Gene: JAK1

3716
JAK1A|JAK1B|JTK3
Janus kinase 1
protein-coding
1p31.3
Ensembl:ENSG00000162434 MIM:147795 Vega:OTTHUMG00000009310 UniprotKB:P23458
NG_023402.2
PubMed
ND
3   
6.706e-1 (AD)  2.517e-1 (ND)   (Frontal_Cortex)
7.584e-1 (AD)  7.644e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RBBP40.925
KPNB10.922
NCOA10.919
SEC31A0.909
SON0.906
LARS0.901
EPRS0.901
CAPRIN10.901
CSNK1A10.9
USO10.9

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.721
OR4F29-0.691
TNFRSF13B-0.239
CTNNA3-0.22
KLRC2-0.216
NANOGNB-0.216
C5orf64-0.209
SH2D1A-0.204
SOX3-0.195
FXYD4-0.193

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB02375MyricetinSmall Molecule529-44-2ExperimentalTarget
DB047162-(1,1-DIMETHYLETHYL)9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLIN-7-ONESmall MoleculeExperimentalTarget
DB08877RuxolitinibSmall Molecule941678-49-5ApprovedTarget
DB08895TofacitinibSmall Molecule477600-75-2Approved|InvestigationalTarget
DB11817BaricitinibSmall Molecule1187594-09-7Approved|InvestigationalTarget
ID Drug Name Action PubMed
C4728291-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole"1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole binds to JAK1 protein"21361338
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of JAK1 protein modified form"21705713
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"CTNNB1 gene mutant form affects the susceptibility to [1,4-bis(2-(3,5-dichloropyridyloxy))benzene affects the expression of JAK1 protein]"21705713
C5544281-nitrosocyclohexyl acetate1-nitrosocyclohexyl acetate affects the reaction [JAK1 protein results in increased phosphorylation of LIF protein]22905257
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of JAK1 mRNA19933214
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl results in increased phosphorylation of JAK1 protein"19632255
C0140242,4,5,2',4',5'-hexachlorobiphenyl"Filipin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased phosphorylation of JAK1 protein]"19632255
C0140242,4,5,2',4',5'-hexachlorobiphenyl"methyl-beta-cyclodextrin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased phosphorylation of JAK1 protein]"19632255
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of JAK1 mRNA"21346803
C5240632-tert-butyl-9-fluoro-3,6-dihydro-7H-benz(h)imidazo(4,5-f)isoquinoline-7-one"2-tert-butyl-9-fluoro-3,6-dihydro-7H-benz(h)imidazo(4,5-f)isoquinoline-7-one inhibits the reaction [OSM protein results in increased phosphorylation of JAK1 protein]"21548952
C0415253,3',4,5'-tetrahydroxystilbene"3,3',4,5'-tetrahydroxystilbene binds to JAK1 protein"18995957
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of JAK1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of JAK1 mRNA"27188386
C0126064-vinyl-1-cyclohexene dioxide4-vinyl-1-cyclohexene dioxide affects the expression of JAK1 mRNA20829426
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of JAK1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of JAK1 mRNA"27188386
C0006253616-hydroxy-3-O-methylkaempferol 6-O-glucopyranoside6-hydroxy-3-O-methylkaempferol 6-O-glucopyranoside promotes the reaction [interferon alfa-2a results in increased expression of JAK1 protein modified form]29031523
C0006253616-hydroxy-3-O-methylkaempferol 6-O-glucopyranoside6-hydroxy-3-O-methylkaempferol 6-O-glucopyranoside promotes the reaction [interferon alfa-2a results in increased phosphorylation of JAK1 protein]29031523
C0006253616-hydroxy-3-O-methylkaempferol 6-O-glucopyranoside6-hydroxy-3-O-methylkaempferol 6-O-glucopyranoside results in increased phosphorylation of JAK1 protein29031523
C0006253616-hydroxy-3-O-methylkaempferol 6-O-glucopyranosideSOCS3 protein inhibits the reaction [6-hydroxy-3-O-methylkaempferol 6-O-glucopyranoside promotes the reaction [interferon alfa-2a results in increased expression of JAK1 protein modified form]]29031523
C0413987,7'-dimethoxy-(4,4'-bi-1,3-benzodioxole)-5,5'-dicarboxylic acid dimethyl ester"7,7'-dimethoxy-(4,4'-bi-1,3-benzodioxole)-5,5'-dicarboxylic acid dimethyl ester results in increased expression of JAK1 protein"16756086
D000082AcetaminophenAcetaminophen results in increased expression of JAK1 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of JAK1 mRNA17562736
D000111AcetylcysteineAcetylcysteine inhibits the reaction [DDT results in increased phosphorylation of JAK1 protein]24820114
D020106AcrylamideAcrylamide results in increased expression of JAK1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of JAK1 mRNA27153756
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of JAK1 mRNA28522335
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [CTF1 results in increased expression of JAK1 protein]"16534557
D000547AmantadineAmantadine results in increased expression of JAK1 protein16756086
D000638AmiodaroneAmiodarone affects the expression of JAK1 mRNA19483382
D000643Ammonium ChlorideAmmonium Chloride affects the expression of JAK1 mRNA16483693
D034341Aristolochic AcidsAristolochic Acids inhibits the reaction [EPO protein results in increased phosphorylation of JAK1 protein]26136230
D001151ArsenicArsenic results in decreased expression of JAK1 mRNA19654921
C006632arsenic trioxidearsenic trioxide inhibits the reaction [IL6 protein results in increased phosphorylation of JAK1 protein]12492118
C006632arsenic trioxidearsenic trioxide results in increased phosphorylation of JAK1 protein19951532
C000596027baricitinibbaricitinib inhibits the reaction [OSM protein results in increased phosphorylation of and results in increased activity of JAK1 protein]23968543
C000596027baricitinibbaricitinib results in decreased activity of JAK1 protein23968543
D001553BenzbromaroneBenzbromarone affects the expression of JAK1 mRNA19483382
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of JAK1 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of JAK1 mRNA"20018196
D004958EstradiolEstradiol affects the expression of JAK1 mRNA23557687
C006780bisphenol Abisphenol A results in decreased expression of JAK1 mRNA22576693
C006780bisphenol Abisphenol A results in increased methylation of JAK1 gene22576693
C006780bisphenol Abisphenol A results in increased expression of JAK1 mRNA25181051
D000069286BortezomibBortezomib results in decreased expression of JAK1 mRNA20977926
D002065BuspironeBuspirone results in decreased expression of JAK1 mRNA24136188
D019328Buthionine SulfoximineButhionine Sulfoximine results in increased expression of JAK1 mRNA15878706
D019256Cadmium ChlorideCadmium Chloride results in decreased phosphorylation of JAK1 protein19635391
D002211CapsaicinCapsaicin results in decreased phosphorylation of and results in decreased activity of JAK1 protein17505005
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased phosphorylation of JAK1 protein28428136
D002251Carbon Tetrachloridehesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of JAK1 protein]28428136
D002251Carbon TetrachlorideSilymarin inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of JAK1 protein]28428136
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of JAK1 mRNA26062544
D002251Carbon TetrachlorideRutin inhibits the reaction [Carbon Tetrachloride results in increased expression of JAK1 mRNA]26062544
D000068579CelecoxibCelecoxib results in decreased expression of JAK1 mRNA28201806
D002994ClofibrateClofibrate results in decreased expression of JAK1 mRNA17585979
D002994ClofibrateClofibrate affects the expression of JAK1 mRNA19483382
D003042CocaineCocaine results in decreased expression of JAK1 mRNA11299316
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of JAK1 mRNA15467011
D019327Copper SulfateCopper Sulfate results in increased expression of JAK1 mRNA19549813
D003474CurcuminCurcumin results in decreased expression of JAK118462866
C057862cyanoginosin LRcyanoginosin LR results in increased expression of JAK1 mRNA17654400
D016572CyclosporineCyclosporine results in increased expression of JAK1 mRNA25562108
D003634DDTAcetylcysteine inhibits the reaction [DDT results in increased phosphorylation of JAK1 protein]24820114
D003634DDTDDT results in increased phosphorylation of JAK1 protein24820114
D003634DDTINCB018424 inhibits the reaction [DDT results in increased phosphorylation of JAK1 protein]24820114
C007262deoxynivalenoldeoxynivalenol results in increased expression of JAK1 mRNA22454431
D004041Dietary FatsDietary Fats results in increased expression of JAK1 mRNA23409006
D002117CalcitriolJAK1 protein affects the reaction [[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] affects the expression of and affects the activity of CASP1 protein]26091108
D004121Dimethyl SulfoxideDimethyl Sulfoxide results in decreased expression of JAK1 mRNA22169935
D004147DioxinsDioxins affects the expression of JAK1 mRNA20463971
D004221DisulfiramDisulfiram results in decreased expression of JAK1 mRNA20530235
C012301domoic aciddomoic acid results in increased expression of JAK1 mRNA18936300
D004642EmodinEmodin inhibits the reaction [IL6 protein results in increased phosphorylation of JAK1 protein]23848338
D004642EmodinEmodin results in decreased phosphorylation of JAK1 protein23848338
C044101endotoxin, Escherichia coli"endotoxin, Escherichia coli results in increased expression of JAK1 mRNA"15919760
D000431EthanolEthanol promotes the reaction [IL10 protein results in increased phosphorylation of JAK1 protein]20052772
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of JAK1 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of JAK1 mRNA16467188|1794274
D005001EthionineEthionine affects the expression of JAK1 mRNA19483382
D005038EthylnitrosoureaEthylnitrosourea results in increased phosphorylation of JAK1 protein27725143
C077139fidarestatfidarestat inhibits the reaction [IL13 protein results in increased phosphorylation of JAK1 protein]21203431
C077139fidarestatfidarestat results in decreased phosphorylation of JAK1 protein21203431
D005372Filipin"Filipin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased phosphorylation of JAK1 protein]"19632255
D005839GentamicinsGentamicins results in increased expression of JAK1 mRNA22061828
C013015hesperetinhesperetin analog affects the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased phosphorylation of JAK1 protein]]28428136
C013015hesperetinhesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of JAK1 protein]28428136
D017313FenretinideFenretinide results in increased expression of JAK1 protein15059897
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of JAK1 protein18951874
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of JAK1 mRNA18951874
C540383INCB018424INCB018424 inhibits the reaction [DDT results in increased phosphorylation of JAK1 protein]24820114
C540383INCB018424INCB018424 results in decreased activity of JAK1 protein24883332|2630039
C554043interferon alfa-2a6-hydroxy-3-O-methylkaempferol 6-O-glucopyranoside promotes the reaction [interferon alfa-2a results in increased expression of JAK1 protein modified form]29031523
C554043interferon alfa-2a6-hydroxy-3-O-methylkaempferol 6-O-glucopyranoside promotes the reaction [interferon alfa-2a results in increased phosphorylation of JAK1 protein]29031523
C554043interferon alfa-2ainterferon alfa-2a results in increased expression of JAK1 protein modified form29031523
C554043interferon alfa-2ainterferon alfa-2a results in increased phosphorylation of JAK1 protein29031523
C554043interferon alfa-2aSOCS3 protein inhibits the reaction [6-hydroxy-3-O-methylkaempferol 6-O-glucopyranoside promotes the reaction [interferon alfa-2a results in increased expression of JAK1 protein modified form]]29031523
C554043interferon alfa-2aSOCS3 protein inhibits the reaction [interferon alfa-2a results in increased expression of JAK1 protein modified form]29031523
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of JAK1 mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of JAK1 mRNA23430699|2382885
C410337K 7174K 7174 results in increased expression of JAK1 mRNA24086573
D008043Linseed OilLinseed Oil results in increased expression of JAK1 mRNA23409006
C440499lipopolysaccharide, Escherichia coli O111 B4"[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IFNG protein] results in increased phosphorylation of JAK1 protein"20060843
C440499lipopolysaccharide, Escherichia coli O111 B4"Quercetin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IFNG protein] results in increased phosphorylation of JAK1 protein]"20060843
D008070LipopolysaccharidesJAK1 protein affects the reaction [[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] affects the expression of and affects the activity of CASP1 protein]26091108
D008070Lipopolysaccharideshesperetin analog affects the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased phosphorylation of JAK1 protein]]28428136
D008070LipopolysaccharidesIL10 protein affects the reaction [resveratrol promotes the reaction [Lipopolysaccharides results in increased phosphorylation of JAK1 protein]]25576658
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of JAK1 mRNA15919760
D008070LipopolysaccharidesLipopolysaccharides results in increased phosphorylation of JAK1 protein25576658|2842813
D008070LipopolysaccharidesPPARG protein affects the reaction [Lipopolysaccharides results in increased phosphorylation of JAK1 protein]28428136
D008070Lipopolysaccharidesresveratrol promotes the reaction [Lipopolysaccharides results in increased phosphorylation of JAK1 protein]25576658
D008148LovastatinLovastatin results in decreased activity of JAK1 protein17507688
C015329lycopenelycopene results in increased expression of JAK1 mRNA16886892
C545385MequindoxMequindox results in increased expression of JAK1 mRNA21146578
D008627Mercuric ChlorideMercuric Chloride affects the expression of JAK1 mRNA20353558
D008627Mercuric ChlorideMercuric Chloride results in decreased phosphorylation of JAK1 protein16896058|1963539
D008731MethoxychlorMethoxychlor affects the expression of JAK1 mRNA20829426
C108732methyl-beta-cyclodextrin"methyl-beta-cyclodextrin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased phosphorylation of JAK1 protein]"19632255
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of JAK1 mRNA23458150
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of JAK1 mRNA28001369
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of JAK1 mRNA"20188158
D008775MethylprednisoloneMethylprednisolone inhibits the reaction [IL4 protein results in increased phosphorylation of JAK1 protein]11997017
C008493methylselenic acidmethylselenic acid affects the expression of JAK1 mRNA14617803
C008493methylselenic acidmethylselenic acid results in increased expression of JAK1 mRNA18548127
D008798Mevalonic AcidMevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CTF1 results in increased expression of JAK1 protein]]16534557
D015735MifepristoneMifepristone affects the localization of JAK1 protein19439560
D015735MifepristoneMifepristone results in increased expression of JAK1 mRNA19439560
C406082monomethylarsonous acidmonomethylarsonous acid inhibits the reaction [IL7 protein results in increased phosphorylation of JAK1 protein]26921788
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased phosphorylation of JAK1 protein26518055
C040015myricetinmyricetin binds to JAK1 protein18995957
C040015myricetinmyricetin inhibits the reaction [EGF protein results in increased phosphorylation of JAK1 protein]18995957
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of JAK1 mRNA"15585362
C012655nimesulidenimesulide results in decreased expression of JAK1 mRNA24136188
D009569Nitric OxideNitric Oxide deficiency results in decreased expression of JAK1 mRNA15878706
D009853OmeprazoleOmeprazole affects the expression of JAK1 mRNA19483382
D010100OxygenOxygen deficiency results in increased expression of JAK1 mRNA24205000
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of JAK1 protein26879310
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in decreased expression of JAK1 mRNA17616710
D010634PhenobarbitalPhenobarbital results in decreased expression of JAK1 mRNA23091169
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of JAK1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of JAK1 mRNA26272509
C006253pirinixic acidpirinixic acid affects the expression of JAK1 mRNA19483382
C545373ponatinibponatinib results in decreased activity of JAK1 protein19878872
D011192Potassium DichromatePotassium Dichromate results in increased expression of JAK1 protein23718831
C045362prochlorazprochloraz results in increased expression of JAK1 mRNA21470553
C045950propiconazolepropiconazole results in increased expression of JAK1 mRNA21278054
D011441PropylthiouracilPropylthiouracil affects the expression of JAK1 mRNA19483382
D011794QuercetinQuercetin inhibits the reaction [IL6 protein results in increased phosphorylation of JAK1 protein]22394507
D011794QuercetinQuercetin results in decreased expression of JAK1 mRNA21632981
D011794QuercetinQuercetin results in decreased phosphorylation of JAK1 protein27175602
D011794Quercetin"Quercetin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IFNG protein] results in increased phosphorylation of JAK1 protein]"20060843
C059514resveratrolresveratrol results in decreased expression of JAK1 mRNA25667456
C059514resveratrolresveratrol results in decreased expression of JAK1 protein22254182
C059514resveratrolresveratrol results in decreased phosphorylation of JAK1 protein26911335
C059514resveratrolIL10 protein affects the reaction [resveratrol promotes the reaction [Lipopolysaccharides results in increased phosphorylation of JAK1 protein]]25576658
C059514resveratrolresveratrol promotes the reaction [Lipopolysaccharides results in increased phosphorylation of JAK1 protein]25576658
D015474IsotretinoinIsotretinoin results in increased expression of JAK1 mRNA20436886
C089730rosiglitazonerosiglitazone inhibits the reaction [IFNG protein results in increased phosphorylation of JAK1 protein]12584205
D012402RotenoneRotenone inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of JAK1 protein]15748169
D012402RotenoneRotenone results in decreased phosphorylation of JAK1 protein19635391
D012431RutinRutin inhibits the reaction [Carbon Tetrachloride results in increased expression of JAK1 mRNA]26062544
D012838SilymarinSilymarin inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of JAK1 protein]28428136
D019821SimvastatinMevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CTF1 results in increased expression of JAK1 protein]]16534557
D019821SimvastatinSimvastatin inhibits the reaction [CTF1 results in increased expression of JAK1 protein]16534557
C009277sodium arsenatesodium arsenate results in increased expression of JAK1 mRNA16882884
C017947sodium arsenitesodium arsenite inhibits the reaction [IFNG protein results in increased activity of JAK1 protein]15116095
C017947sodium arsenitesodium arsenite inhibits the reaction [IL6 protein results in increased activity of JAK1 protein]15116095
C017947sodium arsenitesodium arsenite inhibits the reaction [IL6 protein results in increased phosphorylation of JAK1 protein]15116095
C017947sodium arsenitesodium arsenite inhibits the reaction [JAK1 protein results in increased phosphorylation of STAT3 protein]15116095
C017947sodium arsenitesodium arsenite results in decreased expression of JAK1 mRNA12679051
C017947sodium arsenitesodium arsenite results in decreased phosphorylation of and results in decreased activity of JAK1 protein15116095
D013141Spiro CompoundsSpiro Compounds analog results in decreased phosphorylation of JAK1 protein25320076
D013458Sulfur DioxideSulfur Dioxide promotes the reaction [OVAL protein results in increased expression of JAK1 mRNA]29288730
D013605T-2 ToxinT-2 Toxin results in increased expression of JAK1 mRNA22454431
C061133tamibarotenetamibarotene affects the expression of JAK1 mRNA15498508
D013629TamoxifenTamoxifen affects the expression of JAK1 mRNA17555576
C004648testosterone enanthatetestosterone enanthate results in increased expression of JAK1 mRNA25603467
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to JAK1 gene]19574409
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of JAK1 mRNA19574409
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of JAK1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of JAK1 mRNA18691609|1993321
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of JAK1 mRNA22298810
D013752TetracyclineTetracycline results in increased expression of JAK1 mRNA16917069
D013755Tetradecanoylphorbol AcetateJAK1 protein affects the reaction [[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] affects the expression of and affects the activity of CASP1 protein]26091108
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of JAK1 mRNA25613284
D019284ThapsigarginThapsigargin results in increased expression of JAK1 protein24648495
D013806Theophylline[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of JAK1 protein18951874
D013853ThioacetamideThioacetamide affects the expression of JAK1 mRNA19483382
D013893ThiramThiram results in decreased expression of JAK1 mRNA20530235
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of JAK1 mRNA28111298
C479163tofacitinibtofacitinib inhibits the reaction [OSM protein results in increased phosphorylation of and results in increased activity of JAK1 protein]23968543
C479163tofacitinibtofacitinib inhibits the reaction [OSM protein results in increased phosphorylation of JAK1 protein]21548952
C479163tofacitinibtofacitinib results in decreased activity of JAK1 protein24883332
C479163tofacitinibtofacitinib results in decreased activity of JAK1 protein21155605|2770819
C483909torcetrapibtorcetrapib results in increased expression of JAK1 mRNA23228038
D014118Toxins, Biological"Toxins, Biological affects the expression of JAK1 mRNA"19682533
D014212TretinoinTretinoin results in decreased expression of JAK1 mRNA15498508
D014212TretinoinTretinoin results in increased expression of JAK1 mRNA21934132
C012589trichostatin Atrichostatin A affects the expression of JAK1 mRNA28542535
C012589trichostatin Atrichostatin A results in increased expression of JAK1 mRNA24935251
C046488trimethyltintrimethyltin results in increased expression of JAK1 mRNA20833246
D014520UrethaneUrethane results in increased expression of JAK1 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of JAK1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of JAK1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of JAK1 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of JAK1 mRNA23179753|2627250
D014635Valproic AcidValproic Acid results in increased expression of JAK1 mRNA20546886
C066075vanadium pentoxideJAK1 protein affects the reaction [vanadium pentoxide results in increased activity of STAT1 protein]18322232
C025643vinclozolinvinclozolin results in decreased expression of JAK1 mRNA21126777
D024483Vitamin K 3Vitamin K 3 affects the expression of JAK1 mRNA20829426
C088658zoledronic acidzoledronic acid results in increased expression of JAK1 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004713protein tyrosine kinase activity-EXP1386289  8232552  10825200  
GO:0004713protein tyrosine kinase activity-TAS-  
GO:0004715non-membrane spanning protein tyrosine kinase activity-TAS-  
GO:0005088Ras guanyl-nucleotide exchange factor activity-TAS-  
GO:0005131growth hormone receptor binding-IBA21873635  
GO:0005131growth hormone receptor binding-ISS10502458  
GO:0005515protein binding-IPI7759950  10993906  16273093  16710296  21220115  26175413  
GO:0005524ATP binding-IEA-  
GO:0019903protein phosphatase binding-IPI11909529  
GO:0031625ubiquitin protein ligase binding-IPI24882218  
GO:0031730CCR5 chemokine receptor binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000165MAPK cascade-TAS-  
GO:0006468protein phosphorylation-TAS1848670  
GO:0019221cytokine-mediated signaling pathway-IBA21873635  
GO:0019221cytokine-mediated signaling pathway-TAS-  
GO:0035556intracellular signal transduction-TAS8232552  
GO:0035722interleukin-12-mediated signaling pathway-TAS-  
GO:0035723interleukin-15-mediated signaling pathway-TAS-  
GO:0038110interleukin-2-mediated signaling pathway-IDA11909529  
GO:0038110interleukin-2-mediated signaling pathway-TAS-  
GO:0038111interleukin-7-mediated signaling pathway-TAS-  
GO:0038113interleukin-9-mediated signaling pathway-TAS-  
GO:0038114interleukin-21-mediated signaling pathway-TAS-  
GO:0046677response to antibiotic-IDA16280321  
GO:0060333interferon-gamma-mediated signaling pathway-TAS-  
GO:0060334regulation of interferon-gamma-mediated signaling pathway-TAS-  
GO:0060337type I interferon signaling pathway-TAS-  
GO:0070102interleukin-6-mediated signaling pathway-TAS-  
GO:0070106interleukin-27-mediated signaling pathway-TAS-  
GO:0070757interleukin-35-mediated signaling pathway-TAS-  
GO:1903672positive regulation of sprouting angiogenesis-IGI20299512  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA10502458  
GO:0005737cytoplasm-IDA10502458  
GO:0005768endosome-TAS-  
GO:0005829cytosol-TAS-  
GO:0005856cytoskeleton-IEA-  
GO:0005925focal adhesion-HDA21423176  
KEGG ID KEGG Term
hsa04380Osteoclast differentiation
hsa04630Jak-STAT signaling pathway
hsa05140Leishmaniasis
hsa05145Toxoplasmosis
hsa05160Hepatitis C
hsa05200Pathways in cancer
hsa05212Pancreatic cancer
Reactome ID Reactome Term Evidence
R-HSA-1059683Interleukin-6 signalingTAS
R-HSA-1059683Interleukin-6 signalingIEA
R-HSA-110056MAPK3 (ERK1) activationTAS
R-HSA-112409RAF-independent MAPK1/3 activationTAS
R-HSA-112411MAPK1 (ERK2) activationTAS
R-HSA-1169408ISG15 antiviral mechanismTAS
R-HSA-1169410Antiviral mechanism by IFN-stimulated genesTAS
R-HSA-1266695Interleukin-7 signalingIEA
R-HSA-1266695Interleukin-7 signalingTAS
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1280215Cytokine Signaling in Immune systemIEA
R-HSA-162582Signal TransductionTAS
R-HSA-168256Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-372790Signaling by GPCRTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-392451G beta:gamma signalling through PI3KgammaTAS
R-HSA-397795G-protein beta:gamma signallingTAS
R-HSA-447115Interleukin-12 family signalingTAS
R-HSA-447115Interleukin-12 family signalingIEA
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-449147Signaling by InterleukinsIEA
R-HSA-449836Other interleukin signalingTAS
R-HSA-451927Interleukin-2 family signalingTAS
R-HSA-451927Interleukin-2 family signalingIEA
R-HSA-512988Interleukin-3, 5 and GM-CSF signalingTAS
R-HSA-5673001RAF/MAP kinase cascadeTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5684996MAPK1/MAPK3 signalingTAS
R-HSA-6783589Interleukin-6 family signalingTAS
R-HSA-6783589Interleukin-6 family signalingIEA
R-HSA-6783783Interleukin-10 signalingTAS
R-HSA-6785807Interleukin-4 and 13 signalingTAS
R-HSA-6788467IL-6-type cytokine receptor ligand interactionsTAS
R-HSA-877300Interferon gamma signalingTAS
R-HSA-877300Interferon gamma signalingIEA
R-HSA-877312Regulation of IFNG signalingTAS
R-HSA-877312Regulation of IFNG signalingIEA
R-HSA-8854691Interleukin-20 family signalingTAS
R-HSA-8983432Interleukin-15 signalingTAS
R-HSA-8983432Interleukin-15 signalingIEA
R-HSA-8984722Interleukin-35 SignallingTAS
R-HSA-8985947Interleukin-9 signalingTAS
R-HSA-9020558Interleukin-2 signalingTAS
R-HSA-9020591Interleukin-12 signalingTAS
R-HSA-9020591Interleukin-12 signalingIEA
R-HSA-9020956Interleukin-27 signalingTAS
R-HSA-9020956Interleukin-27 signalingIEA
R-HSA-9020958Interleukin-21 signalingTAS
R-HSA-909733Interferon alpha/beta signalingTAS
R-HSA-909733Interferon alpha/beta signalingIEA
R-HSA-912526Interleukin receptor SHC signalingTAS
R-HSA-912694Regulation of IFNA signalingIEA
R-HSA-912694Regulation of IFNA signalingTAS
R-HSA-913531Interferon SignalingTAS
R-HSA-913531Interferon SignalingIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25104439Genetic variation in the JAK/STAT/SOCS signaling pathway influences breast cancer-specific mortality through interaction with cigarette smoking and use of aspirin/NSAIDs: the Breast Cancer Health Disparities Study. (2014 Aug)Slattery MLBreast Cancer Res Treat
22121102JAK/STAT/SOCS-signaling pathway and colon and rectal cancer. (2013 Feb)Slattery MLMol Carcinog
27003425Inflammatory and Immune Response Genes Polymorphisms are Associated with Susceptibility to Chronic Obstructive Pulmonary Disease in Tatars Population from Russia. (2016 Aug)Korytina GFBiochem Genet