in decreased expression of ITPR3 mRNA	15498508
D013629	Tamoxifen	Tamoxifen affects the expression of ITPR3 mRNA	14699072
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of ITPR3 mRNA	21570461
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ITPR3 mRNA	25613284
D019284	Thapsigargin	Thapsigargin results in decreased expression of ITPR3 mRNA	22378314
D013849	Thimerosal	Thimerosal results in decreased expression of ITPR3 mRNA	27188386
D014212	Tretinoin	Tretinoin results in decreased expression of ITPR3 mRNA	15498508\|2193413
D014212	Tretinoin	Tretinoin results in increased expression of ITPR3 mRNA	20488242
C012589	trichostatin A	trichostatin A results in increased expression of ITPR3 mRNA	24935251
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of ITPR3 mRNA"	26179874
C013320	tris(2-butoxyethyl) phosphate	tris(2-butoxyethyl) phosphate affects the expression of ITPR3 mRNA	29024780
C022884	undecane	undecane results in decreased expression of ITPR3 protein	17337753
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITPR3 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of ITPR3 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of ITPR3 mRNA	19101580\|2317975
C034028	vanadyl sulfate	vanadyl sulfate results in increased expression of ITPR3 mRNA	16330358
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of ITPR3 gene	25560391
C025643	vinclozolin	vinclozolin results in decreased expression of ITPR3 mRNA	23034163
C029297	vinylidene chloride	vinylidene chloride results in increased expression of ITPR3 mRNA	26682919
D024483	Vitamin K 3	Vitamin K 3 affects the expression of ITPR3 mRNA	20044591\|2341063

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000822	inositol hexakisphosphate binding	-	ISS	-
GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	-	IBA	21873635
GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	-	IDA	10828023
GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	-	ISS	-
GO:0005509	calcium ion binding	-	IBA	21873635
GO:0005515	protein binding	-	IPI	10611319 19052258 19553469 21062895 25996873
GO:0015278	calcium-release channel activity	-	ISS	-
GO:0035091	phosphatidylinositol binding	-	IBA	21873635
GO:0035091	phosphatidylinositol binding	-	IEA	-
GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding	-	ISS	-
GO:0070679	inositol 1,4,5 trisphosphate binding	-	IBA	21873635
GO:0070679	inositol 1,4,5 trisphosphate binding	-	IDA	8288584

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0007186	G-protein coupled receptor signaling pathway	-	ISS	-
GO:0007204	positive regulation of cytosolic calcium ion concentration	-	ISS	-
GO:0007613	memory	-	IEA	-
GO:0030168	platelet activation	-	TAS	-
GO:0048016	inositol phosphate-mediated signaling	-	IEA	-
GO:0050796	regulation of insulin secretion	-	TAS	-
GO:0050913	sensory perception of bitter taste	-	IEA	-
GO:0050916	sensory perception of sweet taste	-	IEA	-
GO:0050917	sensory perception of umami taste	-	IEA	-
GO:0051209	release of sequestered calcium ion into cytosol	-	IBA	21873635
GO:0051209	release of sequestered calcium ion into cytosol	-	IEA	-
GO:0051260	protein homooligomerization	-	ISS	-
GO:0051291	protein heterooligomerization	-	ISS	-
GO:0051592	response to calcium ion	-	IDA	19052258
GO:0060291	long-term synaptic potentiation	-	IEA	-
GO:0060402	calcium ion transport into cytosol	-	ISS	-
GO:1903779	regulation of cardiac conduction	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005640	nuclear outer membrane	-	ISS	-
GO:0005654	nucleoplasm	-	IEA	-
GO:0005730	nucleolus	-	IEA	-
GO:0005737	cytoplasm	-	ISS	-
GO:0005783	endoplasmic reticulum	-	ISS	-
GO:0005789	endoplasmic reticulum membrane	-	IBA	21873635
GO:0005789	endoplasmic reticulum membrane	-	IDA	21062895
GO:0005789	endoplasmic reticulum membrane	-	ISS	-
GO:0005789	endoplasmic reticulum membrane	-	TAS	-
GO:0005886	plasma membrane	-	IBA	21873635
GO:0005886	plasma membrane	-	IDA	21062895
GO:0005887	integral component of plasma membrane	-	IDA	10828023
GO:0005903	brush border	-	ISS	8288584
GO:0016020	membrane	-	HDA	19946888
GO:0016529	sarcoplasmic reticulum	-	IBA	21873635
GO:0030659	cytoplasmic vesicle membrane	-	IBA	21873635
GO:0030667	secretory granule membrane	-	IBA	21873635
GO:0031095	platelet dense tubular network membrane	-	TAS	-
GO:0043025	neuronal cell body	-	ISS	-
GO:0043209	myelin sheath	-	ISS	-
GO:0043235	receptor complex	-	IDA	23382219
GO:0045177	apical part of cell	-	ISS	8288584

KEGG ID	KEGG Term
hsa04020	Calcium signaling pathway
hsa04070	Phosphatidylinositol signaling system
hsa04114	Oocyte meiosis
hsa04270	Vascular smooth muscle contraction
hsa04540	Gap junction
hsa04720	Long-term potentiation
hsa04730	Long-term depression
hsa04742	Taste transduction
hsa04912	GnRH signaling pathway
hsa04970	Salivary secretion
hsa04971	Gastric acid secretion
hsa04972	Pancreatic secretion
hsa05010	Alzheimer's disease

Reactome ID	Reactome Term	Evidence
R-HSA-109582	Hemostasis	TAS
R-HSA-111885	Opioid Signalling	IEA
R-HSA-112040	G-protein mediated events	IEA
R-HSA-112043	PLC beta mediated events	IEA
R-HSA-114508	Effects of PIP2 hydrolysis	TAS
R-HSA-1280218	Adaptive Immune System	IEA
R-HSA-1280218	Adaptive Immune System	TAS
R-HSA-139853	Elevation of cytosolic Ca2+ levels	TAS
R-HSA-1430728	Metabolism	IEA
R-HSA-1430728	Metabolism	TAS
R-HSA-1489509	DAG and IP3 signaling	IEA
R-HSA-162582	Signal Transduction	IEA
R-HSA-162582	Signal Transduction	TAS
R-HSA-163685	Integration of energy metabolism	IEA
R-HSA-163685	Integration of energy metabolism	TAS
R-HSA-168249	Innate Immune System	IEA
R-HSA-168256	Immune System	IEA
R-HSA-168256	Immune System	TAS
R-HSA-194138	Signaling by VEGF	IEA
R-HSA-195721	Signaling by WNT	IEA
R-HSA-2029480	Fcgamma receptor (FCGR) dependent phagocytosis	IEA
R-HSA-2029485	Role of phospholipids in phagocytosis	IEA
R-HSA-2454202	Fc epsilon receptor (FCERI) signaling	IEA
R-HSA-2871809	FCERI mediated Ca+2 mobilization	IEA
R-HSA-372790	Signaling by GPCR	IEA
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-381676	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	TAS
R-HSA-3858494	Beta-catenin independent WNT signaling	IEA
R-HSA-388396	GPCR downstream signalling	IEA
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-397014	Muscle contraction	IEA
R-HSA-397014	Muscle contraction	TAS
R-HSA-4086398	Ca2+ pathway	IEA
R-HSA-416476	G alpha (q) signalling events	TAS
R-HSA-418346	Platelet homeostasis	TAS
R-HSA-418360	Platelet calcium homeostasis	TAS
R-HSA-418594	G alpha (i) signalling events	IEA
R-HSA-422356	Regulation of insulin secretion	IEA
R-HSA-422356	Regulation of insulin secretion	TAS
R-HSA-4420097	VEGFA-VEGFR2 Pathway	IEA
R-HSA-5218921	VEGFR2 mediated cell proliferation	IEA
R-HSA-5576891	Cardiac conduction	IEA
R-HSA-5576891	Cardiac conduction	TAS
R-HSA-5578775	Ion homeostasis	IEA
R-HSA-5578775	Ion homeostasis	TAS
R-HSA-5607763	CLEC7A (Dectin-1) induces NFAT activation	IEA
R-HSA-5607764	CLEC7A (Dectin-1) signaling	IEA
R-HSA-5621481	C-type lectin receptors (CLRs)	IEA
R-HSA-76002	Platelet activation, signaling and aggregation	TAS
R-HSA-9006925	Intracellular signaling by second messengers	IEA
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	IEA
R-HSA-983695	Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	IEA
R-HSA-983695	Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	TAS
R-HSA-983705	Signaling by the B Cell Receptor (BCR)	IEA
R-HSA-983705	Signaling by the B Cell Receptor (BCR)	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
28193307	Heritability and GWAS Studies for Monocyte-Lymphocyte Ratio. (2017 Apr)	Lin BD	Twin Res Hum Genet