Gene info: ID 3716

Gene: JAK1

GENE ID: 3716

Synonyms: JAK1A|JAK1B|JTK3

Description: Janus kinase 1

Gene type: protein-coding

Location: 1p31.3

dbXrefs: Ensembl:ENSG00000162434 MIM:147795 Vega:OTTHUMG00000009310 UniprotKB:P23458

RefSeq: NG_023402.2

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 3

Sherlock p-value : 6.706e-1 (AD) 2.517e-1 (ND) (Frontal_Cortex)

Pascal p-value : 7.584e-1 (AD) 7.644e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
RBBP4	0.925
KPNB1	0.922
NCOA1	0.919
SEC31A	0.909
SON	0.906
LARS	0.901
EPRS	0.901
CAPRIN1	0.901
CSNK1A1	0.9
USO1	0.9

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.721
OR4F29	-0.691
TNFRSF13B	-0.239
CTNNA3	-0.22
KLRC2	-0.216
NANOGNB	-0.216
C5orf64	-0.209
SH2D1A	-0.204
SOX3	-0.195
FXYD4	-0.193

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB02375	Myricetin	Small Molecule	529-44-2	Experimental	Target
DB04716	2-(1,1-DIMETHYLETHYL)9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLIN-7-ONE	Small Molecule		Experimental	Target
DB08877	Ruxolitinib	Small Molecule	941678-49-5	Approved	Target
DB08895	Tofacitinib	Small Molecule	477600-75-2	Approved\|Investigational	Target
DB11817	Baricitinib	Small Molecule	1187594-09-7	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C472829	1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole	"1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole binds to JAK1 protein"	21361338
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of JAK1 protein modified form"	21705713
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"CTNNB1 gene mutant form affects the susceptibility to [1,4-bis(2-(3,5-dichloropyridyloxy))benzene affects the expression of JAK1 protein]"	21705713
C554428	1-nitrosocyclohexyl acetate	1-nitrosocyclohexyl acetate affects the reaction [JAK1 protein results in increased phosphorylation of LIF protein]	22905257
C548651	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of JAK1 mRNA	19933214
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"2,4,5,2',4',5'-hexachlorobiphenyl results in increased phosphorylation of JAK1 protein"	19632255
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"Filipin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased phosphorylation of JAK1 protein]"	19632255
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"methyl-beta-cyclodextrin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased phosphorylation of JAK1 protein]"	19632255
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of JAK1 mRNA"	21346803
C524063	2-tert-butyl-9-fluoro-3,6-dihydro-7H-benz(h)imidazo(4,5-f)isoquinoline-7-one	"2-tert-butyl-9-fluoro-3,6-dihydro-7H-benz(h)imidazo(4,5-f)isoquinoline-7-one inhibits the reaction [OSM protein results in increased phosphorylation of JAK1 protein]"	21548952
C041525	3,3',4,5'-tetrahydroxystilbene	"3,3',4,5'-tetrahydroxystilbene binds to JAK1 protein"	18995957
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of JAK1 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of JAK1 mRNA"	27188386
C012606	4-vinyl-1-cyclohexene dioxide	4-vinyl-1-cyclohexene dioxide affects the expression of JAK1 mRNA	20829426
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of JAK1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of JAK1 mRNA"	27188386
C000625361	6-hydroxy-3-O-methylkaempferol 6-O-glucopyranoside	6-hydroxy-3-O-methylkaempferol 6-O-glucopyranoside promotes the reaction [interferon alfa-2a results in increased expression of JAK1 protein modified form]	29031523
C000625361	6-hydroxy-3-O-methylkaempferol 6-O-glucopyranoside	6-hydroxy-3-O-methylkaempferol 6-O-glucopyranoside promotes the reaction [interferon alfa-2a results in increased phosphorylation of JAK1 protein]	29031523
C000625361	6-hydroxy-3-O-methylkaempferol 6-O-glucopyranoside	6-hydroxy-3-O-methylkaempferol 6-O-glucopyranoside results in increased phosphorylation of JAK1 protein	29031523
C000625361	6-hydroxy-3-O-methylkaempferol 6-O-glucopyranoside	SOCS3 protein inhibits the reaction [6-hydroxy-3-O-methylkaempferol 6-O-glucopyranoside promotes the reaction [interferon alfa-2a results in increased expression of JAK1 protein modified form]]	29031523
C041398	7,7'-dimethoxy-(4,4'-bi-1,3-benzodioxole)-5,5'-dicarboxylic acid dimethyl ester	"7,7'-dimethoxy-(4,4'-bi-1,3-benzodioxole)-5,5'-dicarboxylic acid dimethyl ester results in increased expression of JAK1 protein"	16756086
D000082	Acetaminophen	Acetaminophen results in increased expression of JAK1 mRNA	22230336
D000082	Acetaminophen	Acetaminophen affects the expression of JAK1 mRNA	17562736
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [DDT results in increased phosphorylation of JAK1 protein]	24820114
D020106	Acrylamide	Acrylamide results in increased expression of JAK1 mRNA	28959563
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of JAK1 mRNA	27153756
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in increased expression of JAK1 mRNA	28522335
C095512	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [CTF1 results in increased expression of JAK1 protein]"	16534557
D000547	Amantadine	Amantadine results in increased expression of JAK1 protein	16756086
D000638	Amiodarone	Amiodarone affects the expression of JAK1 mRNA	19483382
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of JAK1 mRNA	16483693
D034341	Aristolochic Acids	Aristolochic Acids inhibits the reaction [EPO protein results in increased phosphorylation of JAK1 protein]	26136230
D001151	Arsenic	Arsenic results in decreased expression of JAK1 mRNA	19654921
C006632	arsenic trioxide	arsenic trioxide inhibits the reaction [IL6 protein results in increased phosphorylation of JAK1 protein]	12492118
C006632	arsenic trioxide	arsenic trioxide results in increased phosphorylation of JAK1 protein	19951532
C000596027	baricitinib	baricitinib inhibits the reaction [OSM protein results in increased phosphorylation of and results in increased activity of JAK1 protein]	23968543
C000596027	baricitinib	baricitinib results in decreased activity of JAK1 protein	23968543
D001553	Benzbromarone	Benzbromarone affects the expression of JAK1 mRNA	19483382
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of JAK1 mRNA	22228805
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of JAK1 mRNA"	20018196
D004958	Estradiol	Estradiol affects the expression of JAK1 mRNA	23557687
C006780	bisphenol A	bisphenol A results in decreased expression of JAK1 mRNA	22576693
C006780	bisphenol A	bisphenol A results in increased methylation of JAK1 gene	22576693
C006780	bisphenol A	bisphenol A results in increased expression of JAK1 mRNA	25181051
D000069286	Bortezomib	Bortezomib results in decreased expression of JAK1 mRNA	20977926
D002065	Buspirone	Buspirone results in decreased expression of JAK1 mRNA	24136188
D019328	Buthionine Sulfoximine	Buthionine Sulfoximine results in increased expression of JAK1 mRNA	15878706
D019256	Cadmium Chloride	Cadmium Chloride results in decreased phosphorylation of JAK1 protein	19635391
D002211	Capsaicin	Capsaicin results in decreased phosphorylation of and results in decreased activity of JAK1 protein	17505005
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased phosphorylation of JAK1 protein	28428136
D002251	Carbon Tetrachloride	hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of JAK1 protein]	28428136
D002251	Carbon Tetrachloride	Silymarin inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of JAK1 protein]	28428136
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of JAK1 mRNA	26062544
D002251	Carbon Tetrachloride	Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of JAK1 mRNA]	26062544
D000068579	Celecoxib	Celecoxib results in decreased expression of JAK1 mRNA	28201806
D002994	Clofibrate	Clofibrate results in decreased expression of JAK1 mRNA	17585979
D002994	Clofibrate	Clofibrate affects the expression of JAK1 mRNA	19483382
D003042	Cocaine	Cocaine results in decreased expression of JAK1 mRNA	11299316
D003300	Copper	[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of JAK1 mRNA	15467011
D019327	Copper Sulfate	Copper Sulfate results in increased expression of JAK1 mRNA	19549813
D003474	Curcumin	Curcumin results in decreased expression of JAK1	18462866
C057862	cyanoginosin LR	cyanoginosin LR results in increased expression of JAK1 mRNA	17654400
D016572	Cyclosporine	Cyclosporine results in increased expression of JAK1 mRNA	25562108
D003634	DDT	Acetylcysteine inhibits the reaction [DDT results in increased phosphorylation of JAK1 protein]	24820114
D003634	DDT	DDT results in increased phosphorylation of JAK1 protein	24820114
D003634	DDT	INCB018424 inhibits the reaction [DDT results in increased phosphorylation of JAK1 protein]	24820114
C007262	deoxynivalenol	deoxynivalenol results in increased expression of JAK1 mRNA	22454431
D004041	Dietary Fats	Dietary Fats results in increased expression of JAK1 mRNA	23409006
D002117	Calcitriol	JAK1 protein affects the reaction [[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] affects the expression of and affects the activity of CASP1 protein]	26091108
D004121	Dimethyl Sulfoxide	Dimethyl Sulfoxide results in decreased expression of JAK1 mRNA	22169935
D004147	Dioxins	Dioxins affects the expression of JAK1 mRNA	20463971
D004221	Disulfiram	Disulfiram results in decreased expression of JAK1 mRNA	20530235
C012301	domoic acid	domoic acid results in increased expression of JAK1 mRNA	18936300
D004642	Emodin	Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of JAK1 protein]	23848338
D004642	Emodin	Emodin results in decreased phosphorylation of JAK1 protein	23848338
C044101	endotoxin, Escherichia coli	"endotoxin, Escherichia coli results in increased expression of JAK1 mRNA"	15919760
D000431	Ethanol	Ethanol promotes the reaction [IL10 protein results in increased phosphorylation of JAK1 protein]	20052772
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of JAK1 mRNA	17555576
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of JAK1 mRNA	16467188\|1794274
D005001	Ethionine	Ethionine affects the expression of JAK1 mRNA	19483382
D005038	Ethylnitrosourea	Ethylnitrosourea results in increased phosphorylation of JAK1 protein	27725143
C077139	fidarestat	fidarestat inhibits the reaction [IL13 protein results in increased phosphorylation of JAK1 protein]	21203431
C077139	fidarestat	fidarestat results in decreased phosphorylation of JAK1 protein	21203431
D005372	Filipin	"Filipin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased phosphorylation of JAK1 protein]"	19632255
D005839	Gentamicins	Gentamicins results in increased expression of JAK1 mRNA	22061828
C013015	hesperetin	hesperetin analog affects the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased phosphorylation of JAK1 protein]]	28428136
C013015	hesperetin	hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of JAK1 protein]	28428136
D017313	Fenretinide	Fenretinide results in increased expression of JAK1 protein	15059897
D006861	Hydrogen Peroxide	[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of JAK1 protein	18951874
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of JAK1 mRNA	18951874
C540383	INCB018424	INCB018424 inhibits the reaction [DDT results in increased phosphorylation of JAK1 protein]	24820114
C540383	INCB018424	INCB018424 results in decreased activity of JAK1 protein	24883332\|2630039
C554043	interferon alfa-2a	6-hydroxy-3-O-methylkaempferol 6-O-glucopyranoside promotes the reaction [interferon alfa-2a results in increased expression of JAK1 protein modified form]	29031523
C554043	interferon alfa-2a	6-hydroxy-3-O-methylkaempferol 6-O-glucopyranoside promotes the reaction [interferon alfa-2a results in increased phosphorylation of JAK1 protein]	29031523
C554043	interferon alfa-2a	interferon alfa-2a results in increased expression of JAK1 protein modified form	29031523
C554043	interferon alfa-2a	interferon alfa-2a results in increased phosphorylation of JAK1 protein	29031523
C554043	interferon alfa-2a	SOCS3 protein inhibits the reaction [6-hydroxy-3-O-methylkaempferol 6-O-glucopyranoside promotes the reaction [interferon alfa-2a results in increased expression of JAK1 protein modified form]]	29031523
C554043	interferon alfa-2a	SOCS3 protein inhibits the reaction [interferon alfa-2a results in increased expression of JAK1 protein modified form]	29031523
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of JAK1 mRNA	25613284
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in increased expression of JAK1 mRNA	23430699\|2382885
C410337	K 7174	K 7174 results in increased expression of JAK1 mRNA	24086573
D008043	Linseed Oil	Linseed Oil results in increased expression of JAK1 mRNA	23409006
C440499	lipopolysaccharide, Escherichia coli O111 B4	"[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IFNG protein] results in increased phosphorylation of JAK1 protein"	20060843
C440499	lipopolysaccharide, Escherichia coli O111 B4	"Quercetin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IFNG protein] results in increased phosphorylation of JAK1 protein]"	20060843
D008070	Lipopolysaccharides	JAK1 protein affects the reaction [[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] affects the expression of and affects the activity of CASP1 protein]	26091108
D008070	Lipopolysaccharides	hesperetin analog affects the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased phosphorylation of JAK1 protein]]	28428136
D008070	Lipopolysaccharides	IL10 protein affects the reaction [resveratrol promotes the reaction [Lipopolysaccharides results in increased phosphorylation of JAK1 protein]]	25576658
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of JAK1 mRNA	15919760
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased phosphorylation of JAK1 protein	25576658\|2842813
D008070	Lipopolysaccharides	PPARG protein affects the reaction [Lipopolysaccharides results in increased phosphorylation of JAK1 protein]	28428136
D008070	Lipopolysaccharides	resveratrol promotes the reaction [Lipopolysaccharides results in increased phosphorylation of JAK1 protein]	25576658
D008148	Lovastatin	Lovastatin results in decreased activity of JAK1 protein	17507688
C015329	lycopene	lycopene results in increased expression of JAK1 mRNA	16886892
C545385	Mequindox	Mequindox results in increased expression of JAK1 mRNA	21146578
D008627	Mercuric Chloride	Mercuric Chloride affects the expression of JAK1 mRNA	20353558
D008627	Mercuric Chloride	Mercuric Chloride results in decreased phosphorylation of JAK1 protein	16896058\|1963539
D008731	Methoxychlor	Methoxychlor affects the expression of JAK1 mRNA	20829426
C108732	methyl-beta-cyclodextrin	"methyl-beta-cyclodextrin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased phosphorylation of JAK1 protein]"	19632255
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of JAK1 mRNA	23458150
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of JAK1 mRNA	28001369
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of JAK1 mRNA"	20188158
D008775	Methylprednisolone	Methylprednisolone inhibits the reaction [IL4 protein results in increased phosphorylation of JAK1 protein]	11997017
C008493	methylselenic acid	methylselenic acid affects the expression of JAK1 mRNA	14617803
C008493	methylselenic acid	methylselenic acid results in increased expression of JAK1 mRNA	18548127
D008798	Mevalonic Acid	Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CTF1 results in increased expression of JAK1 protein]]	16534557
D015735	Mifepristone	Mifepristone affects the localization of JAK1 protein	19439560
D015735	Mifepristone	Mifepristone results in increased expression of JAK1 mRNA	19439560
C406082	monomethylarsonous acid	monomethylarsonous acid inhibits the reaction [IL7 protein results in increased phosphorylation of JAK1 protein]	26921788
C406082	monomethylarsonous acid	monomethylarsonous acid results in decreased phosphorylation of JAK1 protein	26518055
C040015	myricetin	myricetin binds to JAK1 protein	18995957
C040015	myricetin	myricetin inhibits the reaction [EGF protein results in increased phosphorylation of JAK1 protein]	18995957
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of JAK1 mRNA"	15585362
C012655	nimesulide	nimesulide results in decreased expression of JAK1 mRNA	24136188
D009569	Nitric Oxide	Nitric Oxide deficiency results in decreased expression of JAK1 mRNA	15878706
D009853	Omeprazole	Omeprazole affects the expression of JAK1 mRNA	19483382
D010100	Oxygen	Oxygen deficiency results in increased expression of JAK1 mRNA	24205000
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of JAK1 protein	26879310
C058305	phenethyl isothiocyanate	phenethyl isothiocyanate results in decreased expression of JAK1 mRNA	17616710
D010634	Phenobarbital	Phenobarbital results in decreased expression of JAK1 mRNA	23091169
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of JAK1 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of JAK1 mRNA	26272509
C006253	pirinixic acid	pirinixic acid affects the expression of JAK1 mRNA	19483382
C545373	ponatinib	ponatinib results in decreased activity of JAK1 protein	19878872
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of JAK1 protein	23718831
C045362	prochloraz	prochloraz results in increased expression of JAK1 mRNA	21470553
C045950	propiconazole	propiconazole results in increased expression of JAK1 mRNA	21278054
D011441	Propylthiouracil	Propylthiouracil affects the expression of JAK1 mRNA	19483382
D011794	Quercetin	Quercetin inhibits the reaction [IL6 protein results in increased phosphorylation of JAK1 protein]	22394507
D011794	Quercetin	Quercetin results in decreased expression of JAK1 mRNA	21632981
D011794	Quercetin	Quercetin results in decreased phosphorylation of JAK1 protein	27175602
D011794	Quercetin	"Quercetin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IFNG protein] results in increased phosphorylation of JAK1 protein]"	20060843
C059514	resveratrol	resveratrol results in decreased expression of JAK1 mRNA	25667456
C059514	resveratrol	resveratrol results in decreased expression of JAK1 protein	22254182
C059514	resveratrol	resveratrol results in decreased phosphorylation of JAK1 protein	26911335
C059514	resveratrol	IL10 protein affects the reaction [resveratrol promotes the reaction [Lipopolysaccharides results in increased phosphorylation of JAK1 protein]]	25576658
C059514	resveratrol	resveratrol promotes the reaction [Lipopolysaccharides results in increased phosphorylation of JAK1 protein]	25576658
D015474	Isotretinoin	Isotretinoin results in increased expression of JAK1 mRNA	20436886
C089730	rosiglitazone	rosiglitazone inhibits the reaction [IFNG protein results in increased phosphorylation of JAK1 protein]	12584205
D012402	Rotenone	Rotenone inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of JAK1 protein]	15748169
D012402	Rotenone	Rotenone results in decreased phosphorylation of JAK1 protein	19635391
D012431	Rutin	Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of JAK1 mRNA]	26062544
D012838	Silymarin	Silymarin inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of JAK1 protein]	28428136
D019821	Simvastatin	Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CTF1 results in increased expression of JAK1 protein]]	16534557
D019821	Simvastatin	Simvastatin inhibits the reaction [CTF1 results in increased expression of JAK1 protein]	16534557
C009277	sodium arsenate	sodium arsenate results in increased expression of JAK1 mRNA	16882884
C017947	sodium arsenite	sodium arsenite inhibits the reaction [IFNG protein results in increased activity of JAK1 protein]	15116095
C017947	sodium arsenite	sodium arsenite inhibits the reaction [IL6 protein results in increased activity of JAK1 protein]	15116095
C017947	sodium arsenite	sodium arsenite inhibits the reaction [IL6 protein results in increased phosphorylation of JAK1 protein]	15116095
C017947	sodium arsenite	sodium arsenite inhibits the reaction [JAK1 protein results in increased phosphorylation of STAT3 protein]	15116095
C017947	sodium arsenite	sodium arsenite results in decreased expression of JAK1 mRNA	12679051
C017947	sodium arsenite	sodium arsenite results in decreased phosphorylation of and results in decreased activity of JAK1 protein	15116095
D013141	Spiro Compounds	Spiro Compounds analog results in decreased phosphorylation of JAK1 protein	25320076
D013458	Sulfur Dioxide	Sulfur Dioxide promotes the reaction [OVAL protein results in increased expression of JAK1 mRNA]	29288730
D013605	T-2 Toxin	T-2 Toxin results in increased expression of JAK1 mRNA	22454431
C061133	tamibarotene	tamibarotene affects the expression of JAK1 mRNA	15498508
D013629	Tamoxifen	Tamoxifen affects the expression of JAK1 mRNA	17555576
C004648	testosterone enanthate	testosterone enanthate results in increased expression of JAK1 mRNA	25603467
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to JAK1 gene]	19574409
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of JAK1 mRNA	19574409
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of JAK1 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of JAK1 mRNA	18691609\|1993321
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of JAK1 mRNA	22298810
D013752	Tetracycline	Tetracycline results in increased expression of JAK1 mRNA	16917069
D013755	Tetradecanoylphorbol Acetate	JAK1 protein affects the reaction [[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] affects the expression of and affects the activity of CASP1 protein]	26091108
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of JAK1 mRNA	25613284
D019284	Thapsigargin	Thapsigargin results in increased expression of JAK1 protein	24648495
D013806	Theophylline	[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of JAK1 protein	18951874
D013853	Thioacetamide	Thioacetamide affects the expression of JAK1 mRNA	19483382
D013893	Thiram	Thiram results in decreased expression of JAK1 mRNA	20530235
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of JAK1 mRNA	28111298
C479163	tofacitinib	tofacitinib inhibits the reaction [OSM protein results in increased phosphorylation of and results in increased activity of JAK1 protein]	23968543
C479163	tofacitinib	tofacitinib inhibits the reaction [OSM protein results in increased phosphorylation of JAK1 protein]	21548952
C479163	tofacitinib	tofacitinib results in decreased activity of JAK1 protein	24883332
C479163	tofacitinib	tofacitinib results in decreased activity of JAK1 protein	21155605\|2770819
C483909	torcetrapib	torcetrapib results in increased expression of JAK1 mRNA	23228038
D014118	Toxins, Biological	"Toxins, Biological affects the expression of JAK1 mRNA"	19682533
D014212	Tretinoin	Tretinoin results in decreased expression of JAK1 mRNA	15498508
D014212	Tretinoin	Tretinoin results in increased expression of JAK1 mRNA	21934132
C012589	trichostatin A	trichostatin A affects the expression of JAK1 mRNA	28542535
C012589	trichostatin A	trichostatin A results in increased expression of JAK1 mRNA	24935251
C046488	trimethyltin	trimethyltin results in increased expression of JAK1 mRNA	20833246
D014520	Urethane	Urethane results in increased expression of JAK1 mRNA	28818685
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of JAK1 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of JAK1 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased methylation of JAK1 gene	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of JAK1 mRNA	23179753\|2627250
D014635	Valproic Acid	Valproic Acid results in increased expression of JAK1 mRNA	20546886
C066075	vanadium pentoxide	JAK1 protein affects the reaction [vanadium pentoxide results in increased activity of STAT1 protein]	18322232
C025643	vinclozolin	vinclozolin results in decreased expression of JAK1 mRNA	21126777
D024483	Vitamin K 3	Vitamin K 3 affects the expression of JAK1 mRNA	20829426
C088658	zoledronic acid	zoledronic acid results in increased expression of JAK1 mRNA	24714768

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004713	protein tyrosine kinase activity	-	EXP	1386289 8232552 10825200
GO:0004713	protein tyrosine kinase activity	-	TAS	-
GO:0004715	non-membrane spanning protein tyrosine kinase activity	-	TAS	-
GO:0005088	Ras guanyl-nucleotide exchange factor activity	-	TAS	-
GO:0005131	growth hormone receptor binding	-	IBA	21873635
GO:0005131	growth hormone receptor binding	-	ISS	10502458
GO:0005515	protein binding	-	IPI	7759950 10993906 16273093 16710296 21220115 26175413
GO:0005524	ATP binding	-	IEA	-
GO:0019903	protein phosphatase binding	-	IPI	11909529
GO:0031625	ubiquitin protein ligase binding	-	IPI	24882218
GO:0031730	CCR5 chemokine receptor binding	-	IEA	-
GO:0046872	metal ion binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000165	MAPK cascade	-	TAS	-
GO:0006468	protein phosphorylation	-	TAS	1848670
GO:0019221	cytokine-mediated signaling pathway	-	IBA	21873635
GO:0019221	cytokine-mediated signaling pathway	-	TAS	-
GO:0035556	intracellular signal transduction	-	TAS	8232552
GO:0035722	interleukin-12-mediated signaling pathway	-	TAS	-
GO:0035723	interleukin-15-mediated signaling pathway	-	TAS	-
GO:0038110	interleukin-2-mediated signaling pathway	-	IDA	11909529
GO:0038110	interleukin-2-mediated signaling pathway	-	TAS	-
GO:0038111	interleukin-7-mediated signaling pathway	-	TAS	-
GO:0038113	interleukin-9-mediated signaling pathway	-	TAS	-
GO:0038114	interleukin-21-mediated signaling pathway	-	TAS	-
GO:0046677	response to antibiotic	-	IDA	16280321
GO:0060333	interferon-gamma-mediated signaling pathway	-	TAS	-
GO:0060334	regulation of interferon-gamma-mediated signaling pathway	-	TAS	-
GO:0060337	type I interferon signaling pathway	-	TAS	-
GO:0070102	interleukin-6-mediated signaling pathway	-	TAS	-
GO:0070106	interleukin-27-mediated signaling pathway	-	TAS	-
GO:0070757	interleukin-35-mediated signaling pathway	-	TAS	-
GO:1903672	positive regulation of sprouting angiogenesis	-	IGI	20299512

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IDA	10502458
GO:0005737	cytoplasm	-	IDA	10502458
GO:0005768	endosome	-	TAS	-
GO:0005829	cytosol	-	TAS	-
GO:0005856	cytoskeleton	-	IEA	-
GO:0005925	focal adhesion	-	HDA	21423176

KEGG ID	KEGG Term
hsa04380	Osteoclast differentiation
hsa04630	Jak-STAT signaling pathway
hsa05140	Leishmaniasis
hsa05145	Toxoplasmosis
hsa05160	Hepatitis C
hsa05200	Pathways in cancer
hsa05212	Pancreatic cancer

Reactome ID	Reactome Term	Evidence
R-HSA-1059683	Interleukin-6 signaling	TAS
R-HSA-1059683	Interleukin-6 signaling	IEA
R-HSA-110056	MAPK3 (ERK1) activation	TAS
R-HSA-112409	RAF-independent MAPK1/3 activation	TAS
R-HSA-112411	MAPK1 (ERK2) activation	TAS
R-HSA-1169408	ISG15 antiviral mechanism	TAS
R-HSA-1169410	Antiviral mechanism by IFN-stimulated genes	TAS
R-HSA-1266695	Interleukin-7 signaling	IEA
R-HSA-1266695	Interleukin-7 signaling	TAS
R-HSA-1280215	Cytokine Signaling in Immune system	TAS
R-HSA-1280215	Cytokine Signaling in Immune system	IEA
R-HSA-162582	Signal Transduction	TAS
R-HSA-168256	Immune System	TAS
R-HSA-168256	Immune System	IEA
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-392451	G beta:gamma signalling through PI3Kgamma	TAS
R-HSA-397795	G-protein beta:gamma signalling	TAS
R-HSA-447115	Interleukin-12 family signaling	TAS
R-HSA-447115	Interleukin-12 family signaling	IEA
R-HSA-449147	Signaling by Interleukins	TAS
R-HSA-449147	Signaling by Interleukins	IEA
R-HSA-449836	Other interleukin signaling	TAS
R-HSA-451927	Interleukin-2 family signaling	TAS
R-HSA-451927	Interleukin-2 family signaling	IEA
R-HSA-512988	Interleukin-3, 5 and GM-CSF signaling	TAS
R-HSA-5673001	RAF/MAP kinase cascade	TAS
R-HSA-5683057	MAPK family signaling cascades	TAS
R-HSA-5684996	MAPK1/MAPK3 signaling	TAS
R-HSA-6783589	Interleukin-6 family signaling	TAS
R-HSA-6783589	Interleukin-6 family signaling	IEA
R-HSA-6783783	Interleukin-10 signaling	TAS
R-HSA-6785807	Interleukin-4 and 13 signaling	TAS
R-HSA-6788467	IL-6-type cytokine receptor ligand interactions	TAS
R-HSA-877300	Interferon gamma signaling	TAS
R-HSA-877300	Interferon gamma signaling	IEA
R-HSA-877312	Regulation of IFNG signaling	TAS
R-HSA-877312	Regulation of IFNG signaling	IEA
R-HSA-8854691	Interleukin-20 family signaling	TAS
R-HSA-8983432	Interleukin-15 signaling	TAS
R-HSA-8983432	Interleukin-15 signaling	IEA
R-HSA-8984722	Interleukin-35 Signalling	TAS
R-HSA-8985947	Interleukin-9 signaling	TAS
R-HSA-9020558	Interleukin-2 signaling	TAS
R-HSA-9020591	Interleukin-12 signaling	TAS
R-HSA-9020591	Interleukin-12 signaling	IEA
R-HSA-9020956	Interleukin-27 signaling	TAS
R-HSA-9020956	Interleukin-27 signaling	IEA
R-HSA-9020958	Interleukin-21 signaling	TAS
R-HSA-909733	Interferon alpha/beta signaling	TAS
R-HSA-909733	Interferon alpha/beta signaling	IEA
R-HSA-912526	Interleukin receptor SHC signaling	TAS
R-HSA-912694	Regulation of IFNA signaling	IEA
R-HSA-912694	Regulation of IFNA signaling	TAS
R-HSA-913531	Interferon Signaling	TAS
R-HSA-913531	Interferon Signaling	IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
25104439	Genetic variation in the JAK/STAT/SOCS signaling pathway influences breast cancer-specific mortality through interaction with cigarette smoking and use of aspirin/NSAIDs: the Breast Cancer Health Disparities Study. (2014 Aug)	Slattery ML	Breast Cancer Res Treat
22121102	JAK/STAT/SOCS-signaling pathway and colon and rectal cancer. (2013 Feb)	Slattery ML	Mol Carcinog
27003425	Inflammatory and Immune Response Genes Polymorphisms are Associated with Susceptibility to Chronic Obstructive Pulmonary Disease in Tatars Population from Russia. (2016 Aug)	Korytina GF	Biochem Genet