Gene: IVL

3713
-
involucrin
protein-coding
1q21.3
Ensembl:ENSG00000163207 MIM:147360 Vega:OTTHUMG00000012451 UniprotKB:P07476
NG_033018.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.783e-1 (AD)  9.037e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SPINK50.84
KRT150.76
MUC210.754
LAD10.752
TMPRSS11B0.745
SCEL0.742
FGFBP10.726
TACSTD20.718
ADH70.716
CSTA0.703

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DEPDC1-0.217
PCDHB10-0.215
CCDC134-0.202
SLC25A51-0.2
WDR76-0.199
PSPN-0.197
PATE2-0.196
LURAP1L-0.189
DHDH-0.186
FAM180A-0.18

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of IVL protein"10769631
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of IVL mRNA19933214
C0388644-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid"4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in decreased expression of IVL mRNA"8853895
C0331704-bromo-A-231874-bromo-A-23187 results in increased expression of IVL mRNA16621454
C0022024-oxoretinoic acid4-oxoretinoic acid results in increased expression of IVL mRNA17034753
C0418194-oxoretinol4-oxoretinol results in increased expression of IVL mRNA17034753
D000082AcetaminophenAcetaminophen affects the expression of IVL mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of IVL gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of IVL mRNA19770486
C103303alitretinoinalitretinoin results in decreased expression of IVL mRNA8853895
C103303alitretinoinalitretinoin results in increased expression of IVL mRNA17034753
D000966Antimony Potassium TartrateAntimony Potassium Tartrate results in decreased expression of IVL mRNA28713220
D000966Antimony Potassium TartrateAntimony Potassium Tartrate results in decreased expression of IVL protein28713220
C004984apocarotenalapocarotenal results in increased expression of IVL mRNA17034753
D001149ArsenatesArsenates results in decreased expression of IVL mRNA9219563
C006632arsenic trioxidearsenic trioxide results in increased expression of IVL protein25419056
C015001arsenitearsenite results in decreased expression of IVL mRNA18633435
C015001arsenitearsenite results in decreased expression of IVL protein18633435
C015001arseniteJAG1 protein inhibits the reaction [arsenite results in decreased expression of IVL mRNA]18633435
C015001arsenitetyrphostin AG 1478 inhibits the reaction [arsenite results in decreased expression of IVL mRNA]18633435
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of IVL mRNA"25351596
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of IVL mRNA19770486
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of IVL mRNA25566086
D019207beta Carotenebeta Carotene results in increased expression of IVL mRNA17034753
D004958EstradiolEstradiol results in decreased expression of IVL mRNA28701262
D004958Estradiolfulvestrant inhibits the reaction [Estradiol results in decreased expression of IVL mRNA]28701262
D004958EstradiolEstradiol results in increased expression of IVL mRNA19484750
C095105bexarotenebexarotene results in decreased expression of IVL mRNA8853895
C006780bisphenol Abisphenol A affects the expression of IVL mRNA28701262
C006780bisphenol Afulvestrant affects the reaction [bisphenol A affects the expression of IVL mRNA]28701262
C006780bisphenol Abisphenol A results in decreased expression of IVL mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of IVL mRNA20006635
C055085calcipotrienecalcipotriene results in decreased expression of IVL protein7508215
D002118CalciumCalcium results in increased expression of IVL mRNA10469331
D002118CalciumNPS R-467 promotes the reaction [Calcium results in increased expression of IVL mRNA]10469331
D002840ChromatesChromates results in decreased expression of IVL mRNA9219563
D002994ClofibrateClofibrate results in increased expression of IVL mRNA10951269|1758597
D002994ClofibrateClofibrate results in increased expression of IVL protein10951269
D003033Coal TarCoal Tar inhibits the reaction [[IL4 protein co-treated with IL13 protein] results in decreased expression of IVL mRNA]23348739
D003033Coal TarCoal Tar results in increased expression of IVL mRNA23348739
D003474CurcuminCurcumin inhibits the reaction [MAP3K1 protein results in increased expression of IVL mRNA]17148446
D003474CurcuminCurcumin inhibits the reaction [PRKCD protein results in increased expression of IVL mRNA]17148446
D003474CurcuminCurcumin inhibits the reaction [PRKCE protein results in increased expression of IVL mRNA]17148446
D003474CurcuminCurcumin inhibits the reaction [PRKCH protein results in increased expression of IVL mRNA]17148446
D003474CurcuminCurcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IVL mRNA]17148446
D003703DemecolcineDemecolcine results in increased expression of IVL mRNA23649840
D002117CalcitriolCalcitriol results in decreased expression of IVL protein7508215|8950452
D004237DiuronDiuron results in increased expression of IVL mRNA21551480
D005419FlavonoidsFlavonoids results in decreased expression of IVL mRNA18035473
D005557FormaldehydeFormaldehyde results in increased expression of IVL mRNA23649840|2766457
C070081fulvestrantfulvestrant affects the reaction [bisphenol A affects the expression of IVL mRNA]28701262
C070081fulvestrantfulvestrant inhibits the reaction [Estradiol results in decreased expression of IVL mRNA]28701262
D005839GentamicinsGentamicins results in decreased expression of IVL mRNA22061828
D006427HeminHemin results in decreased expression of IVL mRNA20006635
C098607JP8 aviation fuelJP8 aviation fuel results in decreased expression of IVL protein17337753
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of IVL protein24736545
C561695(+)-JQ1 compoundSOX2 protein inhibits the reaction [(+)-JQ1 compound results in increased expression of IVL protein]24736545
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of IVL mRNA26644586
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of IVL mRNA"24972896
C015329lycopenelycopene results in decreased expression of IVL protein10769631
C044659molybdatemolybdate results in decreased expression of IVL protein7848924
D009151Mustard GasMustard Gas results in increased expression of IVL mRNA21524694
D009151Mustard GasMustard Gas results in increased expression of IVL protein21524694
D009151Mustard GasMustard Gas results in decreased expression of IVL mRNA15674843
D009532NickelNickel results in increased expression of IVL mRNA25583101
D009538NicotineNicotine results in decreased expression of IVL protein16011614
C419410N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in decreased expression of IVL mRNA"18633435
C419410N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in decreased expression of IVL protein"18633435
C111654NPS R-467NPS R-467 promotes the reaction [Calcium results in increased expression of IVL mRNA]10469331
C026209oltiprazoltipraz results in decreased expression of IVL protein10769631
D052638Particulate MatterParticulate Matter results in increased expression of IVL mRNA28341207
C032208perillyl alcoholperillyl alcohol results in decreased expression of IVL protein10769631
C014153pirimiphos methylpirimiphos methyl results in decreased expression of IVL mRNA27845199
C006253pirinixic acidpirinixic acid results in increased expression of IVL mRNA10951269
C006253pirinixic acidpirinixic acid results in increased expression of IVL protein10951269
D059808PolyphenolsPolyphenols results in decreased expression of IVL protein10769631
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of IVL mRNA20006635
D011192Potassium DichromatePotassium Dichromate results in increased expression of IVL mRNA23608068
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of IVL mRNA14699072
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of IVL mRNA19059307
C407502Ro 16-9100Ro 16-9100 results in decreased expression of IVL protein10769631
D012822Silicon DioxideSilicon Dioxide results in increased expression of IVL mRNA25351596
C009277sodium arsenatesodium arsenate results in decreased expression of IVL mRNA11485391|1272780
C009277sodium arsenatesodium arsenate results in decreased expression of IVL protein7848924
C017947sodium arsenitesodium arsenite affects the reaction [FOSL1 protein binds to IVL promoter]20006635
C017947sodium arsenitesodium arsenite affects the reaction [FOS protein binds to IVL promoter]20006635
C017947sodium arsenitesodium arsenite affects the reaction [JUNB protein binds to IVL promoter]20006635
C017947sodium arsenitesodium arsenite inhibits the reaction [EP300 protein binds to IVL promoter]20006635
C017947sodium arsenitesodium arsenite results in decreased expression of IVL mRNA11485391|1272780
C017947sodium arsenitesodium arsenite results in decreased expression of IVL protein20006635|2871322
C017947sodium arsenitesodium arsenite results in increased expression of IVL mRNA19524636
C017947sodium arsenitesodium arsenite results in increased expression of IVL protein18572023|1952463
D053260SootSoot results in increased expression of IVL mRNA26551751
C120232SR 11238SR 11238 results in decreased expression of IVL mRNA8853895
D013629TamoxifenESR2 protein affects the reaction [Tamoxifen results in decreased expression of IVL mRNA]14699072
D013629TamoxifenTamoxifen affects the expression of IVL mRNA14699072
D013629Tamoxifen[Tamoxifen co-treated with ESR2 protein] results in decreased expression of IVL mRNA19059307
D013629TamoxifenTamoxifen results in decreased expression of IVL mRNA15590111
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of IVL mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of IVL mRNA19770486|1993321
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of IVL mRNA17035482
D013755Tetradecanoylphorbol AcetateCurcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IVL mRNA]17148446
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of IVL mRNA17148446
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of IVL mRNA10866668
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of IVL mRNA27480279
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of IVL mRNA27404394
D014212TretinoinTretinoin analog results in decreased expression of IVL mRNA1318502
D014212TretinoinTretinoin inhibits the reaction [IL1A protein results in increased expression of IVL mRNA]17214633
D014212TretinoinTretinoin results in decreased expression of IVL mRNA17214633
D014212TretinoinTretinoin results in increased expression of IVL mRNA16249480|1703475
D014212TretinoinTretinoin results in increased expression of IVL protein8396608|9716179
C045951tungstatetungstate results in decreased expression of IVL protein7848924
C101044tyrphostin AG 1478tyrphostin AG 1478 inhibits the reaction [arsenite results in decreased expression of IVL mRNA]18633435
C101044tyrphostin AG 1478tyrphostin AG 1478 results in increased expression of IVL protein18633435
C022884undecaneundecane results in decreased expression of IVL protein17337753
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid results in decreased expression of IVL protein10769631
D014635Valproic AcidValproic Acid affects the expression of IVL mRNA17963808
D014638VanadatesVanadates results in decreased expression of IVL mRNA20006635|9219563
D014638VanadatesVanadates results in decreased expression of IVL protein7848924
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of IVL gene25560391
D014750VincristineVincristine results in increased expression of IVL mRNA23649840
D014801Vitamin AVitamin A results in increased expression of IVL mRNA17034753
D015032ZincZinc deficiency results in increased expression of IVL mRNA19111725
D015032ZincZinc inhibits the reaction [Zinc deficiency results in increased expression of IVL mRNA]19111725

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005198structural molecule activity-IDA42494  10908733  
GO:0005515protein binding-IPI21044950  
GO:0030674protein binding, bridging-IDA10908733  
GO ID GO Term Qualifier Evidence PubMed
GO:0010224response to UV-B-IDA16639001  
GO:0018149peptide cross-linking-IDA10908733  
GO:0018153isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine-TAS1601889  
GO:0030216keratinocyte differentiation-IDA10908733  
GO:0070268cornification-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001533cornified envelope-IDA10908733  
GO:0001533cornified envelope-TAS-  
GO:0005737cytoplasm-IDA42494  16639001  
GO:0005813centrosome-IDA-  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0016604nuclear body-IDA-  
GO:0070062extracellular exosome-HDA19199708  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-6805567KeratinizationTAS
R-HSA-6809371Formation of the cornified envelopeTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21141061[Case of intravascular lymphoma diagnosed by transbronchial lung biopsy, with transient spontaneous remission]. (2010 Nov)Takahashi RNihon Kokyuki Gakkai Zasshi