Gene: IVD

3712
ACAD2
isovaleryl-CoA dehydrogenase
protein-coding
15q15.1
Ensembl:ENSG00000128928 MIM:607036 Vega:OTTHUMG00000129984 UniprotKB:P26440
NG_011986.2
PubMed
0   ANCO-SNPs
ND
1   
4.422e-1 (AD)  4.351e-1 (ND)   (Frontal_Cortex)
1.724e-1 (AD)  3.679e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MED290.893
COQ90.875
DCAKD0.874
FAM213A0.867
ACAA10.866
CYB5R10.865
TSPAN30.863
CRAT0.862
TK20.861
GORASP10.86

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.772
OR4F29-0.725
MTRNR2L6-0.255
C17orf112-0.241
CLEC6A-0.24
CETP-0.239
OR6C74-0.233
HMHB1-0.227
FOXE1-0.225
KRTAP4-8-0.225

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of IVD mRNA"19162173
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of IVD mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of IVD mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of IVD mRNA"18648102
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of IVD mRNA"25380136
D000082AcetaminophenAcetaminophen results in decreased expression of IVD mRNA25704631
D000082AcetaminophenAcetaminophen affects the expression of IVD mRNA17562736
D000082AcetaminophenAcetaminophen results in increased expression of IVD protein21329376
D016604Aflatoxin B1Aflatoxin B1 affects the expression of IVD protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of IVD mRNA19770486
D000643Ammonium ChlorideAmmonium Chloride affects the expression of IVD mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of IVD mRNA24449571
C006780bisphenol Abisphenol A affects the expression of IVD mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of IVD mRNA21932408
C013418bromfenacoumbromfenacoum results in increased expression of IVD protein28903499
D002104CadmiumCadmium results in increased oxidation of IVD protein24496640
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of IVD mRNA20674023
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of IVD mRNA27339419
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of IVD mRNA15963342
D002737ChloropreneChloroprene results in increased expression of IVD mRNA23125180
D002994ClofibrateClofibrate results in decreased expression of IVD mRNA23811191
D002994ClofibrateClofibrate results in decreased expression of IVD mRNA22300585
C018021cobaltous chloridecobaltous chloride results in decreased expression of IVD mRNA19320972
D003300CopperCopper results in decreased expression of IVD mRNA22465980
D019327Copper SulfateCopper Sulfate results in decreased expression of IVD mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of IVD mRNA20106945|2556210
D016572CyclosporineCyclosporine results in decreased expression of IVD mRNA19770486
D064730Dexrazoxane[Doxorubicin co-treated with Dexrazoxane] results in increased expression of IVD mRNA26873546
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of IVD mRNA17361019|2126653
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of IVD protein28934723
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of IVD mRNA19638242
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of IVD mRNA"22485181
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of IVD mRNA25380136
D004237DiuronDiuron results in decreased expression of IVD mRNA21551480
D004317Doxorubicin[Doxorubicin co-treated with Dexrazoxane] results in increased expression of IVD mRNA26873546
D004317DoxorubicinDoxorubicin results in decreased expression of IVD mRNA26873546
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of IVD protein20227414
D005485FlutamideFlutamide results in decreased expression of IVD mRNA24136188
D005557FormaldehydeFormaldehyde results in decreased expression of IVD mRNA23649840
C069837fullerene C60fullerene C60 results in increased expression of IVD mRNA19167457
C056933fumonisin B1fumonisin B1 results in decreased expression of IVD mRNA16221962
C039281furanfuran binds to IVD protein22240984
C010974glyphosate[Surface-Active Agents co-treated with glyphosate] results in increased expression of IVD mRNA22467014
D017313FenretinideFenretinide results in decreased expression of IVD mRNA28973697
D017313FenretinideFenretinide results in increased expression of IVD mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of IVD mRNA21179406
C410337K 7174K 7174 results in decreased expression of IVD mRNA24086573
C008261lead acetatelead acetate results in increased expression of IVD protein20797405
D008694MethamphetamineMethamphetamine results in decreased expression of IVD protein19826936
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of IVD mRNA23103053
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of IVD mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of IVD protein"21135415
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of IVD mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of IVD mRNA"25554681
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of IVD mRNA25380136
C051752nefazodonenefazodone results in decreased expression of IVD mRNA24136188
C028007nickel monoxidenickel monoxide results in increased expression of IVD mRNA19167457
C012655nimesulidenimesulide results in decreased expression of IVD mRNA24136188
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in decreased expression of IVD mRNA17616710
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of IVD protein19954255
C522391perfluorododecanoic acidperfluorododecanoic acid results in decreased expression of IVD protein26168851
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of IVD mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of IVD protein26879310
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of IVD mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of IVD mRNA19162173
D010695PhlorhizinPhlorhizin results in decreased expression of IVD mRNA22538082
C006253pirinixic acidpirinixic acid results in decreased expression of IVD mRNA23811191
D010936Plant ExtractsPlant Extracts results in increased expression of IVD mRNA23557933
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of IVD mRNA19162173
D011374ProgesteroneProgesterone results in decreased expression of IVD mRNA23018184
D011374ProgesteroneProgesterone results in increased expression of IVD mRNA20726854
C015586propiverinepropiverine binds to IVD protein29273565
C502851quinocetonequinocetone results in increased expression of IVD mRNA27046791
C059514resveratrolresveratrol results in increased expression of IVD protein25505154
C089730rosiglitazonerosiglitazone results in decreased expression of IVD mRNA17245590
D012715Sesame OilSesame Oil results in increased expression of IVD mRNA29191790
C016104sodium bichromatesodium bichromate results in decreased expression of IVD mRNA25993096
D013501Surface-Active Agents[Surface-Active Agents co-treated with glyphosate] results in increased expression of IVD mRNA22467014
D013739TestosteroneTestosterone results in decreased expression of IVD mRNA20403060
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of IVD mRNA21570461
D013853ThioacetamideThioacetamide results in decreased expression of IVD mRNA23411599
C009495titanium dioxidetitanium dioxide results in decreased expression of IVD mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of IVD mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of IVD protein24486158|2731939
D014241TrichloroethyleneTrichloroethylene results in decreased expression of IVD mRNA19448997
C012589trichostatin Atrichostatin A results in increased expression of IVD mRNA15901671
D014520UrethaneUrethane results in decreased expression of IVD mRNA28818685
C406224valdecoxibvaldecoxib results in decreased expression of IVD mRNA24136188
D014635Valproic AcidValproic Acid results in increased expression of IVD mRNA15901671
D014635Valproic AcidValproic Acid affects the expression of IVD mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of IVD mRNA23179753
D014635Valproic AcidValproic Acid results in increased methylation of IVD gene29154799
D014635Valproic AcidValproic Acid results in decreased expression of IVD mRNA21427059
D014640VancomycinVancomycin results in increased expression of IVD mRNA18930951
C025643vinclozolinvinclozolin results in increased expression of IVD mRNA22570695|2303416
C029297vinylidene chloridevinylidene chloride results in decreased expression of IVD mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008470isovaleryl-CoA dehydrogenase activity-EXP3597357  9214289  
GO:0008470isovaleryl-CoA dehydrogenase activity-IBA21873635  
GO:0008470isovaleryl-CoA dehydrogenase activity-IDA3597357  
GO:0008470isovaleryl-CoA dehydrogenase activity-ISS-  
GO:0050660flavin adenine dinucleotide binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006552leucine catabolic process-IEA-  
GO:0006552leucine catabolic process-ISS-  
GO:0009083branched-chain amino acid catabolic process-TAS-  
GO:0033539fatty acid beta-oxidation using acyl-CoA dehydrogenase-IDA3597357  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IBA21873635  
GO:0005759mitochondrial matrix-ISS-  
GO:0005759mitochondrial matrix-TAS-  
KEGG ID KEGG Term
hsa00280Valine, leucine and isoleucine degradation
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-70895Branched-chain amino acid catabolismTAS
R-HSA-71291Metabolism of amino acids and derivativesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21562205Copy number variation in glutathione S-transferases M1 and T1 and ischemic vascular disease: four studies and meta-analyses. (2011 Aug 1)Norskov MSCirc Cardiovasc Genet