Gene: JAK2

3717
JTK10|THCYT3
Janus kinase 2
protein-coding
9p24.1
Ensembl:ENSG00000096968 MIM:147796 Vega:OTTHUMG00000019490 UniprotKB:O60674
NG_009904.1
PubMed
CD|ND
28   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.250e-1 (AD)  1.403e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
XRN10.874
USP150.871
NUP2050.863
SMCHD10.858
PRPF4B0.855
ZMYM60.848
SLC30A70.848
CTDSPL20.847
LYST0.846
IDE0.844

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.391
HES5-0.383
OR4F29-0.374
BTBD17-0.343
PLA2G5-0.307
HES6-0.295
NEU4-0.288
RBP1-0.285
ARSF-0.28
S100A1-0.279

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB047162-(1,1-DIMETHYLETHYL)9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLIN-7-ONESmall MoleculeExperimentalTarget
DB05243XL019Small Molecule-InvestigationalTarget
DB071615-phenyl-1H-indazol-3-amineSmall MoleculeExperimentalTarget
DB071624-(3-amino-1H-indazol-5-yl)-N-tert-butylbenzenesulfonamideSmall MoleculeExperimentalTarget
DB080674-[(2-{4-[(CYCLOPROPYLCARBAMOYL)AMINO]-1H-PYRAZOL-3-YL}-1H-BENZIMIDAZOL-6-YL)METHYL]MORPHOLIN-4-IUMSmall MoleculeExperimentalTarget
DB08877RuxolitinibSmall Molecule941678-49-5ApprovedTarget
DB08895TofacitinibSmall Molecule477600-75-2Approved|InvestigationalTarget
DB11817BaricitinibSmall Molecule1187594-09-7Approved|InvestigationalTarget
ID Drug Name Action PubMed
C56123411-(2-pyrrolidin-1-ylethoxy)-14,19-dioxa-5,7,26-triazatetracyclo(19.3.1.1(2,6).1(8,12))heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene"11-(2-pyrrolidin-1-ylethoxy)-14,19-dioxa-5,7,26-triazatetracyclo(19.3.1.1(2,6).1(8,12))heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene results in decreased activity of JAK2 protein"21604762
C56123411-(2-pyrrolidin-1-ylethoxy)-14,19-dioxa-5,7,26-triazatetracyclo(19.3.1.1(2,6).1(8,12))heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene"11-(2-pyrrolidin-1-ylethoxy)-14,19-dioxa-5,7,26-triazatetracyclo(19.3.1.1(2,6).1(8,12))heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene results in decreased activity of JAK2 protein mutant form"21604762
D0140131,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt"1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased phosphorylation of JAK2 protein]]"15677497
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of JAK2 mRNA"19162173
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of JAK2 protein modified form"21705713
C5083881-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea"[1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea affects the activity of CHRNA7 protein] inhibits the reaction [[PNU-282987 binds to and results in increased activity of CHRNA7 protein] which results in increased phosphorylation of JAK2 protein]"21715663
C09724015-deoxy-delta(12,14)-prostaglandin J2"15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of JAK2 protein]"12847270
C09724015-deoxy-delta(12,14)-prostaglandin J2"Acetylcysteine inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of JAK2 protein]]"12847270
C09724015-deoxy-delta(12,14)-prostaglandin J2"Glutathione inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of JAK2 protein]]"12847270
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of JAK2 mRNA"27291303
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of JAK2 mRNA"19114083
C5859122,4-dihydroxy-N-(4-hydroxyphenyl)benzamide"2,4-dihydroxy-N-(4-hydroxyphenyl)benzamide results in decreased activity of JAK2 protein"24144632
C1079462,7-dihydroxynaphthalene"2,7-dihydroxynaphthalene results in decreased expression of JAK2 mRNA"28940058
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"[alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine promotes the reaction [[Dexamethasone co-treated with INS protein co-treated with PRL protein] results in increased expression of CTNNB1 mRNA]]"11751460
C5308022-(benzylaminocarbonyl)-3-(3,4-dihydroxystyryl)acrylonitrile"2-(benzylaminocarbonyl)-3-(3,4-dihydroxystyryl)acrylonitrile inhibits the reaction [[Promegestone co-treated with PRL protein] results in increased localization of and results in increased phosphorylation of and results in increased activity of JAK2 protein]"20562009
C0212962-ethoxyethanol2-ethoxyethanol results in increased expression of JAK2 mRNA19643169
C5240632-tert-butyl-9-fluoro-3,6-dihydro-7H-benz(h)imidazo(4,5-f)isoquinoline-7-one"2-tert-butyl-9-fluoro-3,6-dihydro-7H-benz(h)imidazo(4,5-f)isoquinoline-7-one inhibits the reaction [OSM protein results in increased phosphorylation of JAK2 protein]"21548952
C011775(3,4-dihydroxyphenylamino)-2-imidazoline"(3,4-dihydroxyphenylamino)-2-imidazoline inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased phosphorylation of JAK2 protein]]"15677497
C0350553,4-dihydroxyphenyllactic acid"3,4-dihydroxyphenyllactic acid inhibits the reaction [tert-Butylhydroperoxide results in decreased phosphorylation of JAK2 protein]"29128606
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of JAK2 mRNA"25380136
C5550214-acetylantroquinonol B4-acetylantroquinonol B results in decreased expression of JAK2 protein26235807
C5550214-acetylantroquinonol B4-acetylantroquinonol B results in decreased expression of JAK2 protein modified form26235807
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of JAK2 mRNA19191707
C5689627-(2-aminopyrimidin-5-yl)-1-((1-cyclopropyl-2,2,2-trifluoroethyl)amino)-5H-pyrido(4,3-b)indole-4-carboxamide"7-(2-aminopyrimidin-5-yl)-1-((1-cyclopropyl-2,2,2-trifluoroethyl)amino)-5H-pyrido(4,3-b)indole-4-carboxamide results in decreased activity of JAK2 protein"21942426
C5689627-(2-aminopyrimidin-5-yl)-1-((1-cyclopropyl-2,2,2-trifluoroethyl)amino)-5H-pyrido(4,3-b)indole-4-carboxamide"7-(2-aminopyrimidin-5-yl)-1-((1-cyclopropyl-2,2,2-trifluoroethyl)amino)-5H-pyrido(4,3-b)indole-4-carboxamide results in decreased activity of JAK2 protein mutant form"21942426
D000082AcetaminophenAcetaminophen affects the expression of JAK2 mRNA17562736
C056165acetovanilloneacetovanillone inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased phosphorylation of JAK2 protein]]15677497
D000111Acetylcysteine"Acetylcysteine inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of JAK2 protein]]"12847270
D000111AcetylcysteineAcetylcysteine promotes the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of JAK2 protein]12847270
C016601afimoxifeneafimoxifene promotes the reaction [GH1 protein results in increased phosphorylation of JAK2 protein]17272397
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of JAK2 mRNA19770486
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of JAK2 mRNA"23195993
D000450AldosteroneAldosterone results in increased phosphorylation of JAK2 protein15932931
D000450AldosteroneDactinomycin inhibits the reaction [Aldosterone results in increased phosphorylation of JAK2 protein]15932931
D000450AldosteroneSpironolactone inhibits the reaction [Aldosterone results in increased phosphorylation of JAK2 protein]15932931
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of JAK2 mRNA28522335
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [glycine-extended gastrin 17 results in increased phosphorylation of and results in increased activity of JAK2 protein]"19153190
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [JAK2 protein results in increased activity of KCNMA1 protein mutant form]"24696148
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"[alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [[LEP protein co-treated with bisphenol A] results in decreased activity of CASP3 protein]"23850738
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"[alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [[LEP protein co-treated with bisphenol A] results in decreased expression of CASP3 protein]"23850738
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"[alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [[LEP protein co-treated with Estradiol] results in decreased activity of CASP3 protein]"23850738
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"[alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [[LEP protein co-treated with Estradiol] results in decreased expression of CASP3 protein]"23850738
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"[alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [LEP protein results in decreased activity of CASP3 protein]"23850738
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"[alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [LEP protein results in decreased expression of CASP3 protein]"23850738
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"[alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] which results in decreased susceptibility to TNF protein"18606683
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased phosphorylation of JAK2 protein"20197088
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [deoxynivalenol results in increased expression of JAK2 mRNA]"22454431
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [T-2 Toxin results in increased expression of JAK2 mRNA]"22454431
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein"12847270|2010708
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein]"18976543
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [CTF1 results in increased expression of JAK2 protein]"16534557
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [CTF1 results in increased expression of JAK2 protein modified form]"19100119
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [CTF1 results in increased phosphorylation of JAK2 protein]"18400235
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Glucose results in increased phosphorylation of JAK2 protein]"20060012
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[[volinanserin binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein]"18976543
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide promotes the reaction [Quercetin analog results in decreased expression of JAK2 protein]"23907460
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein"15932931
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"[alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [HTR2A protein results in increased secretion of Corticosterone]"19304867
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"[alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [HTR2A protein results in increased secretion of OXT protein]"19304867
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"[alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [olanzapine results in decreased activity of HTR2A protein]"19304867
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"[alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [olanzapine results in increased expression of RGS7 mRNA]"19304867
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"[alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [olanzapine results in increased expression of RGS7 protein]"19304867
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased expression of JAK2 protein"23907460
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide affects the activity of JAK2 protein"11751460
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein"11823534|1239342
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"[alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine promotes the reaction [[Dexamethasone co-treated with INS protein co-treated with PRL protein] results in increased expression of CTNNB1 mRNA]]"11751460
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"[alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [[Dexamethasone co-treated with INS protein co-treated with PRL protein] results in increased expression of CTNNB1 mRNA]"11751460
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased phosphorylation of JAK2 protein"17993459
D017311AmlodipineAmlodipine results in increased expression of JAK2 protein modified form18298949
D000643Ammonium ChlorideAmmonium Chloride affects the expression of JAK2 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of JAK2 mRNA24449571
C071942arctigenin"arctigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of JAK2 protein]"21426947
D001151ArsenicArsenic affects the methylation of JAK2 gene25304211
C006632arsenic trioxidearsenic trioxide inhibits the reaction [IL6 protein results in increased phosphorylation of JAK2 protein]12492118
C006632arsenic trioxidearsenic trioxide results in decreased expression of JAK2 protein11721366
D001310Auranofin[Auranofin co-treated with IL6 protein] results in decreased phosphorylation of JAK2 protein20542334
C099015azaspiraneazaspirane inhibits the reaction [IL6 protein results in increased phosphorylation of JAK2 protein]15705788
C545606AZD 1480AZD 1480 binds to and results in decreased activity of JAK2 protein21138246
C545606AZD 1480AZD 1480 results in decreased activity of JAK2 protein mutant form21138246
C000596027baricitinibbaricitinib inhibits the reaction [OSM protein results in increased phosphorylation of and results in increased activity of JAK2 protein]23968543
C000596027baricitinibbaricitinib results in decreased activity of JAK2 protein23968543
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of JAK2 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of JAK2 mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of JAK2 mRNA22228805
D004958Estradiol"[alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [[LEP protein co-treated with Estradiol] results in decreased activity of CASP3 protein]"23850738
D004958Estradiol"[alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [[LEP protein co-treated with Estradiol] results in decreased expression of CASP3 protein]"23850738
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of JAK2 mRNA19619570
D004958EstradiolEstradiol inhibits the reaction [GH1 protein results in increased phosphorylation of JAK2 protein]17272397
D004958EstradiolEstradiol results in decreased expression of JAK2 mRNA19619570
D004958EstradiolEstradiol results in increased expression of JAK2 mRNA26865669|2871154
C006780bisphenol A"[alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [[LEP protein co-treated with bisphenol A] results in decreased activity of CASP3 protein]"23850738
C006780bisphenol A"[alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [[LEP protein co-treated with bisphenol A] results in decreased expression of CASP3 protein]"23850738
C006780bisphenol Abisphenol A results in increased expression of JAK2 mRNA28711546
C006780bisphenol Abisphenol A affects the methylation of JAK2 promoter27824486
C006780bisphenol Abisphenol A results in increased expression of JAK2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of JAK2 gene28505145
D001786Blood GlucoseJAK2 gene mutant form results in decreased susceptibility to Blood Glucose28100771
D019328Buthionine SulfoximineButhionine Sulfoximine results in decreased expression of JAK2 mRNA15878706
D020122tert-Butylhydroperoxide"3,4-dihydroxyphenyllactic acid inhibits the reaction [tert-Butylhydroperoxide results in decreased phosphorylation of JAK2 protein]"29128606
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased phosphorylation of JAK2 protein29128606
D002101Cacodylic AcidCacodylic Acid results in decreased expression of JAK2 mRNA17720352
D019256Cadmium ChlorideCadmium Chloride results in decreased phosphorylation of JAK2 protein19635391
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of JAK2 mRNA23741332
D002118CalciumJAK2 protein promotes the reaction [LEP protein results in increased transport of Calcium]20107083
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of JAK2 mRNA17484886
C024714caryophyllenecaryophyllene inhibits the reaction [TNF protein results in increased phosphorylation of JAK2 protein]28624443
C016299chelerythrinechelerythrine results in decreased phosphorylation of and results in decreased activity of JAK2 protein15746188
C418118CI 1044CI 1044 results in increased expression of JAK2 mRNA17569694
D002996ClomipheneClomiphene results in decreased expression of JAK2 mRNA26865669
D003024Clozapine"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein]"18976543
D003024Clozapine[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein18976543
D003024Clozapine[[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein18976543
C075384coniferaldehydeconiferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of JAK2 protein]27378624
C075384coniferaldehyde"coniferaldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of JAK2 protein]"27378624
D003345Corticosterone"[alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [HTR2A protein results in increased secretion of Corticosterone]"19304867
C038106cucurbitacin Icucurbitacin I inhibits the reaction [glycine-extended gastrin 17 results in increased phosphorylation of and results in increased activity of JAK2 protein]19153190
C038106cucurbitacin Icucurbitacin I results in decreased activity of JAK2 protein19153190
D003474CurcuminCurcumin results in decreased expression of JAK2 protein16959222
D016572CyclosporineCyclosporine results in increased expression of JAK2 mRNA20106945|2556210
D016572CyclosporineCyclosporine results in increased activity of JAK2 protein22155090
D016572CyclosporineCyclosporine results in increased phosphorylation of JAK2 protein23958496
D016572Cyclosporinesulforafan inhibits the reaction [Cyclosporine results in increased phosphorylation of JAK2 protein]23958496
D003609DactinomycinDactinomycin inhibits the reaction [Aldosterone results in increased phosphorylation of JAK2 protein]15932931
D003630DaunorubicinDaunorubicin results in decreased expression of JAK2 mRNA26537877|2894005
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of JAK2 mRNA23640034
C014347decitabinedecitabine results in decreased expression of JAK2 protein modified form19379557
C014347decitabinedecitabine results in decreased methylation of JAK2 promoter18055864
C014347decitabine"decitabine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of JAK2 protein]"24440346
C007262deoxynivalenol"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [deoxynivalenol results in increased expression of JAK2 mRNA]"22454431
C007262deoxynivalenoldeoxynivalenol results in increased expression of JAK2 mRNA22454431
C007262deoxynivalenolstattic inhibits the reaction [deoxynivalenol results in increased expression of JAK2 mRNA]22454431
D003907Dexamethasone"[alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine promotes the reaction [[Dexamethasone co-treated with INS protein co-treated with PRL protein] results in increased expression of CTNNB1 mRNA]]"11751460
D003907Dexamethasone"[alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [[Dexamethasone co-treated with INS protein co-treated with PRL protein] results in increased expression of CTNNB1 mRNA]"11751460
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of JAK2 mRNA21266533
D002945CisplatinCisplatin results in decreased expression of JAK2 mRNA27392435
D002945CisplatinAURKA protein mutant form inhibits the reaction [JAK2 gene mutant form results in decreased susceptibility to Cisplatin]21557940
D002945CisplatinJAK2 protein mutant form results in decreased susceptibility to Cisplatin21557940
D004041Dietary FatsDietary Fats results in decreased phosphorylation of JAK2 protein27417254
D004041Dietary Fats"methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate inhibits the reaction [Dietary Fats results in decreased phosphorylation of JAK2 protein]"27417254
D004052DiethylnitrosamineJAK2 gene mutant form results in decreased susceptibility to Diethylnitrosamine28100771
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of JAK2 mRNA26865669
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of JAK2 mRNA15591538
D004075DiglyceridesJAK2 gene mutant form results in increased abundance of Diglycerides28100771
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of JAK2 mRNA25380136
D011397Promegestone"2-(benzylaminocarbonyl)-3-(3,4-dihydroxystyryl)acrylonitrile inhibits the reaction [[Promegestone co-treated with PRL protein] results in increased localization of and results in increased phosphorylation of and results in increased activity of JAK2 protein]"20562009
D011397Promegestone[JAK2 protein co-treated with PRL protein] promotes the reaction [Promegestone results in increased phosphorylation of HLTF protein]20562009
D011397Promegestone[Promegestone co-treated with PRL protein] results in increased localization of and results in increased phosphorylation of and results in increased activity of JAK2 protein20562009
D004317DoxorubicinDoxorubicin results in decreased expression of JAK2 mRNA26537877|2894005
D004642EmodinEmodin inhibits the reaction [IL6 protein results in increased phosphorylation of JAK2 protein]23848338
D004642EmodinEmodin results in decreased phosphorylation of JAK2 protein23848338
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of JAK2 mRNA22079256
D000069347Erlotinib HydrochlorideErlotinib Hydrochloride results in decreased phosphorylation of JAK2 protein23894143
D004970EstroneEstrone results in increased expression of JAK2 mRNA26865669
D008656MestranolMestranol results in increased expression of JAK2 mRNA26865669
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of JAK2 mRNA23649840
D005485FlutamideFlutamide results in decreased expression of JAK2 mRNA24793618
D005620Freund's Adjuvant[Urethane co-treated with Freund's Adjuvant] results in increased expression of JAK2 mRNA12400877
D005632FructoseFructose results in decreased phosphorylation of JAK2 protein22426011
D005632FructoseQuercetin inhibits the reaction [Fructose results in decreased phosphorylation of JAK2 protein]22426011
D005632FructoseRutin inhibits the reaction [Fructose results in decreased phosphorylation of JAK2 protein]22426011
C070081fulvestrantfulvestrant results in decreased expression of JAK2 mRNA26865669
C039281furanfuran results in increased methylation of JAK2 gene22079235
D019833GenisteinGenistein results in increased expression of JAK2 mRNA26865667|2686566
D005944GlucosamineGlucosamine inhibits the reaction [IL1B results in increased expression of JAK2 mRNA]17109745
D005944GlucosamineGlucosamine results in increased expression of JAK2 mRNA17109745
D005944GlucosamineIL1B affects the reaction [Glucosamine results in increased expression of JAK2 mRNA]17109745
D005947Glucose"1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased phosphorylation of JAK2 protein]]"15677497
D005947Glucose"(3,4-dihydroxyphenylamino)-2-imidazoline inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased phosphorylation of JAK2 protein]]"15677497
D005947Glucoseacetovanillone inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased phosphorylation of JAK2 protein]]15677497
D005947GlucoseGlucose promotes the reaction [AGT protein results in increased phosphorylation of JAK2 protein]15677497
D005947GlucoseRotenone inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased phosphorylation of JAK2 protein]]15677497
D005947GlucoseValsartan inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased phosphorylation of JAK2 protein]]15677497
D005947Glucose"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Glucose results in increased phosphorylation of JAK2 protein]"20060012
D005947GlucoseGlucose results in increased phosphorylation of JAK2 protein20060012
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of JAK2 mRNA22634610
D005978Glutathione"Glutathione inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of JAK2 protein]]"12847270
D005978GlutathioneGlutathione promotes the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of JAK2 protein]12847270
C086854glycine-extended gastrin 17"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [glycine-extended gastrin 17 results in increased phosphorylation of and results in increased activity of JAK2 protein]"19153190
C086854glycine-extended gastrin 17cucurbitacin I inhibits the reaction [glycine-extended gastrin 17 results in increased phosphorylation of and results in increased activity of JAK2 protein]19153190
C086854glycine-extended gastrin 17glycine-extended gastrin 17 results in increased phosphorylation of and results in increased activity of JAK2 protein19153190
C081021Go 6976Go 6976 results in decreased phosphorylation of and results in decreased activity of JAK2 protein15746188
C081021Go 6976Go 6976 results in decreased phosphorylation of and results in decreased activity of JAK2 protein15746188
D006046Gold[Quercetin analog co-treated with Gold analog] results in decreased phosphorylation of JAK2 protein27470402
D006589HexestrolHexestrol results in increased expression of JAK2 mRNA26865669
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased phosphorylation of JAK2 protein19635391
D006861Hydrogen PeroxideHydrogen Peroxide inhibits the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of JAK2 protein]12847270
C540383INCB018424INCB018424 results in decreased activity of JAK2 protein24883332|2630039
C540383INCB018424JAK2 gene mutant form affects the susceptibility to INCB01842426300391
C544151jinfukangjinfukang results in decreased expression of JAK2 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of JAK2 mRNA26387944
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased phosphorylation of JAK2 protein22904298
D007608Kainic AcidEPO protein inhibits the reaction [Kainic Acid results in decreased expression of JAK2 protein]18711747
D007608Kainic AcidEPOR protein promotes the reaction [EPO protein inhibits the reaction [Kainic Acid results in decreased expression of JAK2 protein]]18711747
D007608Kainic AcidKainic Acid results in decreased expression of JAK2 protein18711747
D007649KetamineKetamine results in decreased expression of JAK2 mRNA20080153
C482199lipopolysaccharide, E coli O55-B5"decitabine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of JAK2 protein]"24440346
C482199lipopolysaccharide, E coli O55-B5"DNMT1 mutant form inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of JAK2 protein]"24440346
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of JAK2 protein"24440346
C482199lipopolysaccharide, E coli O55-B5"SOCS1 mutant form inhibits the reaction [DNMT1 mutant form inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of JAK2 protein]]"24440346
C440499lipopolysaccharide, Escherichia coli O111 B4"lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of JAK2 protein"26298005
C440499lipopolysaccharide, Escherichia coli O111 B4"Methylthiouracil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of JAK2 protein]"26298005
C440499lipopolysaccharide, Escherichia coli O111 B4"arctigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of JAK2 protein]"21426947
C440499lipopolysaccharide, Escherichia coli O111 B4"coniferaldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of JAK2 protein]"27378624
C440499lipopolysaccharide, Escherichia coli O111 B4"lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of JAK2 protein"21426947|2737862
D008070LipopolysaccharidesLipopolysaccharides results in increased activity of JAK2 protein24486434
D008070Lipopolysaccharides[Lipopolysaccharides results in increased activity of JAK2 protein] which results in increased activity of STAT3 protein24486434
D008070LipopolysaccharidesLipopolysaccharides results in increased phosphorylation of JAK2 protein25576658
D008148LovastatinLovastatin results in decreased activity of JAK2 protein17507688
C581039LY2784544JAK2 gene mutant form affects the susceptibility to LY278454426300391
C581039LY2784544LY2784544 results in decreased activity of JAK2 protein26300391
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of JAK2 mRNA21641980
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of JAK2 mRNA26378955
D008555MelittenMelitten results in decreased phosphorylation of JAK2 protein22027265
D008558MelphalanMelphalan results in decreased expression of JAK2 mRNA22363485
C545385MequindoxMequindox results in increased expression of JAK2 mRNA21146578
D008627Mercuric ChlorideMercuric Chloride results in decreased phosphorylation of JAK2 protein16896058|1963539
D008628MercuryMercury affects the expression of JAK2 mRNA23920476
C445068methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate"methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate inhibits the reaction [Dietary Fats results in decreased phosphorylation of JAK2 protein]"27417254
C005219methyl cellosolvemethyl cellosolve results in increased expression of JAK2 mRNA19643169
D008748MethylcholanthreneMethylcholanthrene results in decreased expression of JAK2 mRNA22978700
D008767Methylmercury CompoundsMethylmercury Compounds affects the expression of JAK2 mRNA23920476
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of JAK2 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of JAK2 mRNA"20188158
D008779Methylthiouracil"Methylthiouracil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of JAK2 protein]"26298005
D008798Mevalonic AcidMevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CTF1 results in increased expression of JAK2 protein]]16534557
D008942MitoxantroneMitoxantrone results in decreased expression of JAK2 mRNA26537877|2894005
C000621033napabucasinnapabucasin results in decreased expression of JAK2 mRNA25605917
C073873naphtho(1,2-b)furan-4,5-dione"naphtho(1,2-b)furan-4,5-dione results in decreased phosphorylation of JAK2 protein"20197088
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of JAK2 mRNA25380136
C546012N-(cyanomethyl)-4-(2-((4-(4-morpholinyl)phenyl)amino)-4-pyrimidinyl)benzamideN-(cyanomethyl)-4-(2-((4-(4-morpholinyl)phenyl)amino)-4-pyrimidinyl)benzamide results in decreased phosphorylation of JAK2 protein27470402
D009532NickelNickel affects the expression of JAK2 mRNA14575637
D009532NickelNickel results in decreased expression of JAK2 mRNA23195993
D009532NickelNickel results in increased expression of JAK2 mRNA24768652|2558310
D009532Nickeltrichostatin A inhibits the reaction [Nickel affects the expression of JAK2 mRNA]14575637
C022838nickel chloridenickel chloride affects the expression of JAK2 mRNA22546817
D009538NicotineJAK2 results in increased susceptibility to Nicotine20943775
D009538NicotineNicotine results in decreased expression of JAK2 mRNA29155039
D009569Nitric OxideJAK2 protein promotes the reaction [IFNG protein results in increased abundance of Nitric Oxide]12847270
D009569Nitric OxideNitric Oxide deficiency results in decreased expression of JAK2 mRNA15878706
C558013NSC 689534NSC 689534 results in increased expression of JAK2 mRNA20971185
D019319Okadaic AcidJAK2 protein affects the reaction [[PNU-282987 binds to and results in increased activity of CHRNA7 protein] which results in decreased susceptibility to Okadaic Acid]21715663
C076029olanzapine"[alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [olanzapine results in decreased activity of HTR2A protein]"19304867
C076029olanzapine"[alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [olanzapine results in increased expression of RGS7 mRNA]"19304867
C076029olanzapine"[alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [olanzapine results in increased expression of RGS7 protein]"19304867
C076029olanzapine[olanzapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein18976543
C076029olanzapine[[olanzapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein18976543
C076029olanzapineolanzapine results in increased activity of JAK2 protein19304867
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of JAK2 mRNA23948077
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of JAK2 mRNA27153767
D010665PhenylpropanolaminePhenylpropanolamine results in increased expression of JAK2 mRNA24792324
D010665PhenylpropanolaminePhenylpropanolamine results in increased expression of JAK2 protein24792324
D010712Phosphatidic AcidsPhosphatidic Acids results in increased phosphorylation of JAK2 protein16354768
C006253pirinixic acidpirinixic acid results in increased expression of JAK2 mRNA18445702
D010936Plant ExtractsPlant Extracts results in increased expression of JAK2 mRNA23557933
C498513PNU-282987"[1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea affects the activity of CHRNA7 protein] inhibits the reaction [[PNU-282987 binds to and results in increased activity of CHRNA7 protein] which results in increased phosphorylation of JAK2 protein]"21715663
C498513PNU-282987JAK2 protein affects the reaction [[PNU-282987 binds to and results in increased activity of CHRNA7 protein] which results in decreased susceptibility to Okadaic Acid]21715663
C498513PNU-282987[PNU-282987 binds to and results in increased activity of CHRNA7 protein] which results in increased phosphorylation of JAK2 protein21715663
C545373ponatinibponatinib results in decreased activity of JAK2 protein19878872
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of JAK2 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of JAK2 mRNA22079256
D011374ProgesteroneProgesterone results in increased expression of JAK2 mRNA20864642
C107773pterostilbenepterostilbene results in decreased phosphorylation of JAK2 protein23313376
D011794Quercetin[Quercetin analog co-treated with Gold analog] results in decreased phosphorylation of JAK2 protein27470402
D011794QuercetinQuercetin results in decreased phosphorylation of JAK2 protein24275163|2561156
D011794QuercetinQuercetin results in increased expression of JAK2 mRNA21632981
D011794QuercetinQuercetin results in decreased phosphorylation of JAK2 protein24275163
D011794Quercetin"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide promotes the reaction [Quercetin analog results in decreased expression of JAK2 protein]"23907460
D011794QuercetinQuercetin analog results in decreased expression of JAK2 protein23907460
D011794QuercetinQuercetin analog results in increased phosphorylation of JAK2 protein23907460
D011794QuercetinQuercetin inhibits the reaction [Fructose results in decreased phosphorylation of JAK2 protein]22426011
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride promotes the reaction [GH1 protein results in increased phosphorylation of JAK2 protein]17272397
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in decreased expression of JAK2 mRNA26865669
D017382Reactive Oxygen SpeciesReactive Oxygen Species results in increased activity of JAK2 protein20523355
C059514resveratrolresveratrol results in decreased phosphorylation of JAK2 protein23372833|2691133
C059514resveratrolresveratrol inhibits the reaction [IFNG protein results in increased activity of JAK2 protein]21189227
C089730rosiglitazonerosiglitazone inhibits the reaction [IFNG protein results in increased phosphorylation of JAK2 protein]12584205
D012402RotenoneRotenone inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of JAK2 protein]15748169
D012402RotenoneRotenone inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased phosphorylation of JAK2 protein]]15677497
D012402RotenoneRotenone results in decreased phosphorylation of JAK2 protein19635391
D012431RutinRutin inhibits the reaction [Fructose results in decreased phosphorylation of JAK2 protein]22426011
D012822Silicon DioxideSilicon Dioxide results in decreased expression of JAK2 mRNA25351596
D019821SimvastatinMevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CTF1 results in increased expression of JAK2 protein]]16534557
D019821SimvastatinSimvastatin inhibits the reaction [CTF1 results in increased expression of JAK2 protein]16534557
D019821SimvastatinSimvastatin inhibits the reaction [CTF1 results in increased expression of JAK2 protein modified form]19100119
D019821SimvastatinSimvastatin inhibits the reaction [CTF1 results in increased phosphorylation of JAK2 protein]18400235
D019821SimvastatinSimvastatin results in decreased expression of JAK2 mRNA16414398
D019821SimvastatinSimvastatin results in decreased phosphorylation of JAK2 protein18400235
C017947sodium arsenitesodium arsenite inhibits the reaction [IFNG protein results in increased activity of JAK2 protein]15116095
C017947sodium arsenitesodium arsenite results in increased expression of and results in increased phosphorylation of JAK2 protein28444938
C017947sodium arsenitesodium arsenite results in increased expression of JAK2 mRNA28444938
D013141Spiro CompoundsSpiro Compounds analog results in decreased phosphorylation of JAK2 protein25320076
D013148SpironolactoneSpironolactone inhibits the reaction [Aldosterone results in increased phosphorylation of JAK2 protein]15932931
C517409statticstattic inhibits the reaction [deoxynivalenol results in increased expression of JAK2 mRNA]22454431
C517409statticstattic inhibits the reaction [T-2 Toxin results in increased expression of JAK2 mRNA]22454431
C041711St. Thomas' Hospital cardioplegic solutionSt. Thomas' Hospital cardioplegic solution results in increased expression of JAK2 mRNA16214533
C041711St. Thomas' Hospital cardioplegic solutionSt. Thomas' Hospital cardioplegic solution results in increased expression of JAK2 protein16214533
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of JAK2 mRNA21641980
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of JAK2 mRNA26378955
C016766sulforafansulforafan inhibits the reaction [Cyclosporine results in increased phosphorylation of JAK2 protein]23958496
D013605T-2 Toxin"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [T-2 Toxin results in increased expression of JAK2 mRNA]"22454431
D013605T-2 Toxinstattic inhibits the reaction [T-2 Toxin results in increased expression of JAK2 mRNA]22454431
D013605T-2 ToxinT-2 Toxin results in increased expression of JAK2 mRNA22454431
D016559TacrolimusTacrolimus results in increased phosphorylation of JAK2 protein23958496
C004648testosterone enanthatetestosterone enanthate results in increased expression of JAK2 mRNA25603467
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of JAK2 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of JAK2 mRNA19619570
D013749TetrachlorodibenzodioxinAHR gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of JAK2 mRNA]22978700
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of JAK2 mRNA21570461|2821309
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of JAK2 mRNA22978700
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of JAK2 mRNA17942748|1868492
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of JAK2 mRNA22298810
C528327TG101348JAK2 gene mutant form affects the susceptibility to TG10134826300391
C528327TG101348TG101348 results in decreased activity of JAK2 protein26300391
D058924ThienopyridinesThienopyridines binds to JAK2 protein22087750
C479163tofacitinibJAK2 gene mutant form affects the susceptibility to tofacitinib26300391
C479163tofacitinibtofacitinib inhibits the reaction [IL6 protein results in increased phosphorylation of JAK2 protein]21844139
C479163tofacitinibtofacitinib inhibits the reaction [OSM protein results in increased phosphorylation of and results in increased activity of JAK2 protein]23968543
C479163tofacitinibtofacitinib inhibits the reaction [OSM protein results in increased phosphorylation of JAK2 protein]21548952
C479163tofacitinibtofacitinib results in decreased activity of JAK2 protein26300391
C479163tofacitinibtofacitinib results in decreased activity of JAK2 protein21155605
C012589trichostatin Atrichostatin A inhibits the reaction [Nickel affects the expression of JAK2 mRNA]14575637
D014520UrethaneUrethane results in increased expression of JAK2 mRNA28818685
D014520Urethane[Urethane co-treated with Freund's Adjuvant] results in increased expression of JAK2 mRNA12400877
D014520UrethaneUrethane results in increased expression of JAK2 mRNA12400877
D014635Valproic AcidValproic Acid results in decreased expression of JAK2 mRNA25716160
D014635Valproic AcidValproic Acid results in increased expression of JAK2 mRNA29154799
D014635Valproic AcidValproic Acid results in increased methylation of JAK2 gene29154799
D000068756ValsartanValsartan inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased phosphorylation of JAK2 protein]]15677497
C066075vanadium pentoxidevanadium pentoxide results in decreased expression of JAK2 mRNA17459161
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of JAK2 gene25560391
C025643vinclozolinvinclozolin results in increased expression of JAK2 mRNA23555832
D014800VitalliumVitallium analog results in increased expression of JAK2 mRNA23825117
D014801Vitamin AVitamin A affects the localization of JAK2 protein15963505
D002762CholecalciferolCholecalciferol results in increased expression of JAK2 mRNA17170073
C079049volinanserin"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[[volinanserin binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein]"18976543
C079049volinanserin[volinanserin binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein18976543
C079049volinanserin[[volinanserin binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein18976543
C519885WP1066WP1066 results in decreased phosphorylation of JAK2 protein18056455|1824554
C519885WP1066WP1066 results in increased degradation of JAK2 protein18056455
D015215Zidovudine[Zidovudine co-treated with IFNA1 protein] results in increased expression of JAK2 mRNA20370541
C088658zoledronic acidzoledronic acid results in increased expression of JAK2 mRNA24714768
C067172zopolrestatzopolrestat results in decreased phosphorylation of and results in decreased activity of JAK2 protein15746188

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004672protein kinase activity-TAS-  
GO:0004713protein tyrosine kinase activity-EXP9111318  15143187  20304997  
GO:0004713protein tyrosine kinase activity-IDA23061660  
GO:0004713protein tyrosine kinase activity-ISS-  
GO:0004713protein tyrosine kinase activity-TAS-  
GO:0004715non-membrane spanning protein tyrosine kinase activity-TAS-  
GO:0005088Ras guanyl-nucleotide exchange factor activity-TAS-  
GO:0005102signaling receptor binding-IPI11201744  
GO:0005131growth hormone receptor binding-IBA21873635  
GO:0005131growth hormone receptor binding-ISS-  
GO:0005143interleukin-12 receptor binding-ISS-  
GO:0005515protein binding-IPI9516124  11679576  11694501  11970898  15821101  16437163  
17474147  18692472  19234114  20353823  21806020  24931576  
25092874  26175413  
GO:0005524ATP binding-IEA-  
GO:0008022protein C-terminus binding-IEA-  
GO:0019901protein kinase binding-IDA10925297  
GO:0020037heme binding-IDA21036157  
GO:0031702type 1 angiotensin receptor binding-IEA-  
GO:0033130acetylcholine receptor binding-IEA-  
GO:0035401histone kinase activity (H3-Y41 specific)-IBA21873635  
GO:0035401histone kinase activity (H3-Y41 specific)-IDA19783980  
GO:0042169SH2 domain binding-IPI9727029  
GO:0042393histone binding-IDA19783980  
GO:0042802identical protein binding-IPI21841788  22820988  
GO:0043548phosphatidylinositol 3-kinase binding-IEA-  
GO:0043560insulin receptor substrate binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO:0051428peptide hormone receptor binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000165MAPK cascade-TAS-  
GO:0000186activation of MAPKK activity-IEA-  
GO:0002250adaptive immune response-IEA-  
GO:0006468protein phosphorylation-TAS9670957  
GO:0006915apoptotic process-ISS-  
GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process-ISS-  
GO:0007165signal transduction-ISS-  
GO:0007167enzyme linked receptor protein signaling pathway-ISS-  
GO:0007186G-protein coupled receptor signaling pathway-IEA-  
GO:0007204positive regulation of cytosolic calcium ion concentration-IEA-  
GO:0007259JAK-STAT cascade-TAS9670957  
GO:0007260tyrosine phosphorylation of STAT protein-IBA21873635  
GO:0007260tyrosine phosphorylation of STAT protein-ISS-  
GO:0007498mesoderm development-TAS9590174  
GO:0007596blood coagulation-TAS-  
GO:0008285negative regulation of cell proliferation-ISS-  
GO:0008631intrinsic apoptotic signaling pathway in response to oxidative stress-IEA-  
GO:0010667negative regulation of cardiac muscle cell apoptotic process-IEA-  
GO:0010811positive regulation of cell-substrate adhesion-IDA10925297  
GO:0014068positive regulation of phosphatidylinositol 3-kinase signaling-ISS-  
GO:0018108peptidyl-tyrosine phosphorylation-ISS-  
GO:0019221cytokine-mediated signaling pathway-IBA21873635  
GO:0019221cytokine-mediated signaling pathway-IDA8609418  
GO:0019221cytokine-mediated signaling pathway-ISS-  
GO:0019221cytokine-mediated signaling pathway-TAS-  
GO:0022408negative regulation of cell-cell adhesion-IEA-  
GO:0030041actin filament polymerization-NAS10925297  
GO:0030154cell differentiation-ISS-  
GO:0030155regulation of cell adhesion-IBA21873635  
GO:0030218erythrocyte differentiation-IBA21873635  
GO:0030218erythrocyte differentiation-ISS-  
GO:0030335positive regulation of cell migration-IEA-  
GO:0031103axon regeneration-IEA-  
GO:0031959mineralocorticoid receptor signaling pathway-IEA-  
GO:0032024positive regulation of insulin secretion-IEA-  
GO:0032496response to lipopolysaccharide-ISS-  
GO:0032516positive regulation of phosphoprotein phosphatase activity-IEA-  
GO:0032731positive regulation of interleukin-1 beta production-IEA-  
GO:0032760positive regulation of tumor necrosis factor production-ISS-  
GO:0033160positive regulation of protein import into nucleus, translocation-IEA-  
GO:0033194response to hydroperoxide-IEA-  
GO:0033209tumor necrosis factor-mediated signaling pathway-IDA8609418  
GO:0034612response to tumor necrosis factor-IDA8609418  
GO:0035409histone H3-Y41 phosphorylation-IBA21873635  
GO:0035409histone H3-Y41 phosphorylation-IDA19783980  
GO:0035556intracellular signal transduction-ISS-  
GO:0035722interleukin-12-mediated signaling pathway-IDA7528775  
GO:0035722interleukin-12-mediated signaling pathway-TAS-  
GO:0038155interleukin-23-mediated signaling pathway-TAS-  
GO:0042531positive regulation of tyrosine phosphorylation of STAT protein-ISS-  
GO:0042976activation of Janus kinase activity-ISS-  
GO:0042981regulation of apoptotic process-IBA21873635  
GO:0043388positive regulation of DNA binding-IEA-  
GO:0043392negative regulation of DNA binding-ISS-  
GO:0043524negative regulation of neuron apoptotic process-IEA-  
GO:0045429positive regulation of nitric oxide biosynthetic process-IEA-  
GO:0045597positive regulation of cell differentiation-IEA-  
GO:0045822negative regulation of heart contraction-IEA-  
GO:0046425regulation of JAK-STAT cascade-ISS-  
GO:0046677response to antibiotic-IDA16280321  
GO:0046777protein autophosphorylation-ISS-  
GO:0048008platelet-derived growth factor receptor signaling pathway-IEA-  
GO:0050727regulation of inflammatory response-IDA10925297  
GO:0050729positive regulation of inflammatory response-IEA-  
GO:0050731positive regulation of peptidyl-tyrosine phosphorylation-ISS-  
GO:0050867positive regulation of cell activation-IEA-  
GO:0051091positive regulation of DNA-binding transcription factor activity-IEA-  
GO:0051770positive regulation of nitric-oxide synthase biosynthetic process-ISS-  
GO:0060333interferon-gamma-mediated signaling pathway-TAS-  
GO:0060334regulation of interferon-gamma-mediated signaling pathway-TAS-  
GO:0060396growth hormone receptor signaling pathway-IDA10925297  
GO:0060397JAK-STAT cascade involved in growth hormone signaling pathway-ISS-  
GO:0060397JAK-STAT cascade involved in growth hormone signaling pathway-TAS-  
GO:0060399positive regulation of growth hormone receptor signaling pathway-ISS-  
GO:0061180mammary gland epithelium development-ISS-  
GO:0070102interleukin-6-mediated signaling pathway-TAS-  
GO:0070106interleukin-27-mediated signaling pathway-TAS-  
GO:0070671response to interleukin-12-IDA7528775  
GO:0070757interleukin-35-mediated signaling pathway-TAS-  
GO:0097191extrinsic apoptotic signaling pathway-ISS-  
GO:0097296activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway-ISS-  
GO:1902728positive regulation of growth factor dependent skeletal muscle satellite cell proliferation-IEA-  
GO:1904037positive regulation of epithelial cell apoptotic process-IEA-  
GO:1904707positive regulation of vascular smooth muscle cell proliferation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA10502458  19783980  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IDA10502458  
GO:0005829cytosol-TAS-  
GO:0005856cytoskeleton-IEA-  
GO:0005886plasma membrane-IDA-  
GO:0005901caveola-ISS-  
GO:0005925focal adhesion-IDA-  
GO:0016363nuclear matrix-IEA-  
GO:0031904endosome lumen-TAS-  
GO:0045121membrane raft-ISS-  
KEGG ID KEGG Term
hsa04062Chemokine signaling pathway
hsa04630Jak-STAT signaling pathway
hsa04920Adipocytokine signaling pathway
hsa05140Leishmaniasis
hsa05145Toxoplasmosis
Reactome ID Reactome Term Evidence
R-HSA-1059683Interleukin-6 signalingTAS
R-HSA-1059683Interleukin-6 signalingIEA
R-HSA-109582HemostasisTAS
R-HSA-110056MAPK3 (ERK1) activationTAS
R-HSA-112409RAF-independent MAPK1/3 activationTAS
R-HSA-112411MAPK1 (ERK2) activationTAS
R-HSA-1170546Prolactin receptor signalingIEA
R-HSA-1170546Prolactin receptor signalingTAS
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1280215Cytokine Signaling in Immune systemIEA
R-HSA-1433557Signaling by SCF-KITTAS
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-1640170Cell CycleTAS
R-HSA-1643685DiseaseTAS
R-HSA-168256Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-2586552Signaling by LeptinIEA
R-HSA-3214858RMTs methylate histone argininesTAS
R-HSA-3247509Chromatin modifying enzymesTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-392451G beta:gamma signalling through PI3KgammaTAS
R-HSA-397795G-protein beta:gamma signallingTAS
R-HSA-447115Interleukin-12 family signalingIEA
R-HSA-447115Interleukin-12 family signalingTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-449147Signaling by InterleukinsIEA
R-HSA-451927Interleukin-2 family signalingTAS
R-HSA-453279Mitotic G1-G1/S phasesTAS
R-HSA-4839726Chromatin organizationTAS
R-HSA-512988Interleukin-3, 5 and GM-CSF signalingTAS
R-HSA-512988Interleukin-3, 5 and GM-CSF signalingIEA
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-5673000RAF activationTAS
R-HSA-5673001RAF/MAP kinase cascadeTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5684996MAPK1/MAPK3 signalingTAS
R-HSA-6783589Interleukin-6 family signalingTAS
R-HSA-6783589Interleukin-6 family signalingIEA
R-HSA-6785807Interleukin-4 and 13 signalingTAS
R-HSA-6788467IL-6-type cytokine receptor ligand interactionsTAS
R-HSA-6802946Signaling by moderate kinase activity BRAF mutantsTAS
R-HSA-6802949Signaling by RAS mutantsTAS
R-HSA-6802952Signaling by BRAF and RAF fusionsTAS
R-HSA-6802955Paradoxical activation of RAF signaling by kinase inactive BRAFTAS
R-HSA-6802957Oncogenic MAPK signalingTAS
R-HSA-69231Cyclin D associated events in G1TAS
R-HSA-69236G1 PhaseTAS
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-877300Interferon gamma signalingTAS
R-HSA-877300Interferon gamma signalingIEA
R-HSA-877312Regulation of IFNG signalingIEA
R-HSA-877312Regulation of IFNG signalingTAS
R-HSA-8854691Interleukin-20 family signalingTAS
R-HSA-8984722Interleukin-35 SignallingTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS
R-HSA-9020591Interleukin-12 signalingIEA
R-HSA-9020591Interleukin-12 signalingTAS
R-HSA-9020933Interleukin-23 signalingIEA
R-HSA-9020933Interleukin-23 signalingTAS
R-HSA-9020956Interleukin-27 signalingIEA
R-HSA-9020956Interleukin-27 signalingTAS
R-HSA-912526Interleukin receptor SHC signalingTAS
R-HSA-913531Interferon SignalingTAS
R-HSA-913531Interferon SignalingIEA
R-HSA-982772Growth hormone receptor signalingTAS
R-HSA-982772Growth hormone receptor signalingIEA
R-HSA-983231Factors involved in megakaryocyte development and platelet productionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26437571Oxidative status in treatment-naive essential thrombocythemia: a pilot study in a single center. (2017 Sep)Iurlo AHematol Oncol
25807961Thrombosis in thrombocythemic Ph- myeloproliferations is associated with higher platelet count prior to the event: results of analyses of prothrombotic risk factors from a registry of patients treated with anagrelide. (2016 Jan)Schwarz JEur J Haematol
26253658M2 polarized macrophages induced by CSE promote proliferation, migration, and invasion of alveolar basal epithelial cells. (2015 Sep)Fu XInt Immunopharmacol
25104439Genetic variation in the JAK/STAT/SOCS signaling pathway influences breast cancer-specific mortality through interaction with cigarette smoking and use of aspirin/NSAIDs: the Breast Cancer Health Disparities Study. (2014 Aug)Slattery MLBreast Cancer Res Treat
25259522A new IRAK-M-mediated mechanism implicated in the anti-inflammatory effect of nicotine via alpha7 nicotinic receptors in human macrophages. (2014)Maldifassi MCPLoS One
28750889Reciprocal activation of alpha5-nAChR and STAT3 in nicotine-induced human lung cancer cell proliferation. (2017 Jul 20)Zhang YJ Genet Genomics
24312736A case of erythrocytosis in a patient treated with an aromatase inhibitor for breast cancer. (2013)Iyengar ACase Rep Hematol
20943775alpha4beta2 nicotinic receptors partially mediate anti-inflammatory effects through Janus kinase 2-signal transducer and activator of transcription 3 but not calcium or cAMP signaling. (2011 Jan)Hosur VMol Pharmacol
22614008Nicotine/cigarette smoke promotes metastasis of pancreatic cancer through alpha7nAChR-mediated MUC4 upregulation. (2013 Mar 14)Momi NOncogene
21151631Cerebral Venous Thrombosis and Venous Infarction: Case Report of a Rare Initial Presentation of Smoker's Polycythemia. (2010 Nov 22)Raval MCase Rep Neurol
22121102JAK/STAT/SOCS-signaling pathway and colon and rectal cancer. (2013 Feb)Slattery MLMol Carcinog
23193966Contribution of JAK2 and STAT3 variants to the genetic susceptibility of recurrent spontaneous miscarriage in a Tunisian population. (2013 Jan)Messaoudi SGenet Test Mol Biomarkers
21953826Janus Kinase V617F mutation in cigarette smokers. (2012 Jan)Weinberg IAm J Hematol
26281600[R-value comprehensive evaluation of effect of three methods for lung-kidney comprehensive evaluation study on R value of three methods for regulating and invigorating lung and kidney in regulating lung inflammation signaling pathways in COPD rats]. (2015 Apr)Cui HXZhongguo Zhong Yao Za Zhi
27925044Application of prognostic score IPSET-thrombosis in patients with essential thrombocythemia of a Brazilian public service. (2016 Oct)Navarro LMRev Assoc Med Bras (1992)
24894179Lyn regulates cytotoxicity in respiratory epithelial cells challenged by cigarette smoke extracts. (2014)Wang WCurr Mol Med
22891616Characterization of blood donors with high haemoglobin concentration. (2013 Feb)Magnussen KVox Sang
25482056Fetal lung and placental methylation is associated with in utero nicotine exposure. (2014 Nov)Chhabra DEpigenetics
22825367Extrahepatic portal venous system thrombosis in recurrent acute and chronic alcoholic pancreatitis is caused by local inflammation and not thrombophilia. (2012 Oct)Rebours VAm J Gastroenterol
23802852Lung adenocarcinoma biomarker incidence in Hispanic versus non-Hispanic white patients. (2014 Mar)McQuitty EArch Pathol Lab Med
18386616Arterial stenosis and atherothrombotic events in polycythemia vera and essential thrombocythemia. (2006)Cucuianu ARom J Intern Med
24142566When water does not clear the smut from the smoke. (2013 Oct 18)Bonadies NBMJ Case Rep
29085634Prevalence of the Janus kinase 2 V617F mutation in Philadelphia-negative myeloproliferative neoplasms in a Portuguese population. (2017 Oct)Azevedo APBiomed Rep
24482100Hereditary gene mutations in Korean patients with isolated erythrocytosis. (2014 Jun)Jang JHAnn Hematol
25007143Pulmonary adenocarcinoma with signet ring cell features: a comprehensive study from 3 distinct patient cohorts. (2014 Dec)Boland JMAm J Surg Pathol
17543182Mediating effect of dopamine D3 receptors on Jak2 and GABAAalpha1 expression in mouse brains induced by cocaine. (2007 May 20)Liu NYChin Med J (Engl)
25198511Induction of murine macrophage M2 polarization by cigarette smoke extract via the JAK2/STAT3 pathway. (2014)Yuan FPLoS One
22084670Gender and Vascular Complications in the JAK2 V617F-Positive Myeloproliferative Neoplasms. (2011)Stein BLThrombosis